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Lee, Beom H.,Kim, Joo H.,Lee, Sun Y.,Jin, Hye Y.,Kim, Kwi‐,Joo,Lee, Jin‐,Joo,Park, Jung‐,Young,Kim, Gu‐,Hwan,Choi, Jin‐,Ho,Kim, Kyung M.,Yoo, Han‐,Wook Blackwell Publishing Ltd 2011 Liver International Vol.31 No.6
<P><B>Abstract</B></P><P><B>Introduction and aims: </B> Wide phenotypic and genotypic heterogeneities in Wilson's disease (WD) have been reported, hampering the study of their correlations. The goal of this study was to identify the factors related to these diversities.</P><P><B>Methods: </B> Clinical courses and molecular genetic characteristics were analysed in 237 unrelated Korean WD families. The average follow‐up period was 8.2 ± 5.8 years.</P><P><B>Results: </B> Presenting phenotypes were classified as H1 (12.2%), H2 (42.4%), N1 (21.6%), N2 (0.4%), NX (0.4%), presymptomatic (22.4%) and other (0.4%), modifying the guidelines by Ferenci and colleagues. Age at presentation was youngest and cirrhosis was rarest in the presymptomatic group. Decompensated cirrhosis was the highest in the H1 group. Favourable outcome was rarest in the N1 group. Forty‐seven (11 novel) <I>ATP7B</I> mutations were identified in 85% of the 474 alleles. Multiplex ligation‐dependent probe amplification assays in <I>ATP7B</I> and analyses of <I>ATOX1</I> and <I>COMMD1</I> genes identified no additional mutations. Yeast complementation assays demonstrated functional perturbation of the seven novel missense mutants. Five major mutations, p.Arg778Leu, p.Ala874Val, p.Asn1270Ser, p.Lys838SerfsX35 and p.Leu1083Phe, accounted for 63% of the alleles. H1 was more common, age at presentation was younger and N1+N2+NX tended to be less common in patients with nonsense, frame shifting or splicing mutations than in those with missense mutations alone. Patients with both mutations in the transduction (Td) or the ATP hinge domain showed presymptomatic or hepatic manifestations but no neurological manifestation.</P><P><B>Conclusions: </B> The presenting phenotype strongly affects the clinical outcome of WD, and is related to the <I>ATP7B</I> mutation type and location, providing an evidence for genotype–phenotype correlations in WD.</P>
레지오넬라 폐렴의 진단용 바이오마커의 발굴 : A/J 마우스 감염 모델에서 Legionella pneumophila의 독력 유전자들의 발현양상 분석
김승민,심희선,김희남,심호기,윤영경,김정연,박윤선,박대원,손장욱,김민자 대한감염학회 2010 감염과 화학요법 Vol.42 No.1
Background: Legionella pneumophila is the causative agent of Legionnaires’ disease, a severe form of pneumonia. After L. pneumophila is inhaled through contaminated aerosols, it is phagocytized by alveolar macrophages, multiplies in a specialized phagosome approximately 10 h postinfection, and eventually leads to the death of host cells. Currently available diagnostic tests for Legionella pneumonia have some limitations. This study was conducted to find diagnostic biomarkers for Legionella pneumonia using virulence gene expression profiling in a murine experimental model. Materials and Methods: A/J mice were intranasally inoculated with L. pneumophila serogroup 1, and lungs were harvested 4, 8, 24, and 48 h postinfection. The strain grown in buffered yeast extract broth was used as reference samples. Cy-dye labeled cDNA samples were prepared with total RNA from lungs or broth culture, and hybridized on the oligo-microarray slide containing 2,895 genes of L. pneumophila serogroup 1. Virulence gene expression patterns were analyzed using a MIDAS software from TIGR (www.tigr.org). Results: Among a total of 332 virulence genes examined, 17 genes including sidA, lepB, the genes related to flagella assembly (fliR and fliP), LPS lipid A biosynthesis, and the enhanced entry protein EnhA were up-regulated at all four time points. We further confirmed by quantitative real-time reverse transcription PCR that the expression of fliP gene was highly expressed in lung tissue as well as in bronchoalveolar lavage fluids from the mouse infected with L. pneumophila serogroup 1. Conclusions: Through gene expression analysis of L. pneumophila in a mouse model, several candidate biomarkers for diagnosing Legionnaires’ disease could be identified.
