삼색도장버섯(Daedaleopsis tricolor)에서 추출한 조다당류의 면역 활성 및 항암 효과

심성미 ( Sim Seong Mi ),임경환 ( Im Gyeong Hwan ),김정완 ( Kim Jeong Wan ),이우윤 ( Lee U Yun ),김하원 ( Kim Ha Won ),이민웅 ( Lee Min Ung ),이태수 ( Lee Tae Su ) 한국균학회 2003 韓國菌學會誌 Vol.31 No.3

조선시대 모란도 제작 양상의 일면

심성미(Sim Sung-mi) 한국민화학회 2011 한국민화 Vol.- No.2

매미눈꽃동충하초(Paecilomyces sinclairii)로부터 추출한 조다당류의 면역 활성과 항암 효과에 관한 연구

심성미 ( Sim Seong Mi ),임경환 ( Im Gyeong Hwan ),이우윤 ( Lee U Yun ),김정완 ( Kim Jeong Wan ),심미자 ( Sim Mi Ja ),이민웅 ( Lee Min Ung ),이태수 ( Lee Tae Su ) 한국균학회 2003 韓國菌學會誌 Vol.31 No.3

19세기 모란도 성행과 조선사회의 부귀지향

심성미 ( Sung Mi Sim ) 한국불교미술사학회(한국미술사연구소) 2016 강좌미술사 Vol.46 No.-

이 논문은 19 세기 조선사회에서 대거 유행한 모란도 성행의 원인과 배경을 규명하는 것이다. 19 세기 이전 조선회화사에서 모란도의 회화적 존재감은 미미하다. 매화, 대나무, 난 등의 유교적 덕목을 상징하는 소재의 그림이 조선시대 전반에 걸쳐 성행했던 점과 비교해 보면, 조선시대 문인화 가들이 의도적으로 모란을 그리지 않았음을 알 수 있다. 모란은 부귀의 상징성이 매우 강한 꽃이다. 모란의 상징은 조선시대 유가적 문인들에게는 항상 조심하고 경계해야 하는 부정적 이미지로 작용 하였다. 이러한 내용은 문인들이 남긴 시문에서 확인할 수 있다. 하지만 19 세기에 이르면 이러한 양상은 급변한다. 모란은 19 세기 대중이 애호하는 회화적 소재로 각광받았다. 허련(1808-1893)은 ``허모란``이라는 별칭을 얻을 만큼 묵모란도 작품을 많이 그렸고 현재 60 여점의 묵모란도가 남아있으며, 그의 영향을 받은 다른 작가들이 그린 동일한 화풍의 묵모란 도가 다수 전하고 있다. 한편, 19 세기 민간의 생활공간 장식과 의례에 광범위하게 사용되었던 민화에서 모란도가 차지하는 비중은 매우 크다. 병풍 전체 화폭에 모란을 단독 畵材로 그린 모란병 이 많이 남아있고, 화조도 병풍에서도 모란은 필수 화재로 선호되었으며 심지어 화조도 병풍 1 틀의 2-3개 화폭이 모란으로 채워지기도 하였다. 결국 우리나라 회화사에서 모란도는 19 세기에 와서 그 꽃을 활짝 피우게 되었다. 그렇다면 19 세기 모란도의 대중적인 성행은 어디에서 연유된 것일까? 이러한 의문을 모란이 상징하는 ``부귀``에 초점을 맞추어 19 세기 조선사회의 사회변동적 상황에서 해답을 찾았다. 조선의 19세기는 전통적 사회체계를 흔드는 새로운 사상적 움직임과 변혁에 대한 욕구가 적극적으로 표출되었던 격변의 세기였다. 결과적으로 19 세기는 강고하게 지탱되어온 신분차별의 견고한 틀이 와해되는 역사적인 전환점을 맞이한다. 19 세기 조선사회의 변동구조 속에서 가장 힘을 잃어가는 것은 관념적인 유교의 도덕 가치관이었고, 가장 힘을 얻기 시작한 것은 현실적인 경제 이익의 추구였다. 경제적인 부의 성취가 신분제 사회를 대신하는 새로운 권력구조의 기준으로 부각되는 사회적 변모 양상이 모란도가 대중적으로 애호 받았던 배경이 되었다. 19 세에 이르러 모란도가 꽃을 활짝 피운 이유는, 19 세기 조선 지식인들에게 ``부귀``가 비로소 추구해야 할 가치 덕목으로 용인되었고, 사회 전반에 걸쳐 대중적으로 부귀지향적 성향이 대두되었기 때문이다. This study aims to find out reasons and background on prevalence of peony paintings in the Chosun dynasty during the 19th century. In terms of the Chosun painting history, peony paintings could not have been in the spotlight until 19th century. Comparing to popularity of the Four Gracious Plants - plum, orchid, chrysanthemum and bamboo symbolizing virtues of Confucianism in Chosun, it seems that literary artists in Chosun intentionally did not paint peony paintings. Peony has been strongly recognized as a symbol of wealth. Due to the symbolism, Confucian writers tried to keep peony away - at that time, the symbolism was not positive meaning but had strong negative images for them. The negative image of the peony can be easily found in their poems and verses. However, this trend was dramatically changed at the turns of the 19th century. In this century, the public loved peony as a painting subject. Heo Ryeon(1808-1893), also known as "Peony Heo", drew a lot of black ink peony paintings - until now, 60 pieces of them have remained. Many painters greatly impressed with his work also drew black ink peony paintings in a similar style. Meanwhile, peony paintings have significant weight in folk paintings widely used in living space ornaments and rituals in the 19th century. Many folding screens themed by peony as a single subject are well preserved. Especially, in flowers and birds folding screens, peony has been loved as a essential subject and some folding screens fill their 2~3 screens with peonies. In other words, the peony paintings started to blossom in 19th century. Therefore, this study questions why peony painting were becoming popularly thriving in the 19th century. The research focuses on "wealth" peony represents and finds out the reason from an ideological shift in Chosun during the 19th century. In Chosun, 19th century had seen drastic changes with the emergence of ideology reforming a social structure and people had actively expressed desire for revolution. As a result, in the 19th century, Chosun faced historical turning point would abolish social status discrimination strongly placed before that. In this situation, tangible economic interest started taking center stage, while moral value based on ideological confucianism continued to be fading. The new power structure that wealth attainment replaces the existing status system was emerged and this social transition led to the trend peony paintings attracted the public. The reason peony paintings drew attention in the 19th century can be explained with two factors. First, intellectuals were allowed for the first time to seek wealth as a virtue, and second, throughout the society, the trend of pursuing wealth widely spreaded in the 19th century.

