The Evolving Policy Debate on Border Closure in Korea

Su-Jin Kang,Jihyun Moon,Heewon Kang,Heekyoung Nam,Sangwoo Tak,Sung-Il Cho 대한예방의학회 2020 Journal of Preventive Medicine and Public Health Vol.53 No.5

302 Copyright © 2020 The Korean Society for Preventive Medicine J Prev Med Public Health 2020;53:302-306 • https://doi.org/10.3961/jpmph.20.213 The Evolving Policy Debate on Border Closure in Korea SuJin Kang1, Jihyun Moon2, Heewon Kang1, Heekyoung Nam3, Sangwoo Tak1, Sung-il Cho1,3 1Institute of Health and Environment, Seoul National University, Seoul, Korea; 2Samsung Advanced Institute of Health Science and Technology, Sungkyunkwan University, Seoul, Korea; 3Department of Public Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Korea Brief Report Objectives: In this paper, we aimed to investigate the evolving debate over border closure in Korea during the coronavirus disease 2019 (COVID-19) pandemic, to address the main themes associated with border closure, and to discuss the factors that need to be considered when making such decisions. Methods: We collated and reviewed previously conducted review studies on border closures during infectious disease outbreaks to derive relevant themes and factors. Results: According to our systematic review on border closures and travel restrictions, the effects of such containment efforts are limited. We suggest considering the following factors when determining whether to impose border closure measures: (1) disease characteristics, (2) timeliness of implementation, (3) transmission delay and the basic reproduction number, (4) globalization and pandemics, and (5) social and economic costs. Conclusions: Our assessment indicates that the effects of border closures are at best temporary and limited. Alternative measures must be contemplated and implemented to suppress the spread of COVID-19 in particular and infectious diseases more broadly.

傷寒論에 대한 精神醫學的 硏究

文相泰,辛容玹,具炳壽 대한한방신경정신과학회 2000 동의신경정신과학회지 Vol.11 No.1

This study was aimed to get the course which is caused by Neuropsychiatric symptoms in Sang-Han. Therefore this study is based on 『Euhak-Ipmun. Sang-Han』(『醫學入門.傷寒』) classfied mainly by symptoms. The results were summerized as follows: 1. Neuropsychiatric symptoms in 『Euhak-Ipmun. Sang-Han』(『醫學入門. 傷寒』) are explained as Pal-Gang(八綱), which shows those are settled down to a systematic oriental medical theory. 2. Pal-Bup (八法) used in the cure of symptomatische psychose in 『Euhak-Ipmun. Sang-Han』(『醫學入門. 傷寒』), which is intended to boost the effect of cure, choosing the respondent cure method about various causes. 3. Pal-Gang(八綱) and Pal-Bup(八法) in『Euhak-Ipmun. Sang-Han』(『醫學入門·傷寒』) are improved by Lee-Chun(李 ) who added Jang-gi(張機)'s Sang Han theory and new medical thought in the ages of Geum. Won. 4. Lee-Chun(李 ) believed that Neuropsychiatric symptoms which appeared in Sang Hang is caused by the "Unbalance(不平)". So he wanted to reach harmony of "Jeong(精), QI(氣), Shin(神), Hyul(血)" after improving the status of "Unbalance(『不平』)" toward the status of "Balance(平)".

중증 외상환자에서 염기 결핍수치의 유용성

문준동,김수진,문철규,최성혁,전정민,이성우,홍윤식 대한응급의학회 2001 대한응급의학회지 Vol.12 No.3

Background: This study's objective was to determine the prognostic value of the base deficit measured in the emergency department(ED) and to determine whether base deficit can provide information not provided by advanced injury scoring system. Methods: This study was a retrospective analysis of data collected for two years. Thirty-two severe trauma patients who were admitted to the Emergency Department of Korea University Hospital were included in this study. The patients were divided into two groups: the normal base deficit group(-3 mmol/L to 3 mmol/L) and the elevated base deficit group(>3 mmol/L). The base-deficit value, age, sex, head injury, organ failure rate, and survival were considered, and the also Revised Trauma Score(RTS), Acute Physiology And Chronic Health Evaluation(APACHE II), and Injury Severity Score(ISS) were measured. Result: The elevated base-deficit group showed a lower survival rate and a higher organ failure rate compared to the normal base deficit group. Logistic Regression showed a strong association between base deficit and mortality rate. Among the previous injury scoring Systems(RTS, APACHE II, ISS), base deficit had the strongest correlation with RTS. By using base deficit value and the RTS together, we obtained a higher positive predictive value than that obtained by using base deficit or RTS alone. Conclusion: The admission value of the base deficit in the ED is a useful tool in predicting the outcome in severe trauma patients, and it can be an adjunct to previous injury scoring systems. As an advanced injury scoring System is developed in the future, the base deficit may have some significant role.

