간세포암과 감별이 어려웠던 악성중피종 치험 1예

김선문,허원석,채경훈,강윤세,정재훈,김연수,박기오,문희석,이엄석,김석현,성재규,이병석,이헌영,신경숙,조준식,송인상,강대영 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Malignant peritoneal mesothelioma is a rare neoplasm that arises from the mesothelium of a serosal cavity and is a rapidly fatal disease with a median survival of 4 to 12 months for untreated cases. Recently, we experienced a case with malignant peritoneal mesothelioma who was suspected hepatocelluar carcioma by abdominal CT scan and was confirmed by biopsy including immunohistochemical stain(calretinin) after surgery. We performed tumor excisions and wedge resection of the liver(segment Ⅷ)and inserted Tencoff catheter in abdominal cavity at 25th day of post-operation. We treated with intraperitoneal paclitaxel(25mg/m^(2)/day for 5 days) six courses monthly. She was well tolerable and is still living without any evidence of recurrence for 14th month of post-operation.

Gilbert 증후군에서 열량 제한 시험과 Phenobarbital 자극 시험의 의의(14예)

이헌영,채경훈,정재훈,강윤세,김연수,문희석,박기오,이엄석,김선문,김석현,성재규,이병석,이강욱 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Gilbert 증후군은 인구의 7%에서까지 나타날 수 있는 매우 흔한 증후군으로서 비진행성인 양성의 만성적 경과를 치하며, 간질환의 증상과 징후가 없는 경한 비포합형 고빌리루빈혈증이 특징인 일종의 체질적인 증상으로서 혈장 빌리루빈 농도에 대한 사춘기의 영향 때문에 10대와 20대에 자주 진단이 된다. 따라서 임상적인 중요성은 미약하지만 높은 빈도가 예상되는 점에 그 중요성이 부여되어야 할 것이다. 따라서 적정한 임상적 진단법으로 기왕에 소개된 열량제한 시험과 phenobarbital 유도 시험을 시행하고 이들의 진단적 가치를 알아보기 위하여 본 연구를 시행하였다. 1990년 7월부터 1999년 4월까지 충남대학교병원에 내원하여 HBsAg, IgG anti-HBc 및 anti-HCV가 음성이고, 간 초음파 스캔에서 이상이 없으며, 혈청 AST, ALT 및 AP가 정상인 비음주자에서 경한 비포합형 고빌리루빈혈증이 있는 14예의 환자들을 대상으로 ^(99m)Tc-DISID 스캔을 시행하였으며, 기저 치 총빌리루빈 및 포합형 빌리루빈 치를 측정한 다음에 하루에 400Kcal로 48시간동안 제한한 열량 제한 시험을 시행하였고, phenobarbital을 하루 60mg씩 5일간 투여한 후에도 각각 총빌리루빈과 포합형 빌리루빈 치를 검사하여 비포합형을 구하였다. 대상 환자들은 모두 14예로서 남자가 11예(78.6%)였고 여자가 3예(21.4%)여서 3.7:1로 남자에서 많았으며, 20대가 6예(42.9%), 30대가 역시 6예(42.9%) 및 40대가 2예(14.2%)로서 2,30대가 대부분(85.8%)이었다. 열량 제한 시험 후의 총빌리루빈 치, 비포합형 및 포합형 빌리루빈 치들은 평균 각각 5.5±2.7, 4.2±2.3 및 1.3±10mg/dL 로서, 시험 전 치들인 3.0±0.8, 2.2±0.8 및 0.7±0.4mg/dL 보다 유의하게(p=0.001, p=0.001, p=0.023) 상승하였다. 포합형 빌리루빈 치도 유의하게 상승하였으나 비포합형의 상승보다는 훨씬 낮아서 주로 비포합형이 증가하였다. phenobarbital 투여 중 설사가 발생하여 중단한 1예를 제외한 13예에서 열량 제한 시험 후에 상승하였던 총, 비포합형 및 포합형 빌리루빈 치가 phenobarbital 유도 시험후에는 2.0±1.1, 1.5±0.8 및 0.5±0.4mg/dL로서 열량 제한 시험 결과보다 유의하게 낮아졌고(p=0.00, p=0.000, p=0.001), 열량 제한 시험 전의 기초치들인 3.0±0.8, 2.2±0.8 및 0.7±0.4mg.dL 보다도 더욱 낮아졌으며 유의한 차이(p=0.001, p=0.02, p=0.005)를 나타내었다. 14예에서 시행한 ^(99m)-Tc DISIDA 스캔에서 9예(64.3%)가 정상이었고, 5예(35.7%)에서는 심장 및 신장으로의 간외 섭취가 3예였고, 60분까지 소장 배출이 없는 배설 지연 예와 담낭 수축 불량 예가 각각 1예 씩 발견되었다. Phenobarbital 투여시험에서 민감도가 열량제한시험에 비해 더 높았다(92.3%와 50.0%). Gilbert 증후군에서 1일 400 Kcal로 48시간의 열량제한 시험과 1일 60mg의 phenobarbital을 5일간 투여하는 유도 시험은 편리하고 유용한 임상적인 진단법으로 이용할 수 있다고 생각된다. 그러나 열량 제한 시험에서는 증가 기준의 통일이 필요하다고 유추되며 phenobarbital 유도 시험이 민감도가 더 높은 것으로 생각된다. Gilbert's syndrome is very frequent and benign chronic process characterized by mild, intermittent, unconjugated hyperbilirubinemia without any symptom and sign of liver disease. Previously intoduced caloric restriction test and phenobarbital stimulation test as two appropriate clinical tests had been examined and their diagnostic values were reevaluated. Fourteen patients with mild, persistent, unconjugated hyperbilirubinemia were included. Subsequently caloric restriction has been applicated by 400 Kcal/day for 48 hours and phenobarbital has been prescribed by 60 mg/day for 5 days. Therafter serum levels of total and direct bilirubin were measured. Most of the patients were third and fourth decade(85.8%) and male predominant. Each basal serum levels of total, indirect and direct bilirubin were 3.0±0.8, 2.2±0.8 and 0.7±0.4 mg/dL. After caloric restriction test, each levels were increased significantly to 5.5±2.7, 4.2±2.3 and 1.3±1.0 mg/dL(p=0.001, p=0.001, p=0.023). After phenobarbital stimulation test for 13 patients had been practiced, increased levels of each bilirubin after caloric restriction test were decreased significantly to 2.0±1.0, 1.5±0.8 and 0.5±0.4 mg/dL(p=0.000, p=0.000, p=0.001) and these levels were significantly lower than basal levels(p=0.001, p=0.02, p=0.005). The sensitivities of caloric restriction test were 85.7%, 50.0%, and 71.4%, 35.7%(1.0, 1.5 mg increase of total bilirubin and 1.0, 1.5 mg/dL increase of indirect bilirubin). The sensitivities of phenobarbital stimulation test were 93.2% and 92.3% at criteria of 1.5 mg/dL increase of total bilirubin and indirect bilirubin. On the diagnosis of Gilbert syndrome, caloric restriction test and phenobarbital stimulation test are convenient and useful diagnostic tools in clinical face. And also phenobarbital stimulation test has higher sensitivity than caloric restriction test. Furthermore, standardization of bilirubin increment would be necessary in caloric restriction test.

