기능적-자기공명촬영장치를 이용한 저작시 두뇌활성화부위

이병황,유태민,이종헌,박경주 대한구강악안면병리학회 2014 대한구강악안면병리학회지 Vol.38 No.2

This study were to perform for verifying the activation areas in the human's brain during mastication by using functional-MRI (f-MRI)device on the basis of hypothesis regarding anatomical-physiological parts of brain processing the information of motor and sensoryfunction, and to perform further more for a providing basic provisional foundation about diagnosis, treatment and prognosis of abnormalocclusion as applying functional MRI. Generally healthy 10 volunteers who have a normal occlusion were selected. The half of membersof volunteers was female. Age distributions were approximately alike. Before taking a f-MRI, sufficient practice was carried out asstrict standards and made volunteers be not sensible to sweet taste of gum through chewing gum for 30 minutes before taking af-MRI. Functional images for all volunteers were firstly obtained, and then anatomical images were next. The functional images consistedof echo-planar image volumes which were sensitive to BOLD (blood oxygenation level-dependent) contrast in axial orientation. Thevolume covered the whole brain with a 64×64 matrix and 42 slices. Images with 64 volumes were acquired under periodic mastication. The orofacial sensorimotor cortex was primary responsible cerebral part during mastication and insula. And also supplementary motorarea and cerebellum in brain were intimately connected with mastication. Other numerous anatomical parts of brain were activatedin each volunteer during mastication, but there was no statistical significance in this experiment. Differences according to gender andage were no significance in this study. The f-MRI device showed the accurate and detailed image in activation area of brain throughvaluable device. It suggested that f-MRI might be helpful to establish the basis of funtional standard occlusion depend on activationarea of brain. This study were to perform for verifying the activation areas in the human's brain during mastication by using functional-MRI (f-MRI)device on the basis of hypothesis regarding anatomical-physiological parts of brain processing the information of motor and sensoryfunction, and to perform further more for a providing basic provisional foundation about diagnosis, treatment and prognosis of abnormal occlusion as applying functional MRI. Generally healthy 10 volunteers who have a normal occlusion were selected. The half of members of volunteers was female. Age distributions were approximately alike. Before taking a f-MRI, sufficient practice was carried out as strict standards and made volunteers be not sensible to sweet taste of gum through chewing gum for 30 minutes before taking a f-MRI. Functional images for all volunteers were firstly obtained, and then anatomical images were next. The functional images consisted of echo-planar image volumes which were sensitive to BOLD (blood oxygenation level-dependent) contrast in axial orientation. The volume covered the whole brain with a 64×64 matrix and 42 slices. Images with 64 volumes were acquired under periodic mastication. The orofacial sensorimotor cortex was primary responsible cerebral part during mastication and insula. And also supplementary motor area and cerebellum in brain were intimately connected with mastication. Other numerous anatomical parts of brain were activated in each volunteer during mastication, but there was no statistical significance in this experiment. Differences according to gender and age were no significance in this study. The f-MRI device showed the accurate and detailed image in activation area of brain through valuable device. It suggested that f-MRI might be helpful to establish the basis of funtional standard occlusion depend on activation area of brain.

