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RISS 활용도 분석
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일본/중국/유럽자료
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최신/인기 학술자료
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해외논문구매대행(E-DDS)
http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
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RISS 인기검색어
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- 저자 : 김종춘 (검색결과 439 건)
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Anti-inflammatory Effects of Pinitol (3-O-methyl-chiro-inositol) in Rats
김종춘,이상민,박소양,신동호,김성호,신용철 한국실험동물학회 2006 Laboratory Animal Research Vol.22 No.1
This study evaluated the anti-inflammatory effect of a natural compound, pinitol (3-O-methyl-chiro-inositol) against acute or subacute inflammation in rats. The single oral administration of pinitol at 5 and 20 ㎎/㎏ showed a significant inhibition of paw edema in a dose-dependent manner. Although no statistically significant difference was noted, the 7-day administration of pinitol at 5 and 20 ㎎/㎏ also showed a tendency to decrease the weights of granuloma formed by cotten pellet implantation. It was concluded that pinitol has an anti-inflammatory effect on acute and subacute inflammation. These results suggest that a pinitol can be developed as an anti-inflammatory drug or a functional food to prevent or attenuate various types of inflammation-related diseases.
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새로운 반합성 Rifamycin 유도체 KTC-1의 랫트 주산기 및 수유기 시험
김종춘,정문구,한상섭,노정구 한국독성학회 1995 Toxicological Research Vol.11 No.1
A perinatal and postnatal study of KTC-1, a new semisyntheitic rifamycin antituberculous drug, was conducted in Sprague-Dawley rats. Dosages of KTC-1 0, 12, 27.6, and 63.5 mg/kg/day were administered to dams orally by gavage from day 17 of gestation to day 21 of lactation. All pregnant rats were allowed to deliver naturally for postnatal examination of their offspring. At 63.5 mg/kg/day, weakness, dark-red discharge around eyes, a loss in body weight, and a decrease in food and water consumption were observed in dams. An increase in the weight of adrenal gland and spleen, and a decrease in the weight of kidney and heart were also found. An increase in neonatal deaths during the lactation period, a loss in body weight, a delay in physical development, a decrease in traction ability, an increase in the number of errors and the time required for the multiple T-maze trial were found in F1 offspring. In addition, an increase in the incidence of visceral variations and retarded ossification were observed in F1 4 day old rats. An increase in the incience of skeletal anomalies was seen in F2 fetuses. There were no sings of maternal toxicity or embryotoxicity at 12 and 27.6 mg/kg/day. From the results mentioned above, it can be concluded that the no-effect dose levels(NOELs)for dams, F1 offspring, and F2 fetuses are 27.6 mg/kg/day.
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새로운 반합성 Rifamucin 유도체 KTC-1의 랫트 수태능력 시험
김종춘,정문구,노정구 한국독성학회 1996 Toxicological Research Vol.12 No.1
The effect of KTC-1, a new semisynthetic rifamycin antituberculous drug, on general toxicity, reproductive capability and fetal development was investigated in Sprague-Dawley rats. Male rats were administered KTC-1 with mashed feed from 63 days before mating to the end of mating period, and female rats were given from 14 days before mating to day 7 of gestation at dose levels of 0, 375, 750, and 1,500 ppm. The females were sacrificed on day 21 of gestation for examination of their fetuses. At 1,500 ppm, a reduction in body weight gain and testis atrophy were observed in male rats. Histological examination revealed testicular atrophy, absence or decrease of germinal cells, and vacuolization of Sertoli cells in testis. A reduction in body weight gain, a decrease in food consumption were found in female rats. In addition, decreases in the number of corpora lutea, iraplantations, and the litter size of live fetuses were seen. Mating, fertility, and pregnancy performances were also affected. There were no external abnormalities observed by examination of fetuses. At 750 ppm, a reduction in the body weight gain of male and female rats and decreases in the number of implantations and litter size were found. At 375 ppm, no treatment-related effects were observed. The results suggest that the no-effect dose levels (NOELs) of KTC-1 are 375 ppm for males and females on general toxicity, 750 ppm for males and females on reproductive capability, and 375 ppm for fetuses on embryonic development.
