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축구선수의 Detraining과 Retraining이 혈청지질 및 호르몬농도에 미치는 영향
정정화,박재현,채종훈,성혜련,황지인,윤미숙,노금선,윤종관,윤영학,노순덕,정경숙,박일규,김은희,박현태,박상갑 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.1
The purpose of this study was to investigate the effects of detraining and retraining on serum lipid and hormones in soccer players. Subjects were seven male high-school soccer players. V˙O_2max was determined for each subjects by administering a treadmill test(initial speed: 90m/min, grade: 5%, increasing speed per 3 min: 30m/min). Serum lipid(T-C, TG, HDL-C LDL-C) and hormones(epinephrine, norepinephrine, growth hormones, cortisol) were assayed pre and post detraining in 10, 20, 30 days after retraining. The repeated ANOVA was used to determine significant differences. The 0.05 level of significance was as critical level for the study. The results of the study were as follows: 1. V˙O_2max(ml/min) were 3576.3±204.2ml/min pre detraining, 3234.1±198.9 ml/min post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/min) were 3601.4±170.9 ml/min. There were significantly(p<.05) increased in retraining periods. 2. V˙O_2max(ml/kg/min) were significantly(p<.05) decreased from 62.3±2.9 ml/kg/min to 55.9±4.7 ml/kg/min in detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/kg/min) were 62.4±3.4ml/kg/min, 62.7±2.3ml.kg/min, 67.3±7.2ml/kg/min respectively. There were significantly(p<.05) increased in retraining periods. 3. T-C were significantly (p<.05) increased from 166.6±8.5mg/dl to 175.3±10.3 mg/dl in detraining. In 10, 20, 30 days after retraining, T-C were 160.1± 3.2mg/dl, 156.7±3.7mg/dl, 140.3±9.0mg/dl. There were significantly(p<.05) decreased in retraining periods. 4. HDL-C were 61.4±6.6mg/di pre detraining, 5.3±6.6mg/dl post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, HDL-C were 56.9±7.1mg/dl, 56.4±9.2mg/dl, 57.7±9.1mg/dl respectively. There were no significant difference in retraining periods. 5. The hormones(epinephrine. norepinephrine, growth hormone, cortisol) were changed as same patterns. Epinephrine were 26.0±7.0[g/ml pre detraining, 24.6±3.2pg/ml post detraining. In 10, 20, 30 days after retraining, epinephrine were 26.9±5.6pg/ml, 30.6±6.2pg/ml, 29.4±5.6pg/ml respectively. There were no significant difference in retraining periods. In conclusion, HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were decreased, T-C, LDL-C and TG were increased in detraining. But HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were increased, T-C, LDL-C and TG were decreased in retraining.
과민성 장 증후군의 증상 경감을 위한 비약물적 접근 고찰
최명애,김금순,안경주,채영란,최정안,홍해숙,박미정,이경숙,신기수,정재심 대한기초간호자연과학회 2005 Journal of korean biological nursing science Vol.7 No.2
There have been many trials of clinical efficacy of multicomponent and single component treatments for irritable bowel syndrome(IBS). We reviewed effects of non phamacological treatments in the IBS. Though the efficacy of multi-component approaches was unclear, several results suggest that cognitive behavioral therapy was effective in improving gastrointestinal symptoms of IBS. As a single component, cognitive therapy and relaxation with or without biofeedback could improve the symptoms and psychological health of IBS patients. Yoga, meditation, self-help information and hypnotherapy could be applicable to IBS.