뇌자기공명영상촬영술상 병변을 관찰할 수 없는 허혈성 뇌경색

김진석,김태완,임정근 啓明大學校 醫科大學 1998 계명의대학술지 Vol.17 No.4

1. 임상적으로 뇌졸중이 의심되어 증상 발생후 24시간에서 2개월까지 Brain MRI을 실시한 722명의 환자들 중 결과가 가음성인 환자는 모두 22명 (3.1%)이었다. 2. Brain MRI상 병변은 관찰되지 않으나 임상 양상 및 신경학적 이상 소견으로 추정되는 병변의 위치를 구분해 보면 뇌간부가 13명 (59%)으로 가장 많았고, 피질하부 8명 (36%), 피질 1명 (4.5%)의 순 이었다. 3. 대뇌혈관 (large cerebral artery)폐쇄 보다는 분지 동맥 (branch artery)이나 소 관통동맥 (small perforating artery)의 폐쇄에 의한 것으로 추정되는 허혈성 뇌경색의 병변의 빈도가 높았다. 4. 병력, 뇌졸증 위험 인자, 임상 양상, 심전도 검사, 심초음파 검사 및 뇌혈관조영술등에서 혈전성 뇌경색은 12명 (55%), 색전성 뇌경색은 3명 (13%), 원인이 확실하지 않은 경우는 7명(32%)으로 혈전성 뇌경색의 빈도가 뚜렷하게 높았다. 5. T1강조 영상, T2,강조 영상 및 FLAIR sequence를 같이 실시함으로써 허혈성 뇌경색의 조기 발견은 과거의 연구 보고에 비하여 상당히 높아졌으나 계속적으로 Brain MRI상 가음성인 허혈성 뇌경색이 있음으로, 허혈성 뇌경색의 조기 진단에는 새로운 기법인 확산강조 자기공명영상, 관류강조 자기공명영상, 자기공명 분광경 등의 다른 특수한 Brain MRI이 필요할 것으로 생각되며, 항상 신경학적인 검사를 통한 임상적인 진단이 선행되어야 한다. Background : Brain magnetic resonance imaging (MRI) is more sensitive than computed tomography in the diagnosis of acute ischemic stroke, but may not visualize all acute ischemic stroke. For deeper understanding of MRI negative strokes, we reviewed case histories, abnormal neurological finding, and localized ischemic lesions presumedly which were not present in brain MRI scans. Methods : Patients with a clinically definite first ischemic stroke and absence of corresponding lesion in brain MRI scans were studied retrospectively with hospital records dating from January 1994 to November 1996 and prospectively from December 1996 to August 1997. Patient with transient ischemic stroke, postictal paralysis, central nervous system infection, demyelinating disease, hemiplegic migraine, functional or hysterical cause, multiple cerebral infarction, scans within 24 hours and equivocal findings were excluded. Brain MRI was scanned with T2WI, T1WI and FLAIR sequence. Results: We studied 722 patients with clinically diagnosed definite acute ischemic stroke during the study period and identified 22 patients (3.1%) with the absence of corresponding lesion in brain MRI scan. The ischemic strokes without brain lesions on MRI scan were clinically localized to the brain stem (n=13, 59%), subcortex (n=8, 36%) and in the cortex (n=1, 4.5%). Perforating arterial and thrombotic ischemic lesions seemed to be more common than large arterial & embolic lesions. Risk factors was not different between MRI positive and MRI negative ischemic stroke. Summary: Acute ischemic stroke with absence of brain lesion in MRI scans is more common in brain stem and subcortex than in the cortex. There is some potential limitation of standard MRI scan for diagnosis of acute ischemic stroke, therefore further scans with new imaging studies such as perfusion/diffusion weighted magnetic resonance imaging are required in selected cases.

초극소 저체중 출생아의 뇌 MRI 상 Maturation Score의 의의

송인규,김수영,김규리,김윤주,신승한,이승현,이재명,이주영,김지영,손진아,이진아,최창원,김이경,천정은,김우선,김한석,김병일,김인원,최중환 대한신생아학회 2011 Neonatal medicine Vol.18 No.2

