Adiponectin Attenuates the Inflammation in Atopic Dermatitis-Like Reconstructed Human Epidermis

( Hee-seok Seo ),( Ki Hyun Seong ),( Chang-deok Kim ),( Seong Jun Seo ),( Byung Cheol Park ),( Myung Hwa Kim ),( Seung-phil Hong ) 대한피부과학회 2019 Annals of Dermatology Vol.31 No.2

Background: Atopic dermatitis (AD) is a chronic disorder, with a vicious cycle of repetitive inflammation and deterioration of the epidermal barrier function. Adiponectin, an adipokine, has anti-inflammatory effects on various metabolic and inflammatory disorders. Recently, its level was found to be reduced in serum and tissue samples from AD patients. Objective: We aimed to investigate the effects of adiponectin on epidermal inflammation and barrier structures in AD skin. Methods: A three-dimensional in vitro epidermal equivalent model mimicking AD was obtained by adding an inflammatory substance cocktail to normal human epidermal equivalents (HEEs). The expression of epidermal differentiation markers, primary inflammatory mediators, and lipid biosynthetic enzymes was compared between adiponectintreated AD-HEEs, untreated control AD-HEEs, and normal HEEs. Results: Adiponectin co-treatment 1) inhibited the increase in mRNA expression of major inflammatory mediators (carbonic anhydrase II, neuron-specific NEL-like protein 2, thymic stromal lymphopoietin, interleukin-8, tumor necrosis factor-alpha, and human beta-defensin-2) from keratinocytes in AD-inflammatory HEEs, 2) enhanced the expression of lipid biosynthetic enzymes (fatty acid synthase, HMG CoA reductase, and serine-palmitoyl transferase), and 3) promoted the expression of differentiation factors, especially filaggrin. We also found that the expression of adiponectin receptor-1 and -2 decreased in the epidermis of chronic AD lesion. Conclusion: Activation of the adiponectin pathway is expected to enhance epidermal differentiation and barrier function as well as attenuate inflammatory response to AD as a therapeutic approach. (Ann Dermatol 31(2) 186∼195, 2019)

국내에서 분리된 Extended-Spectrum β-Lactamase 생성 Escherichia coli와 Klebsiella pneumoniae의 빈도 및 유형

홍성근,김선주,정성훈,장철훈,조성란,안지영,신종희,이혜수,송원근,어영,염종화,용동은,이경원,정윤섭 대한임상미샐물학회 2003 Annals of clinical microbiology Vol.6 No.2