검은 비늘버섯 Pholiota adiposa로부터 항치매성 Butyrylcholinesterase 저해물질의 생산

한상민, 박선정, 문정수, 이종수 배재대학교 자연과학연구소 2021 自然科學論文集 Vol.32 No.1

본 연구에서는 식용버섯 유래의 새로운 항치매성 butyrylcholinesterase(BChE) 저해물질을 생산할 목적으로 식용버섯 추출물들의 BChE 저해활성을 측정하였다. 식용버섯들 중에서는 검은비늘버섯의 물 추출물이 42.7 %의 BChE 저해활성을 보여 최종 선발하였다. 또한 검은비늘버섯 자실체를 30 ℃에서 24시간 물 추출하였을 때 BChE 저해활성이 가장 높았다. n this paper, screening potent edible mushroom with high anti-dementia butyrylcholinesterase(BChE) inhibitory activity and optimal extraction condition of BChE inhibitors were described. Among various edible mushroom, the water extract from Pholiota adiposa fruiting body had high BChE inhibitory activity of 42.7 %. BChE inhibitor from P.adiposa fruiting body was maximally extracted when its fruiting body was trated with distilled water for 24 hr at 30 ℃.

조기진통의 진단과 처치

성문수,김현찬 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5

Prematurity and intra-uterine growth retardation(IUGR) and two main cause of low birth weight(LBW), a major contributor to infant mortality. The majority of LBW infants in developing countries is due to IUGR, while most LBW infants in industrialized countries are due to preform birth. The preform birth rate of almost 10% of birth has remained little changed for several decades, despite in changes in clinical practice and technology. Between 75~80% of those deliveries are due to either preform labor or preform prematurity of membranes. There is not yet complete understanding of the cause of preform labor. Preventive and treatment efforts aimed at single etiology have been unsuccessful to date, since the cause are multifactorial. Accurate diagnosis of preform labor remains a problematic issue. New techniques such as transvaginal cervical sonography and fetal fibronectin are increasingly important in diagnosis and intervention planning. Neither test can, at present, recommended for screening of general population since there is no effective intervention for a positive test. Future directions in research include development of new tocolytic agents and clarification of the best use of adjunctive therapies for lung maturity.

항치매성 acetylcholineaterase 함유 검은 비늘버섯 추출물의 PC12 신경세포사 저해 효과

문정수, 한상민, 이종수 배재대학교 자연과학연구소 2021 自然科學論文集 Vol.32 No.1

본 연구에서는 부분 정제된 acetylcholinesterase 저해물질을 함유한 검은비늘버섯 추출물의 신경세포 PC12에 대한 세포독성을 조사하고 PC12 신경세포 저해효과를 조사하였다. 검은 비늘버섯 추출물은 세포 생존에 영향을 미치지 않았고 무처리군의 85.6%에 비해 19.3%로 세포사 저해효과가 우수하였다. Dementia disease has been increased because of the significant increase in life expectancy over sixty-five years of age in Korea. This studies were carried out to develop new anti-dementia compounds such as acetylcholinesterase(AChE) inhibitor from edible mushrooms.. AChE inhibitor from water extract of finally selected Pholiota adiposa were partially purified by Sephadex G-50 gel permeation chromatography and RP-HPLC. The partial purified acetylcholinesterase inhibitor-containing Pholiota adiposa extracts showed high cell viability and also showed apoptotic inhibitory effects against PC12 neuron-like cells.

서로 다른 이중에너지 방사선흡수기계 기종 (Hologic QDR 4500-A 와 Lunar EXPERT-XL)간의 골밀도 교차 보정

문대혁,김기수,이희경,김재승,신중우,조진만,김상욱 대한핵의학회 1999 핵의학 분자영상 Vol.33 No.3

Purpose: A cross-calibration equation is needed to compare bone mineral density measured by different dual X-ray absoptiometry systems. We performed this study to establish appropriate cross-calibration equations between two different dual X-ray absorptiometry systems. Materials and Methods: Bone mineral density of anterior-posterior lumbar spine (L2-4 level) and femoral neck were measured in 109 women (55±11yr) using two different dual X-ray absorptiometry systems (Lunar EXPERT-XL) and Hologic QDR 4500-A). Bone mineral density values measured by two systems, including area, bone mass content, bone mineral density and percentile of young normals were compared and cross-calibration equations between two systems derived. Results: The bone mineral density values of 109 women measured by Lunar system were 0.958±0.17 g/cm2 at L2-4 and 0.768±0.131 g/cm2 at femur neck, which were significantly higher (13±6% at L2-4 and 19±7% at femur neck, p<0.001) than those (0.851±0.144 g/cm2 at L2-4 and 0.649±0.108 g/cm2 a neck) by Hologic system. Bone mineral content and percentile of young normals measured by Lunar system were also significantly higher than those by Hologic system (p<0.001), whereas there was no difference in area (p>0.05). There was a high correlation between bone mineral density values of L2-4 and femoral neck obtained with both dual X-ray absortiometry systems (r=0.96 and 0.95, respectively). Cross-calibration equations relating the bone mineral density were Lunar=1.1287×Hologic-0.0027 for L2-4 and Lunar=l.1556×Hologic+0.0l82 for femoral neck. Conclusion: We obtained cross-calibration equations of bone mineral density between Lunar EXPERT-XL and Hologic QDR 4500-A. These equations can be useful in comparing bone mineral density obtained by different dual X-ray absorptiometry systems.

