Rifampicin에 의한 것으로 추정되는 위막성 대장염1예

김수현,이은우,정종혁,문승현,김동한,양혁승,오영상,김호동,김도현,박혁,박정환,박경옥,이영직 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Pseudomembranous colitis, caused by altering the normal colonic flora and allowing the multiplication of Clostridium difficile, is an deleterious adverse effect of antibiotics. But it is rarely reported by rifampicin. Rifampicin is one of the first line drug in the treatment of tuberculosis and many patients are exposed to its potential adverse effects. We experienced a patient that had abdominal discomfort and hematochezia due to pseudomembranous colitis after receiving antituberculous medication, and which was probably caused by rifampicin. A 82 years old man was admitted with abdominal discomfort and hematochezia for one week. On the past history he had been diagnosed as endobronchial tuberculosis about 4 months ago. Colonoscopy revealed multiple discrete whitish mucosal lesion on rectosigmoid colon, and histologic findings were consistent with pseudomembranous colitis. The antituberculous agents were discontinued and vancomycin was administered. The patient's symptoms were resolved within several days. There was no recurrence after reinstitution of the antituberculous agents excluding rifampicin. We report here on a case of pseudomembranous colitis probably due to rifampicin.

AC8A-T6 알루미늄 合金材의 切削加工 特性에 關한 硏究

최현민,김경우,김우순,김용환,김동현,채왕석 한국공작기계학회 2002 한국공작기계학회 추계학술대회논문집 Vol.2002 No.-

In this study, examined the cutting characteristics of alumuminum alloy AC8A-T6 that is used to present car piston materials. And in been holding materials machining empirically escape as result that experiment comparison changing the cutting speed and feed on various condition to choose efficient machining condition. The following results can be summarized from this research. 1.As the cutting speed decreased, principal cutting force and thrust cutting force is increased, and reason that cutting force interacts greatly in the low cutting speed is thought by result by BUE's stabilization. 2.The feed speed and cutting speed increase, friction factor is decrescent and the cause appeared the thrust cutting force is fallen than cutting force relatively because chip flow according to increase of the feed rate is constraint. 3.Though specific cutting resistance grows cutting area and the feed rate are few, the cause was expose that shear angle decreases by rake face of tool gets into negative angle remarkably as wear of a cutting tool or defect part of workpiece is cut. 4.Cutting speed do greatly depth of cut is slow, surface roughness examined closely through an experiment that becomes bad, and know that it can get good surface that process cutting speed because do feed rate by 0.1㎜/rev low more than 250m/min to get good surface roughness can.

백서의 우울모형에서의 칼슘통로 길항제 에타베린(Ethaverine)의 항우울효과

이상경,김선희,김록우,윤성환,김용관,김경태,김영훈 대한신경정신의학회 2000 신경정신의학 Vol.39 No.2

연구목적: 본 전임상연구에서는 우울증의 두가지 동물모형을 통해 에타베린이 단독 혹은 이미프라민과 병용처치 되었을 때의 효과를 알아보고자 하였다. 방법: 표준화된 검사법인 강제수영검사를 사용하여 옹성백서에게 에타베린(20mg/kg) 및 이미프라민 (20mg/kg)을 단독 혹은 병용 처치하였을 때의 부동시간의 변화를 관찰하였고, 경도의 만성 스트레스를 3주간 가한 후 4주간 에타베린과 이미프라민을 단독 혹은 병용 처치하였을때의 자당섭취량의 변화를 관찰하였다. 결과: 약물을 1회 단기처치 및 7일간 장기처치한 강제수영검사에서 이미프라민 및 에타베린 단독처치는 대조군에 비하여 부동시간의 단축을 보였고 에타베린은 이미프라민의 부동시간 감소에 대한 증강작용을보였다. 경도의 만성스트레스 실험에서도 3주간의 스트레스로 인하여 감소된 백서의 자당섭취량을 이미 프라민 및 에타베린이 회복시켰으며, 치료초기에 두 약물의 병용처치효과가 두드러졌다. 결론: 본 연구의 결과는 에타베린이 향우울 효과를 가지고 있음을 시사하며, 삼환계 항우울제인 이미프라민의 항우울효과를 증강시키므로 에타베린의 임상적 활용 가능성을 보여준다. Objectives: This pre-clinical study was performed to assess the effects of ethaverine in the two kinds of behavioral models of depression in rats. Methods: We observed the changes of the immobility time in the froced swimming test and the quantity of sucrose consumed in the chronic mild stress model, using ethaverine(20mg/kg) alone, imipramine(20mg/kg) alone, or ethaverine and imipramine concomitantly. Results: In the forced swimming test, both single treatment and chronic treatment(for 7days) with imipramine or ethaverine significantly reduced the immobility time, and concomitant chronic treatment with ethaverine potentiated the effect of imipramine. In the chronic mild stress model, both imipramine and ethaverine reversed the decreased sucrose consumption induced by 3-week stress and concomitantly treated ethaverine potentiated the effect of imi-pramine in the early phase of treatment. Conclusions: The data suggest that ethaverine can be used alone or concomitantly with other antidepressants in the clinical situation.

