Multi-media and multi-pathway aggregate exposure assessment for polycyclic aromatic hydrocarbons to the inhabitant in Tae-an county after Hebei-spirit oil spill

Kim Chan-Kook(김찬국),Woo-Chul Jeong,Jonil Hur,Pan-Soo Park,Tae-Woo Lee,Hwi-Soo Seol,Jung-hyeon Park,Jong-Heop Lee,Jong-Ho Kim,Byeong-Kyu Kwak,Jong-Hyeon Lee 대한직업환경의학회 2010 대한직업환경의학회 학술대회 논문집 Vol.45 No.-

정신질환의 수술적 치료

김문찬,이태규 대한생물치료정신의학회 2001 생물치료정신의학 Vol.7 No.1

Since Moniz began his clinical investigation, almost a century has passed. Cycles of acceptance and rejection of this theory have been its hallmark-more so than for any other method of treatment. The introduction of psychotropic medications reduced the need for psychiatric surgery but did not eliminate it. In the 1970s there was great agitation over the possibility that psychosurgery would be used. It is essential, however, to be ever mindful that these neurosurgical attempts to benefit the psychiatrically disabled do have the potential to alter human behavior in the general population. This review aimed at giving a compact and systemized account of the clinical guidelines in the management of patients with psychiatric disorder.

상부위장관 출혈을 일으킨 Warfarin Sodium에 의한 위점막내 혈종 1예

이봉규,김태원,박찬국,김만우 조선대학교 부설 의학연구소 1998 The Medical Journal of Chosun University Vol.23 No.2

A case of warfarin sodium-induced intramural hematoma and upper gastrointestinal bleeding is described, and the literature on this adverse effect is reviewed. A 83-year-old woman who has been receiving warfarin came to a emergency room because of hematemesis. She had a history of cerebral infarction. Physical examination was anemic conjunctiva, no abdominal mass and melena. The emergency gastroscopic finding was submucosal mass. Her hemoglobin and hematocrit concentration had falled to 6.7g/㎗ and 20%, Her prothrombin time (PT) was 130 sec and partial prothrombin time (aPTT) was 133 sec. The patient underwent an emergency exploratory laparotomy. The name of operation was hemigastrectomy with gastrojejunostomy(Billorth-Ⅱ). The pathology report indicated the presence of submucosal hematoma formation with mucosal ischemic necrosis and mucosal ulceration and regenerating epithelium.

光彈性 및 有限要素法에 依한 Dove-tail Notoh의 應力集中에 關한 硏究

崔圭夏,趙熙燦,安台煥 충주대학교 1990 한국교통대학교 논문집 Vol.24 No.-

When a load is put on the parts of the rapidly changing section area like in notch, fillet, keyway, screwthread etc, there may occur some stress concentration, crack and fracture in the structures of machines, buildings, bridges, ships, aircrafts, industrial plant machines, atomic power plant machines and the machines for civil engineering architecture or agriculture. Many researchers such as Neuber, Frocht, Vicentini, Flynn etc. have tried to find out the cause of fracture by photoelastic experiments. When Tuner settled the aircraft structure analysis by finite element method in 1956. Agyris, Ritz, C.A. Felippa, J.T. Oden, Zienkiewicz etc. extended the finite element method to wide applicaton to hydrodynamics, electric field, thermal transmission, underground water, soil, atomic technology, the ground, biotechnics, and even to the stress concentration problem which is one of the machine design field. There are some struchural analysis methods of the strength of materials, photelastic and the finite element method. They have the same object for design of strength and stiffness, but each method and priciple is very different. In this paper I studied the stress concentration and the stress distribution on dove-tail notch by photoelastic and finite element method and tried to show the relasation of stress concentration.

Interleukin-2와 결핵균 30 kDa 항원이 구개편도 및 말초혈액 T 세포 증식에 미치는 상승효과

박정규,박찬권,조은경,김화중,백태현,고필준,김병국,남부현,나기상,박찬일 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.1

