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        • SCOPUSKCI등재

          유행성 출혈열환자의 Radio Renogram

          김명재 대한핵의학회 1967 핵의학 분자영상 Vol.1 No.2

          서울대학교 의과대학 부속병원에 입원하였던 유행성출혈열 15예에 대하여 결핍기, 이뇨기 및 회복기에 신기능검사를 하는 동시에 131I-OIH를 사용하여 renogram을 실시하여 다음과 같은 결론을 얻었다. 1) 유행성출혈열의 renogram상의 변화는 양측성이고 양측신의 변화정도는 대부분의 renogram에서 경시적으로 비슷한 정도의 이상치를 정시하였다. 2) 핍뇨기의 renogram의 특징은 initial spike의 높이가 전반적으로 정상보다 낮아지는 것 같고 maximal amplitude가 20분까지에도 나타나지 않고 단속적인 상승을 보이는 secretory phase가 관찰되며 excretory phase는 관찰되지 않았다. 즉 급성뇨관폐색이나 급성탈수시의 renogram상과 유이한 형상을 정시하였다. 3) 이뇨기에서는 secretory phase의 경사도가 정상보다 완만하나 Tmax는 정상 범위내에 있었고 T½은 20분이상으로 지연되며 뇨량의 증가에도 불구하고 큰 amplitude의 완만한 terminal descent를 보이는데 이는 주위조직의 방사도 osmotic diuretic 및 신세뇨관세포의 저하된 clearance의 결과라고 추측된다. 4) 회복기의 renogram은 이뇨기때보다는 예리한 곡선을 그러나, 역시 maximal amplitude에 이르는 second ascent의 경사가 완$quot; (131)^I-O-Iodohippurate renogram in 15 cases of epidemic hemorrhagic fever (E.H. fever) during oliguric, diuretic and convalescent phase were analysed quantitatively and qualitatively, namely by its configuration, Tmax T½ and renal index of Hirakawa. The results were as following: 1) Changes on the renogram in E.H. fever showed simultaneous bilateral renal impairment. 2) The characteristic configurations of renogram in the oliguric phase were:① Moderately decreased absolute amplitude of initial spike. ② Continous rising second slope. ③ No appearance of terminal descent. Those were most likely to those of renogram in acute ureteral obstruction or acute dehydration state. 3) During the diuretic phase, the renogram showed the point of maximal amplitude, but the steepness of 2nd slope was markedly decreased. The appearance pf terminal descents was observed with unusually high amplitude despite of the tremendously large amount of urinary output during this phase. 4) In convalescence, the renogram were essentially al in configuration, but the renal index of Hirakawa was not recovered until this phase. 5) Renogram in E.H. fever showed the characteristic patterns in each phase of its clinical course. 6) (131)^I-OIH-Renogram might be an useful method for the evaluation of renal function in E.H. fever during its course.

        • SCOPUSKCI등재
        • KCI등재

          헌법판례상의 규범구체화 개념의 분석과 평가

          김명재 전남대학교 법학연구소 2016 법학논총 Vol.36 No.1

          '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

          Das Wort “Konkretisierung” des Rechtes befindet sich in der Judikatur des koreanischen Verfassungsgerichtes. Die Konkretisierung ist von Bedeutung in der juristischen Methodik. Das Verfassungsgericht weist den Richter auf die Auslegung als Methode für die Normkonkretisierung, d.h. “Konretisierung durch Auslegung” hin. Analyse und Einschätzung vom Konkretisierungskonzept in der Verfassungsjudikatur ist erforderlich im Anschluß an die Aufgabe von Rationalitätserhaltung der juritischen Argumentation im Gerichtsverfahren. Diese Arbeit erfüllt sich durch den Vergleich mit dem Konzept von “Konkretisierung statt Auslegung” bei Friedrich Müller. Nach dem Schluß von meiner Arbeit ist das Konkretisierungskonzept des koreanischen Verfassungsgerichgtes bleibt noch in der rechtspostivistischen Denkweise anders als das Konzept “Konkretisierung statt Auslegung” von F. Müller. 헌법판례에는 구체화라는 용어가 방법론적 의미를 가지고 많이 사용된다. 헌법재판소는 법적 논증의 방법으로서 “해석에 의한 구체화”라는 방법을 제시하는데, 이 개념을 분석하고 평가하는 작업은 긴요하다. 이러한 작업은 뮬러의 “해석 대신에 구체화”라는 컨셉과의 비교를 통해서 수행된다. 분석작업을 통해서 얻은 자료를 가지고 보면 헌법판례상의 “해석에 의한 구체화”라는 개념은 뮬러의 컨셉과는 달리 종래의 법실증주의 방법론에 여전히 머물러 있거나 적어도 완전히는 벗어나지는 못한 것으로 보인다.

