알쯔하이머성 치매의 언어정보처리과정 특성 연구

변선경,정옥란 대구대학교 특수교육재활과학연구소 2004 再活科學硏究 Vol.22 No.1

알쯔하이머성 치매는 신경 화학적 구성, 뇌조직의 변화에 의해 특성 지어지는 진행성으로 퇴행하는 질병이며, 사실적 지식의 계층적 구조화된 체계, 의미기억의 중요한 손상을 보여준다. 알쯔하이머성 치매환자의 어휘-의미장애의 특징을 의미-범주과제를 이용한 연합성과 의미범주를 통해 연구하였다. 연구대상은 치매집단을 중증도에 따라 세 집단으로 분류한 뒤, 각 9명씩 27명으로 하였다. 연구결과 범주에 따른 연합성 이해 차이에는 유의미한 차이를 나타내지 못했다. 치매의 정도에 따른 연합성 이해는 유의미한 차이를 보였다. 이러한 결과는 치매의 의미적 결함은 범주보다는 연합성에 결함이 있다고 볼 수 있으며, 이는 어휘-의미수준의 손상의 결과라고 볼 수 있다. The goal of this paper was to address 2 issues relevant to the semantic impairment in Alzheimer's disease: (1) stimulus associative effects (2) semantic category effects (contrasting living with non-living categories). The subjects of this study were divided into 3 groups based on K-Mini Mental state Examination (K-MMSE) scale: probable AD, mild AD, and moderate AD group. Twenty-seven patients with AD were given a semantic category task. The response were analyzed by one-way ANOVA to determine any significant difference among 3 groups. The result of this study revealed the following findings: (1) semantic category effect didn't a difference influence semantic association, (2) The AD group showed a significant on semantic association, (3) There was a significant correlation between the AD group and semantic association. In sum, the present results indicated that semantic impairment in AD involved a progressive deterioration of lexical-semantic representation.

저선량 감마선 조사가 왕겨의 항산화능에 미치는 영향

정석문,김정한,김동열,육홍선,변명우,이승철 慶南大學校 附設 基礎科學硏究所 2002 硏究論文集 Vol.16 No.-

왕겨에 200, 400, 600, 800 및 1000 Gy의 저선량의 감마선을 조사하여 항산화능의 변화를 관찰하였다. 총 페놀 화합물의 양은 무처리구의 경우 0.184 mM를 나타내었고, 200 Gy로 감마선을 조사하였을 때는 0.215 mM로 약간 증가함을 보였으나 이후 차츰 감소하였다. 전자 공여능은 무처리구에 비해 처리구의 경우 조사 선량별로 조금씩의 차이만 있을 뿐, 조사 선량에 대한 왕겨의 전자 공여능은 유의적인 큰 변화 없이 비슷한 활성을 보였다. Fe^2+-ions 킬레이팅 활성은 무처리구의 경우 68.25%를 나타내었으며, 200, 400, 600 및 800 Cy 에서는 각각 86.45, 85.61, 86.65 및 82.84%로서 무처리구보다는 증가함을 보였으나, 1000 Gy에서는 74.67%로 감소하였다. 지질 과산화 억제능은 무처리구에 비해 처리구는 약간의 증가를 보였으나 효과는 미비하였다. We studied the effect of small-dose of γ-irradiation to rice hull(RH) for its antioxidant ability. The RH was treated with 200, 400, 600, 800, and 1000 Gy of γ-ray at 70 Gy/min. Total phenol amount of unirradiated RH was 0,184 mM, after irradiation at 200 Gy it increased to 0,215 mM, while irradiation above 400 Gy up to 1000 Gy decreased that to unirradiated level. The electron donating ability of RH did not show significant change depend on irradiation. The chelating ability for Fe^2+ of unirradiated RH was 68.25 %, while that of 200, 400, 600 and 800 Gy irradiated RH showed 86.45, 85.61, 86.65 and 82.84 % respectively, but, 1000 Gy was decreased to 74.67 %. According to TBARS analyses, inhibition ability of lipid peroxidation by RH was not affected by γ-irradiation.

