일부 크롬 폭로 근로자들에 있어서 변이원성 지표로서의 소핵검사

윤형렬,김장락,홍대용 大韓産業醫學會 1993 대한직업환경의학회지 Vol.5 No.1

This study was conducted to investigate the possibility of utilizing micronucleus test for buccal mucosa and blood lymphocyte as an indicator for the evaluation of chromium mutagenicity in workers(n=40) exposed to chromium trioxide(CrO₃) and controls(n=40) in Pusan and Changwon cities form April 1 to August 30, 1992. Urine chromium concentration was measured by atomic absorption spectrophotometer. Self-recorded questionnaire were used to collect information on the relevant characteristics of the study subjects. The results were as follows. 1. The mean frequencies of micronucleus in buccal mucosa, blood lymphocytes and average urine chromium concentration of chromium platers were significantly higher than those for controls(p<0.01). 2. The mean frequencies of micronucleus in buccal mucosa and blood lymphocyte of chromium platers by smoking habit were significantly higher than those of controls(p<0.01). However, the difference of mean frequencies of micronucleus between smokers and non-smokers were not statistically significant(p>0.05). 3. The frequencies of micronucleus in buccal mucosa and blood lymphocyte were highly correlated(r=0.7706). Some of the other variables were also correlated, for example, urine Cr concentrations and frequencies of micronucleus in blood lymphocyte(r=0.7259), urine Cr concentrations and frequencies of micronucleus in buccal mucosa(r=0.6247), age and work duration(r=0.4032), work duration and frequencies of micronucleus in buccal mucosa(r=0.3603), age and frequencies of micronucleus in blood lymphocyte(r=0.3260), work duration and frequencies of micronucleus in blood lymphocyte(r=0.3231), age and frequencies of micronucleus in buccal mucosa(r=0.2760). 4. According to the results of multiple classification analysis, frequencies of micronucleus in buccal mucosa were statistically associated with occupation and work duration, frequencies of micronucleus in blood lymphocyte associated with occupation and work duration, and urine Cr concentrations associated with occupation. The results suggested that micronucleus test in buccal mucosa and blood lymphocyte could be used as a biological indicator for evaluating toxic effects of chromium.

한랭노출과 고혈압의 연관성

장태원,김윤규,윤동영,이창희,홍영습,신해림,정갑열,김준연 大韓産業醫學會 2001 대한직업환경의학회지 Vol.13 No.4

Objectives : This study was carried out to suggest preventive methods for hypertension in cold-exposed workers. Methods : In 11 refs·iteration industries, 68 workers working in refrigerated areas more than one time per day were selected as the exposed group, and 68 workers not exposed to cold were selected as the control group. We interviewed the subjects with a questionnaire covering occupational history, and conducted clinical and laboratory tests including measurements of blood pressure and core temperature. Results : The systolic blood pressure in the exposed group(130.0±13.3 mmHg) was significantly higher than that recorded In the control group(118.3±12.1 mmHg), as was the diastolic blood pressure in the exposed group(82.7±8.5 mmHg) versus the control group(77.4±8.7 mmHg). The core temperature in the exposed group(36.1±0.7℃) was significantly lower than that experienced in the control group (36.4±0.5℃). In logistic regression analysis, age, cold exposure severity and milk intake were significant variables, with odds ratios of 5.204(95 % CI 1.440∼18.812), 2.674(95 % CI 1.080∼6.618), and 0.364(95 % Cl 0.141∼0.942) , respectively. Conclusions : Our study suggests that cold-exposed workers have higher a higher risk of hypertension, and that their core temperature is lower. Risk factors affecting hyper-tension of cold-exposed workers include age, cold exposure severity and milk intake. For the prevention of hypertension, cold-exposed workers should minimize cold-exposure time as much as possible.

