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          치과 임상에서 조직유도재생술의 의미

          장현선 대한구강악안면병리학회 2018 대한구강악안면병리학회지 Vol.42 No.4

          Guided tissue regeneration(GTR) is regenerative operating technique at dental clinic. The vertical bone defect can be treated by GTR. The purpose of this study is to present the importance of GTR at dental clinic. The vertical bone defect was observed on distal side of mandibular right 2nd molar. The patient had been treated scaling, root planing and GTR. Both nonresorbable occluding membrane and resorbable occluding membrane can be used as GTR operation. The former was used in this study. Nonresorbable occluding membrane can exclude epithelial cells from healing defect. The Bio-Oss bone graft used at GTR operation. A radiograph demonstrates that the regenerative part was observed by GTR. In conclusion, GTR operating effect has importance on vertical defect at dental clinic.

        • KCI등재

          볼에 발생한 혈관지방종: 증례 보고

          김진수,이승준,김창현,박재억 대한구강악안면병리학회 2018 대한구강악안면병리학회지 Vol.42 No.5

          Lipomas are the most common benign mesenchymal tumors composed of mature adipocytes. They are usually slow-growing, soft and asymptomatic masses. Angiolipomas are rare benign soft tissue tumors that are distinguished from common lipomas by a marked degree of vascularization. The diagnosis and prognosis of angiolipomas are based entirely on the findings of histological evaluations. Angiolipoma, showing characteristics of both lipoma and hemangioma, usually develop in the trunk and extremities, and rarely arise in the head and neck region. Angiolipoma of the cheek is very rare. This report presents the clinical and histopathological features of infiltrating angiolipoma excised from the cheek.

        • KCI등재

          경부 림프절 전이를 모방한 이소성 갑상선 증례

          권순모,송상현,조은애산드라,김현실,남 웅 대한구강악안면병리학회 2018 대한구강악안면병리학회지 Vol.42 No.4

          Cervical neck dissection is a frequent technique during treatment for oral squamous cell carcinoma (SCC). Occasionally, specimens harvested as cervical lymph nodes reveal thyroid tissue and need differentiation with metastatic thyroid cancer and ectopic thyroid tissue. Here, we report a case of an ectopic thyroid tissue with lymphocytic thyroiditis mimicking thyroid cancer metastasis at the cervical lymph node.

        • KCI등재

          치근단 병소로 나타난 하악골의 성인 고립 근섬유종

          윤정훈 대한구강악안면병리학회 2018 대한구강악안면병리학회지 Vol.42 No.5

          Myofibroma is a benign tumor composed of fibroblasts and myofibroblasts, occasionally occurring most commonly as a solitary lesion of soft tissue, skin, or bone in children younger than 3 years of age. Solitary lesion of myofibroma is exceedingly rare in adult jaws. This report describes a rare case of myofibroma in the mandible that occurred in a 41-year-old Korean woman.

        • KCI등재

          하악과두에 생긴 박리성 뼈연골증의 조직학적 관찰

          정필훈,김성민,이석근 대한구강악안면병리학회 2018 대한구강악안면병리학회지 Vol.42 No.5

          A 57 years old female complained of severe pain on the right temporomandibular joint (TMJ) area. Her right condyle had been partly resected under surgical operation 13 years ago due to condyle hypertrophy, thereafter she felt dull pain on TMJ area and recently the lesion became severely swelled and painful leading to cancer phobia. The present radiological views showed slightly enlarged and sclerosed condyle with increased radiopacity, but its articular sliding function was almost disable during mouth opening. The patient’s TMJ lesion was carefully managed with conservative physiotherapy and pain treatment. The microsection of condyle head obtained from the previous operation was re-evaluated histologically, and it was finally diagnosed as osteochondrosis dissecans (OCD), exhibiting hyperplastic proliferation of cartilage in condyle head and marked vascular dilatation in epiphyseal zone. This abnormal cartilage tissue was distinguishable from normal cartilage tissue found in the peripheral cartilaginous cap of the same microsection. The involved cartilage cap showed thick hypertrophic chondrocyte zone with horizontal and vertical clefts accompanying diffuse hyaline degeneration. The superficial fibrous zone of cartilage cap was thickened and frequently peeled off, while lower hypertrophic zone of cartilage cap was highly cellular and proliferative. Consequently, the endochondral ossification became aberrant and resulted pre-mature apoptosis of many hypertrophic chondrocytes, followed by diffuse and mild inflammatory reaction in the underlying marrow tissue. Therefore, it was suggested that this hypertrophic condyle lesion, OCD, be differentiated depending on radiological and histological features from ordinary condyle hyperplasia, osteochondroma, and osteoarthritis, and that the pathological confirmation of OCD may provide a reliable modality for dental and medical treatment of chronic and painful TMJ lesion.