Purpose: The aim of this study was to investigate the effect of perinatal risk factors on brain maturation and the relationship of brain maturation and neurodevelopmental outcomes with brain maturation scoring system in brain MRI. Methods: ELBWI infants born at the Seoul National University Children’s Hospital from January 2006 to December 2010 were included. A retrospective analysis was performed with their medical record and brain MR images acquired at near full term. We read brain MRI and measured maturity with total maturation score (TMS). TMS is a previously developed anatomic scoring system to assess brain maturity. The total maturation score was used to evaluate the four parameters of maturity: (1) myelination, (2) cortical infolding, (3) involution of glial cell migration bands, and (4) presence of germinal matrix tissue. Results: Images from 124 infants were evaluated. Their mean gestational age at birth was 27.1±2.1 weeks, and mean birth weight was 781.5±143.9 g. The mean TMS was 10.8±2.0. TMS was significantly related to the postmenstrual age (PMA) of the infant, increasing with advancing postmenstrual age (P<0.001). TMS showed no significance with neurodevelopmental delay, and with brain injury, respectively. Conclusion: TMS was developed for evaluating brain maturation in conventional brain MRI. The results of this study suggest that TMS was not useful for predicting neurodevelopmental delay, but further studies are needed to make standard score for each PMA and to re-evaluate the relationship between brain maturation and neurodevelopmental delay. 목적: ELBWI의 출생과 생존율이 증가함에 따라 그들의 삶의 질의 향상을 위해 신경학적 발달을 예측 및 평가하고 재활 치료를 통해 발달 지연을 최소화 하기 위한 많은 연구가 이루어지고 있다. 뇌 손상의 평가 및 신경학적 발달을 예측하기 위하여 뇌 MRI의 촬영이 많이 이루어지고 있고, 연구를 통해 다양한 프로토콜이 개발되고 있다. 저자들은 Childs 등이 제안한 뇌 성숙도를 점수화 하는 방법을 통해 ELBWI의 주산기에 발생하는 위험 인자와 뇌성숙의 관계, 뇌 성숙과 신경학적 발달 지연과의 관계에 대해 확인하고자 한다. 방법: 교정 주령 만삭 근처에 뇌 MRI를 시행한 ELBWI 124명을 대상으로 의무 기록을 후항적으로 분석하여 주산기적 위험 인자를 확인하였고, 뇌 MRI에서 뇌 성숙도를 점수화(TMS) 하고, 동반 되는 이상 소견을 판독하였으며, BSID III를 시행하여 신경학적 발달에 대한 평가를 하였다. 주산기적 위험 인자와 TMS의 관계, 뇌 MRI에서 관찰 되는 이상 소견과 TMS의 관계, TMS와 BSID III 결과의 관계에 대한 분석을 하였다. 결과: 대상 환자의 평균 출생 재태 주령은 27.1±2.1주, 평균 출생 체중은 781.5±143.9 g 이었다. 뇌 성숙도 점수의 평균은 10.8±2.0점이었다. 주산기적 위험 인자와의 관계 분석에서는 MRI 검사 당일의 PMA만이 통계학적으로 유의한 관계를 보였고 (P<0.001), BSID III에서 확인되는 신경학적 발달 지연이나 뇌 MRI에서 이상 소견과 뇌 성숙도 점수 간에는 통계학적으로 유의한 상관 관계가 없었다. 결론: Conventional 뇌 MRI에서 뇌 성숙도를 평가하여 신경학적 발달을 예측하고, 뇌 성숙에 영향을 주는 주산기적 위험 인자를 찾고자 하였으나 MRI 검사 당일의 PMA 외에는 통계학적으로 의미 있는 결과가 없었다. 하지만 수초화 등의 뇌 성숙의 정도가 신경학적 발달에 영향을 줄 것으로 추측되므로 향후 더 다양한 교정 주수에 촬영된 영상과 여러 임상 환자군의 영상에 대한 분석 및 BSID III 등 신경학적 발달 검사와의 관계에 대한 연구가 필요하다.

두통을 호소하는 소아청소년에서 Brain MRI의 유용성

박상욱(Sang Wook Park),박현아(Hyun A Park),김동욱(Dong Wook Kim) 대한소아신경학회 2017 대한소아신경학회지 Vol.25 No.3

Purpose: In this study, the authors classified the pediatric headache patients accor­ding to the presence of associated symptoms or signs, and the duration of headache. The purpose of this study is to evaluate the clinical usefulness of brain MRI in pediatric headache. Methods: Total 1859 patients diagnosed with headache, migraine, other headache syndromes were recruited in the patients at the age of 4-14 years who visited Inje University Ilsan Paik Hospital between 2012 and 2016. 216 patients who met the ex clusion criteria were excluded. Of total 1643 patients, 304 patients had brain MRI, and the brain MRI results were retrospectively analyzed. Results: The mean age of 304 patients who had brain MRI was 9.4 years. Among the 316 brain MRI results of total 304 patients, the most common finding was normal in 58.5%, followed by incidental findings (23.4%) and pathologic findings (18.0%). The patients group with associated symptoms or signs with headache showed less normal findings, more incidental and pathologic findings than those without as sociated symptoms or signs. The MRI findings of two groups showed significant difference (P=0.049). The patients group with less than 3 months of headache showed less normal findings, more incidental and pathologic findings than those with more than 3 months of headache. The MRI findings of the two groups showed significant difference (P=0.001). Conclusions: Brain MRI should be performed with careful history taking and neuro logic evaluation to rule out the underlying intracranial diseases especially in case of headaches with associated symptoms or signs.

