체질량지수와 간기능 이상과의 관련성

윤혜은,류소연,강명근,박종,김기순 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.1

Objective: To investigate the relationship between body mass index (BMI) and liver function abnormalities in the general population in Korea. Methods: The study subjects were 5765 persons who were received questionnaire survey and health examination of national health and nutrition survey in 1998, 20-59 years in age and had no history of viral hepatitis. BMI was categorized by quartile and abnormal liver functions were defined aspartate aminotransferase (AST) >30 U/L or alanine aminotransferase (ALT) >35 U/L in serum level. In order to identify the association of BMI and abnormal liver function, chi-square test and multivariate logistic regression analysis were used. Results: The abnormality rates of AST were 35.0% in male and 13.4% in female. The abnormality rates of ALT were 35.8% in male and 11.1% in female. After controlling for the other covariates, the multivairate logistic regression analysis showed that BMI was the significant related factor of abnormal AST (male; odds ratio=1.25; 95% confidence interval=1.15-1.36, female; odds ratio=1.14; 95% confidence interval=1.02-1.26) and abnormal ALT (male; odds ratio=1.87; 95% confidence interval=1.71-2.04, female; odds ratio=1.56; 95% confidence interval=1.38-175). Conclusions: We identify that BMI was the significant risk factor of non-viral liver disease with abnormal liver functions. A large-scale investigation will be suggested in the future to demonstrate the causal-effect issue between abnormal liver function and obesity.

직무스트레스가 실업에 미치는 영향

정윤경,김형렬,박소영,홍정연,고상백,장세진 대한산업의학회 2007 대한직업환경의학회지 Vol.19 No.2

팬티스타킹의 치수표시에 관한 연구

노주연,주소령,남윤자,문지연 한국의류학회 2003 한국의류학회지 Vol.27 No.5

The pantyhose is a close-fitting garment, and consumers are highly sensitive to any progress made in fitting the garment to their lower body and comfort. However, the pantyhose manufactured in Korea are only one-sized. The purpose of this study is to suggest a sizing system for pantyhose. The results of this study are as follows: 1. As a results of questions regarding the sizing system of pantyhose, 88.2% of people who responded to our questionnaire preferred multi-sized pantyhose. In particular, larger women opposed to thin women expressed some dissatisfaction in the length and the width of the pantyhose. In addition, most of women preferred and indication of the sizing system and the body size of the control dimension (body mass and height). 2. The 13 species of pantyhose that were manufactured abroad are of all sizes, and only one type of pantyhose if one-sized. However, most domestic pantyhose except one, are one-sized. 3. As a result of the experiment, the spandex content in pantyhose was approximately 12~18%. Moreover, the elongation rate was approximately 200~370%, which differed according to the features of the material. The stretch size of the pantyhose had varies greatly, and has not yet been standardized. 4. The methods for indicating the pantyhose size in this study are the square method and the stair method. The characteristics of the square method are simple, but the coverage is relatively low. The characteristic of the stair method are so complicated that older women have a low preference for this method. However, the coverage rate is high.

일부 의과대학생의 음주 실태와 관련 요인

류소연,윤혜은,김기순,박종,강명근,박계남 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.2

Objectives : This study was performed to investigate the drinking status and the related factors with problem drinking in some medical students. Methods : The study subjects were 345 premedical students (freshmen and sophomore) and medical students (sophomore) in a medical school who replied to the self-administered questionnaire survey during March 2002. The questionnaire was composed of general characteristics, drinking status, social value about drinking, health status, satisfaction of life and alcohol use disorders identification test (AUDIT) . Results : The experience rate of drinking was 88.8% in male and 88.3% in female and it was tended to increase with going up the grade. Prevalence of hazardous, dependence, harmful and problem drinking classified by AUDIT score criteria were 66.2%, 3.0%, 7.0% and 5.1% in male and 34.9%, 0.9%, 1.9%, 1.9% in female. In male, the statistically significant related factors to Al JDIT scores were grade, religion, maternal drinking status, social value about drinking, affectionate feelings of those around one and satisfaction of life. Only social value about drinking was statistically significant correlated factor with AUDIT scores in female. As a result of multiple regression analysis, the related factors with AUDIT scores were sex, maternal drinking status, satisfaction of life and social value a bout drinking. Conclusion : The experience rate of drinking in medical students was higher than that in other college students. Grade, family drinking history, negative psychological feelings, social value about drinking were risk factors to problem drinking.