Frequency of CYP2C9 alleles in Koreans and their effects on losartan pharmacokinetics
Bae, Jung-woo,Choi, Chang-ik,Kim, Mi-jeong,Oh, Da-hee,Keum, Seul-ki,Park, Jung-in,Kim, Bo-hye,Bang, Hye-kyoung,Oh, Sung-gon,Kang, Byung-sung,Park, Hyun-joo,Kim, Hae-deun,Ha, Ji-hey,Shin, Hee-jung,Kim, Springer Science and Business Media LLC 2011 Acta pharmacologica Sinica. Vol.32 No.10
최희정,박정은,손희정,김금미,변정란,고영엽,김도영,문일환 梨花女子大學校 醫科大學 醫科學硏究所 1993 EMJ (Ewha medical journal) Vol.16 No.3
저자들은 1983년 1월부터 1993년 2월까지 이화여대 부속병원을 내원하여 궤양성 대장염으로 진단받은 환자 36예에 대하여 후향적 방법으로 분석하여 다음과 같은 결과를 얻었다. 1) 발병연령은 20대에서 가장 호발하였으며 남녀비는 1:1.7로 여자에서 더 많았다. 2) 병력기간은 6개월이내가 전체의 63.9%로 대다수를 차지했다. 3) 임상증상은 혈변이 31예(86.1%)로 가장 많았으며 다음으로 복통 27예 (75.0%), 설사 26예(72.2%), 발열 11예(30.6%), 체중감소 10예(27.8%)의순이 었다. 4) 경중도(severity)를 나누어보면 중등도가 52.8%로 가장 많았고 중증이 33.3%, 경증이 13.9%의순이었다. 5) 해부학적 위치에 따른 병변은 pancolitis 36.1%, 직장과 S자상결장이 16.6% , 좌측결장과 직장만침범된 경우가 각각 13.8%, 횡행결장까지가 8.3%,backwash ileitis가 동반된 경우가 11.1%였다. 6) 혈액학적 검사소견은 비특이적이나 빈혈, 백혈구다증, 적혈구 침강속도 상승, 저알부민혈증,전해질장애, 혈청 transaminase 및 alkaline phosphatase상승등을 보였다. 7) 내시경 소견은 점막궤양을 보이는 경우가 27예(77.1%)로 가장 많았고 충혈이 18예(51.4%), 출혈15예(42.5%), 점막의 friability 8예(22.9%), 가성폴립 8예(22.9%), 과립상 7예(20.2%) 등의 소견을보였다. 8) 바륨대장 조영술 소견은 과립상이 18예(62.1%)로 가장 많았고 대장 팽찰부 소실 16예(53.2%), 내강협소 10예(34.5%), 연통모양의 강직 4예(13.8%), 가성폴립 1예(3.4%) 등을 보였고, 정상소견도3예(10.3%)에서 있었다. 9) 조직생검의 병리학적 소견은 염증소견이 30예(83.3%)로 가장 많았고, cryptitis가 20예(55.6%),궤양이 18예(50%), goblet cell 고갈 7예(19.4%),가성폴립 7예(19.4%), 괴상 5예(13.9%), 과립상 3예(8.3%) 등을 보였다. 10) 내과적 치료로 70.8%에서 호전되었고 17.7%에서 재발되었다. 수술은 내과적 치료에 실패한4예를 포함한 6예(16.7%)에서 실시되었으며 장천공 2예의 응급수술이 있었고 4예는 선택적 수술이 었다. Objects : Ulcerative colitis is an waxing and waning inflammatory bowel disease characterizedby rectal bleeding and diarrhea, affecting principally the mucosa of the rectum and colon.Its incidience is being higher in Europe and America and it also seems to be rising increasinglyin our country because diagnostic methods are much developed and Korean life styles arewesternized. So, we investigated its clinical characteristics. Mothods : We analyzed 36 cases of ulcerative colitis which had been treated in the Hospitalof Ewha Womans' University from Jan. 1983 to Feb. 1993. retrospectively. Results : 1) The most prevalent age group was 3rd decade and male to female ratio was 1:1.77. 2) The duration of symptoms was less than 6 months in 63.9%. 3) The most common clinical manifestation was hematochezia(86.1%). abdominal pain(75.0%). diarrhea(72.2%). fever(30.6%), weight loss(27.8%) in the order of frequency. 4) According to the severity. moderate type was shown in 52.8%, severe in 33.3% and mildin 13.9%. 5) According to the anatomical distribution of the lesion pancolitis was shown in 36.1%,the involvement of the rectum and sigmoid colon in 16.6%, the left-sided colon in 13.8%.rectum only in 13.8%, transverse colon in 8.3% and backwash ileitis in 11.1%, respectively. 6) The hematologic laboratory finding was non-specific including anemia. leukocytosis. increased erythrocyte sedimentation rate, bypoalburninemia, electrolyte imbalance, increased serumtransaminase and alkaline phosphatase. 7) Colonoscopy revealed ulceration(77.1%) commonly, including hyperemia(51.4%). bleeding(42.5%), mucosal friability(22.9%), pseudopolyp(22.9%). granularity(20.2%). 8) The Barium enema showed granularity commonly and loss of haustral marking(55.2%),luminal narrowing(34.5%), lead pipe rigidity(13.8%), pseudopolyp(3.4%). Also, normal finding was shown in 10.3%. 9) The most common histopathologic finding was inflammation(83.3%) and ryptitis(55.6%), ulceration(50%), goblet cell depletion(19.4%), pseudopolyp(19.4%). necrosis(13.9%), granolarity(8,3%) were also noted. 10) With the medical treatment 76.5% of the cases showed initial improvement of the symptom, but the recurrence developed in 17.7%. The surgery was performed in 6 cases of patients(16.7%). Emergency operation was performed in 2 cases due to bowel perforation and electiveoperation in 4 cases.