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남혜영,김헤련,심성미,이재은,김준우,박혜경,한복기,전재필 한국유전체학회 2011 Genomics & informatics Vol.9 No.3
The Epstein-Barr virus-transformed lymphoblastoid cell line (LCL) is one of the major genomic resources for human genetics and immunological studies. Use of LCLs is currently extended to pharmacogenetic studies to investigate variations in human gene expression as well as drug responses between individuals. We evaluated four common internal controls for gene expression analysis of selected hematopoietic transcriptional regulatory genes between B cells and LCLs. In this study, the expression pattern analyses showed that TBP (TATA box-binding protein) is a suitable internal control for normalization,whereas GAPDH (glyceraldehyde-3-phosphate dehydrogenase) is not a good internal control for gene expression analyses of hematopoiesis-related genes between B cells and LCLs at different subculture passages. Using the TBP normalizer, we found significant gene expression changes in selected hematopoietic transcriptional regulatory genes (downregulation of RUNX1 , RUNX3 , CBFB , TLE1, and NOTCH2 ; upregulation of MSC and PLAGL2) between B cells and LCLs at different passage numbers. These results suggest that these hematopoietic transcriptional regulatory genes are potential cellular targets of EBV infection,contributing to EBV-mediated B-cell transformation and LCL immortalization.
Cylindrical metric을 사용한 블록기반 컬러 영상 분할
남혜영,김보람,김욱현,Nam Hyeyoung,Kim Boram,Kim Wookhyun 대한전자공학회 2005 電子工學會論文誌-SP (Signal processing) Vol.42 No.3
In this paper we proposed the block-based color image segmentation method using the cylindrical metric to solve the problems such as long processing time and over segmentation due to noise and texture properties in the conventional methods. In the proposed method we define the new similarity function and the merge condition between regions to merge initial regions with the same size considering the color and texture properties of chromatic and achromatic regions which is defined according to the HSI color values, and we continue to merge boundary blocks into the adjacent region already segmented to maintain edges until the size of block is one. In the simulation results the proposed method is better than the conventional methods in the evaluation of the segmented regions of texture and edge region, and we found that the processing time is decreased by factor of two in the proposed method. 본 논문에서는 잡음이나 질감특성에 의한 과분할과 긴 처리시간 등의 기존 영역분할 방법이 갖는 문제점을 해결하기 위해 Cylindrical metric을 사용한 블록단위의 컬러영상분할방법을 제안하였다. 제안한 방법에서는 일정 크기로 분할된 블록들로 이루어진 초기 영역들을 병합하기 위해 HSI 컬러값에 따라 분류된 채색(chromatic) 영역과 비채색(achromatic) 영역의 컬러특성과 질감특성을 고려하여 영역간의 유사도 함수와 병합조건을 새로이 정의하며, 영역 병합 후의 명확한 윤곽검출을 위해 영역간의 경계부분에 위치하는 외곽블록들을 추출하여 기존 영역에 병합하는 과정을 화소레벨까지 반복한다. 모의실험을 실시한 결과, 질감영역과 윤곽영역의 분할에서 제안한 방법이 기존의 방법에 비해 우수한 것으로 나타났으며, 처리시간은 제안한 방법에서 2배 정도 단축됨을 알 수 있었다.
Poly(L-DOPA) Core-Templated Calcium Phosphate-Mineralized Nanoparticles for Cancer Therapy
남혜영,김다은,이홍재,이상천 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.1
To date, polymer micelles mineralized with natural inorganic species, such as calcium phosphate (CaP) or calcium carbonate, have been utilized as smart nanocarriers for cancer therapy. In this work, we describe a CaP-mineralized polymer micelle that can protect the drug release in blood and trigger the facilitated release at endosomal pH. It is known that CaP is naturally found as the main mineral component in bone. We selected doxorubicin (DOX) as an anticancer drug, and the DOX-loaded polymer micelles (DOX-PMs) were prepared by self-assembly of poly(ethylene glycol)-b-poly(L-3,4-dihydroxyphenylalanine) copolymer in the presence of DOX. For mineralization of DOX-PMs, the calcium cations and phosphate anions were sequentially added to the aqueous solution of DOX-PMs. The DOX-loaded mineralized polymer micelles described in this work may serve as a robust nanocarrier for cancer chemotherapy.
Endosomal pH-Responsive poly(L-DOPA) core-templated mineralized nanoparticles for cancer therapy
남혜영,이홍재,이상천 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1
To date, polymer micelles have been utilized as smart nanocarriers for cancer therapy. One of the recent issues is to improve the robustness of the polymer micelles, because the stability in the blood stream after i.v. injection is the prerequisite for successful delivery to tumor tissues. Herein, we describe a calcium phosphate (CaP)-mineralized polymer micelle for the design of a biocompatible nanocarrier. It is known that CaP is naturally found as the main mineral component in bone. We selected doxorubicin (DOX) as an anticancer drug, and the DOX-loaded polymer micelles (DOX-PMs) were prepared by self-assembly of poly (ethylene glycol)-b-poly(L-3,4-dihydroxyphenylalanine) copolymer in the presence of DOX. For mineralization of DOX-PMs, the calcium cations and phosphate anions were sequentially added to the aqueous solution of DOX-PMs. The DOX-loaded mineralized polymer micelles described in this work may serve as a robust nanocarrier for cancer chemotherapy.