데이타흐름 시스템에서의 성능평가에 관한 연구

유관종,최종석,신지수,변승환 충남대학교 자연과학연구소 1989 忠南科學硏究誌 Vol.16 No.1

A concept of data flow computer is a radical departure from that of Von Neumann type computers since the central concept of sequential execution is discarded. Data flow model offers an entirely new way of view the execution of program. This paper describes the data flow graph partitioning algorithm for enhancing the efficiency of the data flow architecture which consists of Processing Elements, Distributor, Arbitrator and Global Memory, and evaluate the performance of the proposed data flow system.

Free Communications : P2 ; Cannabinoid Receptors : Its Impact in Epidermal Differentiation and Possible Role in Treatment of Psoriasis

( Ji Seok Kim ),( Chan Hee Nam ),( Ji Yeon Yoo1 ),( Hyun Jung Kim ),( Se Kyoo Jeong ),( Sung Ku Ahn ),( Seung Phil Hong ) 한국피부장벽학회 2014 한국피부장벽학회지 Vol.16 No.2

Purpose: There are researches indicating that in human skin, the cannabinoid receptors exist, which take a part of endocannabinoid system. Nonetheless, the possible association of cannabinoid receptors with the pathogenesis of psoriasis has not yet been fully elucidated. Through this research, we tried to document the association between cannabinoid system, epidermal differentiation and psoriasis. Methods: Using human keratinocyte (KC), the expression of cannabinoid receptor-1 (CB1R) and -2 (CB2R) was analyzed according to the degree of differentiation. Also we examined for changes in differentiation marker of KC after application of CBR agonist. In addition, murine model applied with imiquimod to induce psoriasis symptoms was used to evaluate the effect of topical CBR agonist on inflammation and skin barrier function. Results: Compared to normal human skin, CBR expression was reduced in epidermis of psoriasis skin. Western blotting revealed the expression of both CB1R and CB2R in undifferentiated KC. The expression level of CB1R increased as the differentiation progressed in KC as with involucrin, K1 and K10. On the other hand, there was no change of CB2R in the process of differentiation. Furthermore, CB1R agonist partly increased expression of proteins associated with epidermal differentiation. Through this we could speculate that the CB system may be associated with proteins related to epidermal differentiation. Moreover, inflammation and barrier function in murine models with psoriasis symptoms were improved after 3 days-application of topical CB1R agonist. Conclusion: Cannabinoid receptors in human skin might be related to the differentiation of KC, and since its activation could improve skin barrier condition in murine psoriasis model, it can be expected to be a new therapeutic target for treatment of psoriasis.

정신분열병의 임상적 고위험군의 특징 : '서울청년클리닉'의 자연 추적 관찰 예비연구

유소영,이경진,강도형,이승재,하태현,위휘,이애라,송지연,김성년,권준수 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.1

Objectives : The aims of this study were to identify the intake and following process for subjects at high risk of transition to schizophrenia and to examine the neurocognitive, social, and emotional functions of the subjects compared with healthy controls. Methods : Symptomatic individuals judged at high risk for schizophrenia ('clinical high risk') within Youth Clinic were assessed and followed up. They performed a neurocognitive function test, a social function test and an affective function test. Twenty healthy controls were recruited in this study. Results : Among eighty-two subjects contacted through the Youth clinic, sixteen subjects were judged as the clinical high risk group. Fourteen subjects among the clinical high risk group showed deficits in several domains of neurocognitive functions, such as visual recall memory, verbal short term memory and executive function. Social and affective functions are also impaired in the Cli-nical high risk group compared with healthy controls. Two of 15 subjects (13%) developed a psychotic disorder within 6 months. Conclusion : This study illustrates the state of follow-up study for a clinical high risk group. Despite low numbers and short durations, some impairment of several functions in the clinical high risk group suggests possible predictors of psychosis.

