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Retinoic Acid 국소도포와 부분적 절제술로 호전된 Favre - Racouchot 증후군
김경문 ( Kyoung Moon Kim ),손상욱 ( Sang Wook Son ),이길주 ( Gil Joo Lee ),홍승현 ( Seung Hyun Hong ),김일환 ( Il Hwan Kim ),오칠환 ( Chil Hwan Oh ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.2
Favre-Racouchot syndrome is a disease of senile or actinic processes and another name is nodular elastosis with cysts and comedones. Clinically, facial skin shows, especially lateral to the eyes, multiple open and cystically dilatated comedones and can be defined as cutaneous disturbances characterized by a degenerative process of the dermis associated with cysts and comedones. Sunlight is a strong causative factor and dermal degenerative processes result in this condition. We report the case of a 78-year-old man who showed multiple yellowish papules on both sides of cheeks, the periorbital and, malar areas. He had had this condition for 25-years. His job used to involve physical labor and much exposure to sunlight. An excisional biopsy specimen from the facial malar lesion showed cystically dilated comedones with basophilically degenerated dermal tissue. We performed a therapeutic excision on the two large nodular lesions on both malar areas and applied topical tretinoin. The Patients clinical appearance was much improved 2 months later. (Korean J Dermatol 1998;36(2): 313-316)
이승동 ( Seung Dong Lee ),이지현 ( Ji Hyun Lee ),김경문 ( Kyoung Moon Kim ),유동수 ( Dong Soo Yu ),박철종 ( Chul Jong Park ),박영민 ( Young Min Park ),조상현 ( Sang Hyun Cho ),이준영 ( Jun Young Lee ),강훈 ( Hoon Kang ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.8
Background: Pyoderma gangrenosum (PG) is a rare noninfectious skin disorder characterized by chronic recurrent painful ulcers. Because of its low incidence and diagnostic difficulty, there were few comprehensive studies of the clinical features of PG in Korea. Objective: Our purpose was to delineate the clinical features of PG. Methods: 22 patients who presented with PG at 6 hospitals of Catholic Medical Center over ten years were enrolled in this study. We reviewed all medical records of the patients. Results: The mean age was 47.9 years. The male to female ratio was 1:1.4. Cases in children account for 2 out of twenty two. Sixty-one percent of the patients had lesions on their lower legs. The typical ulcerative variant was found in 19 patients, bullous PG in 3 patients. An association with other internal diseases was noted in 9 patients. Two cases were developed in heavy alcoholics. 15 patients were treated with systemic corticosteroid, 12 cases with systemic corticosteroid only, one case with systemic corticosteroid and cyclosporine, one case with systemic corticosteroid and dapsone, one case with systemic corticosteroid, cyclosporine and colchicine. 1 patient was treated with cyclosporine and colchicine, 1 patient with colchcine, rifampicin and antibiotics. Five cases were treated with antibiotics only. In the only systemic corticosteroid therapeutic group, the response rate was 83%. 3 patients experienced recurrence and 3 patients showed positive pathergy reactions. Conclusion: PG is a rare disease with the ulcerative variant being most frequent. The lower legs were the most commonly affected sites. PG was accompanied with systemic disease in 46% of the cases. Comparing with foreign literature, the response rate of treatments was generally fine and the recurrence rate was low. (Korean J Dermatol 2008;46(8):1028~1035)
서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1997)
김재홍,문득곤,김정수,김용준,임동진,박상훈,김희성,이민수,송기훈,김갑형,김형석,성소영,이인섭,김석우,황지환,조창근,김경문,부태성 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.3
Background : In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. Objective & Methods : For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1997. 99 strains of N. gonorrhoeae were isolated, among which 45(45.5%) were PPNG. Conclusion : The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 45.5% in 1997.
Antisense c-fos oligonucleotide 및 cytokines가 배양한 섬유아세포에서 collagenase와 collagen α2(Ⅰ) mRNA에 미치는 영향
김경문,김용상,계영철,김수남 고려대학교 의과대학 1997 고려대 의대 잡지 Vol.34 No.3
Cellular protooncogene encode proteins with three major sites of action: the cell surface membrane, cytosol, and nucleus. The nuclear acting group of protooncogenes include c-fos, c-myc, c-myb, c-erbA, p53, and c-jun. These genes function as AP-1 complex is a kind of transcriptional factor. The complex consists of several distinct proteins including those encoded by the protooncogenes c-jun and c-fos and other members of the fos family of genes. The c-fos protein interacts with c-jun/AP-1 and stimulates transcription of collagenase promoter gene. Transforming growth factor β and tumor necrosis fator α regulate several kinds of protooncogenes, collagenase and collagen α2(I) mRNA. The aim of this study was to evaluate the relationship of protooncogene c-fos and cytokines on cultured human skin fibroblasts. Fibroblasts were cultured with DMEM under antisense c-fos 15 ㎍/ml of media with transforming growth factor β 5 ng/ml of media or tumor necrosis factor α10 ng/ml of media. After 8 hours culture, isolation of total RNA from the cultured fibroblasts, northern blotting with collagenase and collagen type a2(I) probe was performed. The results were as follows; 1. After antisense c-fos oligonucleotide treatment on cultured human skin fibroblasts, collagenase mRNA levels were more incresased and collagen α2(I) mRNA levels were more decreased than control group. 2. In the group treated with antisense c-fos oligonucleotide and tranforming growth factor-β, collagenase mRNA level was elevated and collagen α2(I) mRNA level was reduced, comparing with the group treated with transforming growth factor-β only. 3. In the group treated with antisense c-fos oligonucleotide and tumor necrosis factor-α, collagenase mRNA level was reduced and collagen α2(I) mRNA level was increased, comparing with the group treated with tumor necrosis factor-α only.
배양한 켈로이드 섬유아세포에서 Retinoic acid에 의한 collagen α2(Ⅰ) mRNA의 변화
김경문,양재석,김영도,계영철,김수남 고려대학교 의과대학 1997 고려대 의대 잡지 Vol.34 No.3
Keloids are acquired cutaneous lesions with a strong genetic predisposition and they are characterized by an excessive accumulation of the extracellular connective tissue matrix. Treatment of keloid is very difficult. There are several kinds of treatment modalities. Intralesional injection of steroid is most widely used. Cryotherapy, surgical resection with radiation therapy and silicon gel sheet were introduced. A recent report has also suggested that retinoids may be useful for treatment of keloids and hypertrophic scars. The objective of this study is to evaluate the effects of retinoic acid on keloid. After starting keloid fibroblast culture with DMEM under several concentrations of all-trans retinoic acid, we cultured fibroblasts again under 10^(-5)M of all-trans retinoic acid for 4, 8, 24 hours. After isolation of total RNA from the cultured fibroblasts, northern blotting with collagen type α2(I) probe was performed. The results were as follows; 1. The collagen α2(I) mRNA expressions were increased in high concentration (10^(-5), 10^(-6)M) of all-trans retinoic acid. 2. The collagen α2(I) mRNA expression were decreased in low concentration(10^(-7), 10^(-8), 10^(-9)M) of retinoic acid. 3. In the time course observation, collagen α2(I) mRNA expressions were decreased gradually but at 24hours, collagen α2(I) mRNA expression were incresed slightly.