Developpe devant 수행시 지향각(Orientation angles)을 이용한 골반과 하지의 신체정렬

박기자,권문석,이경화 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.6

The purpose of this study was to persnet proper alignment of pelvis and lower extremity using orientation angles during a developpe devant. Data were collected by Kwon3D program. Two females professional modern dancer were participated in this experiment. Subjects performed a developpe devant in meddle heights(about 90 deg.) The results were as follows: First, in axes of X, pelvis, left thigh, left shank were aligned from 0° to 3° and left foot was aligned from 92° to 94°. Second, in axes of Y, pelvis(-ll°~-8°), left thigh(-6°~-2°), left shank(5°~8°), left foot(12°~18) were aligned. Third, in axes of Z, pelvis(5°~10°), left thigh(-20°~-15°), left shank(27°~32°), left foot(7°~10) were aligned.

言語演習室을 使用한 TEST에 관한 硏究

朴文錫 동아대학교 어학연구소 1984 언어와 언어교육 Vol.1 No.1

Learning and testing are closely related with each other. Testing is to evaluate the students' progress in learning and the analysis of its results often provides with opportunities of re-exaimning the methods of teaching and learning. There are many types of test. However, it must have reliability and validity. Though the traditional essay-type test has good points in testing the learner's abilities of articulation and expression as well as of producing correct papers, its serious drawbacks are lack of reliability and validity owing to the limited scope of presenting questions and tendency to allow subjective judgement on the part of the examiner in the process of checking papers. Hence a more plausible type of test, the objective test, has been introduced which assures reliability in that there is only one correct answer in each given question and validity in that it is capable of wider scope of presenting questions. But it also has some disadvantages. It tends to make the learner pay little attention to cultivating the ability of articulation and expression and therefore it has, in fact, brought the ability down to lower level. This fact has been shown among the students of our country after the introduction of that type of test. It seems that both types are necessary to make up for the above-said flaws. Chief emphasis on the written English in the past has made paper test universal. But now that greater stress is put on the spoken English as well, aural-oral test is also required. Valette says of the importance of aural-oral test: The test itself, if given at the end of the laboratory period, can be an incentive to the students to apply themselves more seriously to learning the lesson material. Aural-oral test is possible either by the teacher's own voice or by the tape recorder in the classroom, Valette continues. But the position of the teacher or the tape recorder and the resonance of the classroom pose problems, thus damaging the reliability of the test. Test in the language laboratory solves the above-mentioned difficulties. The English language ability can be tested according to four categories. This can be done in the language laboratory. However, the aural-oral test of reading and writing ability can be superfluous since it is essentially the same as the test of listening and speaking. As the function of teaching reading and writing is not included in those of the language laboratory, the test of listening and speaking should be primary in the activities of the language laboratory.