매미눈꽃동충하초(Paecilomyces sinclairii)의 균사 생장과 자실체 형성 조건의 특성

심성미 ( Sung Mi Shim ),이경림 ( Kyung Rim Lee ),임경환 ( Kyung Hoan Im ),이우윤 ( U Youn Lee ),이민웅 ( Min Woong Lee ),이태수 ( Tae Soo Lee ) 한국균학회 2003 韓國菌學會誌 Vol.31 No.1

Optimized Internal Control and Gene Expression Analysis in Epstein-Barr Virus-Transformed Lymphoblastoid Cell Lines

남혜영,김헤련,심성미,이재은,김준우,박혜경,한복기,전재필 한국유전체학회 2011 Genomics & informatics Vol.9 No.3

The Epstein-Barr virus-transformed lymphoblastoid cell line (LCL) is one of the major genomic resources for human genetics and immunological studies. Use of LCLs is currently extended to pharmacogenetic studies to investigate variations in human gene expression as well as drug responses between individuals. We evaluated four common internal controls for gene expression analysis of selected hematopoietic transcriptional regulatory genes between B cells and LCLs. In this study, the expression pattern analyses showed that TBP (TATA box-binding protein) is a suitable internal control for normalization,whereas GAPDH (glyceraldehyde-3-phosphate dehydrogenase) is not a good internal control for gene expression analyses of hematopoiesis-related genes between B cells and LCLs at different subculture passages. Using the TBP normalizer, we found significant gene expression changes in selected hematopoietic transcriptional regulatory genes (downregulation of RUNX1 , RUNX3 , CBFB , TLE1, and NOTCH2 ; upregulation of MSC and PLAGL2) between B cells and LCLs at different passage numbers. These results suggest that these hematopoietic transcriptional regulatory genes are potential cellular targets of EBV infection,contributing to EBV-mediated B-cell transformation and LCL immortalization.

