조혈모세포이식 후 발생한 주폐포자층 폐렴에 대한 고찰

주지현,최정현,이동건,백지연,고윤호,이혜정,김세희,신호진,박윤희,박지영,김유진,신완식,김춘추 대한감염학회 2001 감염 Vol.33 No.4

Background : Pneumocytitis cainii pneumonia (PCP) can occur in immunocompromised hosts especially such as AIDS or cancer patients. Although recent research had focused on PCP in AIDS patients, few studies have described the clinical presentations of PCP in recipients of stem cell transplantation (SCT). We evaluated the clinical manifestations of PCP in SCT patients admitted at St. Mary's hospital, Seoul, Korea. Methods : The medical records of 17 PCP patients undergoing SCT between Feb. 1998 and Feb. 2000 were reviewed. The diagnosis of PCP was confirmed through the demonstration of Pneumocytitis cainii via either cytology of brochoalveolar lavage (BAL) or histological technique of lung biopsy. CMV disease and CMV infection were confirmed by BAL culture and antigenemia respectively . Results : Seventeen patients were all recipients of allogeneic SCT and 7 of 17 patients were performed non-sibling SCT. Patients presented with symptoms including brief period (4 ∼23 days) of fever (76%), dyspnea (70%), cough (64%), and signs such as rare(58.8%), Sixteen patients (94%) had been receiving immunosuppressive agent such as cyclosporine A (64%) or Fk506 (35%) without PCP prophylaxis. Eleven patients (64%) were treated with corticosteroid with mean dose of 16 mg/day prednisolone and mean duration of 4.6 months after post-SCT period. Twelve patients were co-infected with CMV. Another co-infected miCroorganisms were Pseudomonas aeruginosa, Mycobacterium tuberculosis, herpes simplex virus, parainfluenza virus, Average duration of treatment with trimethoprim-sulfamethoxazole (TMP/SMX) was 21 ±9 days. Four patients died, and three of them were related with PCP. Conclusion : PCP developed frequently in patients who were taking immunosuppressive drug due to graft versus host disease or were not taking TMP/SMX prophylaxis. High risk patients showing fever, cough, or dyspnea should be considered to take early bronchoscopic intervention for detection of PCP. When treat for PCP, it also be considered to the possibility of coinfection such as CMV. (Korean J Infect Dis 33:273∼279, 2001)

2009년 인플루엔자 대유행 중 인플루엔자 진료소 방문자의 연령 분포 변화

김백남,곽이경,문치숙,김연숙,김의석,배인규,염준섭,이창섭,허지안 대한감염학회 2010 감염과 화학요법 Vol.42 No.2

The pandemic influenza (H1N1 2009) virus, after being introduced in Korea in April, 2009, spread rapidly nationwide in mid-2009. This study was conducted to characterize trend in age distribution of visitors to Flu-clinics during the pandemic. Demographic, clinical and laboratory data of visitors to flu clinic from Week 36 to 52 (August 30 to December 26) of 2009 were retrieved and collected from electronic databases at 9 hospitals. Visitors 0-6, 7-12, 13-18, 19-29, 30-64, and 65 years or more of age were classified into group I to VI, respectively. A total of 107,467 visitors were seen at Flu-clinics for a 17-week study period. Of those, 32,485 were laboratory-confirmed. Antivirals were prescribed for 62,533 visitors. Numbers of visits, prescriptions of antivirals, and laboratory-confirmed cases of the pandemic influenza (H1N1 2009) peaked at Week 44. A large number of visits by group II and III were followed by those of group I and V, especially around the peak. Numbers of visits by group VI were lowest in all hospitals. In some hospitals, higher number of visits lasted longer in children than in adults while vice versa in other hospitals depending on the location. In summary, the pandemic influenza (H1N1 2009) was presumed to peak in late October and involved majorly children and students in Korea. Unique age distribution of visitors to flu clinic was observed in some hospitals.

