한국인 주요우울장애 환자에서 혈중 ACTH, Cortisol 농도와 해밀턴 우울 평가 척도의 신체증상 항목과의 상관관계

여혜빈,김린,함병주,심세훈,권영준,정희연,정한용,한상우,이민수,이화영 대한생물치료정신의학회 2011 생물치료정신의학 Vol.17 No.2

Objectives:Hypothalamic-Pituitary-Adrenocortical(HPA) system dysregulation plays an important role in the pathophysiology of major depressive disorder. Medically unexplained somatic symptoms comprised the predominant complaints of korean patients with major depressive disorder. It might be related to dysregulation of HPA system and somatic symptoms. The aim of this study was to investigate the association between Hamilton Depression Rating Scale severity and the Plasma Adrenocorticotropic Hormone(ACTH) & Serum Cortisol level in Korean patients with major depressive disorder. Methods:Our study design was prospective. A total 111 hospitalized patients with major depressive disorder (DSM-IV) at Anam Hospital, Korea University Medical Center between Jan 2009 and May 2011 were selected. Hamilton Depression Rating Scale was measured by psychiatrist. Plasma ACTH, Serum Cortisol levels were analyzed at the time of admission. Results:There are significant correlations(p<0.05) between Hamilton Depression Rating Scale of somatic component(HAM-D 11-15 item) and Plasma ACTH and Serum Cortisol level. However, other HAM-D sub items were not significantly correlated with Plasma ACTH and Serum Cortisol level except somatic component. Conclusion:Our Study results suggest that hyperactivity of HPA axis might be correlation with somatic symptoms in korean patients with major depressive disorder.

Interval Weight Training이 체지방량 및 신체밀도에 미치는 영향

박영균,허정행,함경수* 경희대학교 체육과학연구소 2000 體育學論文集 Vol.28 No.-

The purpose of this study was to investigate the effect of interval weight training on the Fat Weight and Body Density. We have selected 24 students from the K-university whom they are studying physical Education. And also divided into 2 groups; control group with 12 students and the other is Training group with 12 students. We have tried interval weight training 3 days in a week on Monday, Wednesday and Friday. To notify the changes of Body Density, We have measured subscapular, triceps, suprauliac, and Abdomen. And also to notify the changes of Fat Weight, We have measured % Fat and L.B.M(Lean Body Mass) The first measurement took before training and the second measurement took after 6 weeks of training. And the results were as follows: 1.For skinfold thickness to control group, the total of 4 parts were 42.15±11.77mm but after 6 weeks it increased to 47.05±12.19mm, but for training group it was 33.56±5.02mm but after 6 weeks training it decreased to 31.45±4.39mm. 2.For fat weight to control group, before training it's 11.17±1.98kg but after 6 weeks it increased to 12.20±2.23kg. For training group, before training 12.20±2.23kg but after 6 weeks it decreased to 9.46±2.52kg. 3.For % fat, control group before training 14.71±2.98% but after 6 weeks it increased to 15.66±3.02%. For training group, before training 13.47±2.11% but after 6 weeks it decreased to 12.52±2.74%. 4.For L.B.M(lean body mass), control group didn't show much of difference before and after the training but for the training group it showed 59.66±7.02kg before training but after 6 weeks it increased to 60.12±6.35kg. For training group, before training 59.84±3.65kg but after 6 weeks it decreased to 60.55±2.99kg.

전자부품 제조업 근로자들의 시력변화에 대한 연구

이용만,안규동,이성수,함정오,김화성,리갑수,이병국 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.2

