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각족 늑막저류에서 Adenosine Deaminase 활성도에 관한 연구
성낙억(Nak Uk Sung),신계철(Kye Chul Shin),이홍재(Hong Jai Lee),이경원(Kyung Won Lee) 대한내과학회 1987 대한내과학회지 Vol.33 No.2
N/A Adenosine deaminase (ADA) ia an enzyme of purine metabolism, which catalizes the irreversible hydrolytic deamination of adenosine to produce inosine and ammonia. ADA is essential for the differentiation of lymphoid cells, particularly T cells, and also plays a role in the maturation of monocytes to macrophage. Therefore ADA levels are related to stimulation of cellular immunity. Recent investigations have demonstrated that the determination of ADA in pleural fluid is useful in the differential diagnosis of pleural effusion. In this study, pleural fluid ADA activities were measured in 127 patients with pleural effusion of various causes, According to the final diagnosis, the patients was devided into 6 groups: tuberculosis was 47 cases, suspected tuberculosis was 23 cases, empyema was 22 cases, pneumonia was 12 cases, malignancy was 12 cases and transudate was 11 cases. The result obtained were as follows: 1) The mean ADA activity in tuberculous effusion was 124.1±6.4 U/L, suspicious tuberculous effusion was 116.2±8.1 U/L, empyema was 112.2±18.3 U/L, parapneumonic effusion was 38.9±4.5 U/L, malignant effusion was 26.8±3.1 U/L, and transudative effusion was 7.4±1.5 U/L. 2) The ADA activities in exudative effusions showed significatnly higher values than those in transudative effusion (P<0.001). 3) The ADA activities in tuberculous effusions and empyema showed no significantly higher values than those in malignant or parapneumonic effusion (P<0. 001). 4) The ADA activities in tuberculous effsuions showed no significant difference compared with empyema (P>0.05). 5) The ADA activites above 50 U/L had a sensitivity of 100% and a specificity of 92% when used as a screening test for tuberculous effusions. 6) In tuberculous effusions, ADA activities showed no significant difference according to age, sex, onset, amount of effusion and association with pulmonary tuberculosis. It is suggested that the measurement of pleural fluid ADA activity, if excluding empyema, is a simple reliable test for the differential diagnosis of tuberculous and malignant pleural effusion.
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Y$(Ba_{1-x}, K_x)_2Cu_3O_y$의 초전도성
이형철,김성래,성낙억,강광용,노지현,장민수 한국전기전자재료학회 1990 電氣電子材料學會誌 Vol.3 No.1
YBa$_{2}$ Cu$_{3}$O$_{7-{\delta}}$의 Ba대신 K를 일부 치환시킨 Y(Ba$_{1-x}$ , $K_{x}$ )$_{2}$Cu$_{3}$O$_{y}$ 에서 x의 값에 따른 초전도 특성의 변화를 연구하였다. XRD 무늬와 Infrared의 투과율로써 상의 변화를 관측하고 온도에 따른 전기저항의 변화를 측정함으로써 초전도성을 조사하였다. Ba 대신 K의 양이 증가할수록 Y(Ba$_{1-x}$ ,K$_{x}$)$_{2}$Cu$_{3}$O$_{y}$ 는 다중상이 되어 갔고 전기저항이 0이 되는 T$_{c}$는 점점 더 낮은 온도로 이동하다가 x.geq.0.6이 되면 초전도 특성을 잃었다.을 잃었다..
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박금수,용석중,김원천,최경훈,성낙억 대한내과학회 1987 대한내과학회지 Vol.33 No.2
Left ventricular thrombosis is found in up to 30%. of cases with dilated cardiomyopathy. The main risk consists of unpredictable systemic embolization which is one of the cause of sudden death. The favorite site for lodgement of cardiac emboli is the middle cerebral artery and consequently cardiogenic cerebellar infarction without evidence of cerebral infarction is very rare. Recently we discovered a case of cerebellar infarction and large left ventricular thrombus by two-dimensional echocardiography in a 26 year old male patient who was previously diagnosed as idiopathic dilated cardiomyopathy. We treated the patient with anticoagulant therapy and found significant resolution of left ventricular thrombus by two-dimensional echocardiography about 1 month later. Therefore this case is reported along with a brief review of the literature.