Widespread use of BCG has not controlled tuberculosis, and more effective vaccines are clearly needed. Although chemotherapy will remain the mainstay of antituberculosis treatment, the use of adjunctive immunotherapeutic modalitites is attractive, particularly in persons with drug-resistant tuberculosis. Administration of IL-2 or IFN-γto tuberculosis patients enhance bacillary elimination. Cell-mediated immunity is the critical protective immune response in tuberculosis. Mycobacterial antigens are recognized by T cells and that elicit production of protective cytokines are potentially important vaccine antigens. The 30 kDa antigen is secreted in large quantities by growing mycobacteria. That antigen elicits greater proliferation in lymphocytes from healthy tuberculin reactors than healthy tuberculin nonreactors. In this study, the T lymphocyte proliferative responses to 30 kDa antigen from Mycobactrium tuberculosis H37Rv were examined by using tonsilar and peripheral blood lymphocytes from PPD(+) and PPD(-) tonsilectomized persons. When cultured with 30 kD antigen, tonsilar mononuclear leukocytes and T cells of PPD(+) demonstrated more ^3H-thymidine incorporation than PPD(-) persons (stimulation index was 2.5 and 1.9, 0.8 and 1.0, repectively). Peripheral blood mononuclear cells (PBMC) and peripheral blood T lymphocytes were shown the similar responses to this antigen. The combination of IL-2 and 30 kDa antigen elicited a significant proliferative responsiveness in tonsilar mononuclear leukocytes and T cells of PPD(+) persons (SI was 20 and 14.1). PBMC and peripheral blood T cells of PPD(+) persons were also shown a significant responsiveness, but PPD(-) persons did not show. These results demonstrate that the 30 kDa antigen and IL-2 have a synergistic stimulatory property in mycobacteria sensitizing lymphocytes.

産婦人科 患者에서 分離된 Ureaplasma urealyticum의 生物學的 性狀

梁熙燦,崔大卿,張明雄,白太鉉,朴鼎圭 충남대학교 의과대학 지역사회의학연구소 1986 충남의대잡지 Vol.13 No.2

Isolation rates of Ureaplasma urealyticum from vaginal swab of 216 patients, 105 prostitutes and 100 college females was investigated. Also, minimal inhibitory concentration of isolated strains about tetracycline and minocycline was studied. The results were summarized as follows; 1. Out of 70 vaginitis patients, isolation rates of Ureaplasma urealyticum and Mycoplasma hominis were 34.3% and 15.7%, respectively. 2. Out of 54 cervicitis patients, isolation rates of Ureplasma urealyticum and Mycoplasma hominis were 37.0% and 11.0%, respectively. 3. Out of 92 other gynecological patients, isolation rates of Ureaplasma urealyticum and mycoplasma hominis were 44.6% and 16.3%, respectively. 4. Out of 105 prostitues, isolation rates of Ureaplasma urealyticum and Mycoplasma hominis were 54.3% and 75.2%, respectively. 5. Out of 100 college students, isolation rates of Ureaplasma urealyticum and Mycoplasma hominis were 23.0% and 7.0% respectively. 6. In the susceptibility patterns of isolated Ureaplasma urealyticum, resistant strains about tetracycline in patients, prostitues and college students were 75.2%, 73.6% and 69.5%, respectively 7. In the susceptibility patterns of isolated Ureaplasma urealyticum, resistant strains about minocycline in patients, prostitues and college students were 91.7%, 87.7% and 73.9%, respectively.

Multi-media and multi-pathway aggregate exposure assessment for polycyclic aromatic hydrocarbons to the inhabitant in Tae-an county after Hebei-spirit oil spill

Kim Chan-Kook(김찬국),Woo-Chul Jeong(정우철),Jong-il Hur(허종일),Pan-Soo Park(박판수),Tae-Woo Lee(이태우),Hwi-Soo Seol(설휘수),Jung-hyeon Park(박정현),Jong-Heop Lee(이종협),Jong-Ho Kim(김종호),Byeong-Kyu Kwak(곽병규),Jong-Hyeon Le 한국환경독성학회 2010 한국독성학회 심포지움 및 학술발표회 Vol.2010 No.11

동일한 환자에서 조혈모세포이식 전후의 호중구감소 기간 중 감염양상에 대한 비교연구 : 중심정맥관 관련 패혈증을 중심으로 Based on Central Venous Catheter Related Septicemia