근접작업이 시력약화의 원인이 될 수 있는가를 알아보기 위하여 전자부품을 제조하는 2개 사업장에서 1991년에서 1993년까지 입사한 근로자들 중에서 근접작업으로 인정되는 마이크로칩을 조립하는 근접작업자 306명을 조사군으로, 대조군은 세탁기 타이머 및 일반 기계기구를 조립하는 작업자 154명, 계 460명을 선정하였다. 이들 대상자는 1991년 입사자는 1993, 1994, 1995년 시력을 조사하였으며, 1992년 입사자는 1993, 1994, 1995년 3년동안 조사를 하였으며, 1993년 입사자는 1994, 1995년 2년간 시력을 조사하였다. 대상자 중에서 입사시 안경을 착용한 근로자는 82명(17.8%)이었다. 따라서 남자 근로자와 안경착용자를 제외한 여성 근로자들 335명만을 추적 조사하여 다음과 같은 결론을 얻었다. 조사군에서 입사시 시력 1.0 이상이었던 근로자의 분포는 취업 1년 후 약 25-35% 정도 감소하였으며, 2년후에는 약 40-60% 정도의 감소를 나타내었고, 3년 후 약 50-65% 정도로 감소하였고 4년후에는 약 65% 이상 감소하였다. 그러나 대조군에서는 1.0 이상의 시력을 보였던 근로자들의 비율이 취업 1년 또는 2년 후 15-30%의 감소를 보이고 있으나 그 이후에는 큰 변동이 없었다. 이들의 시력변화를 근무년수에 따라 알아보기 위하여 조사된 시력을 순위변수로 하여 Kruskall-Wallis 검정을 시행한 결과 조사군, 대조군 모두에서 근속년수에 따른 순위의 합의 평균이 년차적으로 유의하게 감소하였으나, 입사시부터 근속년수에 따른 조사군과 대조군과의 순위합의 평균에 의한 시력차 비교에서 입사시 조사군의 순위합의 평균이 유의하게 높았던 것이 근무기간에 따라 대조군의 평균이 높아지면서 통계적 유의성이 없고 대체적으로 1년 이후부터 변화가 적은 것으로 나타나 근접작업으로 인한 시력약화를 추정할 수 있었다. This study was carried out to investigate that the close distance works were associated with decreased visual acuity. 306 workers were subjects who had been recruited from 1991 to 1993 in two electronic parts manufacturing factories, and 154 workers were controls who had been employed from 1991 to 1993 in launder machine timer and general machine assembly factories. Subjects who had been employed in 1991 and 1992 were follow up from 1993 to 1995, and subjects who had been employed in 1993 were from 1994 to 1995. The male workers as well as glasses wearing workers were excluded. Only 335 female workers were followed up to study the change of visual acuity. The results were as follows; The rate of workers with visual acuity over 1.0 at recruit year in subjects group was decreased about 25-35% after 1 year, 40-60% after 2 years, 50-65% after 3 years, and 65% after 4 years. While, the rate of workers with visual acuity over 1.0 at recruit year in control group was decreased about 15-30% after 1 or 2 years, and there was no more additional visual acuity reduction after then. Kruskall-Wallis test was performed to investigate the change of visual acuity in subject and control group by work duration. The means scores of ranks in both group were significantly decreased by work duration. The mean scores of ranks in subject group at recruit year were significantly higher than those in control group at recruit year, but these differences were disappeared after 1 year work. Therefore, this suggest that close distance workers may be affected their visual acuity.

제품평가요소가 소비자태도에 미치는 영향 : 셀롤러폰과 PCS를 중심으로 Focus on Cellular-Phone and PCS

차수련,함영봉 동국대학교 경영대학원 1998 經營論叢-東國大學校 經營大學院 Vol.22 No.-

The purpose of this study is to offer some cue that to predict consumer attitude in the future market, to make an attitude on the product through the evaluation factors. The attitude was measured with four category as the factor of personal effect : experience, involvement, product knowledge, subjective norm. Involvement was used not to measure the attitude. but to extract of high-involvement. This study largely consist of literature review. hypothesis generation and experiment. At first this studies involved in this topic, and then built systematic models based on literature review and generated several hypothesis about personal factors : experience, product knowledge and subjective norms. On experiment objective, the reason of it to choice, it's definition, and recent situation are reviewed to base the hypotheses. To test hypotheses, I examine reliability, validity, and multi-regression analysis. In experience category, the factors passively influenced the attitude. In product knowledge, is influenced positively or negatively the attitude. Finally, in subjective norm, it's all factors negatively influence the attitude. It is to be against that the previous studies(SB influence positively the attitude.). Shortly, experience and product knowledge influence the consumer attitude, but subjective norm is not on the cellular-phone and PCS. This study has also a limitation that the results difficult generalization because the sample is limited by 20-30 ages. But the study can offer some cue that to predict the attitude and to make an attitude on the products in the future market.

졸참나무 수피의 추출성분

김진규,이상극,함연호,배영수 江原大學校 森林科學硏究所 2002 Journal of Forest Science Vol.18 No.-

졸참나무 수피를 채취하여 아세톤:물(7:3, v/v) 혼합용액으로 추출하고 유기용매를 제거한 후 hexane, CH₂Cl₂, EtOAc 및 수용성으로 분획하여 등결건조하였다. 그 중에서 EtOAc용성 분획물을 MeOH 수용액 및 EtOH-hexane 혼합용액을 사용하여 Sephadex LH-20 칼럼크로마토그래피를 수행하여 (+)-catechin, ellagic acid, taxifolin, taxifolin-3-O-β-D-glucopyranoside를 단리하였다. 단리된 화합물의 구조는 ¹H, ^(13)C-NMR spectrum으로 구조를 구명하였다. The bark of Quercus serrata Thunb were collected, extracted with acetone-H~O(7: 3, v/v), fractionated with hexane, methylene chloride and ethylacetate, and freeze dried to give some dark brown powder. The ethylacetate soluble mixture was chromatographed on a Sephadex LH-20 column using a series of aqueous methanol and ethanol-hexane mixture as eluents. The isolated compounds from &. serrata were (1- 1-catechin, ellagic acid taxifolin and taxifoiin-3-O-ll-D-glucop~anos~de. The structures of isolated compounds were characterized by ¹H, ^(13) C-NMR spectroscopy.