외상성 뇌손상 환자에서 SPECT와 MRI 소견의 비교 연구

김영철 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.2

연구목적과 방법 : 본 연구에서는 외상성 뇌손상후 객관적 이상의 유무를 찾아내는데 MRI와 SPECT중 어느 것이 더 효과적인지 알아보고자 하였다. 1997년 1월부터 1998년 6월까지 18개월동안 이대 목동병원 신경정신과에서 신체감정서가 발부되었던 외상성 뇌손상 환자중 MRI. SPECT, EEG를 모두 시행한 51명을 대상으로 검사결과를 검토하여 두뇌의 이상여부를 어느 검사가 효과적으로 찾아내는지 비교 조사하였으며 그 결과는 다음과 같다. 결 과 : 연구대상 환자중 MRI에서 비정상 소견을 보인 경우는 11명(21.6%)이였으나 SPECT에 이상소견을 보인 경우는 27명(52.9%)이나 되어 SPECT 검사로 뇌손상후의 이상소견을 찾을 수 있는 가능성이 유의하게 높았다.(p〈0.05). 그러나 MRI에서 비정상적인 경우(3명)에서 SPECT가 기능이상을 찾아내지 못했기 때문에 MRI나 SPECT를 단독으로 검사하기보다는 함께 검사하는 것이 외상성 뇌손상 환자에서의 이상여부를 찾아내는데 효과적이라 할 수 있다. 반면 뇌파검사는 뇌의 기능이상을 찾는데 효과적인 검사가 아니었다. 민사소송까지의 기간 및 두 검사 결과에 대한 교육수준이나 성별차이는 유의하지 않았다. 결 론 : 외상성 뇌손상 환자들에서 뇌의 이상유무를 찾아내는 데는 MRI보다 SPECT가 더 효과적 검사법이라 할 수 있지만 두 검사를 동시에 시행하는 것이 추천할만한 방법이라 하겠다. In this study, the author tried to compare the efficiency of SPECT with that of MRI in evaluation of neuropsychiatric sequelae after traumatic brain injury(TBI). Fifty-one patients who were referred from the court for the purpose of assessment of neurobehavioral disability after TBI for 18 mouths from Jan, 1997 to Jun. 1998 were reviewed. The results were as follows : 1) SPECT was more effective to find out brain abnormality than MRI because 27 of 51 patients(52.9%) showed abnormal findings on SPECT but 11(21.6%) on MRI(p〈0.05). 2) There were no abnormal finding on SPECT even three of the patients showed abnormality on MRI. 3) The use of electroencephalogram(EEG) was not a helpful method to evaluate abnormal brain function in patients with chronic sequelae after TBI. 4) The relationship between education level and laboratory findings of MRI and SPECT was not found. These results suggest the SPECT alone or combination with MRI would be helpful to find out abnormal brain function efficiently in patients with sequale after TBI.

만성 외상성 뇌 손상 환자의 정신의학적 후유 장애 평가에서 Tc-99m HMPAO 뇌혈류 SPECT의 역할

소영,이강욱,이선우,지익성,송창준 대한핵의학회 2002 핵의학 분자영상 Vol.36 No.4

Purpose: We studied whether brain perfusion SPECT is useful in the psychiatric disbility evaluation of patients with chronic traumatic brain injury (TBI). Materials and Methods: Sixty-nine patients (M:F=58:11, age 39±14 years) who underwent Tc-99m HMPAO brain SPECT, brain MRI and neuropsychological (NP) tests during hospitalization in psychiatric wards for the psychiatric disability evaluation were included; the severity of injury was mild in 31, moderate in 17 and severe in 21. SPECT, MRI, NP tests were performed 6∼61 months (mean 23 months) post-injury. Diagnostic accuracy of SPECT and MRI to show hypoperfusion or abnormal signal intensity in patients with cognitive impairment represented by NP test results were compared. Results: Forty-two patients were considered to have cognitive impairment on NP tests and 27 not. Brain SPECT showed 71% sensitivity and 85% specificity, while brain MRI showed 62% sensitivity and 93% specificity (p>0.05, McNemar test). SPECT found more cortical lesions and MRI was superior in detecting white matter lesions. Sensitivity and specificity of 31 mild TBI patients were 45%, 90% for SPECT and 27%, 100% for MRI (p>0.05, McNemar test). Among 41 patients with normal brain MRI, SPECT showed 63% sensitivity (50% for mild TBI) and 88% specificity (85% for malingerers). Conclusion: Brain SPECT has supplementary role to neuropsychological tests in the psychiatric disability evaluation of chronic TBI patients by detecting more cortical lesions than MRI. (Korean J Nucl Med 2002;36;232-43)

뇌전증 소아들에서 주의력결핍과잉행동장애와 뇌 MRI 소견의 연관성

문자운(Ja Un Moon),윤다혜(Da Hye Yoon),박선영(Sun Young Park),임수아(Soo Ah Im),이인구(In Goo Lee) 대한소아신경학회 2018 대한소아신경학회지 Vol.26 No.2

