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Jeong, Jeong Hyun,Choi, Bo Young,Kho, A Ra,Lee, Song Hee,Hong, Dae Ki,Lee, Sang Hwon,Lee, Sang Yup,Song, Hong Ki,Choi, Hui Chul,Suh, Sang Won MDPI 2017 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.18 No.11
<P>Epileptic seizures are short episodes of abnormal brain electrical activity. Many survivors of severe epilepsy display delayed neuronal death and permanent cognitive impairment. Donepezil is an acetylcholinesterase inhibitor and is an effective treatment agent for Alzheimer’s disease. However, the role of donepezil in seizure-induced hippocampal injury remains untested. Temporal lobe epilepsy (TLE) was induced by intraperitoneal injection of pilocarpine (25 mg/kg). Donepezil (2.5 mg/kg/day) was administered by gavage in three different settings: (1) pretreatment for three days before the seizure; (2) for one week immediately after the seizure; and (3) for three weeks from three weeks after the seizure. We found that donepezil showed mixed effects on seizure-induced brain injury, which were dependent on the treatment schedule. Pretreatment with donepezil aggravated neuronal death, oxidative injury, and microglia activation. Early treatment with donepezil for one week showed neither adverse nor beneficial effects; however, a treatment duration of three weeks starting three weeks after the seizure showed a significant reduction in neuronal death, oxidative injury, and microglia activation. In conclusion, donepezil has therapeutic effects when injected for three weeks after seizure activity subsides. Therefore, the present study suggests that the therapeutic use of donepezil for epilepsy patients requires a well-conceived strategy for administration.</P>
One-Year Mortality of Acute Kidney Injury in Patients with Acute Myocardial Infarction
( Dae Hun Lim ),( Jong Hyeok Jeong ),( Ji Min Jeong ),( Chang Seong Kim ),( Joon Seok Choi ),( Jeong Woo Park ),( Eun Hui Bae ),( Seong Kwon Ma ),( Soo Wan Kim ) 대한신장학회 2011 Kidney Research and Clinical Practice Vol.30 No.2
Purpose: Acute kidney injury (AKI) is a common complication during hospitalization and is an accepted risk factor for in-hospital mortality. However, the association of severity of AKI with the long-term risk of death is not well known. This study aimed to investigate the incidence and clinical significance of AKI in patients with acute myocardial infarction (AMI). Methods: To examine the effect of the severity of AKI on 1-year risk of death following AMI, we performed an observational study of 1,224 patients admitted for AMI. We evaluated the association between AKI and all-cause mortality. Patients with maintaining hemodialysis treatment (n=7), and who died during hospitalization (n=71) were excluded. Remaining 1146 patients were divided into three groups according to the Acute Kidney Injury Network (AKIN) criteria (Stage-1, -2, and-3). The primary end point of the study was 1-year all-cause mortality after hospital discharge. The relation between the severity of AKI and 1-year mortality after AMI was analyzed. Results: AKI was developed in 222/1,146 (19.3%) patients during the hospital stay. Adjusted hazard ratio for 1-year mortality was 3.064 (95% CI 1.618 to 5.803, p=0.001), 6.112 (95% CI 2.344 to 15.935, p<0.001) and 20.030 (95% CI 5.428 to 73.912, p<0.001) in stage-1, -2, and stage-3 AKI groups compared with that of no AKI group. Conclusion: The severity of AKI is strongly related to 1-year all cause mortality in patients with AMI.