Novel Promoter Polymorphism in RUNX2 Is Associated with Serum Triglyceride Level

신형두,전재필,박병래,배준설,남혜영,심성미,박경수,한복기 한국분자세포생물학회 2008 Molecules and cells Vol.26 No.5

Much research evidence supports the hypothesis that chronic, low-grade inflammation related to innate immunity may play an important role in the pathophysiology of type 2 diabetes mellitus (T2DM). Runt-related transcription factor 2 (RUNX2; MIM# 600211) acts as a scaffold that controls the integration, organization, and assembly of nucleic acids. To examine whether the novel promoter variant in orkuO is associated with the risk of T2DM and related phenotypes, RUNX2-742G >T was genotyped in 378 T2DM patients and 382 normal controls recruited in the Korean T2DM Study. Statistical analysis revealed that RUNX2-742G >T was associated with serum triglyceride level (TG) in nondiabetic controls, although it was not associated with the risk of T2DM. Individuals who carry T/T, T/G, and G/G genotypes had the highest (2.061 ± 0.20), intermediate (2.01 ± 0.19), and the lowest (1.97 ± 0.18) levels of log [TG (mmol/l)] (P = 0.007), respectively. Our data on this important variant of orkuO suggest that lipid metabolism might be affected by genetic polymorphisms in the promoter region.

경기도 화성시 융건릉의 균류상 조사연구

오윤희,김성환,김태형,김혜영,나정은,심성미,이경림,윤영준,이지원,이우윤,김승곤,이민웅,이태수 인천대학교 2002 論文集 Vol.27 No.1

Fungi were collected at Yungunneung, Hwasung City, Gyeonggi-do from November 20, 2001 to September 20, 2002. A total of 121 species of fungi were collected. The Collected fungi belong to 3 divisions, 14 orders, 38 families, 72 genera. Dominant fungal families were Tricholomataceae, Polyporaceae and Russulaceae. On the respect of mycological resources, edible mushrooms were 60 species ; culturable mushrooms were 12 species ; poisonous mushrooms were 12 species ; medicinal mushrooms were 8 species, anti-tumor substance containing mushrooms were 4 species ; ectomycorrizhal mushrooms were 26 species and wood-rotting fungi were 47 species.

The Brain Donation Program in South Korea

김예신,서연림,김승주,배문환,김재범,김윤아,최경찬,허기영,김은주,이중석,강현욱,심성미,임현정,고영호,김병채,이경화,이민철,이호원,임태성,William W. Seeley,김희진,나덕렬,이경훈,서상원 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.10

Purpose: Obtaining brain tissue is critical to definite diagnosis and to furthering understanding of neurodegenerative diseases. The present authors have maintained the National Neuropathology Reference and Diagnostic Laboratories for Dementia in South Korea since 2016. We have built a nationwide brain bank network and are collecting brain tissues from patients with neurodegenerativediseases. We are aiming to facilitate analyses of clinic-pathological and image-pathological correlations of neurodegenerativedisease and to broaden understanding thereof. Materials and Methods: We recruited participants through two routes: from memory clinics and the community. As a baseline evaluation, clinical interviews, a neurological examination, laboratory tests, neuropsychological tests, and MRI were undertaken. Some patients also underwent amyloid PET. Results: We recruited 105 participants, 70 from clinics and 35 from the community. Among them, 11 died and were autopsied. The clinical diagnoses of the autopsied patients included four with Alzheimer’s disease (AD), two with subcortical vascular dementia,two with non-fluent variant primary progressive aphasia, one with leukoencephalopathy, one with frontotemporal dementia(FTD), and one with Creutzfeldt-Jakob disease (CJD). Five patients underwent amyloid PET: two with AD, one with mixed dementia, one with FTD, and one with CJD. Conclusion: The clinical and neuropathological information to be obtained from this cohort in the future will provide a deeper understanding of the neuropathological mechanisms of cognitive impairment in Asia, especially Korea.

Proposal Guidelines for Standardized Operating Procedures of Brain Autopsy: Brain Bank in South Korea

이경화,이민철,서상원,임태성,김은주,김병채,김예신,이호원,전재필,심성미,Duk L. Na,허기영,서연림 연세대학교의과대학 2017 Yonsei medical journal Vol.58 No.5

To obtain an in-depth understanding of brain diseases, including neurodegenerative diseases, psychiatric illnesses, and neoplasms, scientific approach and verification using postmortem human brain tissue with or without disease are essential. Compared to othercountries that have run brain banks for decades, South Korea has limited experience with brain banking; nationwide brain banks started only recently. The goal of this study is to provide provisional guidelines for brain autopsy for hospitals and institutes that have not accumulated sufficient expertise. We hope that these provisional guidelines will serve as a useful reference for pathologistsand clinicians who are involved and interested in the brain bank system. Also, we anticipate updating the provisional guidelines in the future based on collected data and further experience with the practice of brain autopsy in South Korea.