목적: 뇌전증 소아들 중 주의력 결핍 과잉행동장애가 중복된 소아들의 뇌 MRI를 분석하여 ADHD와 뇌 MRI의 연관성을 알아 보고, MRI 의 이상 소견이 ADHD 발생의 위험인자가 될 수 있는지의 여부를 알아보고자 하였다. 방법: 2009년 3월부터 2013년 12월까지 가톨릭대학교 서울성모병원 소아신경과에서 뇌전증을 진단 받고, 항경련제 치료를 받는 6세에서 18세까지의 환자들 중 ADHD 가 중복 되었고 최소 1년 이상 추적 관찰이 가능하였던 55명(남자 36명, 여자 19명)의 소아들을 대상으로 하였다. ADHD의 진단은 정신질환 진단 및 통계편람 (DSM-IV, Diagnostic and Statistical Manual of Mental Disorder, 4thedition)의 기준에 따라 진단하였다. 결과: 뇌 MRI가 정상 소견을 보인 환자들은 대부분 주의력결핍형의 ADHD였으나(28명, 96.5%), 뇌 MRI가 비정상 소견을 보인 환자들은 혼합형이 14명(53.8%)으로 가장 많았으며, 주의력결핍형이 12명(46.2%)으로 MRI이상소견의 유무에 따라 ADHD의 아형에 차이가 있었다. 또한 주의력결핍 및 과잉행동-충동에 관한 각각의 문항 9개 중 양성을 보인 개수를 MRI 소견의 이상유무에 따라 비교한 결과, MRI소견에서 이상이 있는 환자군에서 ADHD 증상이 심한 것으로 평가되었다. 결론: 뇌전증 소아 환자들에서 MRI 이상 소견은 ADHD와 밀접한 연관성을 가지고 있을 뿐 아니라 ADHD 의 중증도와 연관될 수 있음을 말해준다. 따라서 MRI에 이상 소견이 발견되는 뇌전증 환자에서는 조기 ADHD 선별검사를 시행해 이에 대한 대책을 수립하는 것이 치료 및 삶의 질 향상에 도움이 될 것이라고 여겨진다. Purpose: We analyze the brain magnetic resonance imaging (MRI) findings of children with epilepsy and concomitant attention deficit hyperactivity disorder (ADHD) to investigate the correlation between brain MRI and ADHD, and to determine whether abnormal MRI finding can be a risk factor for the development of ADHD. Methods: A total of 55 patients (36 male, 19 female) were diagnosed as ADHD in children with epilepsy at the pediatric neurology department of Seoul St. Mary hospital from March, 2009 to December, 2013. The records of these patients were retrospectively reviewed. Results: 29 patients (52.7%) had normal MRI findings, and 26 patients (47.3%) had abnormal MRI findings. The inattention type of ADHD (96.5%) was the largest type in a group of normal brain MRI findings, but the combined type (53.8%) and the inattention type (46.2%) occupied the majority in a group of abnormal MRI findings. The score of symptom in inattention was 7.44/9 in a group of normal MRI findings, while 8.2/9 in a group of abnormal MRI findings. And the score of symptom in hyperactivity was 2.93/9 in a group of normal MRI findings, while it was 4.8/9 in a group of abnormal MRI findings (P<0.001). 7 patients (12.7%) revealed hippocampal sclerosis out of 26 abnormal MRI findings, and they had significantly higher scores of ADHD symptoms (8.57/9, 4.8/9) compared to normal group (7.83/9, 4.23/9). Conclusion: Abnormal MRI findings in children with epilepsy are not only closely related to ADHD but may also be associated with the severity of ADHD.

