폐경 전후 여성의 식이섭취가 골 밀도에 미치는 여향

홍성철,김문두,김성엽 제주대학교 생명과학연구소 2003 제주생명과학연구 Vol.6 No.1

Objective : To evaluate degree of bone mineral density and prevalence rate of osteoporosis according to age and to search the preventive strategy for osteoporosis, the factors that affect on bone density were studied in pre- and postmenopausal women in korea. Methods : The subjects were 961 premenopausal and 1,167 postmenopausal women who have examined in health promotion center of Yeungnam University Hospital in Daegu city from January, 1999 to January, 2001. The diet pattern of subjectives was analysed through interview with questionnaire. Results : The bone mineral density was statistically higher in women who have taken more calorie, protein, fat, or carbohydrate than recommended amount compared with women who have taken less calorie, protein, fat, or carbohydrate, than recommended amount in pre- and postmenopausal. In the effects of mineral and vitamin intake on bone mineral density, the higher intake of vitamin B12 and niacin increased bone mineral density statistically significantly in postmenopausal women, the women who have taken calcium more than 500 mg/day were revealed increased bone mineral density compared with less intake women in pre- and postmenopausal, and the women who have taken vitamin C more than 100 mg/day were revealed increased bone mineral density compared with less intake women in pre- and postmenopausal. Conclusion : These results suggested that to prevent osteoporosis, the systemized program including balanced diet for promoting anti-osteoporotic factors have to be developed and apply from the thirties whom have maximal bone mineral density.

제주도 고등학교 학생들의 비만 정도, 심혈관 위험인자, 소아시 비만과의 관련성

홍성철,황승욱,현인숙 韓國保健敎育.健康增進學會 2003 보건교육건강증진학회지 Vol.20 No.2

Background: Recently, adolescent obesity was increased and tended to become obese adults, facing increased risk for diabetes, cardiovascular disease. Even before reaching adulthood, adolescent obesity already was experiencing hypertension, dyslipidemia, and diabetes mellitus. The purpose of this study was to find prevalence of obesity of high school students in Jeju island and association between obesity and cardiovascular risk factors and association between childhood obesity and adolescent obesity. Method: The study subjects were 6,064 students of twenty-two high school in Jeju island and health survey data was gathered from high school health examination data and hospital health examination data from Aug. 1999 to Dec. 1999. Adolescent obesity was evaluated by ideal body weight method in 1998 and body mass index. Cardiovascular risk factors were checked total cholesterol, systolic and diastolic blood pressure, fasting blood sugar. In 1,534 students, obesity at primary school is checked by primary and middle school health record. Results: Prevalence of obesity in Jeju island high school students is 12.6% in male students, 13.3% in female students by ideal body weight method and 8.7% in male students, 8.5% in female students by body mass index. Prevalence of obesity of male students in city area and district area of Jeju island were each 12.9%, 10.3% and that of male students in city area was significantly higher. Prevalence of obesity of female students in city area and district area of Jeju island were each 12.9%, 14.2% and not significantly different. Prevalence of obesity of male students in general and commercial school group were each 13.9%, 10.3% and that of general school group was significantly higher. In female students, Prevalence of obesity general and commercial school group was not significantly different. Total cholesterol, systolic and diastolic blood pressure were significantly associated with degree of obesity in male and female students(P<05) and fasting blood sugar was only significantly associated with degree of obesity in male students(P<05). In 1,514 students checked by health record, Odds ratio of obesity at primary and middle school that at high school were 12.96~22.77 and was significantly associated. Conclusion: Prevalence of obesity of high school students in Jeju island is very high and adolescent obsity was significantly associated with cardiovascular risk factors. Mostly childhood obesity tended to become adolescent obsity and program of control of obesity at childhood and adolescence is required.

中.長距離 달리기의 最適戰略에 關한 數理的 模型

洪盛杓,全鍾貴,崔哲圭 忠南大學校體育科學硏究所 1988 體育科學硏究誌 Vol.6 No.1

The mathematical theory of competitive running by Keller, which is based on the Newton's second law of motion, is applied to analyze the track records of the Asian and Korean athlets. In addition, the empirical formular proposed by Toots is used to represent the aver age speed of the runners for various races. The main conclusions arrived at are as follows. 1. According to the Keller theory, running at a constant speed is an optimum strategy throughout the races except the initial two seconds and the final 3 seconds, approximately, for distances greater than certain critical distances. But it is effective to run at a full speed with maximum propulsion, for the short distance sprints. 2. The critical distances obtained from the records are 291m for the World records, and 298 (320m for women) and 303m (330m for women) for Asian and Korean records, respectively. Thus the 400m race may be considered the reference item for the mid-range race. 3. Korean athletes show rather inferior physiological characteristics for the most cases analyzed, with the only exception for the oxygen supply rate of male athelets, which is somewhat greater than that of the Asian records. This may indicate a passilility of future development of superior mid and long distance runner from Korean athletes.

