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        • KCI등재SCOPUS

          정상 성인에서 장 Alkaline Phosphatase의 빈도와 의의

          조성란,허지영,박일중,임인수 대한진단검사의학회 2004 Annals of Laboratory Medicine Vol.24 No.2

          Background : Intestinal alkaline phosphatase (ALP) is more prevalent in individuals of blood group B or O secretors and increases after a meal, especially, high-fat diet. The purpose of this study was to evaluate the prevalence and clinical significance of intestinal ALP in the sera of healthy adults. Methods : Whole blood specimens were obtained from 42 healthy adults after fasting for at least 8 hours, and again at 2 hours after a regular meal. ALP was measured by TBA-200FR and analyzed for isoenzymes by Helena REP system. We also tested their ABO blood groups using GENEDIA anti- A and anti-B sera. Results : The levels of fasting ALP, postprandial ALP, and the difference between the fasting and postprandial ALP (ALP difference) were 57.6±20.8 (12-111) IU/L, 62.3±17.4 (27-120) IU/L, and 4.6± 15.4 (-8~63) IU/L, respectively. Delta ( ) ALP was 27.6±86.3 (-11.4~312.5)%. Among the 42 subjects, 6 were blood group A, 16 group B, 10 group AB, and 10 group O. Intestinal isoenzyme of ALP was detected in two subjects, both of whom were blood group O. The differences in fasting ALP, postprandial ALP, ALP difference, and ALP between ABO blood groups were statistically not significant. Conclusions : Intestinal ALP was detected in 5% of healthy adults, especially, in 20% of blood group O. Intestinal ALP has been known to be of no specific clinical significance. However, when ALP is measured in a non-fasting sample, the presence of intestinal ALP could result in an abnormally high ALP and subsequent unnecessary tests. Therefore, it is recommended that ALP should be measured only after fasting. (Korean J Lab Med 2004; 24: 87-90) 배경 : 장 alkaline phosphatase (ALP)는 주로 O형 또는 B형분비자에서 나타나며 식사, 특히 지방식 후에 증가한다고 알려져있다. 이에 저자들은 건강한 성인에서 장 ALP의 빈도를 파악하고그 임상적 의의를 평가하고자 하였다. 방법 : 정상 성인 42명을 대상으로 8시간 이상 금식한 후와 일상적인 식사 후 2시간 경과 시점에 각각 전혈을 채취하였다. 혈중ALP는 TBA-200FR로 측정하였고 장 분획 존재 유무는 HelenaREP system으로 동위효소 분석을 시행하였다. ABO 혈액형은제네디아 항에이, 항비 혈청을 사용하여 검사하였다. 결과 : 금식 ALP, 식후 ALP, 금식 ALP와 식후 ALP의 차이는 각각 57.6± 20.8 (12~111), 62.3 ± 17.4 (27~120), 4.6 ± 15.4(-8~63) IU/L이었고, 델타 ALP는 27.6 ± 86.3 (-11.4~312.5)%이었다. 총 42명 중 2명(5%)에서 장 분획이 확인되었다. 대상군의 혈액형은 A형이 6명, B형이 16명, AB형이 10명, O형이 10명이었고, 장 ALP가 확인된 2명 모두 O형이었다. 혈액형별 금식ALP, 식후 ALP, 금식 ALP와 식후 ALP의 농도 차 및 델타ALP의 차이는 통계적으로 유의하지 않았다. 결론 : 정상 성인의 5%, 특히 O형의 20%에서 ALP 장 분획이 검출되었다. 장 ALP는 특별한 임상적 의의가 없는 것으로 알려져 있으나 장 분획이 존재하는 경우 식후에 검사를 하면 비정상의 높은 ALP 수치가 나올 수 있고 이로 인해 불필요한 추가 검사를 유발할 수도 있으므로 공복 상태에서의 채혈이 필요하다.

