만성두통 환자의 성격유형 A 행태, 스트레스, 우울 및 두통영향정도의 관계 연구

차남현,임사비나,정인태,김수영,안경애,김건식,이재동,이상훈,최도영,이윤호,이두익 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

To examine an estimate factor and grasp the relation of difference for Ype A Behavior Pattern(TABP), Perceived Stress Questionnaire. Depression and HIT-6 in the Chronic headache client. Method: Data collected by self-reported questionnaires from 38 client in S city who were selected by criteria of IHS, from the 19^(th) of October to 10^(th) of December, 2004. Result: 1) Differences between biographical data by TABP was significant by SaSang constitutions, by Stress was significantly influenced by age, and by Depression were significantly influenced health status and SaSang constitutions. 2) Correlations Coefficients among Study Variables were Stress and Depression(r=.494, p=.002) and Depression and HIT-6(r=.432, p=.010). 3) In regression analysis, HIT-6 were significantly influenced by Depression and Type A Behavior Pattern(TABP). These variables explained 38% and 34% respectively. Conclusion: The result suggest that chronic headache management with psychological aspect, as well as physical aspect should be a focus to enhance the quality of life.

만성두통환자에 대한 침치료가 심박변이도에 미치는 영향

정인태,이상훈,김수영,차남현,김건식,이두익,이재동,임사비나,이윤호,최도영 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

Objective : The purpose of this study was to assess the effect of acupuncture treatment for chronic headache patients using power spectrum analysis of the heart rate variability(HRV). Methods : 15 clinical experiment participants were gathered and through a questionnaire patients who experienced headache for more than 4 hours a day and more than 15 days per month were qualified as Chronic Headache patients. Treatment was applied 2 times a weeks for 8 weeks. The acupoints, GV20, HN23, ST8, HN46, TE17, GB20, LI20, LI11, LI14, ST36, and LR3 were stimulated for 20 minutes. The effects of acupuncture treatment were analyzed using power spectrum analysis of the HRV, HRV was recorded before and after acupuncture treatment. Results : HRV before and after treatment was compared after 8 weeks of acupuncture treatment. Increase in mean values of SDNN and RMSSD were observed but the increases were not statistically significants. Increase in mean values of TP, LF and HF were observed but, the increase was significant(p<0.05) only in TP. Conclusions : The results suggest that acupuncture treatment on chronic headache patients can increase the activity of autonomic nervous system. Further use of HRV for quantitative analysis of acupuncture treatment on autonomic nervous system related symptoms is suggested.

만성두통환자에 대한 동서협진의 임상적 연구

정인태,이상훈,김수영,차남현,김건식,이두익,이재동,임사비나,이윤호,최도영 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

Objective : Because the cause and etiology of chronic headache are not yet fully explained, the treatment of this symptom is not simple. In order to study the effectiveness East-West pain treatment on chronic headache, we evaluated its effect of pain alleviation and quality of life improvement on chronic headache patients who were treated with nerve block and acupuncture, and only acupuncture for eight weeks. Methods : 92 clinical experiment participants were gathered and through a questionnaire patients who experienced headache for more than 4 hours a day and more than 15 days per month were qualified as chronic headache patients. The qualified patients were classified into two groups, nerve block and acupuncture group(EW group, n=49) and acupuncture group(E group, n=43). Treatment was applied 2 times a weeks for 8 weeks. The acupoints, GV20, HN23, ST8, HN46, TE17, GB20, LI20, LI11, LI14, ST36, and LR3 were stimulated for 20 minutes. The effects of two groups were analyzed using VAS scores and BPI(Brief Pain Inventory). Results : The VAS and BPI after four weeks of treatment showed significant improvement among two but differences between the three groups was statistically insignificant. The VAS and BPI of the EW group after eight weeks of treatment showed statistically significant improvement compared to the other two groups. Conclusion : The pain treatment for chronic headache might be contributed to improvement of quality of life as well as alleviation of pain of chronic headache patients. It was suggested that the West pain treatment in combination with East pain treatment might be an useful modality to improve the pain and quality of life in chronic headache patients.