액와 부 유방조직 1예

조소연,임연순,최혜영,명기범 梨花女子大學校 醫科大學 醫科學硏究所 1997 EMJ (Ewha medical journal) Vol.20 No.2

부 유방조직은 발생학적 이상에 의하여 발생하며 주로 사춘기 이후에 증상을 보이는 질환으로 여러 아형이 있으며, 본 증례에서와 같이 임신과 무관하게 액외부에 일측성으로 피부표면의 병변 없이 이소성 선조직만 존재하는 경우는 매우 드물어 문헌고찰과 함께 보고한다. A case of unilateral accessory axillary breast tissue developed as a subcutaneous nodule unassociated with menstrual periods, pregnancy, or lactation in a 33-year-old parous woman. Histopathologic finding of the nodule revealed lobules of normal breast tissue forming islands of glandular tissue, This case belongs to one of the unusual forms of supernumerary breast tissue characterized by the presence of aberrant gland tissue alone. The literature is briefly reviewed.

항암제 처리한 백혈병 세포주에서의 Apoptosis 발현

김삼용,윤소현,김현수,김종숙,윤환중,김진경,조덕연 충남대학교 암연구소 1998 癌共同硏究所 硏究誌 Vol.2 No.1

The bcl-2 proto-oncogene encodes a 26 kD protein that promotes cell survival by blocking apoptosis. The bax protein is a member of the bcl-2 familly, now known to form heterodimers with the bcl-2 protein. The ratio of bax to bcl-2 is be critical in determining the fate of the cell in response to stimuli that can induce apoptosis. Extract of Pulsatilla Koreana (SB-31) showed promising antitumor activity in vitro with Topo I inhibitory action. In the present study, the relationship between apoptosis and the apoptosis related proteins, bcl-2 and bax were investigated in human leukemic cell lines HL-60, U-937 and CEM-CM3. All anticancer drugs(adriamycin, etoposide, camptothecin, SB-31) induced extensive apoptosis in HL-60, U-937 cells and CEM-CM3 cells. The expression of bcl-2 and bax protein were determined in cell lines by western blotting before and after incubation with anticancer drugs at different time points. 1) In HL-60 or U-937 cell lines, down regulation of bcl-2 and up-regulation of bax were found after incubation with ADR, VP-16 or camptothecin. 2) In HL-60 or U-937 cell lines, no significant change in bcl-2 or bax protein expression resulted after incubation with SB-31. 3) In CEM-CM3 cells, virtually no change was noted in bcl-2/bax expression after incubation with ADR, VP-16, camptothecin or SB-31. It is suggested that different leukemic cell lines use different pathways of apoptosis activation and a given cell may utilize different pathways of apoptosis activation in response to different cytotoxic agents.

항암제 처리한 백혈병 세포주에서의 Apoptosis 발현

김삼용,윤소현,김현수,김종숙,윤환중,김진경,조덕연 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

The bcl-2 proto-oncogene encodes a 26 kD protein that promotes cell survival by blocking apoptosis. The bax protein is a member of the bcl-2 familly, now known to form heterodimers with the bcl-2 protein. The ratio of bax to bcl-2 is be critical in determining the fate of the cell in response to stimuli that can induce apoptosis. Extract of Pulsatilla Koreana (SB-31) showed promising antitumor activity in vitro with Topo I inhibitory action. In the present study, the relationship between apoptosis and the apoptosis related proteins, bcl-2 and bax were investigated in human leukemic cell lines HL-60, U-937 and CEM-CM3. All anticancer drugs(adriamycin, etoposide, camptothecin, SB-31) induced extensive apoptosis in HL-60, U-937 cells and CEM-CM3 cells. The expression of bcl-2 and bax protein were determined in cell lines by western blotting before and after incubation with anticancer drugs at different time points. 1) In HL-60 or U-937 cell lines, down regulation of bcl-2 and up-regulation of bax were found after incubation with ADR, VP-16 or camptothecin. 2) In HL-60 or U-937 cell lines, no significant change in bcl-2 or bax protein expression resulted after incubation with SB-31. 3) In CEM-CM3 cells, virtually no change was noted in bcl-2/bax expression after incubation with ADR, VP-16, camptothecin or SB-31. It is suggested that different leukemic cell lines use different pathways of apoptosis activation and a given cell may utilize different pathways of apoptosis activation in response to different cytotoxic agents.