정상 성인에서 Amitriptyline이 수면구조와 정신생리적 기능에 미치는 영향

홍성곤,신석철,왕성근 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.1

To investigate the effects of Amitriptyline on sleep structure and psychophysiologic function in normal adults, author applied polysomnography for sleep structure, reaction time for attention and visual analogue test for daytime fatigue, mood and sleepiness to the volunteers. The subjects were 8 healthy young adults, aged from 20 to 24 years old. The results were summarized as follows. 1. In normal adults, there were great individual variations in the ditribution of relative value(%) of sleep structure. 2. Compared with the baseline, total sleep time and sleep efficiency increased significantly in the 2lmg amitriptyline night, and WASO decreased significantly in the second recovery night. 3. Compared with the baseline, the absolute value(minutes) of stage 1 sleep decreased significantly in the amitriptyline, first and second recovery nights, and the relative value(%) of stage 1 sleep decreased significantly in the first recovery night. The absolute and relative value of stage 2 sleep increased significantly in the amitriptyline night. The relative value of slow wave sleep decreased significantly in the first recovery night. 4. Compared with the baseline, the absolute and relative value of REM sleep decreased significantly in the amitriptyline night, the relative value of REM sleep increased significantly in the first and second recovery nights, and REM latency shortened significantly in the first and second recovery nights. 5. Feeling of fatigue, depressed mood and sleepiness increased in the afternoon the day after amitriptyline administration. 6. 1) In the baseline, daytime sleepiness was positive correlation with feeling of fatigue and mood. 2) The day after amitriptyline administration, relative value of REM sleep was negative correlation with feeling of fatigue and sleepiness, daytime fatigue was positive corelation with mood and sleepiness, and daytime mood was positive correlation with sleepiness. 3) In the first recovery day, daytime fatigue was positive correlation with mood and sleepiness, and negative correlation with reaction time, daytime mood was positive correlation with sleepiness, and reaction time was negative correlation with sleepiness. 4) In the second recovery day, total sleep time was positive correlation with the relative value of REM sleep time, the relative value of stage 2 sleep was negative correlation with the relative value of slow wave sleep, the relative value of slow wave sleep was positive correlation with daytime fatigue and mood, daytime fatigue was positive correlation with mood and sleepiness, and negative correlation with reaction time, daytime mood was positive correlation with sleepiness, and reaction time was negative correlation with sleepiness.

제주시 일부 초, 중, 고등학생과 대학생들의 생체전기 저항법에 의한 체성분 조사

홍성철,이상이,현인숙 대한보건협회 2002 대한보건연구 Vol.28 No.2

Purpose : obesity is a frequent nutritional disorder in children and adolescent and its prevalence is increasing in Korea. The aim of this study was to measure body composition using bioelectical impedence in primaty, middle, high and college students in Cheju. Methods : We measured height, weight, and body composition(Fat %, WHR, Fat feee mass) by InBody 3.0 in 1,431 students aged 10-25 years. We also examined degree of obesity comparing standard weight for height, body mass index, and precent of body fat. Results : Fat free mass increased by aging in both sex, higher in male. Fat mass was highest in Primary school in male(12.09±4.86kg), college in female(16.03±4.22kg). Percent of body fat was highest in Primary student(21.64±8.02%), decreased middle(19.96±7.26%), high school(15.07±5.13%), and increased in college student(17.33±5.21%) in male, however, lowest in primary student(22.78±6.10%), increased by aging (middle;25.38±6.19%, high;27.61±5.27%, college;28.27±4.49%) in female. Percent of body fat was significantly higher in female except in primary school age. The prevalence of obesity based on fat % was highest in primary school student(primary, middle, high, college student; 33.3%, 23.3%, 7.6%, 8.2%) in male(≥25%), and highest in college student(11.1%, 26.6%, 32.3%, 38.6%) in female(≥30%), whereness, based on a standard weight for height(≥20%), 13.16%, 10.84%, 6.90%, 10.10% in male, 4.44%, 7.21%, 12.11%, 9.59% in female. Conclusion : It was necessary to evaluate obesity degree by body fat percentage, especially in adolescent and young female