캔 및 병 오렌지쥬스의 저장온도에 따른 Q_10값 및 품질수명의 산정

이남경,윤재영,이서래 이화여자대학교 생명과학연구소 1995 생명과학연구논문집 Vol.6 No.-

현재 국내에서 유통되고 있는 캔 및 병 오렌지쥬스를 20,30,40,50℃에서 24주 동안 저장하면서 4주 간격으로 개봉하여 중금속(Sn,Fe,Pb) 함량, 비타민 C 함량, 갈색도와 pH의 변화에 대한 측정치로부터 온도별 활성화 에너지와 Q_10값을 계산한 다음 shel-life를 예측하였다. 캔쥬스의 품질지표로 삼을 수 잇는 것은 Sn,Fe,Pb함량, 비타민 C 함량이었고, 병쥬스에서는 비타민 C 함량, 갈색도이었으며 이들 품질지표에 대한 Q_10값은 1.3~2.0이었다. 쥬스를 50℃에 저장시 품질 허용한계에 도달하는데 요하는 기간과 Q_10 대표값으로 부터 shel-life를 계산하면 캔쥬스의 경우 10,20,30℃에서 각각 10,6,3개월 이었고, 병쥬스의 경우 각각 24,12,6개월이었다. 국내에서의 쥬스 유통온도를 평균 15℃로 가정할 때 적정 품질수명은 캔쥬스 8개월, 병쥬스 18개월로 평가되엇다. 캔 오렌지쥬스의 안전성을 확보하기 위해서는 식품공전Pb 허용기준(0.3㎎/㎏)의 재검토와 아울러 캔 재질의 개선을 위한 연구노력이 요구된다. Canned and bottled orange juices currently sold in Korean market were stored for 24 wweeks at 20, 30, 50 and 50℃ and analyzed after opening at 4 week intervals. Activation energy, Q_10 values and shelf-life at respective temperatures were calculated from the data on various quality indexes. Proposed indexes were lead, tin, iron and vitamin C contents in canned juices and vitamin C content and browning index in bottled juices and Q_10 values for these parameters were in the range of 1.3~2.0. Shelf-life calculated for canned juices at 10, 20 and 30℃ were 10, 6 and 3 months and that in bottled juices, 24, 12 and 6 months, respectively. When the distriburion temperature of juices in Korea is assumed to be 15℃ average, the optimum shelf-life was estimated to be 8 months in canned juices and 18 months in bottled juices. In order to ascertain the safety of canned orange juices, efforts are needed to re-examine the recommended distribution period, legal limit for lead and improvement of container materials.

Letrozole에 반응을 보인 다발성 폐전이를 동반한 저도 자궁내막 기저육종 1례

이남수,원종호,박희숙 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Low-grade endometrial stromal sarcoma is generally an indolent tumor rich in estrogen and progesterone receptors. Objective responses to hormonal therapy, most commonly with megestrol acetate, have been reported. The patient is a 50-year-old woman who presented with low-grade endometrial stromal sarcoma confined to the vagina in 1992 and was treated with local excision. Approximately 4 years later, the patient had recurrent right ovarian and ileal mass treated with right oophorectomy and segmental resection of ileum. In 2002, multiple lung metastatic lesions were discovered and treated with megestrol acetate. But megestrol acetate showed no response during the period. Letrozole was then given at a daily dose of 2.5 ㎎ with partial response for a duration of 10 months. Letrozole at a daily dose of 2.5 ㎎ may be effective in low-grade endometrial stromal sarcoma.

電子商去來에서의 消費者保護를 위한 法的 問題點에 대한 考察 : 電子認證과 電子署名을 중심으로

남경두,이수진 건국대학교 경제경영연구소 2000 商經硏究 Vol.25 No.1

Electronic certification and electronic signature issues are a vital concern for developing electronic commerce, and a number of initiatives are underway in both the public and private sectors to ensure that businesses and consumers can engage in secure and reliable electronic communications and transactions in the global networked society. In recent years OECD Member countries have undertaken to develop and iMplement may create obstacles to the evolution of national and global information and communications networks and hinder the development of electronic commerce. Both governments and the private sector have recognized the need for international collaboration to develop and efficient and secure information infrastructure. This paper in this area has focused on electronic authentication and signature issues in order to protect consumers. The paper concludes that electronic authentication and signature consensus about specific policy and regulatory issues related to information and communications networks and technologies, including electronic authentication and electronic signature.