기능적-자기공명촬영장치를 이용한 저작시 두뇌활성화부위

이병황,유태민,이종헌,박경주 대한구강악안면병리학회 2014 대한구강악안면병리학회지 Vol.38 No.2

This study were to perform for verifying the activation areas in the human's brain during mastication by using functional-MRI (f-MRI) device on the basis of hypothesis regarding anatomical-physiological parts of brain processing the information of motor and sensory function, and to perform further more for a providing basic provisional foundation about diagnosis, treatment and prognosis of abnormal occlusion as applying functional MRI. Generally healthy 10 volunteers who have a normal occlusion were selected. The half of members of volunteers was female. Age distributions were approximately alike. Before taking a f-MRI, sufficient practice was carried out as strict standards and made volunteers be not sensible to sweet taste of gum through chewing gum for 30 minutes before taking a f-MRI. Functional images for all volunteers were firstly obtained, and then anatomical images were next. The functional images consisted of echo-planar image volumes which were sensitive to BOLD (blood oxygenation level-dependent) contrast in axial orientation. The volume covered the whole brain with a 64×64 matrix and 42 slices. Images with 64 volumes were acquired under periodic mastication. The orofacial sensorimotor cortex was primary responsible cerebral part during mastication and insula. And also supplementary motor area and cerebellum in brain were intimately connected with mastication. Other numerous anatomical parts of brain were activated in each volunteer during mastication, but there was no statistical significance in this experiment. Differences according to gender and age were no significance in this study. The f-MRI device showed the accurate and detailed image in activation area of brain through valuable device. It suggested that f-MRI might be helpful to establish the basis of funtional standard occlusion depend on activation area of brain.

외부병원 필름판독료 수가 개선에 따른 효과평가 연구

김록영,조민호,위세아 건강보험심사평가원 심사평가연구소 2020 연구보고서 Vol.2020 No.0

As part of coverage expansion plan, the government decided to include brain-related MRI scan into the benefit package, and raised external MRI image decipher service fee for healthcare service providers in an attempt to induce appropriate level of service use. As MRI scan of spine and musculoskeletal system are planned to gradually come into national health insurance package, there is a need for a continued improvement of MRI coverage policy. To enable such improvement, this study aims to provide effectiveness assessment and suggestions for proper management measures. This study analyzed policy effectiveness of health service usage pathway before and after MRI inclusion into the benefit package of national health insurance system. Regarding analysis method, 30-day healthcare service use data of patents who received brain-related MRI scan were structured by episode and analyzed with t-test and Logit, in order to see the difference between before and after the policy implementation. The result showed that the increased decipher authority of specialist physicians led to more MRI image decipher cases of external clinics. As a result of increased MRI image decipher fee, there was an uplift of external MRI decipher cases, when compared to before the policy change. It means that more providers chose to use MRI scan taken by other clinic or hospital, rather than performing another scan at their own facility. The type of providers performing MRI scan was divided into two groups: general/tertiary hospitals, and hospitals and clinics. Policy effect was analyzed by patients' route, and it was shown that different routes had different policy effect. Based on the result, raise of MRI decipher fee was proposed for rational use pattern of healthcare resource, such as getting MRI scan with 3 Tesla MRI at a general or tertiary hospital, and visiting a hospital or clinic to get it deciphered. In order to build and operate an efficient and comprehensive healthcare resource management system, exchange of medical image data should be available more easily and conveniently. Such improvement is expected to contribute to reduction of reduced social cost and stabilization of the National Health Insurance fund.

MRI 영상의 전처리와 심층학습에 의한 뇌종양 진단보조 시스템 개발

조용현(Yong-Hyun Cho) 한국지능시스템학회 2018 한국지능시스템학회논문지 Vol.28 No.3

본 논문에서는 MRI 영상의 전처리와 심층학습에 의한 뇌종양 진단을 위한 보조시스템을 개발한다. 여기서 전처리는 DICOM 시스템으로부터 얻어진 MRI 뇌 영상의 이진마스크를 이용해 관심영역을 추출하고, 중간필터와 모폴로지 연산으로 추출된 영역의 잡음을 제거한 후, 크기를 재조정하여 학습부하를 줄인다. 또한 심층학습은 전처리된 영상을 대상으로 합성곱신경망을 이용하여 학습모델을 구현하여 새로이 입력되는 뇌 MRI의 정상과 비정상을 판단한다. 제안된 기법을 T2 MRI 13번째 수평절단 572*816 픽셀의 8비트 RGB 뇌 영상 72개를 대상으로 실험한 결과, 우수한 진단 성능이 있음을 확인할 수 있었다. This paper presents a diagnostic assistant system of brain tumor by the preprocessing and deep learning of MRI images. The preprocessing extracts the region of interest by using a binary mask, and performs the median filter and morphology operation to remove the noise in MRI brain image, and reduce the learning load by resizing the image. And deep learning is performed on preprocessed images using convolutional neural network, determine the normality and abnormality of the newly entered MRI brain image. The proposed method has been applied to diagnose 8 bits RGB 72-brain MRI images of 572*816 pixels. The experimental results show that the proposed method has an excellent diagnoicst performance.