접착제에 따른 유동성 복합 레진 수복물의 미세누출 양상에 관한 연구

박지은,김종수,유승훈 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.3

본 연구는 5급 와동에서 유동성 복합 레진 수복 시 수종의 상아질 접착제에 따른 미세 누출 양상을 비교하고, resin tag 및 혼성층의 형상을 전자 현미경으로 관찰하고 비교 분석하였다. 행동 조절에 어려움이 많은 소아 환자의 접착 수복에서 술식의 간편화 및 시간 단축이 장점으로 부각되고 있는 Aln-in-one 상아질 접착제의 임상 적용 가능성을 평가하고 다음과 같은 결론을 얻었다. 1. 법랑질 변연에서는 II군(AQ Bond Plus)이 가장 높은 미세누출을 보였고 III군(AdheSE^(ⓡ) One), I군(Adper™ Single Bond2) 순으로 감소하였으며, II군은 I군, III군과 통계학적 유의차를 보였고(p<0.05). I군과 III군 사이에는 유의차가 없었다. 2. 상아질 변연에서는 II군, I군, III군의 순으로 미세누출이 증가하였고, 각각 통계학적 유의차를 보였다(p<0.05). 3. I군과 III군에서는 법랑질 변연이 상아질 변연보다 유의하게 낮은 미세누출을 보였으나(p<0.05), II군에서는 통계학적 유의차를 보이지 않았다(p>0.05). 4. 주사전자현미경 소견에서 II군과 III군은 resin tag의 형성이 매우 미약하고 불규칙한 양상을 보인 반면 I군에서는 비교적 긴밀하고 균일한 resin tag가 관찰되었다. 이상의 결과를 종합해보면, AQ Bond Plus와 AdheSE^(ⓡ) One은 처리 과정의 단순화로 인한 시간 절약의 장점을 가지고 있으나 Adper™ Single Bond 2에 비해 상대적으로 높은 미세누출과 약한 결합력을 보인 본 실험의 결과를 미루어 볼 때, 임상적용 시 술식과 case에 따른 선택적 사용이 추천되는 바이다. This study was performed to evaluate the quality of newly offered dentin bonding system (AdheSE^(ⓡ) One) by comparing the degree of microleakage measured with those of several conventional adhesive materials (AQ Bond Plus and Adper™ Single Bond 2). The quality of hybrid layer and resin tags was analyzed by observing restoration/tooth interface under SEM. All-in-one system is in the limelight for having advantage of reducing chair time of children with difficult behavior pattern. Therefore the possibility of clinical application of All-in-one system was evaluated. The results obtained are as follows; 1. At the enamel margin, group II (AQ Bond Plus) showed the highest value of microleakage, and the other groups showed decreased value in order of group III (AdheSE^(ⓡ) One) and I (Adper™ Single Bond 2). There was statistically significant difference between group II and the others(p<0.05), and no statistical difference was found between group I and III. 2. At the dentin margin, microleakage value was increased in order of group II,I,III and significant difference between all groups(p<0.05). 3. In group I and III, microleakage value measured at the enamel margin was significantly lower than that seen at the dentin margin (p<0.05), and there was no statistical difference in group II. 4. Resin tags observed under SEM were very weak and tangled in group I and III while the strong and thick tags were observed in group I. In conclusion, careful case selection and accurate clinical application is recommended in using AQ Bond Plus and AdheSE^(ⓡ) One, giving consideration of the results showing its higher microleakage and weaker strength than Adper™ Single Bond 2.

제1유구치의 조기 상실로 인한 공간 변화에 대한 3차원적 분석

김지연,정다운,곽소연,유승은,박기태 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.2

본 연구는 제1유구치의 조기 상실 시 공간 변화에 대한 분석을 위하여 3-Dimensional Laser Scanner를 이용하여 그 유용성을 평가하고자 하는 예비논문이다. 6세-8세 사이의 제1대구치가 맹출하여 확실한 교합 관계를 이루는 혼합치 열기 어린이 중 편측 제1유구치의 조기 발치가 필요한 6명의 발치 전 후의 모형을 이용하여 다음과 같은 결과를 얻었다. l. 유구치 공간변화는 상악은 실험군과 대조군 모두 현저한 감소를 보이지 않았고, 하악은 실험군에서 3명 중 2명에서 공간감소가 관찰되었다. 2. 치열궁 너비,치열궁 둘레는 초기모형과 최종모형에서 비슷한 값을 보였다. 3. 협설측 경사도 변화는 유견치에서는 상하악 모두 특별한 경향을 보이지 않았으며,제2유구치는 상악은 실험군과 대조군이 유사하였고,하악에서는 3명중 2명에서 실험군이 더 큰 설측경사도 변화를 보였다. 제1대구치는 하악에서 실험군이 더 큰 설측경사도 변화가 관찰되었다. 4. 근원심 경사도 변화 측정에서 유견치는 상하악 모두 특별한 경향이 관찰되지 않았고 제2유구치의 경우 하악에서 실험군이 더 큰 근심경사도 증가가 보였다. 제1대구치는 상악에서 실험군,대조군 모두 원심 경사도가 증가되었다. The purpose of this study was to evaluate a 3-Dimensional laser scanner for the space analysis after loss of a primary first molar. Six children with premature loss of a primary first molar were examined using study models taken before and after the extraction. The results were as follows: 1. There was no change in primary molar space after the extraction of a maxillary primary first molar However, 2 out of 3 children experienced primary molar space loss in extraction side of a mandibular primary first molar. 2. Arch width and arch perimeter showed no difference between initial and final model. 3. All primary canines did not show any changes in inclination. Maxillary primary second molars had similar changes in both extraction and control side. However, 2 out of 3 mandibular primary second molars in extraction side showed more lingual tipping compared to control side. Mandibular permanent first molars tipped more lingually in extraction side. 4. In angulation, primary canines showed nothing of significance. Mandibular primary second molars tipped more mesially in extraction side than in control side. Maxillary permanent first molars have increased distal angulation after extraction of primary first molars in both side.

