성인의 급성 설사에 대한 로페라미드 옥사이드의 효과: 위약과의 무작위 이중 맹검 비교 다시설 시험

박영태,정희진,박중원,이계희,김나영,임선희,윤병철,한동수,이오영 大韓消化器病學會 1998 大韓消化器病學會誌 Vol.31 No.5

40세 이하 관상동맥 질환자에서 장기적 임상 관찰

이승욱,정명호,박종철,박형욱,조상희,김원,김계훈,이상현,강경태,조장현,김남호,김건형,안영근,조정관,박종춘,강정채 全南大醫大 2001 전남의대학술지 Vol.37 No.2

동ㆍ서양인의 의식구조와 수학의 인지적 태도

계영희 고신대학교 자연과학연구소 2006 고신대학교 자연과학연구소 논문집 Vol.13 No.-

이 논문에서는 동양인과 서양인의 의식구조의 차이점과 그 이유 등을 인지심리학적 입장에서 실험한 리처드 니스벳 교수의 저서 〈생각의 지도〉를 소개한 후에,이 결과를 토대로 PISA의 결과에서 특히,수학과목의 성취도에 있어서 우리나라 학생들과 OECD 국가 중 미국 학생들과 인지적 태도에서 어떤 차이를 보이는지 비교하였다. In this paper, we introduced that the differences and reasons about oriental and western consciousness structure by borrowing from Dr. Richard E. Nisbett who is a professor of Michigan University of USA, a writer of <The Geography of Thought>. And then, according to PISA results, we compared Korean students' attitude with that of American students' for recognizant attitude in mathematics accomplishments.

영도지역의 컴퓨터 환경과 활용에 관한 연구

계영희 고신대학교 영도발전연구소 2000 영도연구 Vol.2 No.-

The purpose of this study is to investigate computer environments and residents' ability of using Internet in Youngdo-Gu(District), Busan. In this study, the survey was conducted by questionnaire from 210 residents in Youngdo-Gu (District). The answers to the questionnaire were analyzed on the time of computer used, the necessity of computer education, the ability of using Internet in each age group of 20's, 30's, and 40's. The results showed that there were significant differences among age groups between male and female. Further results were discussed in detail.

일측성 질폐쇄 및 동측 신장 무발생을 동반한 중복자궁 2예

윤일영,여소진,김형문,김정식,김태희,이해혁,남계현,이권해,김준모,김민의 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Uterus didelphys with unilateral obstructed hemivagina and ipsilateral renal agenesis usually presents after menarch with progressive abdominal pain during menses secondary to hematocolpos, and indeed a very rare congenital anomaly due to Mullerian duct malformation. An accurate and prompt diagnosis is of importance to permit treatment and to assure the future fertility of the patient. Pelvic ultrasound, physical examination and pelvic MRI established a diagnosis of hematometracolpos secondary to uterus didelphys with unilateral imperforate hemivagina. An incision in the vaginal septum allowed drainage of the hematocolpos, providing relief of the patients symptoms. We report two case of uterus didelphys with obstructed hemivagina with brief review of the literature.

Paclitaxel 및 Apo-2L/TRAIL이 자궁경부암 세포주 아포토시스에 미치는 영향

김주영,남계현,김태희,이권해,이해혁,배동한 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.2

Objective: TRAIL(also called Apo-2L) is a member of the tumor necrosis factor(TNF) family of cytokines which induces apoptosis cell death in a variety of tumor cell lines. It mediates its apoptotic effects through one of two receptors, DR4 and DR5, which are members of the TNF receptor family, and whose cytoplasmic regions contain death domains. TNF and Fas ligand induces apoptosis in tumor cells; however, their severe toxicity toward normal tissues hampers their application to cancer therapy. We examed if paclitaxed and/or Apo-2LTRAIL induces apoptosis of cervical cancer HeLa, SiHa, ME-180, and CaSki cells. Mehods : We have demonstrated that paclitaxel and Apo-2L/TRAIL induces apoptosis of cervical cancer HeLa, SiHa, CaSki and ME-180 cell lines in a dose-dependent manner. HeLa, SiHa, ME-180 and CaSki were obtained from American Type Culture Colection. Recombinant Human TRAIL(Chmicon). DR4 and DR5 were purchased from Santa Cruz. Paclitaxel, MTT assay Kit, Acridine orange and Ethium bormide were purchased from Sigma. HeLa and SiHa were grown in DMEM. ME-180 and CaSki were grown in RPMI. Tripan blue stain and MTT assay were done for cytotoxicity. Annexin V-FITC and PI(propidium iodide) flowcytometry for apoptosis assay. DR4 and DR% were expressed by Western Blot. Fluorescent Microscopy used Acridine orange(AO) and Ethium bromide(EB). Results : Importantly, concurrent treatment of cervical cancer cells with paclitaxed and Apo-2L/TRAIL induces significantly more apoptosis than Apo-2L/TRAIL alone. Conclusion : We need further studies which reveals possible therapeutic potential in the women with cervical cancer by suing Apo-2L/TRAIL.

