반건식-백필터에 의한 소각배가스 중의 HCI, SOx 제거 (Ⅱ)

배병훈,신남철,조정구,문종익,임경택 동아대학교 환경문제연구소 1998 硏究報告 Vol.21 No.2

A combination of process modification and various additives to a lime-based spray-dryer/fabric-filter system was evaluated for its value in promoting sorbent utilization and simultaneous removal of HC1 and SO₂ from waste incineration flue gas. The variety of operating conditions were tested to evaluate important factors such as spray drying reactor(SDR) outlet temperature, retention time, molar equivalence ratio( MER ), fabric filter velocity, etc. For the sorbent activity enhancement, additives such as KmnO₄, NaOH, NaHCO₃, CaCl₂, a mixture of NaOH and CaCl₂ were added to Ca(OH)₂ at optimum operating condition. The mixture of NaOH and CaCl₂ ( 2 : 1 by weight ) was found to be the best economic additive. When that additive, 10% of Ca(OH)₂ by weight, was added, under the condition of Ca(OH)₂ of MER 1.0, HCl/SO₂ removal efficiencies at fabric filter were 98.3% and 97.1%, respectively.

도시하천 악취물질의 발생원조사에 대한 연구

조정구,배병훈,최금찬,임경택 동아대학교 환경문제연구소 1997 硏究報告 Vol.20 No.1

This study has been carried out to investigate odor characteristics and removal methods on the water quality and sulfuric material of four urban sewage. The results from these experiments are as followings ; 1. For sediment, N contents(%) was shown 0.068mg/l at S-1, 0.109mg/l at S-2, 0.043mg/l at S-3, 1.233mg/l at S-4 and S contents(mg/g) was shown 2.192mg/l at S-1, 2.410mgA at S-2, 1.564mg/l at S-3, 15.146mg/l at S-4. The sample of S-4 was indicated the worst value to 1.233mg/l 2. NH₃, one of the representative odor materials, which was showed the highest value at S-1 in the water, showed the highest value at the S-4 in the air. It means that the cause of odor comes from the disintegration of sediment orgamisms, which has more important effect than the water pollution. 3. To control the odor materials, it is desirable to minimizes the inflow of sewage from pollutant source itself. One of the considering odor method is H₂O₂ or activated carbon input into the sewage, which has several advantages as chemical treatment of odor materials is to be desirable.

부산의 한 대학병원에서 분리된 Acinetobacter baumannii의 PER-1 Extended-Spectrum β-Lactamase 생성 현황

김정만,강현경,정석훈,배일권,권수봉,조병규,김둘만,김현주,김아성 대한임상미샐물학회 2004 Annals of clinical microbiology Vol.7 No.1

Capsicum chinense, 재래종 및 저항성 고추 유전자원에서 역병 저항성 계통 선발

김정훈,여승호,김동우,배수연,한정혜,황희숙,김병수 慶北大學校農業科學技術硏究所 2002 慶北大農學誌 Vol.20 No.-

2000년도에 검정에서 역병에 살아남은 개체들로부터 채종하여 육성한 Capsicum chinense 31계통에 대하여 역병 저항성을 검정한 결과 고도의 저항성을 나타내는 것은 발견되지 않았다. 2001년도의 검정에서 역병에 살아남은 개체로부터 채종한 재래종 26계통에 대하여 다시 역병 저항성 검정을 실시한 결과 KC180, KC230, KC195, KC194에서 다수의 개체가 살아남아 저항성을 나타내었다. 그러나 KC180과 KC230은 각각 AC2258과 CM334와 혼종된 것으로 관찰되었다. KC195와 KC194는 재래종의 형질을 유지하고 있는 것으로 관찰되었다. CM334의 보존 증식과정에 자연교잡이 일어난 것으로 보여 이의 순도향상을 위하여 채종년도별로 시료를 꺼내어 역병저항성 검정을 실시한 결과 가장 오래된 1992년도 채종종자에서부터 약간의 이형주가 관찰도기 시작하여 1995년부터 2001년도까지 시간이 경과함에 따라 많이 변형되어 있는 것을 알 수 있었다. 1992년도 종자에서 이형주를 제거하고 원형의 개체로부터 자식종자를 대량으로 채종하였다. 함께 공시한 AC2258은 순수한 것으로 확인되었다. 1995년도 채종 CM334 종자에서는 비록 혼종은 되었으나 측지발생이 적은 개체들이 발견되어 이들을 개체 선발하여 역병에 저항성이며 측지발생이 적은 계통으로 육성하고 있다. A total of 31 c. chinense lines selected from 2000 screening were tested again for resistance to P. capsici but resistance was not found in the lines. A total of 26 selections from Korean land races tested 2001 spring were tested again for resistance to P. capsici. KC180, KC230, KC195 and KC194 showed moderate resistance to P. capsici. However, it was apparent on the basis of hortivultural characteristics that KC180 and KC230 had been naturally crossed with AC2258 and CM334, respectively. CM334 and AC2248 seed lots that were increased in different years were taken out and tested for resistance to improve their genetic purity because the resistant genetic resources have been showing some off-types in the population. Off-types began to be found in 1992 seed lots and the proportion and degree of the offs was increasing with time up to 2001. Plants true to the type in 1992 seed lots were selected and their inbred seeds were mass produced in a net cage in the greenhouse. AC2258 included in the experiment number of lateral branching at cotyledonary axil, although they were off from the original in the experiment together was uniform. In 1995 seed lost of CM334, plants with resistance to P. capsici and low or no number of lateral branching at cotyledonary axil, although they were off from the original CM334, were found and selection was applied to breed lines fixed in the characters.