경상남도 산업단지별 대기오염질의 농도 특성

박정호,이근선,조인철,변은숙 진주산업대학교 환경문제연구소 1998 環境硏究論文集 Vol.2 No.-

본 연구에서는 경상남도 주요 14개 국가·지방산업단지 지역을 대상으로 실시한 제 1차, 2차 대기질 조사에 의해 얻어진 대기환경기준의 가스상·입자상 오염물질항목과 TSP중 Pb 등 주요 금속원소와 음이온 성분의 농도특성을 산업단지별로 파악한 결과 다음과 같은 결론을 얻었다. 1) 전반적으로 산업단지의 대기질은 1,2차 대기질 조사기간 중 대부분 환경기준을 만족하고 있는 것으로 나타났다. 2) 가스상 오염물질의 평균농도 범위는 SO_2 0.003∼0.033 ppm, O_3 0.017∼0.033 ppm, NO_2 0.014∼0.057 ppm, CO 0.4∼2.7 ppm의 범위를 나타냈다. 3) 입자상 오염물질의 특히 L, F, M 지점은 연평균 환경기준을 초과하는 경우도 나타났다. 4) 전체 음이온 성분의 1차 2차 조사기간 중 평균 농도는 L 〉J 〉N 〉B 지점순으로 나타났으며, 전체 원소성분의 총농도는 옥포, 마천, 유산 산업단지의 순으로 높게 나타났으나 Pb, Cr, Cd, Cu의 중금속 농도만으로는 창원, 죽도, 유산산업단지의 순으로 높게 나타났다.

국내에서 유행하는 HIV의 전파 경로에 따른 Subtype 분포

이주실,남정구,김성순,강춘,최병선,김옥진,박미선,성봉모,서순덕,전수경,변승옥,신영오,조해월 대한감염학회 2001 감염 Vol.33 No.5

Background : Previous data have been reported that subtype B is prevalent in South Korea, but neither the extent nor the proportion of subtypes could be evaluated. This study was designed to analyze the distribution of HIV-1 subtypes, temporal instructions and transmission dynamics between epidemiological groups. Methods : 1,280 Koreans had been diagnosed as HIV seropositive during the period 1985 to 2000. Among them, 134 individuals were selected for this molecular epidemiological study. 134 DNAs were isolated from uncultured or cultured peripheral blood mononuclear cells. V3-V5 (0.7 kb) fragment of HIV-1 env gene was amplified by nested polymerase chain reaction and was sequenced. Results : HIV-1 isolates from thirty-seven homosexuals were all subtype B (100%). On the other hand, 66 isolates from 94 heterosexuals were subtype B (70%) and 28 were non B subtypes (30% : 13 A, 4 C, 2 D, 8 E , 1 G). Only subtype B strains were isolated from 73 males who were infected with HIV inside Korea while 16 B and 20 non B subtype strains were isolated from 36 males who were HIV infected outside of Korea. However, B and non B strains were isolated half and half from females who were infected inside Korea except one. Conclusion : The HIV-1 subtype B strains are prevalent in Korea from the early HIV infection until present in both homo and heterosexuals. Non B strains have been transmitted from men who were infected outside Korea to their spouses and casual partners. So, we need further study to monitor subtype B and non B HIV transmission in epidemiological groups of Korea, (Korean J Infect Dis 33:311∼318, 2001)

정신재활 치료가 정신분열병 환자의 재발율, 입원횟수, 입원일수 그리고 치료 경비에 미치는 효과 : 2년 추적조사 연구

조진석,공지현,김진원,심경순,하준선,김철권,강동호,장정희,변원탄 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.5