병원근무자에 대한 특수건강진단 적용 가능성에 관한 연구

이수일,조병만,조봉수,김영욱,고광욱,문남출,김주원 大韓産業醫學會 1996 대한직업환경의학회지 Vol.8 No.2

병원근무자들에 대한 특수건강진단 적용 여부를 판단하기 위한 기초자료를 제공하기 위해 1995년 3월 10일부터 4주간에 걸쳐 부산시내에 위치하는 2개 종합병원 근무자 830명을 대상으로 설문조사를 시행해 얻은 결과를 요약하면 다음과 같다. 1. 조사된 43개 항목 중 10% 이상의 대상자가 유해요인에 폭로되고 있다고 응답한 항목은 소음, 분진 등 16개 항목이었다. 이 중 분진, 소음 및 스트레스는 연구대상자의 50%이상에서 폭로되고 있다고 응답했으며 그 외 알콜류 소독제(41.3%), 방사선(34.6%), 일반약제(33.3%)의 순으로 폭로되고 있었고 VDT의 경우 25.2%, aldehyde류는 18.7%에서 폭로되고 있는 것으로 나타났다. 2. 대상자의 63.1%에서 병원근무 환경 중에 유해인자가 존재한다고 응답했고 병원의 환경측정이 필요하다고 대답한 사람은 80%에 달했다. 35.7%가 유해인자에 대한 교육을 받은 적이 없다고 응답했다. 전체 응답자의 35.7%가 유해인자에 폭로시 보호 장비를 착용하지 않는다고 응답했고 주기적인(격년) 건강진단은 48.6%에서 받는 것으로 조사되었다. 근무부서의 환기상태는 7.2%만이 좋은 편이라고 응답했다. 이상에서 살펴본 바와 같이 병원근무자들이 여러 가지 유해환경에 노출되고 있고 또, 이로 인해 발생할 수 있는 건강장해에 대한 예방대책이 소홀한 것으로 나타나 병원의 작업환경측정의 시행이 필요하고 이 결과를 바탕으로 병원근무자들에 대한 특수건강진단 적용여부를 결정해야 할 것이다. This study was performed to decide the possibility of special health examination to the hospital employees. We carried out questionnaire survey for 830 subjects at 2 general hospitals located in Pusan city. The summary of this study are as follows. 1. Above 10% of total hospital employees were replied that they exposed to 16 hazard items, such as dust, noise, stress and etc. Among them, over 50% of hospital employees exposed to dust(69.8%), noise(52.3%), stress(60.1%). And hospital employees exposed to alcoholic disinfectant(41.3%), radiation(34.6%), drug(33.3%), VDT(25.2%), and aldehyde(18.7%) also. 2. 63% of the hospital employees replied that there were hazardous factors in hospital environments, and 80% insisted the necessity for hospital environment measuring. 35.7% of respondents replied that they had never taken the education about hazardous factors. 35.7% of the total respondents answered that they didn't use protective equipment when exposed to hazardous factors. And 48.6% answered they took periodic health examination. Only 7.2% replied that ventilation condition of office room was proper. As shown in above results, hospital employees are exposed to various hazards, and turn out neglecting to health problems caused these hazardous factors. So at first, it is necessary to measuring hospital working environment, and then will be decided the possibility of special health examination to the hospital employees.

