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척수압박으로 발현된 급성 골수성 백혈병에 동반된 과립구성 육종 1 례
윤상준,김영곤,김희종,박유환,정춘해,김양수,김태균,박영진,전호종 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1
저자들은 척수압박으로 하지마비를 보인 환자에서 수술 후에 급성 백혈병에 동반된 과립구성 육종으로 진단된 환자 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Granulocytic sarcoma(GS) is an uncommon tumor composed of immature cells of the granulocytic series. Most case of GS occur in the course of acute leukemia and the blast crisis of chronic leukemia, Rarely, however, it may present before leukemia becomes clinically apparent. It may also occur in patients with myeloproliferative disoders. GS has been reported that it occurs in 3% to 9% of patients with acute myelogenous leukemia(AML) and the incidence of GS is reported to be higher in patients with t(8;21). GS occurs relatively commonly in africa and has been reported to affect 10-25% of black children presenting with AML. This is very rare case of granulocytic sarcoma with AML(FAB M5) presented with spinal cord compression which was supported by decompression laminectomy.
김연상,김태진 崇實大學校 1999 論文集 Vol.29 No.1
Zinc oxide was synthesized by using the precipitation method from zinc salts and NH₄0H. The size, morphology and size distribution of the synthesized ZnO powders were studied in terms of zinc salts, pH, and alcohol, ethanolamine, temperature. The minimum pH to dissolve the synthesized zinc hydroxy salt was 12.8 and the maximum pH to precipitate ZnO was 9.2. Ethanolamine such as MEA, DEA, TEA tends to fall pH slowly when heating the solution and make the particles more spherical. Without alcohol and ethanolamine, no spherical particles were obtained. More fine particles were obtained by stirring solution when precipitation occured. The purity of synthesized ZnO was more than 99.5%
음식물 쓰레기 퇴비가 오이 발아와 유묘생장에 미치는 영향
박진영,조경철,김희경,지연태,정순주 全南大學校 農業科學技術硏究所 2001 農業科學技術硏究 Vol.36 No.-
This study was conducted to find out toxicity of compost made of food waste to cucumber seed germination and seedlings growth when it was mixed with Mixlite for bed substrate. Mixlite was solely used as bed soil, or mixed with food waste compost ranging 1% to 100% (w/w). Germination percentage and seedling growth of cucumber were examined in 4 weeks after seedling. When cucumber seeds were sowed in Mixlite mixed with food waste compost at 100, 50, 30, 20, 10 or 1%, germination percentages were 30, 36, 38, 46, 74 and 84% compared to with control(100%), respectively. It showed that germination percentage percentage was adversely affected by the amount of food waste composed mixed in the bed substract. Plant height and hypocotyls diameter, root length and root fresh weight, hypocotyls fresh weight and cotyledon fresh weight of cucumber seedling were similarly adversely affected by the amount of food waste compost. Optimum content of the food waste compost for cucumber nursery substrate was found to be 1% of Mixlite.
정신분열병 환자에서 Risperidone에 의한 Cytokine의 변화
김대진,김원,윤수정,고효진,최보문,전태연 대한신경정신의학회 2000 신경정신의학 Vol.39 No.4
기존의 항정신병약뮬인 haloperidol이나 clozapine과는 약물학적 특성이 다른 대표적인 약물인 risperidone을 사용하여 정신분열병 환자가 치료 전과 4주 치료 후에 어떤 면역학적 차이를 보이는지 6가지 cytokine의 혈장 농도를 측정하여 알아보았다. 방법: 1999년 2월부터 1999년 5월까지 카톨릭대학교 대전성모병원 정신과에 입원한 환자 중 DSM-IV 진단 기준에 의해 정신분열병으로 진단된 환자 25명을 대상으로 하였다. 입원 다음날 아침 8시 risperidone 투여전의 기본적인 cytokine농도를 측정하기 위해 혈액을 채취하였으며 제 2병일에 risperidone 2mg, 제 4병일에 4mg, 제 6병일에 6mg으로 증량하는 방식을 항정신병약물 치료를 하였다. 임상평가는 risperidone 투여 전과 투여 4주 후 정신과 전공의가 각각 PANSS 검사를 시행하였다. 혈장에서 IL-1β,IL-2, IL-6, IL-12, INF-□, TNF-α의 정량 측정은 ELISA kit (Endogen Inc., Woburn, MA, USA)을 사용하여 quantitative ELISA법으로 하였다. 결과: risperidone을 4주간 투여 후 환자 혈장 IL-12 농도가 유의하게 증가되었고 나머지 cytokine 농도는 유의한 변화가 없었다. 결론: 저자들은 연구에서 risperidone 치료 후 IL-12가 증가된 것은 이러한 항정신병약물치료가 면역반응 을 활성화시키는 역할을 한 것으로 시사된다. Objectives: This study was carried out to evaluate immunologic difference between baseline and after 4 weeks drug treatment with atypical antipsychotics(rispreidone) by measurement of serum concentration of 6 cytokines. Methods: The subjets were composed of 25 patients who are admitted at Dajeon St's Marys hospital of psychiatry department and diagnosed as schizophrenia by DSM-IV diagnositc criteria. We measured serum IL-1β, IL-2, IL-6, IL-12, INF-□, TNF-α concenatrations by quantitative ELISA method using ELISA kit(Endogen In., Woburn, MA, USA). The two psyciatrists per-formed PANSS examination between baseline and after 4 weeks risperidone treatments. Results: The serum level of IL-12 was increased significantly after medication of 4 weeks and the serum concentration of IFN-□ showed the tendency of decreasement but not significant. The serum level of the other cytokines showed no significant change. Conclusion: We spectulate that the increasement of IL-12 may contribute to role of activa-tion of immune response by treatment of antipsychotic medication(risperidone). This study is first trial of IL-12 study in neuropsychiatric field and IL-12 which play impor-tant role of immune response becomes interesting subjects in immune research.