생물방제균 Bacillus subtilis YB-70이 생산하는 항진균성 항생물질의 분리 및 구조결정

김용수,손종근,문동철,김상달 영남대학교 약품개발연구소 1997 영남대학교 약품개발연구소 연구업적집 Vol.7 No.-

인삼근부균 Fusarium solani의 생육을 강력히 저해하는 생물방제균을 저병해 인삼경작지 근권토양에서 분리, 선발하여 Bacillus subtilis로 동정한 바 있고, 이 생물방제균 B. subtilis YB-70의 식물근부균 F. solani의 생육에 대한 길항기작이 항진균성 항생물질에 기인된다는 사실을 배양생산물의 분자량별 활성도 검증, 열처리에 의한 잔존 활성도 측정 등에 의해 열에 강한 저분자성 항생물질로 재확인하였고 in vivo test에서도 F.solani에 의한 근부병을 강력히 억제할 수 있음을 하였다. 생물방제균 Bacillus subtilis YB-70이 생산하는 항진균성 항생물질을 pH 침전, 용매추출, silica gel chromatography, LH-20 column chromatography 등을 통해 항생물질 YBS-1A, B로 분리, 정제 할 수 있었으며, 이 물질의 구조를 MS, NMR, amino acid analysis로 추정해 본 결과 YBS-1A는 5종 7개의 amino 산으로 구성된 itulin A 계열 항생물질로 규명되었으며, YBS-1B는 7종 11개의 amino 산으로 구성된 분자량 1,500정도의 itulin A 보다 좀 더 큰 항생물질로 추정되었다. A potential biocontrol bacterium, YB-70 was isolated from a rhizosphere in suppressive soil and identified as strain of Bacillus subtilis. In several biochemical and in vitro antibiosis tests on Fusarium solani with the culture filterates from B. subtilis YB-70, we found that antifungal mechanism of B. subtilis YB-70 was mediated by antibiotic substances produced from the bacterium. These antifungal substances were appeared to be beat-resistanl, micromolecular, and ethyl alcohol soluble. Antifungal agents produced by B. subtilis YB-70 showed strong inhibition against root-rotting fungi F. solani in in vivo pot test. An antifungal substance, YBS-1s, was purified from the culture broth of B. subtilis YB-70 by isoelectronic precipitation, silica gel column chromatography and Sephadex LH-20 column chromatography. Three antifungal agents were isolated from the culture broth of B. subtilis YB-70. Various instrumental analysis by Fab-MASS, ¹H-NMR, ¹³C-NMR, DEPT, and amino acid analyzet revealed that the YBS-1A was a peptide antibiotics of iturin class containing seven amino acids from five different groups, and the other(YBS-1B) was an analogue of iturin class containing seven amino acids from five different groups, and the other(YBS-1B) was an analogue of iturin group composed of 11 amino acids with larger molecular weight of about 1,500 dalton, which was lager than that of iturin A.

혼파초지에서 질소시비수준과 방목율이 목초 및 육우생산에 미치는 영향

현봉수,김문철,김영호,송성언,이승협 제주대학교 농과대학 제주도축산문제연구소 1986 畜産論叢 Vol.1 No.1

Effects of N fertilizer levels and stocking rates on beef production in a mixed pastiire of orchard-grass, perennial ryegrass, tall fescue, red clover and alsike clover were studied using 3 levels of N fertilizer (50, 100 and 200 kg/ha) and 3 stocking rates (3,4 and 5 head /ha). The summarized results are the following; 1. Increasing nitrogen fertilizer on the mixed pasture increased dry matter yield and protein content(P<0.05) of the pasture species. The stocking rate did not influence either dry matter yield or protein content. 2. The percentage of pasture species increased and that of weeds decreased with increasing N fer-tilizer levels. lncreasing stocking rate from 3 to 5 heads/ha significantly influenced that of the other pastures and weeds. 3. Herhage intake per animal increased at the lower stocking rate, but total herbage intake per ha increased at the higher stocking rate, Increasing nitrogen fertilizer decreased herbage intake per animal , but slightly higher intake per animal was obserbed at 5 head stocking rate. 4. No significant difference in weight gain/ha was found among N levels and stocking rates ussd. Live weight gain per animal was greater at the higher N level and also at the louer stocking rate.

Green함수법을 이용한 항내정온도 해석

변성국,곽문수,편종근 明知大學校 産業技術硏究所 1999 産業技術硏究所論文集 Vol.18 No.-

In this study, Green function method which calculates wave heights in harbor with constant depth is examined and the numerical model using by this method is applied. A computation of numerical model in huge harbor or sea area generally needs a long run-time. Green function method which has an effect of reducing run-time is applied to sea area in Saemankum and verified by comparing the results with those of other numerical model and hydraulic model experiment.