부산지역에서 산재보상을 신청한 과로사에 관한 연구

남연,오차재,박정래,이동준,조병만,이수일 大韓産業醫學會 2002 대한직업환경의학회지 Vol.14 No.1

목 적 : 부산지역의 근로복지공단에서 1991년부터 1999년까지 과로사 관련 보상심사가 이뤄진 총 219례를 대상으로 과로사의 발생양상과 그 인정여부에 영향을 밀치는 요인을 밝힘으로써 향후 과로사 관련 연구의 기초적 자료를 제공하고자 하였다. 방 법 : 부산지역의 3개 근로복지공단 지사에 소장된 과로사 심사기록을 대상으로 재해자의 인구통계학적 변수와 소속사업장과 근무환경에 대한 변수, 사망원인질환과 기존질병력, 업무상 과중부하의 성격과 분류, 직무수행성과 직무기인성 여부에 대해 조사하였다. 그리고 행정기관의 과로사 인정에 영향을 미치는 요인들을 평가하였다. 결 과 : 1. 전체 219례 중 135례(61.6 %)가 과로사로 인정을 받았으며, 96년 이후 매년 50례 이상의 보상신청이 이뤄져 왔다. 전체의 30.6 %가 50인 미만의 영세사업장 소속이었고, 직업운전사와 경비 직종이 34.7 %로 높았다. 연령층은 50대 이상이 48.8 % 였고, 하루 12시간 이상의 근무자가 29.6 % 였다. 근무형태에서는 교대근무와 심야근무 등의 불규칙 근무형태가 37.5 %였으며, 새로운업무에 배치된 지 6개월 이내에 발생한 경우가 21.5 %였다. 2. 사망원인으로는 뇌출혈 등의 뇌혈관계 질환이 전체의 49.8 %로 심장질환보다 많았고, 현행법령상의 인정범위에 속하는 경우가 85.4 %였다. 또한 선행질병력이 48.9 %에서 나타났는데, 대다수가 고혈압 등의 순환기 질환으로 확인되어 이들 병력자들의 보건관리에 중점을 둘 필요를 보였다. 3. 운전과 감시·정밀작업, 위험작업, 잦은 장기 출장 등의 위험요인에 노출된 경우가 전체의 53.9 %였고, 재해에 선행된 돌발사건이 전체의 17.8 %에서 관찰되었다. 업무상 과중부하에서 업무량증가와 업무시간연장이 전체의 64.7 % 였고, 6개월 이상의 장기적인 육체적, 정신적 과중부하가 있었던 경우가 42.5 %였다. 이 결과로 볼때 현행 법령상의 장기적인 과로에 대한 인정범위가 보다 확대되어야 할 필요를 보여준다. 4. 과중부하가 발생에 기여한 것으로 평가된 예가 전체의 76.3 %로 실제 인정율보다 높았다. 이중 충분요인으로 작용한 경우가 43.6 %, 부분요인인 경우가 10.4 %, 변경·촉진요인인 경우가 22.3 %였다. 5. 과로사 인정여부와 각 변수간의 로지스틱 회귀분석에서는 해당 업무의 근무경력이 6개월미만인 경우가 교차비 6.76(p=0.016), 사망질환이 법규상의 뇌심혈관계질환에 포함되는 경우가 교차비 3.00(p=0.034)을로 유의하게 높았다. 업무상 과중부하의 증가가 있는 경우는 교차비가 2.02로 높았으나 통계적 유의성은 다소 낮았다(p=0.081). 반면 50대 이상의 고령층과 기존 병력자의 경우는 상대적으로 불인정되는 경향을 보여 현행 행정기관의 인정기준이 과로에 민감한 대상층을 포괄하지 못하고 있음을 보여주었다. 결 론 : 부산지역에서의 과로사는 주로 50인 미만의 영세사업장 중 운전업, 경비업 등에 종사하는 40대 이상의 중·고령층 근로자에서 많았다. 재해자중 다수에서 뇌·심혈관계질환 병력이 확인되었고, 행정기관의 과로사 인정에는 법규상 인정범위의 뇌·심혈관계질환으로 사망한 경우와 재해자의 근무경력이 6개월 미만인 경우에서 인정되는 경우가 의미있게 높았다. 반면 기존 질병력이 있거나 50대 이상의 고령층의 경우 과로사로 인정되지 못하는 경우가 보다 많게 나타났다. 그러나 본 연구에서는 장기적인 과로와 과중부하를 유발하는 고위험직업에서의 과로사 빈도가 높아 현행 법규상의 과로인정기간의 범위를 넓혀야 할 것이고 직업에 대한 고려를 포함하는 인정기준의 검토와 개선이 요구된다. 그리고 과로사를 예방하기 위하여 업무시간 및 업무량의 개선과 관리가 필요할 것으로 판단된다. Onjectives : Karoshi is a word meaning death from work-overload. Work-related diseases due to continuous overwork are primarily cerebro- and cardio-vascular in nature. In korea, despite an increase in the incidence of Karoshi, it is not easy to recognise by workmen's compensation in Korea. This study intended to establish basic information concerning the incidence of Karoshi. Methods : 219 cases were collected based on workers' compensation records of three Busan Regional Centers of Labor Welfare Corporation from 1991 to 1999. The size of workplace, occupation, daily working time, type of working schedule, job tenures, characters of work-overload and duration of work-overload were investigated according of subgroups of general characterictics. Both univariate and multiple logistic regression analyses were userd to estimate the relationship between risk factors and a recognition of Karoshi. Results :1. 61.6 % of total cases were recognized as Karoshi. 30.6 % occurred in a small workplace of less than 50 workers, 34,7 % were drivers or guardss, and 48,8 % were more than 50 years old. Additionally, 29.6 % worked more than 12 hours, 37.5 % were irregular hours and shift workers and 21.5 % of the total had been on the job less than 6 months. 2. Of the causes of death, 49,8 % was cerebro-vascular diseases and it was more than cardio-vascular ones. And 80.4 % of total cases was belonged to the recognition-category of the Labour Ministry's Law. The previous desease history was found on 49.8 % of all cases. Of them, hypertension was most common as 21.9 %. 3. 53.9 % of patients were exposed to job hazards such as driving, monitoring, guarding, risky jobs and frequent long-term official trips. 64.7 % recorded a increased work-overload of job contents and working hours. Of the several types of work-overload, 42.5 % displayed long-term physical and psychotic work-overload and 22.2 % exhibited job characteristic work-overload. 4. In this study, work-overload was associated with the incidence of Karoshi in 76.3 % of cases. This rate was higher than the recognition of Workmen's compensation recorded by the Korea Labor Welfate Corporation. Of these, 43.6 % belonged to sufficient factors, 10.4 % partial factors, and 22.3 % were due to aggravating factors. 5. Logistic regression demonstrated that death due to cerebro- and cardio-vascular disease, short-tenure within 6 month was significantly associated with a recognition of Karoshi (p=0.034, OR=3.00, CI=1.09~8.30/p=0.016, OR=6.76, CI=1.43~32.07 respectively) and that an increase of work-overload was also associated, but its statistical significance was slightly lower(p=0.081, OR=2.02, CI=0.91~4.46). However, no association was found between this recognition and overtime work, hazardous job, irregular work schedule, low-income, injury-onset place, or small size of workplace. The elderly group(>50years old) and those with a previous disease history were negatively associated with recognition although the statistical associaltion was low. Conclusions : Karoshi in Busan occurred frequently in a small workplace of less than 50 workers, especially drivers or guards. Additionally, these cases worked more than 12 hours, were irregular hours and shift workers. The death due to cerebro- and cardio-vascular disease, short-tenure within 6 month was significantly associated with a recognition of Karoshi. However Karoshi in this study occurred frequently in overtime work and high risk groups of work-overload. Therefore, for prevention of Karoshi, work-overload and overtime work need improved and controled.

