기후변화 대응 수단

김종춘 한국자동차공학회 2011 오토저널 Vol.33 No.7

Evalution of Anti-diarrheal Activity of Bamboo Charcoal in Rats

김종춘,양영수,Bo-Kyoung Park,김성호,신동호,박승춘 한국실험동물학회 2006 Laboratory Animal Research Vol.22 No.1

자동차 연료품질에 따른 배출가스 예측연구

김종춘,김지영,김정수,이종태,박용희 한국자동차공학회 2013 한국자동차공학회 학술대회 및 전시회 Vol.2013 No.11

수컷랫드에 있어서 새로운 안트라사이클린계 항암제 DA-125의 생식독성 연구

김종춘,김갑호,신호철,정문구 한국독성학회 1998 Toxicological Research Vol.14 No.2

The toxicity of DA-125. a new anthracycline anticancer agent, on the male reproductive system was studied in Sprague-Dawley rats. Forty male rats were rando$m\ell$y assigned to Jour groups with ten rats in each group and given single intraveneous doses of DA-125 at dose levels of 0. 12.5. 25. and 50 mg/kg body weight. On day 56 after treatment the animals were allowed to mate. and their male reproductive Junctions and organs were examined in detail. Copulated females were sacrificed on day 20 of gestation for examination of embryo-fetal development. One out of ten rats in the 50 mg/kg group died on day 12 after treatment. Clinical signs such as emaciation. sedation, anorexia. swelling. dark material around eye. alopecia. and diarrhea were observed in the 25 and/or 50 mg/kg groups. Reduction in the body weight gain. decrease in the absolute weights of testes. epididymis and seminal vesicles. and/or decrease in the number of testicular sperm heads were also found. Although histopathological changes such as atrophy of seminiferous tubules. loss or decrease of spermatogenic cells. exfoliation of spermatogenic cells. vacuolization of Sertoli cells. decrease of sperm. and/or increase of necrotic spermatogenic cells in epididymal ducts were observed. no adverse effects on the motility and morphology of epididymal sperm. copulation index. fertility index. and embryo-fetal development were detected in the 25 and 50 mg/kg groups. There were no evidences of male reproductive toxicity in the 12.5 mg/kg group. These results show that single intravenouse doses of DA-125 produce significant dose-related testicular atrophy. histopathological changes. and oligozoospermia in rats and $LD_{10}$ for DA-125 appears to be 50 mg/kg body weight.

Anti-inflammatory Effects of Pinitol (3-O-methyl-chiro-inositol) in Rats

김종춘,이상민,박소양,신동호,김성호,신용철 한국실험동물학회 2006 Laboratory Animal Research Vol.22 No.1

This study evaluated the anti-inflammatory effect of a natural compound, pinitol (3-O-methyl-chiro-inositol) against acute or subacute inflammation in rats. The single oral administration of pinitol at 5 and 20 ㎎/㎏ showed a significant inhibition of paw edema in a dose-dependent manner. Although no statistically significant difference was noted, the 7-day administration of pinitol at 5 and 20 ㎎/㎏ also showed a tendency to decrease the weights of granuloma formed by cotten pellet implantation. It was concluded that pinitol has an anti-inflammatory effect on acute and subacute inflammation. These results suggest that a pinitol can be developed as an anti-inflammatory drug or a functional food to prevent or attenuate various types of inflammation-related diseases.

랫드에 있어서 배양배자에 대한 Phenytoin의 최기형성 효과

김종춘,임광현,정문구,노정구,Kim, Jong-Choon,Lim, Kwang-Hyeon,Chung, Moon-Koo,Roh, Jung-Koo 한국독성학회 1998 Toxicological Research Vol.14 No.3