        • KCI등재

          B세포 림프종 환자의 파라핀 조직에서 중합효소연쇄반응법을 이용한 면역글로불린 중쇄유전자 재배열 검출 및 염기서열 분석

          조성란,박일중,밍솅리,김은경,이위교,한재호,박준은,박준성,김효철 대한혈액학회 2007 Blood Research Vol.42 No.4

          배경: 면역글로불린 중쇄 유전자 재배열은 림프종, 백혈병, 다발성 골수종과 같은 악성 B세포 질환에서 최소잔류질환을 검출하는 데 뿐만 아니라 질환의 클론성을 결정할 때 유용하다. 본 연구에서는 B세포 림프종 환자의 파라핀 조직에서 면역글로불린 중쇄 유전자 재배열 검출을 위한 단일 중합효소연쇄반응법을 확립하고, CDR3 유전자 염기서열을 분석하여 재배열에 사용된 JH segment의 종류를 알아보고자 하였다.방법: 2005년 1월부터 2007년 1월까지 아주대병원에서 B세포 림프종으로 진단된 환자 44명으로부터 얻은 파라핀 조직을 대상으로 하였고, 각 환자의 의무기록은 후향적으로 검토되었다. 조직 절편으로부터 DNA를 추출한 후 면역글로불린 중쇄 유전자의 CDR3 영역을 증폭할 수 있는 VH3 및 JHPST 시발체를 사용하여 단일 중합효소연쇄반응법을 시행하였다. 또한 23명의 환자에 대해서는 중합효소연쇄반응 산물의 염기서열 분석을 실시하였다.결과: B세포 림프종 환자 44명 중 26명(59%)에서 면역글로불린 중쇄 유전자(CDR3) 재배열을 검출하였다. 염기서열 분석을 실시한 23명 중 16명(70%)에서만 증폭된 CDR3 유전자 염기서열을 알 수 있었고, 재배열에 사용된 JH segment의 종류를 분류할 수 있었다. DLBCL 환자에서 JH3, JH4, JH5, JH6가 각각 3명(25%), 4명(33%), 1명(8%), 4명(33%)에서 나왔다.

        • KCI등재

          호가스 출판사와 공적 지식인으로서의 버지니아 울프

          조성란 한국제임스조이스학회 2019 제임스조이스저널 Vol.25 No.1

          The purpose of this study is to examine the role of Hogarth Press and publishing in Virginia Woolf as writer and public intellectual. Hogarth Press contributed to Woolf's development as modernist writer and social thinker who rejects patriarchy, war, imperialism and fascism. The selections of the publishing titles by Woolf as publisher reflect Woolf's thoughts as writer. As public intellectual, Woolf's own political and ethical agenda is to expand cultural democracy. The writer and publisher Woolf is also the educator who promotes “cultural literacy” by creating and teaching new method of reading and writing. The Press started initially as private venture to distract Virginia physically from over-extended concentration on writing and intellectual labour. The press offered her creative freedom to write innovative works without publisher's interventions and offered her intellectual networks and economic freedom also. Equally importantly, the Press made social contributions as the center of new discourses, publishing modernist writings and political writings with socio-political critiques of patriarchy, imperialism, faascism, and war. It functioned as a political and artistic haven for writers from the Empire‘s periphery such as C. L. R James. The press helped British psychoanalysis take roots in England by publishing entire translations of Freud and other psychoanalysts. The Press materializes the vision of Outsiders' Society in Three Guineas. It is alternative space in which private and public spaces meet and cross, a heterotopia.