        • KCI등재

          α, γ-Mangostins Induce Autophagy and Show Synergistic Effect with Gemcitabine in Pancreatic Cancer Cell Lines

          김명재,진영원,이은주 한국응용약물학회 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.6

          Pancreatic cancer is one of the most lethal and aggressive cancers in the world. However, no effective treatment is currently available for pancreatic cancer. The objective of this study was to determine the anti-pancreatic cancer effect of α-mangostin (αM) and γ-mangostin (γM) extracted from the pericarp of Garcinia mangostana L.. Both αM and γM reduced the viability of pancreatic cancer cells MIA PaCa-2 and PANC-1 in a dose-dependent manner. These compounds induced apoptosis by increasing c-PARP and c-Caspase 3 levels. They also induced autophagy by increasing levels of microtubule-associated protein 1A/1B light chain 3B (LC3II) in both cell lines while decreasing sequestosome 1 (p62) in MIA PaCa-2. Both αM and γM induced autophagy through increasing phosphorylation levels of AMP-activated protein kinase (p-AMPK) and p38-mitogen activated protein kinase (p-p38) while decreasing phosphorylation level of mammalian target of rapamycin complex 1 (p-mTOR). Of various microRNAs (miRNA), miR-18a was found to be a putative regulatory miRNA for autophagy induced by αM or γM. In combination with gemcitabine, a compound frequently used in pancreatic cancer treatment, αM and γM showed synergistic anti-cancer effects in MIA PaCa-2. Collectively, these results suggest that αM and γM can induce apoptosis and autophagy in pancreatic cancer cells and that their anti-cancer effect is likely to be associated with miR-18a. In conclusion, αM and γM might be used as a potential new therapy for pancreatic cancer.

        • KCI등재후보

          Cyclosporine 을 사용하는 신이식 환자에서의 정상만삭분만 2 예

          김명재,김배영,이태원,오보훈,임천규,안재형 대한내과학회 1992 대한내과학회지 Vol.43 No.4

          Background: A successful pregnancy and delivery in renal-transplanted patients has been increased with the high graft survival rate by the development of the immunosuppressive agents using following renal transplantation. And so attentions have been focused on the effects of immunosuppressive agents on the graft kidney and fetus during pregnancy after renal transplantation. Results: We presented successful pregnancies and fullterm deliveries with cesarean section in two recipients with regimens of cyclosporine, azathioprine and prednisolone after renal transplantation. Conclusion: Cyclosporine, azathioprine and prednisolone have on deliterious effect to the mother and fetus in our two cases but, more study is needed to identify the effects of immunosuppressive agents on the graft kidney and fetus during pregnancy after transplantation.

        • KCI등재후보

          Anti-Neutrophilic Cytoplasmic Autoantibody(ANCA) 연관성 급속 진행성 사구체 신염에 관한 임상경험 2 예

          김명재,양문호,박원도,이태원,임천규,조대옥,안재형,김신규 대한내과학회 1992 대한내과학회지 Vol.43 No.4

          Antineutrophilic cytoplasmic autoantibodies (ANCA) are specific for constituents of neutrophilic granules and monocyte lysosomes, and two types, C-ANCA and P-ANCA was recognized by indirect immunofluorescence microscopy. ANCA are found in patients with necrotizing systemic vasculitis, such as Wegener`s granulomatosis and polyarteritis nodosa and patients with idiopathic crescentic glomerulonephritis. ANCA-associated glomerulonephritis are characterized by necrosis, crescent formation and a paucity of demonstrable immune deposits in renal biopsy. We report two cases of rapidly progressive glomerulonephritis, who had pauci or no immune deposits in renal biopsy and positive C-ANCA in indirect immunofluorescence microscopy.

