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관류자기공명 영상처리 알고리즘을 이용한 대뇌 혈류량 맵의 구현
박병래 한국콘텐츠학회 2005 한국콘텐츠학회논문지 Vol.5 No.5
고양이 뇌 지방색전증을 유발한 후 자기공명 관류영상기법을 이용하여 대뇌혈류량을 정량적으로 분석하고 동적특성 변화를 구현 할 수 있는 기법을 제안한다. 고양이 20마리를 대상으로 한쪽 내경동맥에 리노레익 (n=11)을 주입하여 뇌 지방색전을 유발시켰고, 대조군으로는 이바론 입자 (n=9)를 주입하여 색전이 유발되게 하였다. 그 후 30분과 2시간에 각각 T2강조, 확산강조영상을 획득하고 가장 색전이 많이 일어난 부위에서 관류강조영상을 획득하였다. 획득한 데이터는 IDL 소프트웨어와 자체 개발한 영상처리 알고리즘을 이용하여 신호강도 곡선을 ΔR2* 곡선으로 변환한 후 적분하여 뇌혈류량을 측정하였다. 실험군에서 병변부위의 뇌혈류량은 정상부위에 비해 감소하였으며, 뇌혈류량 비는 시간경과에 따라 유의한 차이가 있었다 (P〈0.005). 뇌 지방색전증의 초기에는 혈류량이 감소하였으나, 2시간에서는 30분에 비해 뇌혈류량이 다소 증가됨을 관찰 할 수 있었다. 뇌경색 발생시 조기에 자기공명확산 및 관류강조영상을 획득하여 개발한 영상처리 알고리즘을 적용하여 뇌 혈류량의 다양한 동적변화 특성 및 혈류역학적 변화를 상대적 관류도 맵으로 얻을 수 있었다. Quantitative analysis compare to dynamic characteristic change of the regional cerebral blood volume(rCBV) after development of cerebral fat embolism in cats using perfusion magnetic resonance(MR) Imaging. Twenty cats were used. Linoleic acid (n=11) were injected into the internal carotid artery using microcatheter through the transfemoral approach. Polyvinyl alcohol (Ivalon) (n=9) was injected as a control group. Perfusion MR images were obtained at 30 minutes and 2 hours after embolization, based on T2 and diffusion-weighted images. The data was time-to-signal intensity curve and ΔR2* curve were obtained continuously with the aid of home-maid image process algorithm and IDL(interactive data language, USA) softwares. The ratios of rCBV increased significantly at 2 hours compared with those of 30 minutes (P< 0.005). In conclusion, cerebral blood flow decreased in cerebral fat embolism immediately after embolization and recovered remarkably in time course. It is thought that clinically informations to dynamic characteristic change of the cerebral hemodynamics to the early finding in cerebral infarction by diffusion weighted imaging(DWI) and perfusion weighted imaging(PWI).
Magnetic Resonance Imaging and Pathologic Correlation of Cerebral Fat Embolism using Oleic Acid
박병래 THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 2004 Journal of biomedical laboratory sciences Vol.10 No.2
To investigate the correlation between the magnetic resonance imaging (MRI) of cerebral fat embolism that is induced by injecting oleic acid into 10 cats, and a pathologic diagnosis. Using a microcatheter, 30 μl of oleic acid was injected into the internal carotid artery of 10 cats. MR T2-weighted image (T2WI), diffusion-weighted image (DWI) and Gadolinium-enhanced T1-weighted image (Gd-enhanced T1WI) were obtained after 30 minutes and 2 hours of embolization. After 30 minutes of the embolization, lesions of very high signal intensity were detected by T2WI in 6 cats, and of slightly high signal intensity in 2 cats; in the remaining 2 cats, signal intensity was normal. DWI showed lesions of very high intensity in 9 cats and of slightly high intensity in one cat. According to the findings of light microscopic examination, infarcted lesions mainly involved the gray matter, but also some white matter. A magnetic resonance imaging diagnosis for cerebral fat embolism that was induced by oleic acid through the internal carotid artery in cats showed high signal intensity on the T2WI and the DWI within an initial 2 hours, and with a well enhancement on the Gd-enhanced T1WI. Considering cellular edema, cerebrovascular injury and extracellular space widening, we assumed pathologically that cytotoxic and vasogenic edema exists at the same time.
韓國 福祉政策의 方向과 課題 : 醫療保障을 중심으로 the Medical Security system
朴炳來 대구효성카돌릭대학교사회과학연구소 1998 사회과학연구 Vol.5 No.-
The purpose of this study is to examine Medicare system of Korea. There are many problems in korean Medicare system, especially unreasonableness of levy a medical premium, limit and level of insurance money payment etc. This study shows that the development of Korean Medicare system was influenced by socio-structural elements and socio-economic aspects. The former is a strong bond of Korean family, nonofficial social support, nonofficial cultural solidarity etc., the latter is the phase and level of economic development. Therefore this study come to the conclusion that its demand for explanation about the relations between the policies of medical insurance and the characteristics of the phase and level of nation development.