정대희(Dae Hui Jeong),김기윤(Ki Yoon Kim),박성혁(Sung Hyuk Park),정충렬(Chung Ryul Jung),전권석(Kwon Seok Jeon),박홍우(Hong Woo Park) 한국자원식물학회 2021 한국자원식물학회지 Vol.34 No.4
최근 전 세계적으로 지구온난화가 가속되면서 작물의 생산에 극심한 피해가 야기되는바 극한의 고온 스트레스에 따른 참당귀의 생육특성 및 지표성분을 확인하고 효율적인 참당귀의재배를 위한 기초자료를 제공하고자 하였다. 2018년, 2019년의 기상관측데이터를 활용하여 실험온도(Control, 28℃, 34℃, 40℃)를 설정하였다. 그리고 식물생장상을 통해 실험온도를 처리하여 실험포지에서 이식 및 생장을 거쳐생육특성 및 유용성분함량을 분석하였다. 실험이 수행되어진 실험포지는 평균 대기온도 19.38℃, 평균 토양온도 21.34℃, 평균대기습도 81.31 %, 평균 토양습도 0.18 ㎥/㎥, 평균 일사량162.05 W/㎡로 관측되었으며, 토양의 이화학적 특성은 사질식양토에 유기물함량 2.66 %, 유효인산 868.52 ㎎/㎏, 전질소 0.14 %, pH 6.65, 칼륨, 칼슘, 마그네슘, 나트륨은 각각 0.95, 7.38, 1.46, 0.15 cmol+ /㎏로 분석되었다. 그리고 활착율(85 %)과 전체높이(38.66 ㎝), 생중량(41.3 g), 건중량(14.24 g) 등과 같은 대부분의 생육특성은 대조구 대비 28℃ 실험구에서 가장 높은 생육을 보였다. 하지만 유용성분함량의 유의성은 확인되지 않았으나대조구 대비 34℃ 실험구에서 가장 높은 값을 나타냈다. 이러한 결과는 고온의 스트레스로 식물체 조직의 노화 및 광합성량 감소, 생장지연 등과 같은 생육장애 요인에 의해 실험구별 생육의 차이가 발생했으며, 유용성분의 함량 또한 실험구별생육장애에 의해 동화산물의 축적이 저조해져 발생된 현상이라판단된다 Recently, the pace of global climate change has tremendously increased, causing extreme damage to crop production. Here, we aimed to examine the growth characteristics and useful components of Angelica gigas under extreme heat stress, providing fundamental data for its efficient cultivation. Plants were exposed to various experimental temperatures (28℃, 34℃, and 40℃), and their growth characteristics and content of useful components were analyzed. At the experimental site, the ambient and soil temperature were 19.38℃ and 21.34℃, ambient and soil humidity were 81.3 % and 0.18 ㎥/㎥, solar radiation was 162.05 W/㎡. Moreover, the soil was sandy-clay-loam (pH 6.65), with 2.66% organic matter, 868.52 ㎎/㎏ soil available phosphate, and 0.14% nitrogen. Values of most growth characteristics, including the survival rate (85%), plant height (38.66㎝), and fresh and dry weight (41.3 g and 14.24 g), were the highest at 28℃. Although the highest content of useful components was observed at 34℃ (3.24%), there were no significant differences across temperatures. Growth characteristics varied across temperatures due to detrimental effects of heat stress, such as accelerated tissue aging, reduced photosynthesis, and delay of growth. Similar content of useful components across temperatures may be due to poor accumulation of anabolic products caused by impaired growth at extremely high temperatures.
정대희(Dae Hui Jeong),김기윤(Ki Yoon Kim),박홍우(Hong Woo Park),정충렬(Chung Ryul Jung),김현준(Hyun Jun Kim),전권석(Kwon Seok Jeon) 한국자원식물학회 2021 한국자원식물학회지 Vol.34 No.1
This study aimed to identify regions with a suitable growth environment for Ligusticum chuanxing Hort. and use basic data to identify appropriate cultivation and stable production strategies. Four main areas of cultivation were selected and the relationship between growth characteristics (aboveground and underground parts) and weather and soil environment was analyzed. Overall growth was found to be significantly higher in Pyeongchang. Atmospheric and soil temperatures showed a significant negative correlation with overall height from the ground, stem diameter, and growth characteristics of the underground part; leaf length and width were positively correlated. As insolation increased, the growth characteristics, excluding leaf size, showed a positive correlation. Soil characteristics such as organic matter (OM), N, P, and K showed negative correlations with the overall height of the upper part and growth characteristics of the underground part, including stem diameter. Analysis of roots indicated that OM, N, P, and K were essential and were absorbed through the soil. The OM, N, P, and K values in the Pyeongchang area, which showed the optimal growth, were lower than those in other areas. It is believed that these results can be used to select cultivation sites for L. chuanxing and establish cultivation technology in future.
