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김성권 ( S G Kim ),시차자 ( C J See ),김경애 ( K A Kim ),김의종 ( E J Kim ),석종성 ( J S Suk ) 대한임상검사과학회 1992 대한임상검사과학회지(KJCLS) Vol.24 No.1
Vitek system, a fully automated in vitro testing system designed for identification and antimicrobial susceptibility test of microorganisms was introduced to The Seoul National University Hospital in 1985. Principal advantages of using this system are rapid identification of microorganisms and rapid reporting of the minimal inhibitory concentration values. Using Vitek system, 248 isolates from culture requested blood specimen in our hospital from April 11. 1991 to August 31. 1991 were identified and minimal inhibitory concentration test were performed. We summarized the data and obtained results as below. 1. 52.3% of catalase +, Gram ( +) cocci, 75% of catalase(-), Gram(+) cocci, 74.8% of Gram (-) glucose fermenters and 57.1% of glucose nonf ermenters were identified within 9 hour. 2. Mic values of 87.6% of Gram ( +) cocci ( catalase +,- ) and 86.6% of Gram ( - ) rods (glucose fermenters and nonfermenters) were obtained within 9 hour. 3. 32.5% of isolated organisms were reported within the test performed day by using Vitek system.
신기능장애 및 혈액투석환자에서의 Pyrazinamide 의 약력학적 연구
김대중(D . J . Kim),김성권(S . K . Kim),이정상(J . S . Lee),한용철(Y . C . Han),이문호(M . H . Lee),이선희(S . H . Lee),신상구(S . G . Shin),박찬웅(C . W . Park) 대한내과학회 1986 대한내과학회지 Vol.31 No.1
The pharmacokinetics of single oral dose(lgm) of pyrazinamide was studied in 20 patients with various degrees of renal insufficiency including 6 patients on long-term hemodialysis. The average 24 hr urinary recovery of pyrazinamide in patients with creatinine clearance 10 to 30 ml/hr/kg, and patients with creatinine clearance lesser than 10 ml/hr/kg were 7.5 and 0.9% of administered dose respectively. Serum half-life of the drug was slightly, but significantly(p<0.05), prolonged in patients with creatinine clearance lesser than 10 ml/hr/kg(half-life; 11.25±2.55 hr) compared with normal subjects(half-life; 8.21±1.38 hr) previously reported. The mean serm half-life of pyrazinamide in patients on longterm hemodialysis was 12.26±2.92 hr. The half-life fell to 3.52±1.17 hr during hemodialysis. It was estimated that approximately 41% of drug in the body was removed into dialysate during 4 hr dialysis. The mean dialysance of pyrazinamide was 91.40±2.83 ml/min. From the observed pharmacokinetics of pyrazinamide in patients with impaired renal function, it is suggested that adjustment of dosage regimen may not be required for patients just with impaired renal function. However, replacement of dialysed fraction of pyrazinamide would be required for the maintenance of adequate serum level.
팽이버섯 배지 부산물의 급여가 산란계의 생산성 및 난질에 미치는 영향
나재천,장병귀,김상호,김지혁,김성권,강희설,이덕수,이상진,정종천,이진건,Na J. C.,Jang B. G.,Kim S. H.,Kim J. H.,Kim S. K.,Kang H. S.,Lee D. S.,Lee S. J.,Cheong J. C.,Lee J. K. 한국가금학회 2005 韓國家禽學會誌 Vol.32 No.2
This study was conducted to evaluate the feeding value of the Flammulina veluipes media by-product(FMB) in laying hens(Hy-Line Brown). A total of three hundreds sixty were fed corn-soy based experimental diets containing 0(control), 5.0(T1), and $10\%(T2)$ FMB for 12 weeks. There were no significant differences among the treatments in egg production, egg weight, egg mass, feed conversion and viability during the experimental period. Feed intake was significantly(P<0.05) lowered in control(120.5g) than 72(123.9g). There were no significant differences among the treatments eggshell breaking strength, thickness and haugh unit, whereas the yolk color of T1 and T2 were significantly love. than control(p<0.05). In conclusion, the FMB can be used as resource of feed in laying hen feed at $5.0\%$ level without effect on performance and egg qualify. However, dietary pigments must be added when the FMB was used as a feed ingredients more than $10\%$ in diets. 팽이버섯 배지 부산물(F. velutipes media by-product)의 사료 자원화를 위하여 산란계 사료에 0, 5 및 $10\%$를 12주간 하이라인 갈색산란계 360수에게 급여하였다. 전 시험 기간 동안의 산란율, 난중, 산란량, 사료요구율 및 생존율은 대조구와 차이를 보이지 않았다. 사료섭취량은 대조구에서 120.5g 으로 T2의 123.9g보다 유의적으로 적었다(p<0.05). 난각강도, 난각두께 및 호우유니트도 시험 전 기간 동안 처리구간에 차이를 보이지 않았다. 그러나 난황색은 대조구, T1, T2에서 각각 7.92, 7.29 및 6.83으로 대조구에 비하여 T2에서 유의적으로 낮았다(p<0.05). 결론적으로 팽이버섯배지부산물을 산란계 사료원료로서 $5\%$를 급여하여 대조구와 비교시 생산성 및 계란의 품질에 미치는 영향이 없었으므로 사료자원으로 이용이 가능하지만, $10\%$를 급여시에 난황색이 현저하게 저하되었으므로 착색제의 첨가가 필요하다고 사료된다.