엔로플록사신 액제의 닭유래 병원세균에 대한 시험관내 항균효과 시험

윤효인,박병권,조준형,정상희,박경환,장범수,김종춘,황윤환,임종환,이내경,박승춘 충남대학교 수의과대학 동물의과학연구소 2000 動物醫科學硏究誌 Vol.8 No.-

In this study the antimicrobial spectrum and sensitivity of a liquid formulation of enrofloxacin against the major six pathogenic bacteria isolated from the diseased poultry in Korea were evaluated in comparison with ciprfloxacin (CFX), gentamicin (GM) and penicillin (PC). A liquid form of enrofloxacin, a test material and ciprofloxacin showed at least 83% antibacterial activity against all of six test pathogenic microorganisms at the fixed concentration of 10 ㎍/㎖. Gentamicin and penicillin revealed much lower antibacterial activity at the same condition. We evaluated the liquid form of enrofloxacin as having widespread antibacterial spectrum against poultry infections. The liquid form of enrofloxacin showed potent antibacterial activity, with the MIC range being 0.12∼2 ㎍/㎖ against Gram positives, 0.06∼2 ㎍/㎖ against Gram negatives and 0.5∼2 ㎍/㎖ against Mycoplasma spp. These values were equivalent to or somewhat higher than those of ciprofloxacin, but much lower than those of gentamicn and penicillin. This new liquid form of enrofloxacin would find its way in application of mixing with drinking water for the prevention and treatment of diverse infections in chickens.

엔로플록사신 액제의 닭 호흡기 및 소화기 감염증에 대한 예방 및 치료효과

윤효인,박병권,조준형,정상희,박경환,장범수,김종춘,황윤환,임종환,이내경,박승춘 충남대학교 수의과대학 동물의과학연구소 2000 動物醫科學硏究誌 Vol.8 No.-

We evaluated the efficacy of the liquid form of enrofloxacin against poultry respiratory and digestive infections, the major problems in the poultry industry, from diverse diagnosis viewpoints. Results obtained through this study were as follows: 1. The liquid form of enrofloxacin showed good acceptability to poultry owing to no abhorrence to the drug by chickens, which indicated its suitability for mixing in drinking water. 2. The application of the enrofloxacin formulation improved the productivity of the chicken farm to a great extent by lowering the death toll of chicken raised in the farm. 3. The use of the drug shortened the days to the market, and increased the body weight at the time of marketing. 4. Preventive and therapeutic effects of the liquid enrofloxacin were observed higher than ampicillin, a major antibiotic used in poultry farming. From above results, the liquid form of enrofloxacin would find its use for the prevention and treatment of digestive and respiratory infections, let alone the growth promotion and feed efficiency, especially in the chicken farming practice.

활성탄상의 heptafluoropropane 합성에서 반응온도의 효과

김재덕,이윤우,임종성,이경환,이윤용 社團法人 韓國火災 ·消防學會 1998 한국화재소방학회논문지 Vol.12 No.1

南韓의 農地改革에 關한 硏究

김지영,송경환 順天大學校 農業科學硏究所 1992 農業科學硏究 Vol.6 No.-

Agrarian reform refers to programs designed to integrate the agricultural sector into the national economy. To discuss agrarian reform in the Republic of Korea, it is necessary to start with the period of japanese occupation. By 1938, 80 percent of the Korean farmers were tenats of the Japanese. Under the tenancy ststem, as much as 50 percent of the crop was paid in rent. At the time of Liberation in 1945, the land tenure relationships were one of high tenancy and large menbers of landlords, reminiscent of a semi-fuedalistic land tenure system. The government finally promulgated the farmland Reform Law(Law No.31) on June 21, 1949. However, implementation was delayed another year due to lack of funds. Thus, on March 10, 1950, the bill was promulgated as Law No, 108 and legislation for farmland reform was completed. As a result of the land tenure reform, 69.5% of all farm famillies were full owner-operators and the balance who lease some land farm only about 7% of the total farm land in "illegal" tenancy. But land and labor productivity have reached considerably higher levels than that which existed prior to land tenure reform. And it appears that the tenure system has facilitated the rational use of resources and thus contributed significantly to the recent rapid growth of the economy.