        • KCI등재후보

          말기신질환 환자에서 성기능장애의 기전과 신이식수술이 성호르몬에 미치는 영향

          김명재,이태원,임천규,김영훈,최병길 대한내과학회 1989 대한내과학회지 Vol.36 No.5

          Sexual dysfunction is a common problem in male patients with end stage renal disease. The pathogenesis of this disorder has been attributed to many of metabolic disturbances of uremia, most notably zinc deficiency, PTH excess, and vitamin D deficiency. To evaluate the effect of renal transplantation on sex hormones, serum LH, FSH, testosterone and prolactin were measured by the method of RIA before and after renal transplantation in male uremic patients with sexual dysfunction. The results were as follows: 1) The basal level of serum LH was significantly higher in patients with end stage renal disease (17.7±5.0 mIU/ml, p $lt; 0.01) compared with the normal range and dropped to the normal range after renal transplantation (7.0±4.1 mIU/ml) 2) The basal level of serum FSH was higher in patients with end stage renal disease (14.4±5.4 mIU/ml) but was not significant statistically. After renal transplantation, the serum FSH was elevated (21.3±9.4 mIU/ ml) but there was a significant change compared with the pretransplantation state (p$gt;0.1). 3) On LH-RH stimulation test, the response of LH was delayed and prolonged in patients with end stage renal disease, and after renal transplantation, the response of LH was improved but still blunted. 4) On LH-RH stimuilation test, there was a normal pattern of FSH response before and after renal transplantation. 5) The basal level of serum testosterone decreased significantly in patients with end stage renal disease (2.87±0.3 ng/ml, p$lt;0.01) compared with the normal range, and recovered to the normal range after renal transplantation (5.23±1.89 ng/ml). 6) The basal level of serum prolactin was significantly higher in patients with end stage renal disease (29.9±20.0ng/ml, p$lt;0.01) and dropped to the normal range after renal transplantation (1.5±0.3ng/ml). 7) The impotence and depressed sexual desire was not improved after 1 month of renal transplantation. Finally, the abnormalites of sex hormones in uremic patients with sexual dysfunction are improved partially after 1 month of renal transplantation, therefore it is necessary for these patients to follow up sex hormones periodically.

        • KCI등재

          헌법상의 양심의 자유의 보호범위

          김명재 한국헌법학회 2007 憲法學硏究 Vol.13 No.3

          Der Schutzbereich der Gewissensfreiheit im VerfassungsrechtKim, Myung-JaeDas Grundrechtssystem fr die Menschenwrde wird durch die Gewhrleistung der Gewissensfreiheit vollendet. Sie bringt aber den Konflikt mit der Rechtsordnung hervor. Um das Gewissen zu schtzen und zugleich die Rechtsordnung zu bewahren, sind der Schutzbereich der Gewissensfreiheit und ihre Grenze zu definieren. Das Gewissen im fornum internum ist unbeschrnkt geschtzt. Die Freiheit der Bildung, Entscheidung, Erhaltung des Gewissens im forum internum ist der Wesensinhalt der Gewissensfreiheit. Die Verwirklichung des Gewissens im formum externum ist auch in Schutz zu nehmen. Die Freiheit der Gewissensverwirklichung durch Begechung oder Unterlassung ist sicher zu stellen. Ihr Genuß ist natrlich durch die Rechtsordnung zu begrenzen. Dennoch ist das Gewissen in diesem Fall grundstzlich maximal zu garantieren. Im Fall des Konfliktes zwischen Gewissen und Rechtsordnung sind andere Antrge als Untersagung der Gewissensverwirklichung zu treffen. Dadurch ist das Gewissen maximal zu schtzen. Andere Antrge sind nicht direkt aus dem verfassungsrechtlichen Artikel fr die Gewissensfreiheit auszulegen. Nach dem bisherigen Erachten des Verfassungsgerichtes sind sie durch die Legislative konkret auszugestalten.

        • KCI등재
        • KCI등재

          우리나라 연안여객업의 보상법제정에 관한 연구

          김명재 한국해운물류학회 2012 해운물류연구 Vol.28 No.3

          This study identifies a reasonable compensation act on the coastal passenger routes in Korea in case that a sea-land bridge should be constructed between the islands across the conventional routes. An comprehensive reviews had been conducted on the industry of passenger routes in order to achieve the goals of this study together with the previous court cases not only in domestic but overseas country in which a reasonable compensation ways, viz., the compensation time and scale, etc. were suggested. The conclusion was that as the current compensation act is not so useful for the coastal passenger firms, a new compensation act must be effected as early as possible in view of both the coastal passenger firms could be satisfied and the Korea passenger routes should be more activated than before. 본 연구는 우리나라 연안여객항로의 활성화를 위한 합리적 보상법마련에 대한 기준을 제시하고 구체적인 보상시기와 보상범위를 제안하였다. 연구의 목적을 달성하기 위하여 우리나라 연안여객업의 현황을 진단하고 각 항로별 취항여객선의 추이변화를 살펴보았다. 또한, 기존의 국내외 문헌연구를 통하여 연육교 등으로 인한 연안여객항로의 피해에 따른 보상사례와 판례 등을 체계적으로 분석하였으며, 연육교 공사와 관련한 보상법안 및 보상시기를 비롯하여 세부적인 피해보상을 위한 구체적인 방안을 제시하였다. 연구결과 기존의 해운법에 제시되어 있는 보상법안은 그 근거와 보상범위가 매우 모호하여 업체에게 실질적인 도움이 되지 못하고 있는 상황이었으며, 따라서 합리적인 보상방안이 조속히 마련되어 연안여객사업에 대한 동기부여와, 정부의 연안해운육성에 대한 정책적 신뢰성을 유지하고, 친환경 수송여건변화에 대한 연안여객업의 건전한 발전을 도모함이 시급한 과제로 대두되었다.

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