유치열기 3급 부정교합 환아에서 facemask의 효과와 재발 양상

김지연,유승은,이지현,박기태 大韓小兒齒科學會 2009 大韓小兒齒科學會誌 Vol.36 No.3

본 연구의 목적은 유치열기 3급 부정 교합 환아에서 facemask를 이용한 악정형 치료 후 골격적 변화와 치료 후 나타나는 재발 양상을 평가하는 것이다. 유치열기 3급 부정교합 환아 15명을 대상으로 구내장치로 bonded expander, 구외장치로 facemask를 이용한 악정형 치료를 평균 12개월 동안 시행하였으며, 1년 간의 follow up 기간 동안 유지 장치는 사용되지 않았다. 치료 시작 전, 치료 직후, 치료 1년 후에 측면두부방사선사진을 촬영하고 전후방 및 수직적 골격관계와 연조직의 변화를 비교분석하였다. 모든 환아에서 치료 직후, 유의할 만한 골격적 전후방 관계의 변화를 보였고 1년 간의 follow-up 기간 동안 재발되는 경향을 보였으나 치료 시작 전과 비교하여 치료 효과는 유지되었다. 수직적 골격적 변화는 치료 직후 증가되었으나 1년 간의 follow up 기간 동안 다시 감소하여 치료 시작 전과 비교하여 차이를 보이지 않았다. 연조직의 변화는 facial convexity 및 상순의 위치가 치료 직후 개선됨을 보였고 1년 간의 follow-up 기간 동안에도 치료 전과 비교하여 치료효과는 유지되었다. 하순의 위치는 치료 직후에 유의할 만한 변화를 보이지 않았다. Facemask는 유치열기 3급 부정교합에 있어서 효과적인 치료 방법이며, 안정적인 치료 결과를 위해서는 적절한 형태의 유지장치가 고려되는 것이 바람직하다. The purpose of this study was to evaluate skeletal and soft tissue changes that occur after using a facemask for treatment of skeletal class Ⅲ malocclusion. and to assess the relapse pattern when no retention appliance was used. Fifteen skeletal class Ⅲ malocclusion patients were treated with a facemask for an average of 12 months. No retention appliance was used during the 1 year follow-up period. Cephalograms were taken during pretreatment, posttreatment, and the 1 year follow-up. Cephalograms were traced, analyzed, and the results were compared between cephalograms. All patients showed significant sagittal skeletal changes after treatment, but they also showed a significant relapse during the 1 year follow-up period when no retention appliance was used. Despite the relapse, the sagittal skeletal changes that remained were still significant. Vertical skeletal change was also significant after treatment, but the total change was not significant after a 1 year follow-up due to relapse. In soft tissue changes, facial convexity and upper lip position improved after treatment and this change remained significant after the 1 year follow-up period. Facemask therapy is therefore an effective method for treatment of skeletal class Ⅲ malocclusion, however, retention is imperative to maintain the treatment effect.

Asphyxiating Thoracic Dystrophy 1례

김영유,이승철,이수중,한지환,황성수,이경일 최신의학사 1992 最新醫學 Vol.35 No.6

Flavobacterium meningosepticum에 의한 균혈증 1예

장성원,유진홍,진승원,김선우,김연식,박순민,이대훈,최민호,최주연,신완식,강문원,강지민 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.1

1996년 6월 카톨릭대학교 부천성가병원에 뇌경색으로 입원했던 61세 남자 환자의 혈액에서 Flavobacterium meningosepticum을 분리하였다. 환자는 폐렴을 동반한 패혈증의 예로 ceftriaxone과 metronidazole을 투여하였으나 입원 48시간만에 사망하였다. Flabovacterium meningosepticum is a rae cause of nosocomial infection which shows multi-drug resistance. It mainly invades patients with impaired immunity. Recently, we experienced a case of F. meningosepticum bacteremia in a patient with chronic debilitated state owing to stroke. The clinical progress was so rapid that he died within 48 hours. Blood culture revealed F. meningosepticum which showed characteristic yellow colony in blood agar plate.

항진균제 알릴아민류의 합성과 생물학적 평가

정병호,조원제,천승훈,박면지,유진철,천문우 朝鮮大學校 1998 藥學硏究誌 Vol.19 No.2

For the development of antifungal agents. modification of naftifine which exhibits significant antimycotic activity was performed by replacing the naphthalene ring of it to hetero cyclic rings such as morpholine. benzothiazole. piperidine and pyridine derivatives. The synthesized compounds were tested in vitro antifungal activity against five different fungi with naftifine as a comparative antimycotic molecule. From the biological evaluation two compounds. (E)-N-(3-phenyl-2-propenyl)-N-(4-piperidinylmethyl)amine(3d) and (E)-N-(3-phenyl-2-propenyl)-N-(3-pyndylmethyl)amine(3D) showed relatively noticeable activity(MIC=50㎍/㎖). On the other hand. the other compounds had no activity.

Agronomic Characterization and Biological Activities of Miscanthus spp. Collected from Different Countries

Ji Hye Yoo(유지혜),Jae Hoo Choi(최재후),Seung Hyuk Choi(최승혁),Ji Young Lee(이지영),Eun Soo Seong(성은수),Kweon Heo(허권),Seon Kang Choi(최선강),Chang Yeon Yu(유창연) 한국약용작물학회 2017 한국약용작물학회 학술대회논문집 Vol.2017 No.2