태풍 내습 시 강수에 의한 대기오염물질 (PM<SUB>10</SUB>, NO₂, CO, SO₂)의 농도 변화 분석

안숙희(Suk-Hee Ahn),박소연(So-Yeon Park),김정윤(Jeoung-Yun Kim),김백조(Baek-Jo Kim) 한국대기환경학회 2014 한국대기환경학회지 Vol.30 No.2

Effectiveness of ultra-wide implants in the mandibular and maxillary posterior areas: a 5-year retrospective clinical study

So-Yeon Kim(So-Yeon Kim),Hyeong-Gi Kim(Hyeong-Gi Kim),Pil-Young Yun(Pil-Young Yun),Young-Kyun Kim(Young-Kyun Kim) 대한구강악안면외과학회 2023 대한구강악안면외과학회지 Vol.49 No.1

Objectives: Ultra-wide implants may be used as a replacement if existing implants fail. This study was conducted to evaluate the factors influencing the prognosis and failure of ultra-wide implants. Patients and Methods: This study evaluated whether sex, age, site, diameter, length, additional surgery, implant stability (primary and secondary), and reason for ultra-wide implant placement affect the 5-year survival and success rates and marginal bone loss (MBL) of ultra-wide implants. Seventy- eight ultra-wide implants that were placed in 71 patients (39 males and 32 females) from 2008 to 2010 were studied. One-way ANOVA analysis was conducted to evaluate the statistical significance of MBL according to the patient’s sex, implant site, and diameter. Independent sample t -tests were used to determine the statistical significance of MBL analysis which was used to determine the significance of the 5-year success and survival rates related to the variables. One-way ANOVA was conducted to evaluate the statistical significance of sex, implantation site, diameter, and MBL. Independent sample t -tests were used to evaluate the correlation between implantability and MBL for implantation reasons, while additional surgery, length, and Kaplan-Meier analysis were used to evaluate 5-year survival and success rates. Results: The mean age of patients was 54.2 years with a survival rate of 92.3% and a success rate of 83.3% over a mean 97.8-month period of observation. MBL averaged 0.2 mm after one year of prosthetic function loading and 0.54 mm at the time of final observation. Success rates correlated with primary stability (P=0.045), survival rates correlated with secondary stability (P=0.036), and MBL did not correlate with any variables. Conclusion: Ultra-wide implants can be used to achieve secure initial fixation in the maxillary and mandibular molar regions with poor bone quality or for alternative purposes in cases of previous implant failure.

LT, Others : PE-128 ; Clinical characteristics of toxocariasis with hepatic involvement

( So Yeon Yun ),( Jung Nam Cho ),( Tae Won Kim ),( Kyung Ho Ha ),( Byung Seok Kim ),( Chang Hyeong Lee ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background/Aim: Toxocariasis is an infection in the human host caused by Toxocara canis (dog roundworm) or Toxocara cati (cat roundworm), and occurs more frequently in children. Clinical manifestations range from no symptoms to eosinophilia or lung, hepatic, ocular or neurological involvement. Most infections in adults are asymtomatic. Toxocariasis rarely causes hepatic lesion. We investigated clinical characteristics in toxocariasis with hepatic involvement. Methods: From January 2008 to March 2012, seventeen toxocariasis patients with hepatic involvement were enrolled in this study. Clinical features, dietary habits, contact with pets, occupational history, allergic disease, peripheral eosinophil count, serum immunoglobulin E (IgE) were evaluated. Hepatic involvement was diagnosed by abdominal computed tomography (CT). All patients were diagnosed as toxocariasis by serological method (enzyme-linked immunosorbent assay, ELISA) and received albendazole (10 mg/kg/day) for 5 days. After treatment with albendazole, follow-up was conducted with abdominal CT, serum eosinophil and IgE. Results: The mean age was 48.7±10.9 years (34-74) and 12 (70.6%) patients were men. Five (29.4%) of 17 patients had abdominal pain, one had cough, and the others (64.7%) had no symptoms. 9 (52.9%) patients had a recent history of eating raw meat. Initial laboratory findings revealed increased eosinophil and IgE levels in most patients. The initial CT showed one or multiple hypodense lesions in the liver. Ultrasonography- guided liver biopsy was performed on 7 (41.2%) patients and it revealed eosinophilic infiltrations. After 1 month of albendazole treatment, eosinophil counts were normalized or had decreased in 15 (88.2%) patients. On follow-up CT, hepatic lesions disappeared within 6 months after therapy in 82.4% of patients. Conclusions: With dietary habits of consuming raw meat in Korea, the occurrence of overt toxocariasis in adults is increasing. Careful history taking and early serologic testing may increase diagnostic yield in patients with hepatic lesion and peripheral eosinophilia.