나비目 終齡幼蟲의 血球에 關한 電顯的 硏究

梁凞永,李鳳熙,鄭啓憲 순천향의과대학 1979 Journal of Soonchunhyang Medical Science Vol.2 No.1

Morphological studies on larval hemocytes of varioius insects were performed in two ways of research. Ⅰ. Finestructures. An electron microscopical study on hemocytes of last instar larvae of 12 species of Lepidoptera was performed to observe cell types, structrues, raions, relationships and their origins. The results are as follows; 1) Prohemocytes are the smallest round cells with large numlesus, poorly developed cytoplasmic organelles and lower composition ratio, accounting for less than 5% of all cell types. Little remarked differences were revealed among prohemocytes of varous insects and they are thought to be the origins of other cell types. 2) Palsmatocytes are relatively large cells with higher composition ration, accounting for about 40%. They could be subdivided into two forms, oval and spindle. Oval cells are rich in cytoplasmic projections and organelles. But the spindle cells include few of them, while nearly all of the spindle cells possess some microtubules as their cytoskeletons. Some marked difference were revealed among different insects. The most exceptional structure was the fibrous bundles located in both nucleus and cytoplasm in Sericinus telamon Donovan. 3) Granular cells are characterized by various granules in cytoplasm, and by higher composition ration, accounting for about 50% of all numbers. They could be subdivided into three forms, oval, round and spindle with fully developed cytoplasmic organelles and Projections. Cellular fractions were often noticed to be enclosed by granular cells, indicating some activities of phagocytosis. Granular cells are the most pleomo rphous of all cell types, and the most exceptional structures are the bundles of microfibrils in Phalerodonta manleyi Leech. 4) Adipohemocyte were found only in Plodia interpunctella Hubner. They are somewhat oval with few cytoplamic projections and less developed organelles. Some granular cells were found to accumulate lipid droplets into the cytoplasm by trapping floating lipid droplets, adn the adipohemocytes are believed to be originated from formers. 5) Sperule cells were found nearly in all specimens and characterized by sperules composed of flocculent materials. They are round or oval with few cytoplasmic organelles. The most conspicuous spherulesof all sperule cells were radial arrangement of sperules in Adristyrannus amurensis Staudinger and presence of the specific granules in Mamestra illoba Butler. Young sperule cells resembled the granular cells and it is possible that they originate from granular cells. 6) Oenocytoids are large cells and were found nearly in all specimens. They could be subdivided into 3 types according to their inclusions, such as microfibrils, microtubules and none of them. Young Oenocytoids resemble the giant plasmatocytes, perhaps in dicating to be originated from the latters. Ⅱ. Composition ratios of cell types from mid 5-instar to late prepupa. Composition ratios of cell types were investigated in phalerodonta manley; Leech and could be summarized as follows; 1) Prohemocytes disappeared from the stage of early prepupa. 2) Plasmatocytes increased in number at mid stages of each inster and decreased nearing to pupal stage. 3) Granular cells reached peak at early prepupal stage. 4) Adipohemocytes heavily increased at late prepupal stage. 5) Sperule cells increased at late stage of each instar and reached peak at late prepupal stage. 6) Oenocytoids increased at late stage of each instar and reached peak at early prepupal stage.

삼부이론을 적용한 창의적 사고 배양 수업안의 개발 : 지구과학 분야를 중심으로 Especially for High School Earth Science Education

최임조,임영구,강용희,유계화 慶北大學校 科學敎育硏究所 2003 科學敎育硏究誌 Vol.27 No.-

The enrichment triad model(Renzulli, 1977) which was originally developed for teaching and learning of gifted and talented children consists of three types of enrichment activities. Type Ⅰ enrichment activities build knowledge for later use in 'gifted behaviors', and type Ⅱ enrichment activities focus on the 'how-to skills,' attitudes and values the student must develop to become and effective investigator, problem solver and producer. Type Ⅲ enrichment activities, the pursuit of real problems and realization of gifted behavior, are the fundamental goal for this model. In this study we developed enrichment activities for high school earth science class. We could summarize enrichment activities as follows: In studying the fossil section, after reporting their research activities on fossil data, students can understand the fossil theory through questioning and answering their homeworks. They can enhance their interest and curiosity by watching the movie 'Jurassic Part'(type Ⅰ enrichment activities). After making replica of fossil samples(type Ⅱ), they can write their research reports or articles concerning fossils(type Ⅲ). Students can extend their knowledge about fossils through these types of enrichment activities. In studying weather map section, after collecting newspaper clippings or searching internet, students present their knowledge about weather and weather maps(type Ⅰ enrichment activities). Learning how to make weather maps and investigating how to analyze them, student can extend their knowledge(type Ⅱ). Through these activities, students can apply their knowledge to everyday life experience(type Ⅲ). The third program is 'igneous rock' section. Students investigate the fossil formation in Korea(type Ⅰ enrichment activities). They can understand the principle of volcanic activities through experiment of volcano eruption model type Ⅱ. Through drawing pictures, writing assignment of experiment activities and playing the role play of igneous rocks, teachers can help students to acquire cause or interest to study the igneous rocks(type Ⅲ). In conclusion, within a classroom instruction teachers would be utilizing all three types of activities, moving from one to the other as class, and individual needs, demand. By selecting what students want to do and making them to produce results of their activities, we are expecting that teachers can cultivate creative thinking and enhance problem solving ability of students.