Classical Swine Fever (Hog cholera) Virus 약독순화주 (Suri 주)의 gp55 Gene 염기서열 분석

김귀현,장경수,강경임,이병형,박종현,안수환,전무형 충남대학교 생물공학연구소 1999 생물공학연구지 Vol.7 No.-

An attenuated classical swine fever virus (CSFV), Suri strain, is a variant derived from a vaccine virus, LOM strain. This study was performed to elucidate the molecular biologcal properties of CSFV Suri strain, and to obtain the basic data for molecular epidemiological approaches for the disease. The truncated form of gp55 gene without the C-terminal trasmembrane domain, in size of 1,023bp, was amplified by RT-PCR and sequenced by dye terminator cyclic sequencing method, and inserted into BamHI site of pAcGP67B baculovirus vector, establishing a cloned pAcHEG plasmid. By the nucleotide sequences determined, 341 amino acid sequences were predicted. As compard the nucleotide and amino acid sequences of gp55 of Suri with the various CSFV, Suri strain showed the high homology over 99.1% with ALD and LOM strains, but comparably the lower homology with Alfort and Brescia. In comparison of amino acid sequence in variable domain of gp55 protein, the similar tendency of homology was observed. In hydrophobicity analysis, all of four CSFV strains revealed the analogous patterns of hydrophobicity. The numbers and locations of N-glycosylation site and cysteine residuse in gp55 were analyzed, those of Suri strain being coincident with ALD and LOM strains. The results suggest that gp55 in Suri strain has the high similarity to those in ALD and LOM strains in terms of the nucleotide and amino acid sequences and the functional properties of gp55 protein.

樹木園 造成地域內 地존作業을 위한 아까시나무 除去試驗

金景河,辛俊煥,李峻雨,兪鐘德,禹保命 서울大學校 農科大學 1985 서울대농학연구지 Vol.10 No.2

This experiment was conducted at the Seoul National University Arboretum at Seodun-dong, Suweon, Kyeonggi-do, Korea (1) to find out methods killing Robinia pseudoacacia L. effectively and (2) to minimize ecological and aesthetic problems. Glycine and 2, 4-D were treated in several concentration following the saw-scratching and cutting of stems on July 22 and 29, 1985. The results were measured on October 17, 1885. The results obtained were as follows: 1. Ecological problems were decreased by these methods. 2. In case of herbicides treatment on section area, aesthetic problems were minimized, and amounts of herbicide consumption were five times as little as in case of spraying plants with herbicides. 3. The death rate amounted to 100% when the ratio of Glycine solution to water was 1:3, so that the concentration, 1:3 was most economical to kill the tree throughly. 4. The death rate amounted to 100% when the ratio of Glycine solution mixed with 2, 4-D to water was 1:4, therefore Glycine solution mixed with 2, 4-D was more effective than pure Glycine solution. Since 2, 4-D solution was less expensive than Glycine solution and only small amounts of 2, 4-D solution was added, it was most economical and effective method that Glycine solution mixed with 2, 4-D was diluted to the concentration, 1:4 and treated on the stem.

제올라이트 촉매에서 m-디이소프로필벤젠의 분해반응

김도일,정경환,김종호,서곤 전남대학교 촉매연구소 2001 觸媒硏究 論文集 Vol.22 No.-

Dealkylation of m-diisopropylbenzene (m-DIPB) was studied on various zeolite catalysts which have different pore structures. The very low dealkylation activity was observed on MFI zeolite because of its small pore size. The m-DIPB low conversions of MOR and FAU zeolites were due to severe deactivation of the catalysts by carbon deposites. On the other hand, the high conversion and the low deactivation in the m-DIPB dealkylation were observed on BEA zeolite with bent pores and MWW zeolite with pillow-type pores. In particular, the MWW zeolite shows a very high conversion, because the polymerization of m-DIPB resulting to carbon deposites is suppressed by sharing one m-DIPB molecule per unit pore. The high selectivity for benzene on MWW zeolite is explained by long retention time of reaction intermediate inducing consecutive dealkylation.