겨우살이의 급여가 육계의 생산성 및 혈액 특성에 미치는 영향
김지혁,김동욱,강근호,장병귀,유동조,나재천,김상호,이덕수,서옥석,최강덕,김성권,이규호,Kim, J.H.,Kim, D.W.,Kang, K.H.,Jang, B.G.,Yu, D.J.,Na, J.C.,Kim, S.H.,Lee, D.S.,Suh, O.S.,Choi, K.D.,Kim, S.K.,Lee, K.H. 한국가금학회 2007 韓國家禽學會誌 Vol.34 No.2
본 연구는 한국산 참나무 겨우살이를 육계에 급여하였을 때 생산성 및 혈액 특성에 미치는 영향을 구명하기 위해 실시하였다. 1일령 Ross 수평아리를 4처리 4반복, 반복당 30수씩 총 480수를 공시하였고, 실험 설계는 무항생제 사료, 항생제 첨가 사료, 겨우살이 0.5% 및 1.0% 처리구로 나누어 총 49일간 사육하였다. 실험 전 기간 처리구간에 사료 섭취량과 일당 증체량에 있어서는 유의차가 없었다. 실험 종료시 공장의 길이에 있어서 겨우살이 1.0% 처리구가 다른 처리구에 비해 증가하는 경향이나 유의하게 증가하였다(P<0.05). 실험 35일째, 맹장내 살모넬라 균수는 겨우살이를 급여함으로써 유의하게 감소하였다(P<0.05). 겨우살이 처리구에서는 대조구(+)에 비해 림프구와 단핵구의 수가 증가하는 경향 또는 유의하게 증가하였다(P<0.05). 따라서, 겨우살이의 사료 내 첨가급여는 육계에서 생산성 및 혈액 성상에 아무런 부정적인 영향을 미치지 않아 항생제 대체 물질로서의 이용 가능성이 있을 것으로 사료된다. The objectives of this study were to examine the effects of Korean mistletoe (KM) on performance and blood characteristics in broiler chickens. A total of four hundred eighty, 1-d-old male broiler chicks (Ross) were divided into 4 groups with 4 replicates of 30 birds each. The treatments were NC (antibiotics-free diet), PC (NC diet added antibiotics), 0.5% KM (NC diet added 0.5% of KM) and 1.0% KM (NC diet added 1.0% of KM), and the birds were raised for 49 days. There were no significant differences in feed intake and body weight gain among treatments. On d 49, the relative length of jejunum in 1.0% KM tended to be increased or significantly (P<0.05) increased compare to those of other groups. On d 35, the colony forming unit of Salmonella spp. of ceca significantly (P<0.05) decreased by feeding KM. The counts of lymphocyte of KM significantly (P<0.05) increased compare to those of the PC.
김연수,한진석,이정상,김병국,이중건,정윤철,이진학,최영진,안규리,김성권,이현순 대한내과학회 1994 대한내과학회지 Vol.46 No.2
Castlemam's disease is an asymptomatic and benign lymph node hyperplasia which is frequently manifested as mediastinal mass in over 70% of cases. Amyloidosis is rarely associated with Castleman's disease. Recently we experienced a patient with nephrotic syndrome due to renal amyloidosis who had been previously diagnosed as Castleman's disease of retroperitoneal lymph node enlargement. A 47-year old woman was admitted because of generalized edema and chest tightness. Five months ago she diagnosed as Castlman's disease-plasma cell type, of retroperitoneal lymph node enlargement. The patient was followed up through outpatient department without any specific medication. Physical examination showed pale conjunctivae, palpable mass on epigastric area and pretibial pitting edema. The hemoglobin, leukocyte count and erythrocyte sedimentation rate were 96 g/L, 5.9×109/L and 127 mm/hour, respectively. The blood urea nitogen was 3.6 mmol/L and creatinine was 88 umol/L. The urinalysis showed 3 positive for albumin. Twentyfour hour urine contained 16.6 grams of protein. A computerized tomographic (CT) scan of the abdomen disclosed multiple lymph node enlargement at mesentery. Percutaneous needle biopsy of kidney showed massive infiltration of pale pinkish amorphous material in the glomerular tuft forming large nodules. Ultrastructural examination exhibited heavy deposition of amyloid fibrils in the mesangium and perpendicular to glomerular basement membrane. Polarizing microscopy with Congo-red stain revealed prominent yellow green birefringence in glomeruli, tubules and interstitium.
Staphylococcus aureus동정에 있어서 Staphyslide-Test(Slide agglutinotion)의 고찰
김성권,석종성,김승곤 최신의학사 1984 最新醫學 Vol.27 No.9
The coagulase test in used to differentiate species within the genus staphylococcus. A positive coagulase test (tube or slide) is usually final diagnostic criterion for the identification of staphylococcus. But this test has many advantages such as the preparation of plasma, the appearance of false positivity by other bacteria and long incubation of negative coagulation. Staphyslide test (Slide agglutination) is known to use the principle that a protein receptor capable of combing with fibrinogen in on staphylococcus aureus. Staphyslide- test is more sensitive and specific than other test for the identification of staphylococcus aureus. 1. Among the total of 104 strain of staphylococcus, illustrations shown positivity in the tests of staphyslide test and coagulase test were 76 strain (73.0%) and 72 strain (69.2%) in each cases. Among the 76 strain those illustrated positive result in staphyslide-test, the four 4 strain illustrated dormant results in the normal coagulase test and coincided point ratio was 94.7%. 2. Among the strain those have illustrated analysis of mannitol in mannitol salt agar, strain shown positive vesulte in the test of staphyslide test and normal coagulase test were 76 strain (93.8%) and 72 strain (88.9%) in each cases. 3. In comparison with 100% of veappearance, repeated test of staphyslide test, the coagulase tube test showed occasional dormancy and reapprearnace was 87%. 4. In staphyslide test, showed good sensibility, peculiarity and reappearance in comparison with the normal coagulase test in metivation of S. aureaus, so it is believed that it has a strong point to obtain prompt results.