Bortezomib과 Dexamthasone으로 치료한 골수외 형질세포종 4예

백종현,이은영,장리라,손창배,신은경,서정아,이지숙,이호섭,이상민,신성훈,김양수 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Despite the use of aggressive local and systemic treatment including autologous stem cell transplantation in multiple myeloma, extramedullary recurrences are common and the prognosis of these patients is poor. Many novel drugs such as thalidomide, lenalidomide and bortezomib improve the response of treatment of multiple myeloma, but some reports failed to describe thalidomide has effect in extramedullary plasmacytoma. Recent data report on the successful treatment plasmacytomas with bortezomib in patients with advanced multiple myeloma. We treated 4 relapsed or refractory extramedullary plasmacytomas with bortezomib at our institution. We recognized all these extramedullary plasmacytomas decreased and showed more than partial response. This report lends support to the efficacy of bortezomib in the treatment of plasmacytoma and describes the safe use of bortezomib. Responses may, however, be of short duration. Therefore, despite our limited experience, we propose that bortezomib may be considered a therapeutic option for such patients who have risk of radiation therapy

사지의 급성동맥 색전증에 대한 응급동맥 색전제거술

박철완,원형섭,박정배,이근,조상훈,표창해,김상일 대한응급의학회 1996 대한응급의학회지 Vol.7 No.2

Acute arterial occlusion of the extremities is often a surgical emergency and is due mostly to arterial embolus. It has infrequently been reported in the emergency department. Cardiac embolism is most commonly the result of atrial fibrillation secondary to valvular heart disease followed by ischemic heart disease. The emergency arterial embolectomy by Fogarty balloon catheter works well when the cause of occlusion is cardiac embolus obstructing normal vessels in a patient with valvular heart disease. Recently we met some patients with acute critical ischemia of the extremities due to arterial emboli in our emergency department. On physical examination, they all had symptoms of 5"P"s(pain, pallor, pulselessness, paresthesia, paralysis). After emergency arterial embolect omy, immediate improvement was observed in all patients. They were discharged within 1 week. We report our experiences with the review of literatures.

[PA-0039] Genetic Diversity of Adenophora verticillata (Pall.) Fisch. using SSR Markers

Dae Hui Jeong(Dae Hui Jeong),Yeong Bae Yun(Yeong Bae Yun),Jeong Hoon Huh(Jeong Hoon Huh),Yurry Um(Yurry Um),Hong Woo Park(Hong Woo Park) 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-

Distinct clinical outcomes of two CIMP-positive colorectal cancer subtypes based on a revised CIMP classification system

Bae, Jeong Mo,Kim, Jung Ho,Kwak, Yoonjin,Lee, Dae-Won,Cha, Yongjun,Wen, Xianyu,Lee, Tae Hun,Cho, Nam-Yun,Jeong, Seung-Yong,Park, Kyu Joo,Han, Sae Won,Lee, Hye Seung,Kim, Tae-You,Kang, Gyeong Hoon Nature Publishing Group 2017 The British journal of cancer Vol.116 No.8