Corynebacterium hofmannii에 依한 전신감염 1예

문대혁,최강원,박석건,이광호 대한감염학회 1984 감염 Vol.16 No.1

Corynebacterium of hoffmannii is a part of normal pharyngeal flora. Human infection caused by C. hofmannii is very rare. All reported cases involve prosthetic or native cardiac valve. This patient sufered from chronic alcohlism, diabetes mellitus, and acute suppurative inflammation of brain, meninges and soft tissue. And he failed to show any clinical response to various antimicrobial therapy and died after discharge.

외국어 습득에 있어서 청해의 중요성

박문석 동아대학교 어학연구소 1990 언어와 언어교육 Vol.9 No.-

One of the issues dealing with foreign language teaching methodology is still being disputed: should listening comprehension be taught ahead or following the demands for oral production? This is the main topic of this research. In an attempt to make as thorough an examination as possible of the ramifications of this issue, the study reviews the role listening comprehension played in the history of foreign language teaching. In order to verify the importance of listening comprehension in foreign language learning, current theories of foreign language acquisition, such as the monitor model, the information processing model, the intake model, and an input-oriented paradigm are also reviewed. The study also presents evidences offered by many scholars that substantiates the advisability of emphasizing aural training before demanding oral production. The author agrees with this view and the study concludes with some of the author's views regarding the sequential development of skills in foreign language instruction.

導滯湯 Extract가 胃腸管機能및 腸內細菌에 미치는 影響

文錫哉,朴鎬湜 圓光大學校 漢醫科大學 1989 圓光漢醫大論文集 Vol.- No.6

In order to grasp the nature Dochaetang effects of Dochaetang on the intestinal movement of rabbit, the transport faculty of meal in small intestine of rat, experimental gastric and duodenal ulcers in rat, and the several intestinal bacterias were investigated by using its water and methanol extract. Dochaetang water extract(DWE) and methanol extract(DME) exhibited the contractile response and augmentation of spontaneous movement in the longitudinal muscle strips of jejunum, ileum and colon also circular muscle strip of colon, which were isolated from rabbits. Augmentation of spontaneous movement and contractile response of jejunum and ileum strips to DWE and DME were inhibited by cyproheptadine or diphenhydramine, but not affected by Ca^+2 free in bath solution. Atropine suppressed the above contractile response, but did not effect the augmentation of spontaneous movement. Atropine markedly decreased the spontaneous movement and contractile respone of longitudinal and circular muscle strips of colon to DWE or DME however cyproheptadine showed a significant inhibition on above two actions of longitudinal muscle strip, no remarkable effect on the two actions of circular muscle strip, and them diphenhydramine inhibited the two actions of longitudinal muscle strip and contractile response of circular muscle strip, but had no effect on the augmentation of spontaneous movement of circular muscle strips of colon to DWE and DME. Ca^+2 free in bath solution did not affect the all actions of longitudinal and circular muscle strips of colon to DWE and DME. DME given orally exhibited a significant increase of transport rate of charcoal meal in digestive organs of rat. DWE(p.o) potently inhibited the development of indomethacin of serotonin induced gastric ulcers and histamine-Carbachol induced doudenal ulcers in rats. DWE showed antibacterial activity against several intestinal bacteria in vitro test.

백일주 양조중 맛성분의 변화

박석규,박필숙,손봉수,문주석 순천대학교 기초과학연구소 1993 基礎科學硏究誌 Vol.4 No.-

Changes in taste components of Backilju, an old Korean cleraed rice wine, were investigated. During brewing, pH and titratable acidity of mash were decreased or increased in the range of 3.41→3.81 and 8.62→6.74, respectively. The final product of Backilju filtrate, fermented for 100 days, contained 0.36% reducing sugar, 2.68% total sugar, 606.6 ㎎% total acid, 2.5 ㎎% volatile acid and 22.9㎎ solid/ml extract. Major volatile components analized by GC/MS methods were 3-methyl-1-butanol acetate, 4-decanol and dimethyl disulfide. Calcium(20.26ppm) was the most abundant, followed by magnesium(3.19ppm) and zinc(1.87ppm). Nucleotides and their related compounds were inosine(0.12→0.44 mM/ml), ADP(0.16→0.33 mM/ml) and hypoxanthine(0.33→0.04 mM/ml). Compared with other Korean traditional Yakju, Backilju contained more total acid and mineral but less sugar and volatile acid.