Risk factors for massive postpartum bleeding in pregnancies with incomplete placenta previa located on the posterior uterine wall

( Ji Yeon Lee ),( Eun Ah Kim ),( Ji Hyon Jang ),( Min Jung Baek ),( Hee Young Cho ),( Young Ran Kim ),( Eun Hee Ahn ),( Sukho Kang ),( Myung Jin Moon ),( Sung Woon Chang ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-

목적: To identify factors associated with massive postpartum bleeding in pregnancies complicated by incomplete placenta previa located on the posterior uterine wall 방법: A retrospective cohort study was performed. Of 718 pregnant women with placenta previa who delivered babies after 24 weeks of gestation between January 2006 and April 2016, we identified 210 healthy singleton pregnancies with incomplete (partial or marginal) placenta previa located on the posterior uterine wall. The cases with intraoperative blood loss (>2,000ml) or transfusion of packed red blood cells (pRBC) (>4) or uterine artery embolization or hysterectomy were defined as massive bleeding. A P value <0.05 was considered statistically significant. 결과: Twenty-three women experienced postpartum profuse bleeding (11.0%). After multivariable analysis, four variables were associated with massive bleeding: experience of 2 or more prior uterine curettage (aOR 4.47, 95%CI 1.29-15.48, p=0.018), short cervical length before delivery (< 2.0cm) (aOR 7.13, 95%CI 1.01-50.25, p=0.049), fetal non-cephalic presentation (aOR 12.48, 95%CI 1.29-121.24, p=0.030), and uteroplacental hypervascularity (aOR 6.23, 95%CI 2.30-8.83, p<0.001). 결론: This is the first study of incomplete placenta previa located on the posterior uterine wall with massive postpartum hemorrhage. Our findings might be helpful to guide obstetric management and provide useful information for prediction of massive postpartum bleeding in pregnancies with incomplete placenta previa located on the posterior uterine wall.

Characteristics and prognosis of patients with colorectal cancer-associated brain metastases in the era of modern systemic chemotherapy.

Baek, Ji Yeon,Kang, Myoung Hee,Hong, Yong Sang,Kim, Tae Won,Kim, Dae Yong,Oh, Jae Hwan,Lee, Seung Hoon,Park, Jin Hong,Kim, Jong Hoon,Kim, Sun Young M. Nijhoff ; Kluwer Academic Publishers 2011 Journal of neuro-oncology Vol.104 No.3

<P>Brain metastases (BM) occur in approximately 20-40% of cancer patients. The present study investigated the clinical outcomes of patients with BM from colorectal cancer (CRC) to assess the benefit of systemic chemotherapy (CT) administered after surgical or radiotherapeutic control of BM and to identify independent prognostic factors associated with survival after BM. Between August 2001 and July 2009, 118 patients with symptomatic BM from CRC received either cranial irradiation or craniotomy at two large cancer centers in South Korea. Retrospective review and statistical analysis of clinical characteristics and outcomes were performed for all patients. Median time from diagnosis of metastatic CRC to detection of BM was 12.2??months (range 0-76.2??months). Thirteen patients (11%) exhibited brain involvement at initial presentation. Median survival after BM development was 4.1??months [95% confidence interval (CI) 3.3-4.9??months]. Forty-six patients (40%) had been treated previously with the chemotherapeutic agents fluoropyrimidine, oxaliplatin, and irinotecan. Patients who received CT after BM exhibited significantly improved survival compared with those who did not (12.4 versus 3.1??months, respectively; P??<??0.001). Multivariate analysis revealed that CT intervention after presentation with BM was significantly associated with survival after BM, and the adjusted hazard ratio was 0.30 (95% CI 0.17-0.51, P??<??0.001). Although BM is a late-stage phenomenon in CRC, approximately two-thirds of patients were still unexposed to irinotecan or oxaliplatin at the development of BM in our study. Thus, additional chemotherapeutic intervention after BM associated with CRC may be beneficial for selected patients.</P>

ALK positive anaplastic large cell lymphoma: primary cutaneous presentation following mosquito bite

( Ji Hae Baek ),( Ji Hae Lee ),( Jin Hee Kang ),( Ji Yeon Shin ),( Baik Kee Cho ),( Hyun Jeong Park ) 대한피부과학회 2012 대한피부과학회 학술발표대회집 Vol.64 No.1

Korean College Students’ Self-Directed Use of Machine Translator in an English Writing Class during the Digital Era: Is This a Crisis or a Chance?