중이 수술후 청력 변화에 대한 임상적 고찰

홍석찬,강성호,이광희 건국대학교 의과학연구소 1994 건국의과학학술지 Vol.4 No.-

statistical analysis of bone conduction loss in chronic otitis media has not been exactly reported until now. Authors studied the relationship between the preoperative bone conduction hearing level and age, nature of middle ear and temporal bone pathology, pneumatization of mastoid in 97 ears of chronic uppurative otitis media performed middle ear surgery at Konkuk University Hospital from March 1992 to December 1992. The results were as following: The mean bone conduction threshold was 16.2±12.4dB. In the cases of ossicular defect, bone conduction loss was greater in total destruction than in partial destruction with statistical significance. Among ossicular defect, incus destruction group showed more bone conduction loss than intact incus group with statistical significance. There was no difference of bone conduction loss according to pathologic findings in middle ear cavity and mastoid antrum, but pathologic groups showed more bone conduction loss than control group with normal temporal bone pneumatization with statistical significance. Comparing pneumatization of mastoid antrum and mastoid process, there was statistically significant bone conduction loss in orders of pneumatic type, diploic type, sclerotic type, cholesteatoma cavity. There was no difference of bone conduction hearing level according to age, sex, and duration of disease process with statistical significance. The results suggest that the bone conduction threshold in chronic otitis media is influenced by artificial elevation due to conductive defect and can be improved by reconstructive surgery.Many patients being followed for chronic suppuration of the middle ear were observed to have sensorineural or mixed type hearing loss. The major cause of this bone conduction loss might be secondary to cochlear biochemical changes occuring through the round window membrane. But, clinical and statistical analysis of bone conduction loss in chronic otitis media has not been exactly reported until now. Authors studied the relationship between the preoperative bone conduction hearing level and age, nature of middle ear and temporal bone pathology, pneumatization of mastoid in 97 ears of chronic suppurative otitis media performed middle ear surgery at Konkuk University Hospital from March 1992 to December 1992. The results were as following: The mean bone conduction threshold was 16.2±12.4dB. Inthe cases of ossicular defect, bone conduction loss was greater in total destruction than in partial destruction with statistical significance. Among ossicular defect, incus destruction group showed more bone conduction loss than intact incus group with statistical significance. There was no difference of bone conduction loss according to pathologic findings in middle ear cavity and mastoid antrum, but pathologic groups showed more bone conduction loss than control group with normal temporal bone pneumatization with statistical significance. Comparing pneumatization of mastoid antrum and mastoid process, there was statistically significant bone conduction loss in orders of pneumatic type, diploic type, sclerotic type, cholesteatoma cavity. There was no difference of bone conduction hearing level according to age, sex, and duration of disease process with statistical significance. The results suggest that the bone conduction threshold in chronic otitis media is influenced by artificial elevation due to conductive defect and can be improved by reconstructive surgery.

Sol-Gel 법으로 제작한 (Pb_xBa_₁-_x)TiO₃박막의 특성에 관한 연구

홍석민,이정아,조정희,김옥경 漢陽大學校 工學技術硏究所 1996 工學技術論文集 Vol.5 No.1

We tried to find optimal condition of (PbxBa1-x)TiO3(x=0.0, 0.2, 0.5, 0.8, 1.0) thin films produced by sol-gel spin coating. Barium acetate, Lead acetate trihydrate and Ti-isopropoxide are used as the coating sol for producing the thin film, and acetic acid, methanol, and distilled water are used as the solvent. It is found that the manufactured sol was at the most stable condition when the component content satisfied H2O/Ba=65, after observing the state transition for a specified period. We coated sol for coating on the various kinds of substrate and pre-annealed on 68℃ and 460℃. Then we annealed them on 700℃ for 30 minutes and found that they showed a good growth of crystal by the XRD measurement. We selected Pt as the bottom electrode, using the substrate Pt/SiO2/Si in order, we raised the different conditional thin films and obtained the capacitor by evaporating Al as the top electrode. We measured the electric capacitance and dielectric loss by changing the frequency for three step as 1, 10, 100kHz for each and calculated the dielectric constant. The dielectric constant of the thin film (PbxBa1-x)TiO3 was decreased below x=0.8 and increased upto x=1.0 as x increases.

실시간 능동 데이터베이스를 위한 다중 버전 동시성 제어 기법

홍석희 慶星大學校 1998 論文集 Vol.19 No.2

In this paper, we extend the multiversion concurrency control algorithm for real-time active databases. Transactions in real-time active databases have the notion of activeness where transactions are generated by external effect and another transactions. Active transactions are mainly characterized by triggering relationships, which mean relations between a transaction that issued another transaction and the generated transaction. In this paper, we suggest two types of data conflicts according to whether triggering relationships are related to the same triggering group or different triggering groups. The proposed algorithm resolves data conflicts by considering these triggering relationships between conflicting transactions as well as priorities and precedence relationships of them.