류재호,노규태,이영석,이영호,권혁찬,김재석,김효진,이영민,박혜원,박근희 대한조혈모세포이식학회 2002 대한조혈모세포이식학회지 Vol.7 No.1

연구배경: 동일한 환자를 대상으로 조혈모세포이식 전 일반 병실에서의 관해유도 항암제치료 및 강화요법으로 인한 호중구감소 기간의 감염양상과 고용량 항암제치료 후 무균실에서의 조혈모세포이식 시 호중구감소 기간의 감염양상을 중심정맥관 관련 패혈증을 중심으로 비교 연구함으로써 효율적인 감염관리지침을 마련하고자 하였다. 대상 및 방법: 1999년 1월부터 2001년 7월까지 2년 7개월간 동아대학교병원 일반병실에서 악성혈액질환으로 항암제 치료를 받다가 조혈모세포이식을 시행받았던 22명을 대상으로 중심정맥관 관련 패혈증의 형태를 비교분석하였다. 결과: 대상 환자들의 일반병실과 무균실에서의 입원기간은 각각 32±13일, 33±19일, 호중구 감소기간은 15±12일, 17±18일, 호중구 감소기간의 발열 횟수는 14회, 14회로서 입원병실의 종류에 따른 차이는 없었다. 환자들의 중심정맥관 사용일수는 일반병실에서 29일(7~545일), 무균실에서 100.5일(25~606일)이었으며, 총 사용일수는 각각 1,515일, 3,250일로서 무균실에서의 중심정맥관 사용일수가 의미 있게 길었다(P=0.001). 중심정맥관 사용 일수에 대한 감염률은 각각 5.28/1,000일, 3.08/1,000일로서 일반병실에서 그 빈도가 높았으나 통계적 유의성은 보이지 않았다(P=0.141). 결론: 중심정맥관 삽입 후 일반병실에서 항암제 치료를 받던 환자가 조혈모세포이식을 위하여 무균실에 입원하는 경우, 중심정맥관을 교체하는 것이 감염관리를 위하여 바람직할 것으로 생각된다. Background: We compared the incidence of central venous catheter (CVC) related septicemia during neutropenic period in the same patient, which developed following chemotherapy for remission induction and consolidation, or hematopoietic stem cell transplantation (HSCT). Methods: We retrospectively reviewed the medical records and laboratory data of 22 patients with hematologic malignancies who received anticancer chemotherapy followed by HSCT at Dong-A University Hospital between January, 1999 and July, 2001. We investigated the duration of hospitalization, duration of neutropenic period, duration of catheterization, microbiologically documented organisms and incidence of CVC related septicemia. Results: The data in general ward (before HSCT) and laminar air flow room (after HSCT) were as follows: duration of hospitalization was 32±13 days and 33±19 days, duration of neutropenic period was 15±12 days and 17±18 days, median duration of catheterization was 29 days (7~545 days) and 100.5 days (25~606 days) (P=0.001), and incidence of CVC related septicemia was 5.28/1000 days and 3.08/1000 days, respectively. In the CVC related septicemia, the most common etiologic organism was coagulase negative staphylococcus. Conclusion: We suggest that the exchange of CVC before admission to laminar air flow room could decrease the incidence of CVC related septicemia in HSCT recipients.

QT연장 증후군 환자에서 Head-Up Tilt Test에 의해 유발된 Torsades De Pointes 1례

전익수,차태준,김길수,김동완,김규종,김찬욱,김성만,주승재,이재우 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

부신피질 자극호르몬 단독결핍 1례

박경식,이승현,최석영,박태규,이동화,이찬우,정성복,이인규 啓明大學校 醫科大學 1997 계명의대학술지 Vol.16 No.3

부신피질 자극호르몬 단독결핍은 국내에서 7례만이 보고된 희귀 질환이며 병인 및 경과 등 아직 불분명한 측면이 많다. 이는 질환지체의 희귀성도 있지만 치료후 자연경과에 대한 장기적인 추적검사가 이루어진 경우가 드물기 때문이기도 하다. 저자들은 비특이적인 전신증상을 주소로 내원한 폐경기후의 56세 여자 환자에서 자가면역질환의 증거없이 고프로릭틴혈증을 보인 부신피질 자극호르몬 단독결핍 1례를 경험하고 1년간의 부신피질호르몬 대치요법후 추적검사를 실시하였기에 문헌 고찰과 함께 보고하는 바이다. Isolated ACTH deficiency is a rare disorder which shows secondary adrenal insufficiency with normal states of other pituitary hormones. A 56-year-old postmenopausal woman complaining general weakness and intermittent mental confusion presented negligible serum cortisol and ACTH level with hyperprolactinemia and mild hyponatremia. Rapid ACTH stimulation test did not show significant increase of serum cortisol level. Combined pituitary stimulation test showed negligible response of cortisol and ACTH, and slightly decreased response of prolactin and gonadotropin. But the responses of TSH and GH were normal. There was no evidence of organic pituitary of hypothalamic lesion in brain MRI and antithyroid autoantibody was not detected in serum. After receiving 12 months of glucocorticoid replacement therapy, she skipped the medicine for 3 weeks and we performed follow-up endocrinologic tests. Serum ACTH and cortisol level was also negligible and prolonged ACTH simulation test showed normal response of serum cortisol. CRF stimulation test showed no response of serum ACTH. Basal prolactin level was decreased to near normal and combined pituitary stimulation test showed normal response of prolactin with slightly blunted response of TSH and GH. We concluded that the case was nonautoimmune origined isolated ACTH deficiency which was accompanied by hyperprolactinemia and resultant deficiency of gonadotropin, so we report this case with review of literatures.