씨름 샅바잡기 유형에 따른 기술 형태 비교 분석

홍장표,윤종홍,소완영 龍仁大學校 武道硏究所 2004 武道硏究所誌 Vol.15 No.1

There has been adjustments in thigh band holding rules in amateur Si Rum competition form year 2001 to 2003. The purpose of this study is to offer the proper ways of couching the athletes and also populate Si Rum competition by researching how methods of thigh band holding-including stand holding started 2001, sited holding, and holdings that were used last 3 years- effects the changes of technique used in competition. By researching and analysing the used techniques and methods of thigh band holding, we came out with conclusion listed below. The most used techniques in each weight division for university team was waist techniques, and follows the order of all-round techniques(transform techniques), leg techniques and hand techniques. In waist techniques, Japchigi had the highest percentage of use. In all-round techniques(transform techniques), Duechigi, and leg techniques, Ahndari-gulgi had the highest percentage of use. By comparing the percentage of techniques used in each weight division, Japchigi had the highest percentage for Kyungjang-gup and Sojang-gup; also Yuksa-gup and Jangsa-gup. For Chungjang- gup, Yongjang-gup and Yongsa-gup, Dulbaejigi had the highest percentage of use. By comparing the percentage of techniques used in sited holding, stand holding, and modem stand holding, waist techniques -as the most important technique in the Si Rum-was shown as the highest percentage of use in all three holdings. Also in this research, it shows the higher percentage of all-round techniques (transform techniques) unlike the other two research shown above. It was shown as the second highest percentage of techniques used in this research. By comparing the three research, for sited holding, in order of waist, leg and hand techniques was shown as the most used techniques and all-round techniques(transform techniques) was not shown. In stand holding, in order of waist, leg, all-round and hand techniques was shown as the most used techniques. In this research, in order of waist, all-round(transform), leg, hand techniques was shown as the most used techniques. In all three research, it is shown that percentage of hand techniques use is decreasing, and also in modem Si Rum, there are more use of transformed techniques rather then textbook style techniques. By putting together results form these research, the most used techniques in Si Rum, waist techniques showed highest percentage of technique use. Also for modem Si Rum, well as the importance of practicing textbook style techniques, practice of followed transformed techniques comes up as important subject. Si Rum is a competition that is effected much by relativity, which means practicing techniques that fits ones physical type is necessary, and in order to achieve victory it is necessary to concentrate the practice in defending and countering techniques for the well used techniques in the competition.

개 대뇌겉질에서 Platelet-Derived Growth Factor α-Receptor의 출생 후 발달에 관한 면역조직화학적 연구

윤영,안병수,김인정,양경철,박선홍,김기훈,박도영,김장만,문정석,장인엽,조하영 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1

Background and Objectives : The localization of platelet-derived growth factor-α receptor (PDGF-α R) was commonly restricted to oligodendrocyte progenitors during late embryonic and postnatal development. However, several studies recently demonstrated that mature neurons could also synthesize PDGF-α, Materials and Methods : In the present study, to analyze the distributional pattern of PDGF-αR during postnatal development of the canine cerebral cortex, we used immunohistochemistry on sections of canine brain tissue. Results : We found that neurons of various regions of cerebral cortex exhibited the immunoreactivity to PDGF-αR as early as postnatal day 0, and slightly decreased after postnatal day 14. Whereas neuronal PDGF-αR were maintained at all ages, the oligodendroglia-like expression of PDGF-αR could not be confirmed. Conclusion : The localization of PDGF-αR in immature and mature neurons supports the several roles of PDGF during development, protection and survival of neurons.