미국과 영국의 직업성질환 감시체계

강성규,송재철,홍윤철,김성아 大韓産業醫學會 2001 대한직업환경의학회지 Vol.13 No.1

직업병을 제대로 예방하기 위해서는 첫 단계로 직업병 발생현황을 정확하게 파악하여야 하는데, 우리나라는 근로자 특수건강진단과 공공보험으로서 산재보험이 있음에도 불구하고 일부 직업병에 대해서는 그 현황을 제대로 파악하지 못하고 있다(강성규 등,2000b) 우리나라의 현재 제도로 잘 파악되지 않는 직업병으로는 천식과 같이 소견은 없으면서 증상이 있거나, 근골격계질환이나 피부질환 같이 유병기간이 짧거나, 암과 같이 발병 후 질병이 계속하여 진행되는 것들이다(강성규 등, 2000a) 이러한 질병에 이환된 근로자는 현실적으로 접근이 어려운 특수건강진단기관의 의사나 산업보건의를 찾기보다는 일반 병원에 방문하여 임상의사의 진료를 받게 된다. 이때 임상의사나 근로자가 질병과 직업과의 관련성을 생각할 수 있다면 산재요양신청을 하게 되고 산재통계에서 공식적으로 직업병으로 집계될 수 있을 것이다. 그러나,실제적으로는 이렇게 진행되는 경우는 거의 없기 때문에 많은 직업병들이 발견되지 않고 있다. 설사, 근로자가 질병이 직업적 노출이나 환경에 의해 발생하였다고 생각한다 하더라도 산재요양에서 얻는 이득이 현 직업을 유지해서 얻는 이득보다 크다는 확신이 서지 않으면 선뜻 산재요양신청을 하지 않을 것이고, 주변에 이러한 사실이 알려지는 것도 꺼리게 될 것이다.직업병감시체계의 첫 번째 목적은 위와 같은 이유로 감추어진 직업병을 통계로 끌어내어 그 크기와 요인을 파악하는 것이다. 규모를 파악한다면 예방우선 순위를 설정하는데 도움을 얻을 것이고, 요인을 파악한다면 구체적인 예방전략을 수립할 수 있을 것이다. 경우에 따라서는 각 개개 사례에 대한 중재를 시도할 수 있을 것이다.직업병에 대한 법적인 보고 의무는 미국과 영국에서 모두 시도하고 있지만, 실제 보고되는 비율은 크지 않다. 오히려, 전문가들이나 산업보건 관계자들이 자율적으로 시도하는 보고체계에서 더 풍부하고 좋은자료를 얻고 있다. 우리나라에서도 현재 법적으로 하고 있는 근로자 건강진단 자료를 감시체계의 한 축으로 활용하고, 다른 한편으로는 의사, 보건관리자, 특수건강진단 기판이 참여하는 직업병감시체계를 구축할 수 있다면, 직업병 예방과 근로자 건강보호라는명제에 한 걸음 더 쉽게 다가갈 수 있을 것이다.

좌심방 석회화와 관련된 반복된 좌심방 혈전 1예

김성훈,우성용,오유경,정우백,임철현,신재원,박철수,윤호중,정욱성,홍순조 대한순환기학회 2004 Korean Circulation Journal Vol.34 No.3

상어 간유 흡인에 의한 급성 지방성 폐렴 1예 : 증례보고

임성경,옥철호,김희규,장태원,정만홍 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.4

저자들은 상어 간유를 과량 복용하고 기침, 호흡곤란을 주소로 내원한 48세 여자 환자에서 방사선 소견과 기관지 폐포 세척액 검사를 통해 급성 지방성 폐렴으로 진단하고 스테로이드에 불응하는 경과를 취하자 우측 전폐 기관지 폐포 세척술을 시행하여 폐 병변과 증상의 호전을 보인 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Acute lipoid pneumonia is uncommon condition of the lungs that results from the aspiration of vegetable, animal, or mineral oils. Shark liver oil (so called Squalene) is taken as a traditional remedy in some Asian countries, and is used widely also in cosmetics. It results in foreign body type inflammatory reaction of the lung and can show various clinical presentations from asymptomatic incidental finding to severe pneumonia leading to acute respiratory failure. Although many cases have been reported, severe lipoid pneumonia requiring steroid or whole lung lavage for treatment is rare. We experienced a case of acute lipoid pneumonia of 48 year old female with dyspnea and cough caused by regular ingestion of large amount Shark liver oil, treated by whole lung lavage. We reported this case with a brief review of related literatures.