        • KCI등재

          조선시대 전통보와 자수를 활용한 셔츠와 액세서리 디자인 개발에 관한 연구

          조성란(Sung Ran Cho), 박선경(Sun Kyung Park), 윤을요(Eul Yo Yun) 한국복식학회 2011 服飾 Vol.61 No.4

          During the era of Joseon Dynasty when the Confucian ideas were prevailing all over the manners of living, most women were usually living separated in the boudoirs, the isolated living quarters exclusively for women, where they used to do much troublesome needleworks for the traditional kerchiefs and embroideries for which they poured out their souls and hand skills. And therefore, nowadays, such works are deemed much valuable for either formative or artistic point of view, and their legitimate cultural designs are receiving much publicity from a number of mass communications as one of the national competitive powers. Thus, I, the researcher for the subject study, have completed 1-year researching lessons on the traditional kerchief and embroidery of Ms. Hyeon-Hee Kim, the Mater-hand, at Korea Traditional Handicrafts Institute of Korea Cultural Heritage Foundation, and then engaged myself in the creative works relevant to the subject by cultivating the power of understanding to such field, restoring the techniques of the traditional handicrafts, reconstructing them into the modern sensual descriptions, and also trying to apply various transformations and modifications to them.

        • 부산 - 경남 지역의 세 병원에서 rpoB 유전자의 PCR-제한 단편 길이 다형성 (PRA)에 의한 비 결핵 항상 균 (NTM)의 종 동정

          조성란,김충환,강민정,박규환,김다혜,정다운,서은혜,이향민,박현경,정진이,이정민,정수영,이준영,조은진,제갈숙 대한임상검사과학회 2013 대한임상검사과학회지(KJCLS) Vol.45 No.2

          Recently, the isolation rate of nontuberculous mycobacteria (NTM) in clinical laboratories and the incidence of NTM infections are on the increase in Korea, but there have been only a few studies that reveal the general aspect of NTM isolation or species distribution. Therefore, this study was performed to examine the species identification by PCR-restriction fragment length polymorphism analysis (PRA, PCR-RFLP), and the clinical significance of mycobacterial cultures. PRA was used during the novel region of the rpoB gene and was developed for rapid and precise identification of mycobacteria to the species level. From January 2012 to April 2012, we examined pre-identified nontuberculous mycobacteria (60 species in 3 hospital of Busan-Kyeongnam area). We confirmed 4 (6.6%) Mycobacterium tuberculosis (MTB) and 56 (93.4%) NTM from 60 pre-identified NTM species by multiplex PCR (MolecuTech MTB-IDR V3, YD Diagnostics, Korea) and PRA (Myco-ID, YD Diagnostics, Korea). The distribution of 56 NTM species were M. intracellulare type I 15 (26.7%), M. avium 14 (25%), M. abscessus 11 (19.5%), M. kansasii type I 3 (5.4%), M. pulveris 2 (3.6%), M. intracellulare type, M. chelonae, M. kansasii type V, M. gallinarum, M. wolinskyi. Respectively, 1 (1.8%) and 6 (10.7%) species were not identified.

        • 폐결핵의 조기진단에 있어서 이중중합효소연쇄반응법의 유용성

          조성란,최영진,김용훈,이철세,김영창,김휘준 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.2

          Background: Pulmonary tuberculosis is a great public health problem in Korea. Early detection of Mycobacterium tuberculosis (M. tuberculosis) in clinical samples becomes more and more important in the control of tuberculosis. Recently, molecular methods have been applied to early detection of M. tuberculosis. Methods: To elucidate the effectiveness of nested polymerase chain reaction (PCR) in early diagnosis of pulmonary tuberculosis, we peformed Acid-fast bacilli (AFB) stain, AFB culture, and nested PCR on 84 sputa. Results: 8 (9.5%) specimens were positive by AFB stain, 17 (20.2%) by AFB culture, and 15 (17.9%) by nested PCR. Using AFB culture as standard method, the sensitivity of AFB stain and nested PCR was 47.1% and 82.4%, respectively. The specificity of AFB stain and nested PCR was 100% and 98.5%, respectively. Conclusions: Nested PCR was more sensitive than AFB stain and had shorter processing time(24-48hrs) than AFB culture. So it may be effective to use nested PCR in order to detect M. tuberculosis when AFB smear Is negative.

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