목 적 : 사회기술훈련, 환자교육, 가족교육, 집단치료, 예술치료, 작업치료와 같은 포괄적인 정신재활 치료를 약물치료와 병행할 경우 약물치료만 시행할 때에 비해 정신분열병 환자의 재발율, 입원횟수, 입원일수, 직접 치료경비 등에 어떤 효과가 있는 지를 알아보기 위함이다. 연구방법 : 1993년 9월부터 1995년 2월까지 양산 신경정신병원의 폐쇄병동에서 퇴원한 20∼35세 사이의 정신분열병 환자 173명을 대상으로 46명에게는 6개월동안 정신재활 치료를 시행하였고 127명에게는 통상적인 외래치료만 시행한 후 연구시작 시점을 포함하여 2년동안 양군에 속한 환자들을 대상으로 재발율, 입원횟수, 입원일수, 직접 치료경비 등을 1년 단위로 추적 조사하였으며, 연구시작 시점을 기준으로 전과 후의 매년 평균 입원횟수, 입원일수, 직접 치료경비도 서로 비교하였다. 결 과 : 정신재활 치료를 약물치료와 병행할 경우 약물치료만 시행할 때에 비해 재발율, 입원횟수, 입원일수, 직접 치료비용이 현저히 감소되었다. 그리고 정신재활 치료를 받은 군에서는 치료 전에 비해 치료 후에 재발율, 입원횟수, 입원일수, 직접 치료비용이 유의하게 감소하였지만 통상적인 외래치료만 받은 군에서는 치료 전과 후간에 유의한 변화를 보이지 않았다. 결 론 : 정신분열병 환자들에게 정신재활 치료를 약물치료와 병행할 경우 약물치료만 시행할 때에 비해 환자의 임상적 경과를 호전시킬 뿐 아니라 가족의 경제적 부담도 줄일 수 있다. Objective : We evaluated the clinical efficacy of a comprehensive psychiatric rehabilitation of schizophrenia, including family psychoeducation, patient education, social skills training, group psychotherapy, art therapy, and occupational therapy. Method : From September 1993 to February 1995, 173 chronic schizophrenics who met DSM-IV criteria and were discharged from a locked ward were assigned into the psychiatric rehabilitation service group(psychiatric rehabilitation group, n=46) or the customary out-patient service group(out-patient group, n=127) prospectively, but not randomly. Assignment was based on preferences of patients and their relatives, Each subject included in the psychiatric rehabilitation group received twice weekly patient education, social skills training, family psychoeducation, group psychotherapy, art therapy, occupational therapy and maintenance chemotherapy during a 6-month period. Those in the out-patient group received individual supportive psychotherapy and maintenance chemotherapy according to their clinical needs for 10-20 minutes once per week. After entry into the study, all subjects were assessed for the number of readmission, days of hospitalization, and the direct treatment costs through the first and second year of follow-ups. These outcome variables were also compared pre-and post-2 years at the time point of entry into the study. Aftercare chemotherapy on a weekly to monthly basis continued for the remainder of the two year follow-up period. Results : With regard to the mean number of hospital admissions per year, the mean days of hospitalization per year, and the direct treatment costs per year, the psychiatric rehabilitation group had significantly decreased all clinical outcomes 2 years after compared with before receiving psychiatric rehabilitation. But there were no significant differences in the all clinical outcomes between before and after study intake in the out-patient group. For the number of relapse regardless of drug compliance, 4 patients(9%) during first year and 14 patients(30%) during second year were relapsed in the 46 subjects of the psychiatric rehabilitation group. In contrast, 75 patients(59%) during first year and 90 patients (71%) during second year relapsed in the out-patient group. When considering the effect of drug noncompliance to relapse, 4(9%) and 14 patients(30%) were relapsed while on medication respectively during the first and second year in the 46 of the psychiatric rehabilitation group, vs. 27(34%) of 79 patients on medication during the first year and 31(46%) of 68 patients on medication during the second year were relapsed in the out-patient group. Conclusions : These results indicate that the comprehensive psychiatric rehabilitation can be useful therapeutic intervention both to improve the clinical outcomes of schizophrenic patients and to reduce the economical burden of their relatives.

정신분열병 환자에서의 한국어판 사회적응 척도의 개발 : 신뢰도 및 타당도 연구

김철권,서지민,김상수,조진석,하준선,김정옥,변원탄 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