진균 세포벽 형성 저해물질 생성 Streptomyces속 세균의 분리 및 수리동정

서원나,박정희,이지영,김인섭,이계준,배무 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.1

본 연구의 목적은 진균의 세포벽 합성을 저해하는 항진균 물질생성 방선균을 개발하는 데 있다. 다양한 환경으로부터 채취한 토양 시료로부터 방선균 선택 배지를 이용하여 860여 방선균을 선택적으로 분리하였다. 분리 균주 중 Penicillium cyclopium, Cryptococcus laurentii, Aspergillus flavus에 특이적 항균 활성 물질을 생산하는 균주 EMS4, EMP22, L234를 각각 선별하였다. 화학적 동정과 형태학적 동정을 통해 분리 균주들이 Streptomyces속 세균임을 알 수 있었다. 총 50개의 주군집, 34개의 부군집 형질을 분석하고, 이 실험 결과를 TAXON program에 적용하여 종의 수리동정을 실시하였다. 그 결과 분리균 EMS4는 Streptomyces의 제 61 주군집에 속하는 Streptomyces lavendulae의 한 균주로 동정되었고, EMP22는 제 1B 주군집에 속하는 S. willmorei의 한 균주로 동정되었으며, L234는 제 3 부군집의 S. aburaviensis의 한 균주로 동정되었다. The aim of the present research program wa to identify and develop stains of actinomycetes producing antifungal antibiotics which inhibit cell wall biosynthesis. 860 strains of Actionomycetes were isolated from various soil samples. Three isolates, EMS4, EMP22, and L234 were selected as the strains producing antifungal antibiotics inducing abnormal morphology against Penicillium cyclopium. Cryptococcus laurentii, and Aspergillus flavus, respectively. Taxonomic unit characters of the strains were tested and the data were analyzed numerically using TAXON program. EMS4, EMP22, and L234 were identified to be a member of Streptomyces lavendulae, Streptomyces willmorei, and Streptomyces aburaviensis, respectively.

진균 세포벽 형성 저해물질 생성 Streptomyces속 세균의 분리 및 수리동정

서원나,박정희,이지영,김인섭,이계준,배무 이화여자대학교 생명과학연구소 1996 생명과학연구논문집 Vol.7 No.-

본 연구의 목적은 진균의 세포벽 합성을 저해하는 항진균 물질생성 방선균을 개발하는 데 있다. 다양한 환경으로부터 재취한 토양 시료로부터 방선균 선택 배지를 이용하여 860여 방선균을 선택적으로 분리하였다. 분리 균주 중 Penicillum cyclopium, Cryptococcus laurentii, Aspergillus flavus에 특이적 항균 활성 물질을 생산하는 균주 EMS4, EMP22, L234를 각각 선별하였다. 화학적 동정과 형태학적 동정을 통해 분리 균주들이 Streptomyces속 세균임을 알 수 있었다. 총 50개의 주군집, 34개의 부군집 형질을 분석하고, 이 실험 결과를 TAXON program에 적용하여 종의 수리동정을 실시하였다. 그 결과 분리균 EMS4는 Streptomyces의 제 61 주군집에 속하는 Streptomyces lavendulae의 한 균주로 동정되었고, EMP22는 제 1B 주군집에 속하는 S. willmorei의 한 균주로 동정되었으며, L234는 제 3 부군집의 S. aburaviensis의 한 균주로 동정되었다. The aim of the present research program was to identify and develop strains of actinomycetes producing antifungal antibiotics which inhibit cell wall biosynthesis. 860 strains of Actinomycetes were isolated from various soil samples. Three isolates, EMS4, EMP22, and L234 were selected as the strains producing antifungal antibiotics inducing abnormal morphology against Penicillium cyclopium, Cryptococcus laurentii, and Aspergillus flavus, respectively. Taxonomic unit characters of the strains were tested and the data were analyzed numerically using TAXON program. EMS 4,EMP22, and L234 were identified to be a member of Streptomyces lavendulae, Streptomyces willmorei, and Streptomyces aburaviensis, respectively.