<P><B>Background:</B></P><P>Colorectal cancer (CRC) is a heterogeneous disease in terms of molecular carcinogenic pathways. Based on recent findings regarding the multiple serrated neoplasia pathway, we revised an eight-marker panel for a new CIMP classification system.</P><P><B>Methods:</B></P><P>1370 patients who received surgical resection for CRCs were classified into three CIMP subtypes (CIMP-N: 0–4 methylated markers, CIMP-P1: 5–6 methylated markers and CIMP-P2: 7–8 methylated markers). Our findings were validated in a separate set of high-risk stage II or stage III CRCs receiving adjuvant fluoropyrimidine plus oxaliplatin (<I>n</I>=950).</P><P><B>Results:</B></P><P>A total of 1287/62/21 CRCs cases were classified as CIMP-N/CIMP-P1/CIMP-P2, respectively. CIMP-N showed male predominance, distal location, lower T, N category and devoid of <I>BRAF</I> mutation, microsatellite instability (MSI) and <I>MLH1</I> methylation. CIMP-P1 showed female predominance, proximal location, advanced TNM stage, mild decrease of CK20 and CDX2 expression, mild increase of CK7 expression, <I>BRAF</I> mutation, MSI and <I>MLH1</I> methylation. CIMP-P2 showed older age, female predominance, proximal location, advanced T category, markedly reduced CK20 and CDX2 expression, rare <I>KRAS</I> mutation, high frequency of CK7 expression, <I>BRAF</I> mutation, MSI and <I>MLH1</I> methylation. CIMP-N showed better 5-year cancer-specific survival (CSS; HR=0.47; 95% CI: 0.28–0.78) in discovery set and better 5-year relapse-free survival (RFS; HR=0.50; 95% CI: 0.29–0.88) in validation set compared with CIMP-P1. CIMP-P2 showed marginally better 5-year CSS (HR=0.28, 95% CI: 0.07–1.22) in discovery set and marginally better 5-year RFS (HR=0.21, 95% CI: 0.05–0.92) in validation set compared with CIMP-P1.</P><P><B>Conclusions:</B></P><P>CIMP subtypes classified using our revised system showed different clinical outcomes, demonstrating the heterogeneity of multiple serrated precursors of CIMP-positive CRCs.</P>

Two-Step Planarization of ECMP and CMP for MEMS Copper Patterns

Jeong, Suk Hoon,Joo, Suk Bae,Lee, Ho Jun,Park, Boum Young,Kim, Hyoung Jae,Jeong, Hae Do Trans Tech Publications, Ltd. 2008 Materials science forum Vol.569 No.-

<P>Chemical mechanical polishing (CMP) has been used as planarization process in the fabrication of semiconductor devices. The CMP process is required to planarize the overburden film in an interconnect process by high relative velocity between head and platen, high pressure of head and chemical effects of an aqueous slurry. But, a variety of defects such as dishing, delamination and metal layer peering are caused by CMP factors such as high pressure, pad bending and strong chemical effect. The electrical energy of the electro-chemical mechanical planarization (ECMP) dissolves copper (Cu) solid into copper ions electrochemically in an aqueous electrolyte. The dissolved copper complex layer or passivation layer is removed by the mechanical abrasions of polishing pad and abrasive. Therefore the ECMP process realizes low pressure processing of soft metals to reduce defects comparing to traditional CMP process. But, if projected metal patterns were removed and not remained on whole wafer surface in final processing stage, Cu layer could not be removed by ECMP process. The two-step process consists of the ECMP and the conventional CMP used in micro patterned Cu wafers. First, the ECMP process removed several tens 'm of bulk copper on Cu patterned wafer within shorter process time than the Cu CMP. Next, residual Cu layer was completely removed by the Cu CMP under low pressure. Total time and process defects are extremely reduced by the two-step process.</P>

Compound K Inhibits Basic Fibroblast Growth Factor-Induced Angiogenesis <i>via</i> Regulation of p38 Mitogen Activated Protein Kinaseand AKT in Human Umbilical Vein Endothelial Cells

Jeong, Arong,Lee, Hyo-Jung,Jeong, Soo-Jin,Lee, Hyo-Jeong,Lee, Eun-Ok,Bae, Hyunsu,Kim, Sung-Hoon Pharmaceutical Society of Japan 2010 Biological & pharmaceutical bulletin Vol.33 No.6

<P>Compound K (CK; 20-<I>O</I>-β-<SMALL>D</SMALL>-glucopyranosyl-20(<I>S</I>)-protopanaxadiol), an active ginseng saponin metabolite, exerts anticancer activity <I>via</I> apoptosis induction in various cancers. In the present study, we investigated the anti-angiogenic activity of CK and its molecular mechanisms in human umbilical vein endothelial cells (HUVECs). Angiogenesis was induced in HUVECS by basic fibroblast growth factor (bFGF), a potent angiogenic growth factor. CK significantly inhibited the proliferation and also attenuated the expression of a proliferating protein cyclin D1 in bFGF treated HUVECs. Also, CK significantly inhibited the migration and tube formation of bFGF treated HUVECs at non-cytotoxic concentrations, reduced secreted level of vascular endothelial growth factor (VEGF) and increased the secreted level of pigment epithelium-derived factor (PEDF) in HUVECs. In addition, CK effectively disrupted bFGF-induced neo-vascularization in the Matrigel plugs excised from mice <I>in vivo</I>. Notably, we have found that CK downregulated the phosphorylation of p38 mitogen-activated protein kinase (MAPK) and AKT in bFGF treated HUVECs. Taken together, our findings for the first time indicate that CK exerts anti-angiogenic activity <I>via</I> inhibition of p38 MAPK and AKT in HUVECs with the potential of a cancer chemopreventive agent.</P>