연구목적: 정신분열병 환자의 사회적응 정도를 측정하는데 사용되는 사회적응 척도의 한국어판을 개발하기 위함이다. 방 법: 사회적응 척도를 번역한 후 정신분열병 환자 67명과 정상인 78명을 대상으로 신뢰도와 타당도를 검증하였다. 결 과: 자료분석 결과 검사-재검사 신뢰도는 0.85, 검사자간 신뢰도는 0.89, 내적 일치도는 0.87로 높은 수치였다. 변별 타당도를 검증하기 위하여 정신분열병 환자군과 정상 대조군을 비교한 결과 정신분열병 환자군에서 사회적응 정도가 유의하게 낮았다. 구성 타당도를 알아보기 위하여 10개 영역간의 상관관계를 측정한 결과 성적적응 영역을 제외한 모든 영역들에서 유의한 상관관계를 보였다. 본 척도의 전반적 평가 영역 결과와 GAF 결과간의 상관성을 통해 간접적으로 검증한 공존 타당도 역시 유의하였다. 결 론: 한국판 사회적응 척도는 우수한 신뢰도와 타당도가 입증되었고 나아가 정신분열병 환자의 사회적응 정도를 평가하는데 유용하게 사용되어질 수 있을 것이다. Objectives: The purpose of this study was to develop the Korean version of the Social Adjustment Scale Ⅱ-Revised Version(KSAS Ⅱ-RV) in the schizophrenics. Methods: KSAS Ⅱ-RV was administered to 67 schizophrenic patients and 78 matched normal controls for examining the reliability and validity. Results: Data analysis showed statistically significant reliabilities and validities of KSAS Ⅱ-RV. The test-retest reliability, inter-rater reliability, and internal consistency for total scores of KSAS Ⅱ-RV were 0.85, 0.89. and 0.87, respectively. Evidence for discriminant validity of KSAS Ⅱ-RV comes from the results that the mean scores of schizophrenic patients were significantly high than those of normal controls. Construct validity was assessed by calculating the 10 inter-subareas correlations of the KSAS Ⅱ-RV, and all except the sexual adjustment area were statistically significant. Significant correlations between the global area scores of KSAS Ⅱ-RV and those of Global Assessment of Functioning Scale lend support for the concurrent validity of this instrument indirectly. Conclusions: KSAS Ⅱ-RV was found to be a valid and reliable instrument which can be used to evaluate the degree of social adjustment in the schizophrenic patients.

포스터전시 : 간경변 환자가 식도정맥류출혈을 주소로 주말에 입원하는 것이 주중에 입원하는 것보다 위험한가?: 단일 기관 경험 (초)

( Sun Jeong Byun ),( Seung Up Kim ),( Jun Yong Park ),( Do Young Kim ),( Kwang Hyub Han ),( Chae Yoon Chon ),( Sang Hoon Ahn ) 대한간학회 2010 Clinical and Molecular Hepatology(대한간학회지) Vol.16 No.3(S)

GO-70 : Small Cell Carcinoma of the Endometrium; A Case Report

( Eun Jeong Jeong ),( Jung Mi Byun ),( Dae Hoon Jeong ),( Young Nam Kim ),( Su Sun Kim ),( Moon Su Sung ),( Kyung Bok Lee ),( Ki Tae Kim ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-

Small cell carcinoma of the endometrium (SCCE) is extremely rare and has a very poor prognosis. The clinical behaviour of this tumor is usually very aggressive. Standard treatments have not been established. The case of a 47-year-old woman suffering from lower abdominal pain and irregular menstruation are presented. Pelvic examination, ultrasonography, magnetic resonance imaging (MRI) and computed tomography (CT) revealed a heterogenous endometrial mass (6.3 × 5 cm) with endocervical and deep myometrial invasion. In imaging study, multiple bilateral internal iliac lymph node was enlarged and right ovarian mass was shown. Serum CA 125 was 29.09 U/ml. An endometrial curettage was performed and the pathologic finding was squamous cell carcinoma. The patient underwent total abdominal hysterectomy, bilateral salpingo-oophorectomy, bilateral Pelvic and para-aortic lymphadenectomy, omentectomy and appendectomy After the operation, She received chemotheraphy with combination of paclitaxel and carboplatin. After three cycles of the chemotherapy, she refused further chemotherapy. The patient died one year after surgery.

Poster Session : Phorbol 12-myristate 13-acetate protects against necrotic cell death in response to death receptor-Ligation

( Hee Sun Byun ),( Kyeong Ah Park ),( Min Ho Won ),( Kuem Jin Yang ),( Sang Hee Shin ),( Long Zhen Piao ),( Jin Young Kwak ),( Ji Won Lee ),( Jong Sun Park ),( Jeong Ho Seok ),( Zheng Gang Liu ),( Gan 한국생화학분자생물학회 (구 한국생화학회) 2006 생화학분자생물학회 춘계학술발표논문집 Vol.2006 No.-

신장 혈관근지방종의 대량출혈을 일으킨 결절성 경화증 1예

변선정 ( Sun Jeong Byun ),이규백 ( Kyu Beck Lee ),이용수 ( Yong Su Lee ),김향 ( Hang Kim ),홍현표 ( Hyun Pyo Hong ),김승권 ( Seung Kwon Kim ),이영래 ( Young Rae Lee ),채승완 ( Sung Wan Chae ),손진희 ( Jin Hee Son ) 대한신장학회 2007 Kidney Research and Clinical Practice Vol.26 No.4