연료성상에 따른 디젤엔진의 질소산화물 및 스모크 배출특성에 관한 연구
남정길(Jeong-Gil Nam),이돈출(Don-Chool Lee),한원희(Won-Hui Han),박정대(Jeong-Dae Park),강대선(Dae-Sun Kang) 한국마린엔지니어링학회 2006 한국마린엔지니어링학회 학술대회 논문집 Vol.2006 No.-
The main objective of this research is to develop a system which will provide a more efficient fuel saving measure for the current marine products industry situation caused by the increased cost of oil. For that function, the developed system has been verified using the medium of blending oil known as the MF 30 class. As a result, MF 30 was confirmed meeting the International Standard for NOx emissions and content of Sulfur. Oil composition and soot level analysis showed that it is acceptable to use MF 30 class in condition of proper engine running operation and pre-refinery treatment.
Genome-Wide SSR 마커를 이용한 주요 산지별 참당귀의 유전다양성 분석
정대희(Dae Hui Jeong),박윤미(Yun Mi Park),김기윤(Ki Yoon Kim),박홍우(Hong Woo Park),전권석(Kwon Seok Jeon),김만조(Mahn Jo Kim),길진수(Jin Su Gil),이이(Yi Lee),엄유리(Yurry Um) 한국약용작물학회 2019 한국약용작물학회지 Vol.27 No.6
Background: Angelica gigas Nakai has been used as an herbal medicine in Eastern Asia for treating disorders in women for a long time. To date there are no studies on the genetic diversity of A. gigas. The present study aimed to study the genetic diversity of A. gigas variants using genomewide simple sequence repeat (SSR) markers. Methods and Results: The genetic diversity of 199 variants of A. gigas cultivated in of different regions, was analyzed using 5 genome-wide SSR markers. The results revealed that the genetic variants were very diverse, and genetic analysis using the 5 SSR markers revealed high diversity among the variants. Conclusions: It is expected that the development of the true Angleical cultivar, by studying the system and group selection, can be achieved by genetic analysis using the developed markers, for generating a genetically fixed lineage and group selection.
손대희 ( Son Dae Hui ),정윤철 ( Jeong Yun Cheol ),유명진 ( Yu Myeong Jin ),정진영 ( Jeong Jin Yeong ) 한국물환경학회 2003 한국물환경학회지 Vol.19 No.1
Zeolite is well known material for its ability to preferentially remove ammonium ions from wastewater. However, its usage has been limited by high cost for chemical regeneration on this purpose. As an alternative, biological regeneration of zeolite has been suggested by some researchers. In this study, the characteristics of biological regeneration of zeolite was studied at various conditions, i.e. changes in microorganism and Na^(+) concentration. In the first test, the percentage of bio-regeneration via nitrification in the columns(MLVSS 2,250㎎/ℓ and 4,500㎎/ℓ) was 2.6 times higher than the column with NaHCO₃(2M980 ㎎/ℓ) addition only. In the second test MLVSS were changed(400, 800 and 3,200㎎/ℓ) but, for alkalinity supply, NaHCO₃ concentration was fixed at 745㎎/ℓ. The regeneration rates were proportional to the MLVSS concentration, but the same amounts of total regenerated nitrogen were achieved in all columns tested. In the third, test the regeneration tests were performed to evaluate effects of Na^(+) concentration on regeneration were tested. The regeneration effficiency was enhanced about 5% when Na^(+) concentration increased from 342 to 734㎎/ℓ. There was no difference in regeneration rate by nitrification. Therefore the higher regeneration efficiency of zeolite could be obtained by nitrification than by chemical methods. The regeneration rates with the fixed Na^(+) concentration were proportional to nitrification rate, and the regeneration efficiencies with the fixed microorganism concentration were highly dependent on cation concentrations such as Na^(+)