잡음제거를 위한 자기동조 제어기 설계

李金源,崔南洙 관동대학교 1996 關大論文集 Vol.24 No.1

In this paper, self-tuning controller is designed, so that Hoo norm of the difference between the desired transfer function and the actual closed loop transfer function is minimized. For solving this problem. Nevanlinna-Pick interpolation method is introduced and 1-step ahead predictor is also utilized for the realizable controller design. A 2nd order system is used for simulation. The effect of the noise to the system output is shown to the rejected in simulation.

골수구성 백혈병 환자에게 발생한 결핵성 림프절염

이창섭,송진수,최평균,조재현,방지환,박경화,박완범,김홍빈,김남중,윤성수,박선양,김병국,오명돈,최강원 대한감염학회 2006 감염과 화학요법 Vol.38 No.5

혈액질환 가운데 결핵 발생이 증가한다고 알려진 것은 호지킨 림프종을 포함한 림프증식성질환 그리고 모양세포성 백혈병 등이 있다. 또한 동종 골수이식을 받은 환자에서도 결핵은 증가한다고 알려져있다. Kaplan 등은 골수구성 백혈병 환자에서 결핵 발생이 증가한다고 보고하였다. 그러나 골수구성 백혈병 환자에서 결핵의 발생이 증가하는 이유에 대해서는 아직까지 정확하게 밝혀지지 않았다. 저자들이 2년 동안 후향적으로 조사한 180명의 성인 골수구성 백혈병 환자들 가운데 결핵이 발생한 환자는 4명이었고, 발생 부위는 모두 림프절이었다. 결핵은 골수구성 백혈병의 특정 아형에만 국한되어 발생하지 않았지만, 50%에서 FAB 분류에 의한 M4였다. 림프절이 종대된 골수구성 백혈병 환자에서 특히, 결핵의 유병율이 높은 나라에서는 결핵성 림프절염도 감별진단에 포함시켜야 한다. During the neutropenic phase, leukemia patients receiving chemotherapy are prone to bacterial and, fungal infections; occasionally mycobacterial, viral and protozoal organisms may also cause infections. Mycobacterium tuberculosis infection was reported very rarely in these patients. This report describes four patients with M. tuberculosis infection identified from 185 adult patients who were diagnosed myelogenous leukemia between January 2003, and December 2004. There was no patient with M. tuberculosis infection from 44 lymphoid leukemia and 11 acute biphenotypic leukemia patients. Sites of infection were all lymph nodes. Three among four patients were presented with lymphadenopathy at initial diagnosis of leukemia, and the other one presented with lymphadenopathy after induction chemotherapy. There was no patient presented with lymphadenopathy during the neutropenic phase. Tuberculous lymphadenitis was presented in a patient with three acute myelogenous leukemia (FAB class 2 M4, 1 M2) and a chronic myelogenous leukemia, accelerated phase. An acute myelogenous leukemia patient had a leukemic cell and tubercle bacilli in the same lymph node. Tuberculosis should also be included as a differential diagnosis in myelogenous leukemia patient with lymphadenopathy, especially in the countries in which the disease is endemic.