Ji-Yeon Baek,Kyeong-Hee Rha 위기관리 이론과 실천 2021 Journal of Safety and Crisis Management Vol.11 No.6

The purpose of this research was to investigate how EFL college learners self-directed their English writing using MT in an English writing class. Specifically, this study focused on 1) What types of errors are identified the most frequently in the students’ writings?, 2) How those errors have been changed through the students’ self-directed revision process?, and 3) In what ways does this activity influence students’ perceptions toward English writing? The participants were six university students who took a 3-credit English writing class, and completed their writings using MT throughout the semester. The students’ written outcomes, in-depth interviews with them and results of writing tests were analyzed. The findings of data analysis indicated that first, the highest frequency of errors was seen in lexical errors at the rate of 65.5%, followed by morphological errors at the rate of 19.7%. Second, there has been a significant decrease in the overall types of errors between the first (35.0%) and second (20.9%) drafts, from the no-use of MT to the use of MT. Lastly, it can be said that the MT-assisted writing practice which took place during a short period of time had positive influence on students’ perceptions toward English writing. Implications for online classes in the Corona era are presented.

TGF-β inactivation and TGF-α overexpression cooperate in an in vivo mouse model to induce hepatocellular carcinoma that recapitulates molecular features of human liver cancer

Baek, Ji Yeon,Morris, Shelli M.,Campbell, Jean,Fausto, Nelson,Yeh, Matthew M.,Grady, William M. Wiley Subscription Services, Inc., A Wiley Company 2010 International journal of cancer: Journal internati Vol.127 No.5

<P>Hepatocellular carcinoma (HCC) results from the cumulative effects of deregulated tumor suppressor genes and oncogenes. The tumor suppressor and oncogenes commonly affected include growth factors, receptors and their downstream signaling pathway components. The overexpression of transforming growth factor alpha (TGF-α) and the inhibition of TGF-β signaling are especially common in human liver cancer. Thus, we assessed whether TGF-α overexpression and TGF-β signaling inactivation cooperate in hepatocarcinogenesis using an in vivo mouse model, MT1/TGFa;AlbCre/Tgfbr2<SUP>flx/flx</SUP> mice (“TGFa;Tgfbr2<SUP>hepko</SUP>”), which overexpresses TGF-α and lacks a TGF-β receptor in the liver. TGF-β signaling inactivation did not alter the frequency or number of cancers in mice with overexpression of TGF-α. However, the tumors in the TGFa;Tgfbr2<SUP>hepko</SUP> mice displayed increased proliferation and increased cdk2, cyclin E and cyclin A expression as well as decreased Cdkn1a/p21 expression compared to normal liver and compared to the cancers arising in the TGF-α overexpressing mice with intact TGF-β receptors. Increased phosphorylated ERK1/2 expression was also present in the tumors from the TGFa;Tgfbr2<SUP>hepko</SUP> mice and correlated with downregulated Raf kinase inhibitor protein expression, which is a common molecular event in human HCC. Thus, TGF-β signaling inactivation appears to cooperate with TGF-α in vivo to promote the formation of liver cancer that recapitulates molecular features of human HCC.</P>

Geriatrics Fact Sheet in Korea 2021

Ji Yeon Baek,Eunju Lee,Hee-Won Jung,Il-Young Jang 대한노인병학회 2021 Annals of geriatric medicine and research Vol.25 No.2

South Korea became an aged society in 2017 and is predicted to become a super-aged society by 2025. Therefore, knowing the trends among older adults and identifying the geriatric burden are crucial for both healthcare professionals and policymakers. We previously summarized the general health and socioeconomic profiles of Korean older adults from the 2017 National Survey of Living Conditions and Welfare Needs of Older Koreans. In this update, we briefly summarized the results of the 2020 National Survey of Living Conditions and Welfare Needs of Older Koreans by categorizing them according to their general aging profile, socioeconomic status, lifestyle, and health status. In addition, we reviewed recent updates in the field of frailty and sarcopenia from population-based community cohorts in Korea. We hope this study will serve as a current reference for nationwide statistical data on common clinical and social parameters used in geriatrics and gerontology.

Korean EFL Learners’ Responses to the Output of Machine Translator in an English Writing Course

Ji-Yeon, Baek,Kyeong-Hee, Rha 한국콘텐츠학회 2021 한국콘텐츠학회 ICCC 논문집 Vol.2021 No.12

Aspect of Geriatric Physician

Ji Yeon Baek 대한외과학회 2022 대한외과학회 학술대회 초록집 Vol.2022 No.11