        • KCI등재

          하악지 영역에 발생한 미분화성 다형성 육종: 수술 후 재발한 증례

          안재명,장승일,홍종락,팽준영 대한구강악안면병리학회 2018 대한구강악안면병리학회지 Vol.42 No.5

          Undifferentiated pleomorphic sarcoma (UPS) in the mandible region is a rare malignant neoplasm. We encountered the case of a patient who had been diagnosed with deep benign fibrous histiocytoma (DBFH) prior to surgery, but the final biopsy revealed the presence of tumor tissues in the resected margin, which indicated a UPS. Therefore, radiotherapy was conducted post-operatively, but the tumor recurred approximately 3 years later and a second surgery was performed. The difference between the initial and final diagnoses was considered to be due to the characteristics of the tumor, as it involved both benign and malignant components. DBFH and UPS can occur in young women. DBFH can transform to a malignancy and UPS may also appear as a benign tumor during early biopsy. Hence, attention should be paid to diagnosis and treatment methods, and ongoing close observation is required.

        • KCI등재

          성장기 환아의 복잡 치관-치근 파절 영구전치의 Root submergence

          조은정,이제우,라지영 대한구강악안면병리학회 2018 대한구강악안면병리학회지 Vol.42 No.5

          Complicated crown-root fractures are considered rare occurrences in young permanent dentition; however, they often present complicated and unpredictable treatment options. The most common treatment option for crown-root fractured teeth is reattachment of fractured segment, but if it is thought impossible to maintain, it should be extracted. However, when unfavorable crown-root fracture occurs in the adolescents, extraction of fractured teeth is expected to be poor due to excessive resorption of alveolar and prosthetic replacement cannot be performed immediately, various treatment options should be considered. This report suggests root submergence in the complex crown-root fracture in growing patients is performed and the functional and aesthetic results including preservation of the alveolar bone are obtained.

        • KCI등재

          구강암 환자의 생존율과 관련된 임상 영향인자들과 암 호발 항원단백인자 조사

          유미현,장민아,김욱규 대한구강악안면병리학회 2021 대한구강악안면병리학회지 Vol.45 No.1

          Autophagy is a cell survival mechanism that works for the survival of cells under various physiological and pathological conditions. ATG5 is a key protein in the process of autophagy propagation and is involved in tumor development and progression. Chemotherapeutic agents targeting ATG5 enhance the host's immune response in various human cancers and intensify the effectiveness of chemotherapy. However, the physiological role of ATG5 protein in oral squamous cell carcinoma (OSCC) has not been fully recognized. The purpose of this study was to examine the correlation between clinico-pathological factors of OSCC patients and ATG5 immunoexpression through immunohistochemistry (IHC) in the tissues of OSCC patients treated at our hospital, and to analyze the regarding influences and their mechanisms. The authors analyzed 20 OSCC patients from National University Dental Hospital, at Pusan National University from January 2002 to December 2007, which were eligible for the study. Data were obtained by reviewing the medical records of the OSCC patients, and ATG5 immunoexpression was obtained using IHC staining in the tissue samples of the OSCC patients. In the tissue sample of OSCC patients, the immunoexpression of ATG5 elevated, in comparison to the normal oral mucosa, and there was a significant correlation with Drinking, Pathological Stage. In regards to Cox regression analysis, Clinical stage, Tumor size, Histopathologic grade, Cervical nodal metastasis, Loco-regional recurrence, and ATG5 expression have statistically significant correlations. These results imply that the changes in the expression of ATG5 proteins in OSCC can be a prominent factor in the OSCC progression and the prognosis of OSCC patients.

        • KCI등재

          조혈세포이식 후 재발한 백혈병 환자의 혀 종물

          최성환,박슬마로,김현실,조은애산드라 대한구강악안면병리학회 2018 대한구강악안면병리학회지 Vol.42 No.4

          Oral examination in a patient with a history of acute lymphoblastic leukemia (ALL) and allogeneic hematopoietic cell transplantation (HCT) needs considerations of leukemia relapse and graft-versus-host disease (GVHD). Oral manifestations may contribute to early detection of relapse or systemic complications making accurate oral examination and diagnosis significant. We report a case of a large tumor like mass arising in a patient with a history of ALL and HCT. The patient had been diagnosed with ALL relapse and was being treated with chemotherapy, and furthermore was suspected of GVHD development.

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