요골동맥을 이용한 관동맥 조영술의 유용성

윤정한,이승환,이한요,김장영,김일회,최윤종,이형준,이명옥,김승년,황성오,홍인수,최경훈 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.10

상추(Lactuca sativa L.)의 ACAT 억제 Diterpenoid, Phytol : 식용 식물자원으로부터 활성물질의 탐색 Development of Biologically Active Compound from Edible Plant Sources

장태오,방면호,송명종,홍윤희,김지영,정대균,배동근,권병목,김영국,이현선,김인호,백남인 한국농화학회 2003 Applied Biological Chemistry (Appl Biol Chem) Vol.46 No.1

鉛暴露 作業者의 鉛中毒 早期發見을 위한 集團檢診法 改善方案에 관한 硏究

홍대용,김장락,정주화,최현림,윤형렬 慶尙大學校 1995 論文集 Vol.34 No.1

This study was carried out to evaluate the feasibility of current lead indicators used in screening lead who were sspeted to have been exposed to lead were selected as 'case'and 207 female workers from non-lead industry were selected for 'control'. The results obtained were as follows: 1. The mean values of blood lead for case and control were 31.4㎍/dl, 22.2㎍/dl,respectively. The difference observed in the mean concentration between case and control was statistically signifi-ant(P<0.01) 2. The mean values for blood ZPP by hematofluorometer for case and control were 31.3㎍/dl, 25.4㎍/dl,respectiely. And difference between two groups was statistically significant(P<0.01). 3. No statistically significant correlation was found between working duation and blood lead, blood ZPPlovel. 4. According to the simple correlation analysis,ZPPand urine lead were found to be statistically correlated with blood lead(P<0.01) 5. According to the discriminant analysis using blood lead as a dependent variable, it showed 89.1% predictability when using 40㎍/dl as a cutting value which is used as a screenig cutting value for industry workers health examination, while 81.8% for 30㎍/dl,77.54% for 20㎍/dl, respectively. 6. Lead related simptons which is used for screening the lead ntoxicated patients were used as a dependent variables in multiple regression analysis to find useful lead indicator. And significant independent variables were found to be ZPP, Age, and Hct. 7. Above results suggest that objective evalution of feasibbility of several lead indicators should be developed to correct the disutility of current lead screeng system in Korea.

연안역의 地上水 거동특성에 관한 연구

강홍윤,Peter Nielsen,장원 大田大學校 環境問題硏究所 1996 환경문제연구소 논문집 Vol.1 No.-

Reliable groundwater modelling is a prerequisite for solving many cibil and environmental engineering problems ranging from water and waste-water management to design of foundations. Field observations of grounwater dynamics in coastal barriers and beaches have revealed that the watertable overheights due to wave action and tidal forcing on the ocean side are sufficient to create a steady drift of salty ground water under narrow coastal barriers and islands. Typically, the difference in ground water level between the ocean side which is exposed to wabes and the landward side which is protected from waves is between 0.5m and 0.9m depending on the wave conditions and the slopes on the two sides. The resulting landward downsloping waterable influences groundwater hydrology in coastal areas. The salinity structure ovserved under the narrow northern Bribie Island showed that the fresh water lens grows thicker towards the mainland side of the barrier and the salt water region is forced deeper. Recently developed theories for groundwater dynemics are presented.

ASEA-SKF 래들용 고알루미나 내화재의 용손성향

박홍채,이윤복,양태영,장윤식,오기동 釜山大學校生産技術硏究所 1997 生産技術硏究所論文集 Vol.53 No.-

ASEA-SKF 래들에 사용된 고알루미나 내화물의 광물 및 화학적 변화를 화학분석, 현미결관찰, X-선회절분석으로 조사하였다. 미사용 벽돌의 주요 광물상은 α-Al₂O₃, mullite, tridymite이었다. 가동면에서 SiO₂결정상이 소실되었으며 mullite와 α-Al₂O₃가 다소 감소하였고 2FeO·SiO₂와 hercynite, FeO, Cr₂O₃상이 생성되었다. 침식율은 강종에 따라 다소간 차이가 있었으며 용강 SF-45와 60분간 반응시켰을때 SK36벽돌의 침식율은 75.9%인 반면에 SK38벽돌의 침식율은 20.47%이었다. 대부분의 용손벽돌에서 가동면으로부터 내부로 감에 따라 열적 및 화학적 스폴링으로 인하여 미세균열이 존재하였다. Mineral and chemical changes of alumina refractories used in ASEA-SKF ladle were examined by chemical analysis, microscopy and X-ray diffraction method. Main minerals in unused high alumina runner bricks were α-Al₂O₃, mullite and tridymite. In working face of high alumina runner bricks, SiO₂phase was not observed, mullite and α-Al₂O₃phases more or less decreased. On the other hand, 2FeO·SiO₂, hercynite, FeO and Cr₂O₃phases were formed. Th corrosion of high alumina runner bricks showed different behavior by using various types of iron melts. Expecially, corrosivites of SK36 bricks and SK38 bricks, which immersed in SF-45 Iron melts for 60min, were 75.9% and 20.47%, respectively. Microcracks in high alumina runner bricks increased from the working face to the inside due to thermal and chemical spalling.