이진열,정순주,지연태,김희경 全南大學校 農業科學技術硏究所 2001 農業科學技術硏究 Vol.36 No.-
This experiment was conducted to investigate the effect of chitosan, oligosaccharides on root and shoot growth promotion and fruit harvest of cucumber. Chitosan solution was made by hydrolysis with enzyme, and diluted in 1,000(50ppm), 3,000(16.7ppm), 5,000(10ppm) and 7,000(7ppm) times. 7,000 times diluted chitosan solution showed the best results on plant height, stem diameter, number of leave, leaf area, and leaf and petiole fresh weight, but fresh stem weight was inhibited in all concentrations of chitosan solution. Also fruit yield was increased 24.7% in 7,000 times diluted chitosan solution.
공분산구조분석법을 활용한 통행수단, 활동 및 통행행태에 대한 인과성 평가
장태연,김대영,김정호,권진영 전북대학교 공학연구원 ( 구 전북대학교 공업기술연구소 ) 2002 工學硏究 Vol.33 No.-
Activities done by individual are usually classified into obligatory and discretionary ones. Simple or complex trip pattern is performed as these activities are linked and various travel modes are used. Individuals try to link several trips as a type of chain to save transportation resources such as travel distance or time, which consequently produces complex trip pattern. These changes in urban transportation environment and less studies on activity-based characteristics make difficult to forecast trips resulting from trip linkage behavior. The purpose of study is to analyze possible causal relationships among activities, travel mode choices and travel patterns, assuming that they are directly influenced by individual or household attributes. Two kinds of models are established to achieve this purpose. One is the allocation model for mode choice for activities by three stage least square estimation method under the restricted conditions. The other is covariance structure model(LISREL) to analyze direct and indirect effect among attributes. As a result, the allocation of travel modes is mainly influenced by variables such as gender, education level, marriage, and children under 13 years old. In LISREL, it is shown that those variables well explain an exogenous personal attributes and only family income do an exogenous household attributes. While trip pattern attributes is well reflected by travel mode attributes, it is less reflected by activity attributes.
전자토모그래피의 정량적 분석에서 대물렌즈 조리개의 영향
김진규,이상희,권희석,정종만,정원구,이수정,주형태,김윤중 韓國電子顯微鏡學會 2008 Applied microscopy Vol.38 No.4
Electron tomography의 정량적 분석을 위해서 대물렌즈 조리개가 투과빔의 강도에 미치는 영향을 평가하였다. Electron tomography에 도입되는 Beer’s law의 올바른 적용을 위해서는 투과빔은 시료의 기울기에 따른 mass thickness의 변화에 의한 효과만을 반영해야 한다. 그러므로 빔 경로상의 대물렌즈 조리개, 홀더 등에 의한 다른 효과는 제거되어야 한다. 본 연구에서는 대물렌즈 조리개의 cut-off 효과를 120 kV TEM과 Quantifoil holey 카본 시료를 이용하여 상세히 평가하였다. 대물렌즈 조리개를 사용하지 않은 경우와 비교할 때, 30 μm 크기의 대물렌즈 조리개를 통과한 투과전자빔의 강도는 약 16.7%의 감소가 일어난다. 또한 55˚이상의 고경사각 기울기에서는 대물렌즈 조리개의 cut-off 효과에 의해 14.2%의 강도 감소가 추가적으로 발생함을 알 수 있었다. Electron tomography에서 정량적 분석을 위해서는 이러한 대물렌즈 조리개의 영향을 고려해야만 한다. 또한 Beer’s law의 올바른 적용을 위해서는 일련의 기울기에 따른 2차원적 영상은 가능하면 대물렌즈 조리개를 사용하지 않은 상태에서 획득하는 것이 바람직하다. We have evaluated the effects of experimental factors on transmitted electron beam intensities for quantitative analysis in electron tomography. For the correct application of Beer’s law in electron tomography, the transmitted beam intensity should reflect the net effect of mass properties on beam path. So, the any other effects of the objective aperture and the specimen holder on beam path should be removed. The cut-off effects of objective aperture were examined using Quantifoil holey carbon film and a transmission electron microscope operated at 120 kV. The transmitted beam intensities with 30 μm objective aperture dropped about 16.7% compared to electron beam intensities without the objective aperture. Also, the additional losses of about 14.2% at high tilt angles were occurred by cut-off effects of the objective apertures. For the precise quantitative analysis in electron tomography, the effect of the objective aperture on transmitted electron beam intensities should be considered. It is desirable that 2-D tilt series images are obtained without the objective aperture for correct application of Bee’s law.