Crawford Ⅲ형과 Ⅳ형 흉복부 대동맥류 4예 보고

문성민,손민수,이길연,이상목,고석환,홍성화,윤충,오수명,박호철 대한혈관외과학회 2003 Vascular Specialist International Vol.19 No.2

고지방식이가 백서 골격근 및 지방조직의 지방분해에 미치는 영향

김철희,정윤이,이성진,박중열,홍성관,김홍규,서교일,이기업 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.24 No.6

연구배경:지방산화의 증가가 골격근에서 인슐린 저항성을 유발한다는 주장이 꾸준히 제기되어 나왔으나, 최근 제2형 당뇨병 환자나 인슐린저항성 상태에서 골격근의 지방산화능이 저하되어 있다는 보고도 있어 논란이 있는 상태이다. 본 연구에서는 고지방식이를 투여하여 인슐린저항성을 유발한 백서에서 microdialysis 기법을 이용하여 조직내의 지방분해 결과로 간질액내로 방출되는 글리세롤 농도를 골격근 및 지방조직에서 직접 측정하여 지방분해의 변화를 알아보고자 하였다. 방법:정상 Sprague­Dawley 백서를 두 군으로 나누어 4주간 고지방식이 및 저지방식이를 투여하였다. 4주간 기저상태 및 고인슐린 정상혈당 클램프 중의 골격근 및 지방조직에 microdialysis probe를 삽입하고 일정한 농도의 글리세롤을 포함하는 dialysate를 통과시켜 주입액과 유출액의 글리세롤 농도 차이로부터 조직 간질의 글리세롤 농도를 산출하엿다. 결과:기저상태에서 골격근 및 지방조직 간질의 글리세롤 농도는 저지방식이군에 비하여 고지방식이군에서 유의하게 낮았다. 고인슐린 정상혈당 클램프 중에는 골격근 및 지방조직 간질의 글리세롤 농도가 양군에서 모두 억제되었는데, 기저 상태와 마찬가지로 골격근 및 지방조직 모두에서 저지방식이군보다 고지방식이 군에서 더 낮았다. 기저 상태에 대한 고인슐린 클램프중의 글리세롤 방출 억제 정도는 저지방식이군에 비하여 고지방식이군에서 덜 억제되는 경향을 보였는데, 골격근조직에서만 통계적으로 유의하였다. 결론:본 연구 결과는 고지방식이에 의한 인슐린저항성 모델에서 골격근 및 지방조직내 지방분해가 억제되어 있음을 보여주며, 기존의 포도당­지방산 cycle 이론과는 달리 조직내 지방산화의 증가보다는 지방산화능의 감소에 따른 세포내 지방축척이 인슐린저항성과 관련될 가능성을 시사하였다. Background : It has been hypothesized that increased fat oxidation reduces glucose utilization in skeletal muscle, and is responsible for the insulin resistance associated with obesity or high-fat feeding. In contrast, there have been reports that fat oxidation capacity was decreased in skeletal muscles from insulin resistant subjects. This study was undertaken to examine whether insulin resistance in high-fat fed rats is associated with increased lipolysis in skeletal muscle and adipose tissue. Methods : Two groups of Sprague-Dawley rats were fed either high-fat or low-fat diets for 4 weeks. Lipolysis in skeletal muscle and adipose tissue was determined by measurement of interstitial 1 glycerol concentrations by a microdialysis method in basal and hyperinsuline mic-euglycemic clamp conditions. Results : In basal state, plasma glycerol levels and interstitial glycerol concentrations of skeletal muscle, and adipose tissue were lower in high-fat fed than in low-fat fed rats. The degree of suppression of glycerol release by the hyperinsuline mia was smaller in the high-fat diet than in the low-fat diet group. However, plasma and interstitial glycerol concentrations during the hyperinsuline mic euglycemic clamps were also lower in the high-fat diet group. Conclusion : Lipolysis was decreased in skeletal muscle and adipose tissue of insulin resistant, high-fat fed rats. These results support the idea that limited fat oxidation capacity resulting in lipid accumulation in tissues, rather than increased fat oxidation perse, is responsible for the insulin resistance associated with high-fat feeding (J Kor Diabetes Asso 24:641~651, 2000).