상지 단순반복작업 근로자의 수근관 증후군 유병률에 관한 조사

손지언,장태원,김윤규,홍영습,정갑열,김동일,이강진,하남진,김상범,김준연 대한산업의학회 2001 대한직업환경의학회지 Vol.13 No.3

목적 : 본 연구는 수근관 증후군의 발생위험이 높은 작업형태에 종사하는 상지 단순반복작업근로자로서 육류 및 어류 가공 사업장과 목재소 근로자에서 근전도검사를 이용하여 수근관 증후군의 유병률을 조사하고자 하였다. 방법 : 상지 단순반복작업근로자로서 육류 및 어류 가공 사업장 근로자 69명과 목재소 근로자 17명을 실험군으로, 관리직, 경리, 경비등 상지의 단순반복작업이 없는 근로자 28명을 대조군으로 선정하여, 작업적 및 병력조사, 이학적 검사와 근전도검사를 통해 수근관 증후군의 유병률을 조사하였다. 결과 : 수근관 증후군의 유병률은 육류 및 어류 가공 사업장과 목재소에서 각각 26.09 % (18명)와 29.41 %(5명)로 조사되었으며, 육류 및 어류가공사업장과 목재소 근로자를 '7년 이상과 미만의 작업기간'으로 층화하여 비교한 결과 '상지부위의 통증 호소 유무', 'Visual Analogue Scale(VAS: 총 10점) 4점 이상 여부', 'Tinel teat 양성 유무', 'Phalen test 양성 유무'는 모두 단기 작업근로자군에서 양성의 빈도가 증가되었고 '수근관 증후군 유무'는 장기작업근로자군에서 양성의 빈도가 증가되었다. 결론 : 육류 및 어류 가공 사업장과 목재소의 수근관 증후군 유병률은 각각 26.09 %와 29.41 %로 육류 및 어류 가공 사업장과 목재소는 1996년 OSHA가 지정한 바와 같이 위험한 작업요인이 있는 작업장으로 분류하여 관리되어야 할 것으로 생각된다. Objectives : This study was carried out to survey on the prevalence of Carpal Tunnel Syndrome(CTS) in high risk jobs(meat and fish processing plant and wood plant), by application of Nerve Conduction Study(NCS), a confirmatory diagnostic method. Methods : Experimental group was 69 workers sampled from meat and fish processing plants and 17 workers sampled from wood plants, who were simple, repetitive workers using upper extremities and control group was 28 workers sampled from managers, secretaries and keepers. All employees were examined through work history, physical examination and NCS. Results : 18 workers(26.09%) in meat and fish processing plants, and 5 workers(29.41%) in wood plants had compatible findings to NIOSH diagnostic criteria for CTS. The experimental group had more symptoms (complaint of upper extremities, Visual Analogue Scale ≥4(VAS: total 10 point)), signs(Tinel and Phalen test) and prevalence of CTS than control group(p<0.05). The prevalence of symptoms and signs were higher in short term workers(<7 years), but the prevalence of CTS was higher in long term workers(≥7 years). Conclusions : The prevalence of CTS in meat and fish processing plant and wood plant were 26.09% and 29.41% respectively. Authors propose that meat and fish processing and wood plants should be managed as a risk job category which were designated by OSHA in 1996