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결핵성 뇌막염 진단에 있어서 뇌척수액 Adenosine Deaminase 활성도에 관한 연구
배선우(Seon Woo Bae),김원천(Won Tsen Kim),전근재(Geun Jae Jeon),성낙억(Nak Uk Sung),최경규(Kyung Gui Choi),최일생(Il Saing Choi) 대한내과학회 1988 대한내과학회지 Vol.34 No.4
N/A The prognosis of tuberculous meningitis is closely linked to the stage at which treatment is started. The cerebrospinal fluid findings, however, are often ambiguous, It has been suggested by recent investigations that ADA activities in cerebrospinal fluid may help differentiate tuberculous meningitis from aseptic meningitis. In this study, cerebrospinal fluid adenosine deaminase activities were measured in 23 cases of tuberculous meningitis, 9 cases of aseptic meningitis, 9 cases of purulent meningitis, 24 cases of miscellaneous neurologic conditions and 23 cases of normal controls. The results obtained were as follows: 1) The mean ADA activity in tuberculous meningitis was 17.39±10,34 U/L, in bacterial meningitis 7.87±8.52 U/L, in aseptic meningitis 2.83±1.92U/L, in miscellaneous neurologic conditions 2.80±5.61U/L and in control 1,09±0.51U/L. 2) The ADA activitiies in tuberculous meningitis showed significantly higher values than in other groups (P<0.001), 3) Cerebrospinal fluid ADA activities differentiated tuberculous meningitis from those with aseptic meningitis being higher than 4.5U/L in all and higher than 6.5U/L in 96% case of tuberculous meningitis, but lower than 6,5U/L in aseptic meningitis and less than 3.5U/L in normal controls. 4) In tuberculous meningitis, ADA activities showed significant correlation with protein in cerebrospinal fluid (P<0.01), but in other groups, no significant correlation with available routine parameters in cerebrospinal fluid. It is suggested that measurement of ADA activity in cerebrospinal fluid is a available test which is relatively easily performed for diagnosis of tuberculous meningitis, especially differential diagnosis with aseptic meningitis.
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방병기,윤영석,이정상,한대석,이호영,김형규,박한철,강종명,김명재,이희발,류석희,윤견일,고행일,오하영,유병희,정영,정석호,나하연,이시래,김기현,원대식,전건웅,조동규,윤경우,김현철,최일균,강영준,채종구,임중규,구완서,최의진,김문재,전성주,송정균,이광훈,성낙억,최영주,최창필,강성귀,나영호,김문중,신영태,김석영,이영규,남궁견 대한신장학회 1988 Kidney Research and Clinical Practice Vol.7 No.2
Since 1981, the Korean Society of Nephrology started annual report on renal replacement therapy in Korea. The annual number of new patients receiving dialysis treatment in 1986, compared with 1985, rose from 825 patients (20.4 per million population) to 957 patitents (23. 3 per million population) and the total number of patients on replacement therapy rose from 1,508 patients (37.3 per million population) to 2,534 patients (61.7 per million population). 1,335 patients (32.6 per million population) of these patients were living on hemodialysis, 573 patients (13.9 per million population) on continuous ambulatory peritoneal dialysis (CAPD) and 621 patients (15.1 per million population) on fun- ctioning renal graft as of December 31, 1986 The common causes of renal failure of new patients were chronic glomerulonephritis (41,6%), followed by diabetic nephropathy (12.6%), hypertensive nephroscler- osis (7.8%), chronic pyelonephritis (2.5%) and others. The annual mortality rate fell from 21.9% in 1981 to 13. 5% in 1986. The common causes of death in patients on dialysis therapy in order were cardiac (32.8%), vascular (14.7%), infective (14.7%) social problems (11.2%). Recently, the number of patients requiring dialysis is rapidly increasing due to expanded medical insurance support for dialysis and improved economic status of our country. Therefore, it is necessary to draw up counterplan for a rapid growth of the number of new patients.
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