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오유경 한국보건복지학회 2007 보건과 복지 Vol.9 No.-
This study aims to claim that the right of choice is offered or judged not by social rehabilitation instructors or experts but residents in group hame and also offer basic materials that gives a guidance to improve a quality of residents' life by expanding social welfare service and opportunities of appropriate education for their need and strengthening their options for their independent lives. For this study, I made up one-to-one questionnaire and postal questionnaire for hame helpers inhabiting in group homes from December in 2006 to January in 2007 and used 112 of 102 questionnaire for the purpose of research. This study analyzes the result fran the degree of home helpers' interfering role according to the residents' right of choice and determination and the degree of their participation. Through this study, as I expected from the purpose of the study, it is revealed that home helpers' role is focused on simply permanent protection for the mentally retarded. As a result, home helpers' interfering role can not help do a passive function as to have a great influence of the mentally retarded' living pattern and improve their the way of thought or living in small communities with their right of choice and determination. There is a lack of home helpers; professional knowledge to help the mentally retarded' daily lives. Therefore, to deal with their personal problems, the degree home helpers' interfering role takes up a great portion on the welfare service for the disabled. In this concern, there should be prompt measure for the base of workers' profession and through the workers' profession and the efficient program for them. the quality of life for group home residents should be improved.
Reduction of Oncogene Expression in Cancer Cells Using siRNA Delivery Systems
오유경,김은중,김영봉,최한곤,심창구 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.5
Recently, siRNA has been emerging as new therapeutic agents for various diseases such as cancers and infectious diseases. However, the evaluation for delivery systems for siRNA has not been fully done. In this study, we designed and delivered siRNA of oncogenic E6 and E7 proteins to several cell lines and tested the delivery efficiencies of various cationic nonviral delivery vectors. Of cationic delivery systems tested in this study, lipid-based Lipofectamine revealed higher delivery efficiency of siRNA to cervical cancer cell line, SiHa, compared to other delivery systems. Notably, the polyethylenimine, which showed the comparable delivery efficiencies in plasmid DNA, did not show significant delivery of siRNA in cervical cancer cells. These results indicate that the mechanisms involved in siRNA delivery might be different from those in plasmid DNA delivery, and that cationic lipid-based delivery vehicles deliver siRNA with higher efficiency to intracellular target sites.
개인기준 완벽주의와 평가염려 완벽주의가 삶의 만족도에 미치는 영향: 주도적 대처의 매개효과
오유경,김은정 한국건강심리학회 2014 한국심리학회지 건강 Vol.19 No.4
본 연구는 개인기준 완벽주의 및 평가염려 완벽주의와 삶 만족도의 관계에서 주도적 대처가 매개하는지를 검증하고자 하였다. 이를 위해 249명의 대학생을 대상으로 다차원적 완벽주의 척도(FMPS), 완벽성향 척도 개정판(APS-R), 주도적 대처 척도(PCI), 삶의 만족도 척도(SWLS)를 사용하였고, 구조방정식 모형을 통해 검증하였다. 그 결과 개인기준 완벽주의 및 평가염려 완벽주의와 삶의 만족도의 관계는 주도적 대처에 의해 완전 매개되는 것으로 밝혀졌다. 즉, 개인기준 완벽주의가 주도적 대처를 매개로 삶의 만족도에 정적인 영향을 미치는 것으로 나타났다. 위의 결과를 토대로 본 연구의 함의와 한계점에 대해 논의하고, 후속 연구의 필요성을 제시하였다. The purpose of this study was to examine if proactive coping mediated the association between two dimensions of perfectionism(personal standards perfectionism and evaluative concerns perfectionism) and satisfaction with life. Two hundred forty-nine undergraduate students participated in this study and were asked to complete the Frost’s Multidimensional Perfectionism Scale(FMPS), Revised Almost Perfect Scale(APS-R), Proactive Coping Scale(PCI) and Satisfaction with Life Scale(SWLS). Structure equations analysis revealed a full mediating effect of proactive coping between two dimensions of perfectionism and satisfaction with life. Finally, the implications and limitations of the present study, and directions for future study were discussed.