발효콩 추출물의 항돌연변이원성 및 세포독성 효과

최승필,이효진,문선영,김수현,이득식,함승시 동아시아식생활학회 2004 동아시아식생활학회지 Vol.14 No.3

This study was carried out to determine the antimutagenic and anticancer effects of fermented soybean using Ames test and cytotoxicity, respectively. The ethyl acetate fraction (200 g/plate) of fermented soybean in the Salmonella typhimurium TA100 strain showed 86.6% of inhibition rate against the mutagenesis induced by N-methyl-N-nitro-N-nitrosoguanidine(MNNG). In addition, the suppression of ethyl acetate fraction with same concentration of fermented soybean in the Salmonella typhimurium TA98 and TA100 strains showed 82.4% and 90.8% inhibition against 3-amino-1,4-dimethyl-5H-pyrido-(4,3-b)indol (Trp-P-1), respectively. The cytotoxicity effects of fermented soybean against the cell lines with human lung carcinoma (A549), human gastric carcinoma (AGS) and human breast adenocarcinoma (MCF-7) were inhibited with the increase of the extract concentration. The treatment of 1.0 ㎎/mL ethyl acetate fraction of fermented soybean showed strong cytotoxicities of 71.6%, 91.5% and 80.7% against A549, AGS and MCF-7, respectively.

방사선 및 기관지경검사상 잠재성이었던 폐의 상피내 암종 1예

정희순,한성구,심영수,김건열,한용철,김주현,박인애,함의근 서울大學校 醫科大學 結核硏究所 1988 結核硏究所 硏究報告 Vol.2 No.1

한국의 노인우울증 환자에서 조발성 우울증과 만발성 우울증의 임상증상의 비교

박기홍,이화영,함병주,이민수,Park, Ki-Hong,Lee, Hwa-Young,Ham, Byung-Joo,Lee, Min-Soo 대한생물정신의학회 2010 생물정신의학 Vol.17 No.3

Objectives : Clinical differences between elderly patients with early and late onset depression have been described although these have been inconsistent. We aimed to compare differences of clinical symptoms using the 17 items Hamilton Rating Scale for Depression(HAM-D-17) between two groups. Methods : Data of 175 elderly patients with a diagnosis of major depressive disorder according to DSM-IV from January 2005 to November 2009 were collected. Seventy five patients were early onset depression and one hundred patients were late onset depression. Depressive symptoms were assessed by the 17-item Hamilton Rating Scale for depression. Results : There were some differences in HAM-D-17 scores between early and late onset depression. Early onset depression patients scored significantly higher in retardation(t = 2.41, p = 0.017) and somatic symptoms( general)(t = 2.37, p = 0.019) than late onset depression patients. Conclusion : We concluded that early onset depression patients have more severe psychomotor retardation and general somatic symptoms than late onset depression patients in Korea. Because of some limitations of this study, further investigations will be needed to validate this study results.

Anti-obesity effects of Mulberry Leaves and Robusta Fermented with Leuconostoc mesenteroides in Highfat Diet Induced Obese Mice

Soo Young Choi,Eui Suk Jeong,Seung Hyun Ryu,Jong Hyung Park,Seung Hoon Ham,Jin Il Park,Hee Yeon Jeon,Jun Young Kim,Inn Goo Kyeong,Mi Ra Lee,Ji Young Shin,Dong Goo Kim,Ki Dong Eom,Yang Kyu Choi 한국실험동물학회 2015 한국실험동물학회 학술발표대회 논문집 Vol.2015 No.8

Anti-obesity effects of mulberry leaves and robusta fermented with Leuconostoc mesenteroides in high-fat diet induced Obese Mice

Soo-Young Choi,Seung-Hyun Ryu,Jin-Il Park,Eui-Suk Jeong,Jong-Hyung Park,Seung-Hoon Ham,Hee-Yeon Jeon,Jun-Young Kim,Inn-Goo Kyeong,Dong-Goo Kim,Ji-Young Shin,Ki-Dong Eom,Yang-Kyu Choi 한국실험동물학회 2016 한국실험동물학회 학술발표대회 논문집 Vol.2016 No.2