RF 마그네트론 스퍼터링 방법에 의한 (Ba, Sr)TiO₃박막의 특성

홍석민,조정희,김호건,김옥경 漢陽大學校 工學技術硏究所 1996 工學技術論文集 Vol.5 No.1

A sputtering target(BaxSr1-xTiO3) is obtained by changing the mol% of Ba and Sr. Pt is evaporated on the SiO2/Si substrate as a bottom electrode, and subsequently the BaxSr1-xTiO3 thin film is sputtered. Or, for obtaining the MIS structure Pt is not used, and directly thin film is sputtered on the Si substrate. Then, the capacitor structures(MIM, MIS) have been obtained by evaporating Al as a top electrode after post-annealing. Our results show that produced thin firm is found to have Perovskite structure according to the XRD measurement and shows better crystal growing phenomena on SiO2/Si substrate than those on Si substrate. And, the existence of polarization is recognized by the hysteresis loop. The capacitor(MIM) structure of BaxSr1-xTiO3 thin film shows that the dielectric constant is increased as the mol% of Ba and the post-annealing temperature increase. MIS structure shows a increase of capacitance with increasing the mol% of Ba.

경막 내 colistimethate 투여로 치료한 다제 내성 cinetobacter baumannii 뇌실염

홍유아,유진홍,김진진,모은영,안건희,정희경,김진석,이현정,정미향,윤승배 대한감염학회 2009 감염과 화학요법 Vol.41 No.4

Acinetobacter species is a non-fermentative aerobic gram-negative coccobacillus that is an important pathogen found in nosocomial infections. Recently, multi-drug resistant Acinetobacter baumannii (MDR-AB) infections have been increasing and pose a serious problem. Most such infections present as bacteremia, pneumonia, or a wound infection; however, CNS infections are very rare. We herein present a case of ventriculitis caused by MDR-AB in a 37-year old man after a neurosurgical intervention. The patient was successfully treated with intrathecal colistimethate.

중국 경제변화와 향후 통상전망

조석홍,이희석 한국통상정보학회 2001 통상정보연구 Vol.3 No.1

As China beings to enforce the open-door and innovation policies, it comes to rise rapidly in international economic stage. For the short time of only 20 years, China makes a great economic power. Up to now, China has tolerated a large population and infinite resources, so at last succeeded in economic polices, and has a fine future prospect in world economy. With the admission to the WT'O, China will have a great influence on Korea. If we are to develop the trade much more, appeared until now after the relations between Korea and China, We should develop Korean economy by investing and trading in IT industries and newly Chinese regions.

여성 복압성 요실금에서 질전벽슬링수술의 효과

신홍석,유진욱,정희창,박동춘 영남대학교 기초/임상의학연구소 2001 Yeungnam University Journal of Medicine Vol.18 No.1

Background: The purpose of this study was to determine the efficacy and safety of the anterior vaginal wall sling in the management of women with stress urinary incontinence. Materials and Methods: From January 1998 to December 1999, 42 patients(31 with genuine stress urinary incontinence and 11 with mixed urinary incontinence, 38 with anatomical incontinence and 4 with intrinsic sphincteric deficiency) underwent anterior vaginal wall sling at Yeungnam University Hospital were studied retrospectively. The mean age was 49.3 years(ranging from 34 to 66 years of age) and the mean follow-up period was 29.4 months(ranging from 16 to 40 months). Intra- and postoperative complication, success rate and patient's satisfaction were evaluated. Results: The mean operation time was 79 minutes(ranging from 65 to 124 minutes) and the mean hospital stay was 5.1 days(ranging from 4 to 10 days). Mean postoperative Foley catheter drainage was 2.1 days(ranging from 1 to 5 days). As a complication, bladder perforation occurred in one patient(2.4%), residual urine sensation developed in seven patients(16.7%), and suprapubic pain was complained in five patients(11.9%), which improved gradually. Vaginal epithelial inclusion cyst occurred in one patient(2.4%) at postoperative 31 months. Four(9.4%) patients with de novo instablility were improved by anticholinergics medication. The success rate was 92.9% and 38 patients(90.5%) were satisfied with this procedure. Conclusion: We consider that the anterior vaginal wall sling to be a safe and effective surgical procedure for the treatment of female stress urinary incontinence, but a longer follow-up is necessary to determine long term effect.

복부 수술과 비복부 수술후 회복기중의 동맥혈액가스 변화

조희원,양홍석,박선규 중앙대부설한국의과학연구소 1990 한국의과학 Vol.22 No.3