The teratogenic potential of the anticonvulsant drug phenytoin (PHT) has been well documented both in the human and in the experimental animals. However there are few reports on the effects of PHT on embryonic development in rats in vitro. The present study was performed to evaluate the teratogenic effects of PHT using whole-embryo culture system in rats. Sprague-Dawley rat embryos were explanted on gestational day (GD) 9.5 and cultured for 48 hrs in the immediately centrifuged and heat-inactivated rat serum containing 0,25,50, or $100{\mu}g$ PHT/mL. At the end of culture period the embryos were scored for morphological development according to the procedure of Van Maele-Fabry, and their total protein contents were determined. At 100 ${\mu}$g/mL of culture medium. PHT caused significant reduction in developmental score and protein content of embryos and a high incidence morphological abnormalities (100%). Characteristic malformations included altered yolk and embryonic circulation, craniofacial hypoplasia, neural tube schisis, branchial arch defects, abnormal ratation, and limb bud hypoplasia, among others. There were no adverse effects on embryonic growth and development at concentrations of 25 and 50 ${\mu}$g /mL of culture medium. The results indicated that the dysmorphogenic effect of PHT on cultured embryos is due to a direct interference with embryonic development.

경유 중 PAHs의 함량에 따른 자동차 배출가스 특성

김종춘,서충열,임윤성,임철수,이종태,윤창완,이상일,황춘식,김상규,김홍규 한국대기환경학회 2007 한국대기환경학회 학술대회논문집 Vol.- No.-

랫드에서 비스페놀 A의 발생독성에 대한 고려홍삼 물추출물의 효과

김종춘,임광현,서정은,위재준,남기열,정문구 한국독성학회 2001 Toxicological Research Vol.17 No.3

The present study was conducted to investigate the effects of Korean red ginseng water extract (KRGWE) on developmental toxicity caused by the environmental estrogen bisphenol A (BPA) in Sprague-Dawley rats. Fifty females successfully mated were randomly assigned to five experimental groups, i.e., group Ⅰ (vehicle control), group Ⅱ (BPA 1000mg/kg), group Ⅲ (KRGWE 400 mg/kg), group Ⅳ (BPA 1000mg/kg & KRGWE 200mg/kg), and group Ⅴ (BPA 1000mg/kg & KRGWE 400mg/kg). The test articles were administered by gavage to mated females from gestational days (GD) 1 through 20 (sperm vaginal lavage = day 0). All females were subjected to caesarean section on GD 21 and their fetuses were examined for external, visceral, and skeletal abnormalities. In the group Ⅱ, significant maternal toxic effects including suppressed body weight, decreased body weight gain during pregnancy, and reduced food consumption were observed in pregnant rats. The minimal developmental toxicity including fetal ossification delay was also found in fetuses. In addition, a tendency for increased pregnancy failure, increased pre- and postimplantation loss, and decreased fetal body weight was observed. However, no fetal morphological abnormalities were seen in surviving fetuses at a dose level of 1000mg BPA/kg. On the other hand, the maternal toxicity and developmental toxicity found in the groups Ⅳ and Ⅴ were comparable to those of the group Ⅱ. There were no adverse signs of either maternal toxicity or developmental toxicity in the group Ⅲ. These results showed that administration of BPA at a dose level of 1000mg/kg to pregnant rats resulted in significant maternal toxicity and minimal developmental toxicity, and that no protective effects on BPA-induced maternal toxicity and developmental toxicity were found by concomitant gavage dosing of KRGWE.

陶磁器의 時代的 變遷과 象形性 意味에 관한 考察

김종춘 京畿大學校 經營大學院 1992 最高經營者課程 經營硏究 Vol.4 No.-

Spatial and Temporal Distribution of Macrobenthos in Intertidal Hard Bottoms in Dokdo Island

김종춘,박강욱,유경동,정성용 한국환경생태학회 2015 한국환경생태학회지 Vol.29 No.2

This study was carried out to measure seasonal changes in the community structure and species composition of marobenthos in the intertidal area of Dokdo. The macrobenthos identified during this study was comprised of 36 species: predominately 25 species of mollusks(69.4 %), 6 species of arthropods(16.7 %), 3 species of echinodermata(8.3 %) and 1 species of cnidaria (5.6 %). The number of marobenthos species ranged from 27 in Spring to 33 in Autumn. In terms of the top 10 dominant species, there were 7 species of mollusks and 3 species of arthropods in the this study. After analyzing the bray-curtis similarity, it was divided into two large groups(A, B). Such group classification matched the SIMPROF(Similarity Profile Analysis) and the one-way ANOSIM(Analysis of similarities) analysis.