[논문]EAF Slag 잔골재를 사용한 콘크리트의 황산염침식 저항성에 관한 실험적 연구

박문수,김영수 釜山大學校生産技術硏究所 2008 生産技術硏究所論文集 Vol.67 No.-

본 연구에서는 전기로슬래그를 사용한 콘크리트의 황산염침식 저항성을 평가하는데 그 목적이 었다. 전기로슬래그의 에이징 방법(공기중,촉진에이징) 및 치환율(0,10, 20, 30, 50%)을 달리하여 10% 의 황산마그네숨 용액에 침지한 후 각 재령에 따른 콘크리트의 황산염 침식 저항성을 평가하였다. 각각의 시편에 대한 콘크리트의 압축강도,황산염 열화지수(S.D.F),중량변화율,미세구조를 분석한 결과,촉진에이정 처리한 전기로슬래그가 공기중에이징 처리한 전기로슬래그보다 우수한 성능을 보임을 알 수 있었으며,촉진에이징 전기로슬래그의 치환율이 30% 까지 증가할 수록 황산염 침식 저항성을 우수해 짐을 알 수 있었다.

법랑모세포 분화와 법랑질 형성과정에서 OD314, Apin protein의 발현 및 기능

박종태,최용석,김흥중,정문진,오현주,신인철,박주철,손호현 대한치과보존학회 2006 Restorative Dentistry & Endodontics Vol.31 No.6

본 연구에서는 법랑모세포 분화와 법랑질 형성에 연관이 있는 OD314 일명 Apin protein의 기능을 밝힐 목적으로, in-situ hybridization에 의한 OD314 mRNA 발현과 법랑모세포 세포주에서 OD314 enamel matrix protein의 발현, 그리고 OD314 유전자를 과발현/억제시킬 수 있는 construct를 제작한 후 법랑질 형성 중에 OD314의 기능을 알아보고자 RT-PCR를 시행하여 다음과 같은 결과를 얻었다. 1. OD314 mRNA는 발생중인 상아모세포보다 법랑모세포에서 강하게 발현되었다. 2. Tuftelin은 석회화 결정이 형성되는 14일까지 발현이 지속되고, 그 이후부터 점차 감소하였다. Amelogenin과enamelin은 7일부터 그 발현이 점점 감소하였다. 3. U6-OD314 siRNA construct를 이용하여 transfection한 법랑모세포 세포주는 OD314와 tuftelin,MMP2 mRNA 발현이 감소하였으며, CM-OD314를 transfection하여 OD314의 과발현을 유도한 경우에는 OD314와 MMP20 mRNA의 발현이 뚜렷이 증대되었다. 이 결과는 OD314가 법랑모세포의 분화와 법랑질의 형성 그리고 석회화 과정에 중요한 역할을 하는 새로운 인자임을 시사한다. This study was aimed to elucidate the biological function of OD314 (Apin protein), which is related to ameloblast differentiation and amelogenesis. Apin protein, calcifying epithelial odontogenic (pindborg) tumors (CEOTs)-associated amyloid, were isolated from CEOTs, and has similar nucleotide sequences to OD314. We examined expression of the OD314 mRNA using in-situ hybridization during tooth development in mice. Expression of OD314 and several enamel matrix proteins were examined in the cultured ameloblast cell line up to 28 days by reverse transcription-polymerase chain reaction (RT-PCR) amplification. After inactivation and over-expression of the OD314 gene in ameloblast cell lines using U6 vector-driven RNA interference and CMV-OD314 construct, RT-PCR were performed to evaluate the effect of the OD314 during amelogenesis. The results were as follows: 1. In in-situ hybridization, OD314 mRNAs were more strongly expressed in ameloblast than odontoblast. 2. When ameloblast cells were cultured in the differentiation and mineralization medium for 28 days, the tuftelin mRNA expression was maintained from the beginning to day 14, and then gradually decreased to day 28. The expressions of amelogenin and enamelin were gradually decreased according to the ameloblast differentiation. 3. Inactivation of OD314 by U6-OD314 siRNA construct down-regulated the expression of OD314, MMP-20, and tuftelin, whereas over-expression of OD314 by CMV-OD314 construct up-regulated the expression of OD314 and MMP-20 without change in tuftelin. These results suggest that OD314 is considered as an ameloblast-enriched gene and may play the important roles in ameloblast differentiation and mineralization.