초등교사의 감정노동, 사회적 지지와 삶의 질 간의 관계
경예빈,김보민,김수정,노지현,송지윤,염소희,이현아,허유림,홍소연,차지영,박수민 이화여자대학교 간호과학대학 2017 이화간호학회지 Vol.- No.51
Purpose: The purpose of this study was to examine the correlation of emotional labor, social support, and quality of life among elementary school teacher. Methods: A correlational descriptive design was used with convenience sampling between July and December, 2016. The survey was self reported questionnaire administered to 130 elementary school teachers in the urban area. Data was statistically analyzed using t-test and one way ANOVA. Results: The average score of participants' emotional labor is 2.80, social support 3.89 and quality of life 3.65 of the total of 5. Emotional labor was negatively correlated to social support (r=-.178, p<.05) and quality of life(r=-.438, p<.001). Social support was positively correlated to quality of life (r=.336, p<.001). Conclusion: This study has significance as a basic data to understand the relation of emotional labor, social support, quality of life among elementary school teachers. Also, nursing interventions suitable for elementary school teachers should be developed to decrease the level of emotional labor, strengthen the social support, and enhance their quality of life.
New feasible quarantine disinfestation using ethyl formate for termites and ants on imported lumber
Kim Dong bin,Kim Kyung won,박민구,Roh Gwang Hyun,Cha Dong H.,Lee Byung ho 한국응용곤충학회 2021 Journal of Asia-Pacific Entomology Vol.24 No.4
The interception of exotic ants and termites from stone and lumber imported into Korea is on the rise, including Solenopsis invicta. Currently, a relatively long exposure (24 h) of methyl bromide (MB) fumigation is the only practical disinfestation option for exotic ants and termites on imported stone and lumber. In this study, ethyl formate (EF) wase evaluated as a potential MB alternative to disinfest ants and termites in imported lumber, with a focus on S. invicta. As S. invicta is not established in Korea, we first determined whether Reticulitermes speratus, established in Korea, could be considered as an EF surrogate of S. invicta. From 1 h EF fumigation trials, workers of S. invicta were more sensitive to EF than those of R. speratus based on lethal concentration × time causing 99% mortality (LCt 99% ), supporting that R. speratus can be used as an EF surrogate of S. invicta. When R. speratus workers were further fumigated with EF for 4 h at four different temperatures, LCt 99% values for R. speratus workers were 108.00, 63.31, 77.24, and 67.24 g h/m 3 at 2, 5, 13, and 23 ◦ C, respectively. From scale-up (0.65 m 3 ) and commercial scale (76.4 m 3 ) trials containing two infestation-prone lumber species, lauan (Shorea spp.) and acacia (Acacia spp.), 140 g/m 3 EF at >5 ◦ C for 4 h resulted in the complete control of R. speratus workers, suggesting that 140 g/m 3 4 h-EF-fumigation may be applicable as a potential MB-alternative treatment for disinfestation of invasive S. invicta on imported lumber.
Kim, Su Jae,Cha, Su Young,Kim, Ji Young,Shin, Jong Moon,Cho, Yong Chan,Lee, Seunghun,Kim, Won-Kyung,Jeong, Se-Young,Yang, Y. S.,Cho, Chae Ryong,Choi, H. W.,Jung, Myung-Hwa,Jun, Byeong-Eog,Kwon, Ki-Yon American Chemical Society 2012 The Journal of Physical Chemistry Part C Vol.116 No.22
<P>There have been many studies of ferromagnetism in ZnCoO, and the results have been controversial. Secondary phases, such as Co oxides and Co metal clusters, in ZnCoO are easily produced during treatment, but the formation conditions are not well understood. We fabricated samples under hydrogen-injection conditions at different heat-treatment temperatures and examined the conditions by using synchrotron X-ray analysis under which Co<SUB>3</SUB>O<SUB>4</SUB> appeared or was transformed into Co metal. We investigated the transforming process of the ferromagnetic origin from intrinsic to extrinsic nature via intermediate region competition by Co–H–Co and Co metal cluster and suggest conditions that induce ferromagnetic spin ordering in ZnCoO due to Co–H–Co complexes through hydrogen mediation.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2012/jpccck.2012.116.issue-22/jp300536w/production/images/medium/jp-2012-00536w_0010.gif'></P>
Song, Joon Young,Noh, Ji Yun,Lee, Jacob,Woo, Heung Jeong,Lee, Jin Soo,Wie, Seong-Heon,Kim, Young Keun,Jeong, Hye Won,Kim, Shin Woo,Lee, Sun Hee,Park, Kyung-Hwa,Kang, Seong Hui,Kee, Sae Yoon,Kim, Tae H KOREAN ACADEMY OF MEDICAL SCIENCE 2018 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.33 No.7
<P>Since 2013, the Hospital-based Influenza Morbidity and Mortality (HIMM) surveillance system began a H7N9 influenza surveillance scheme for returning travelers in addition to pre-existing emergency room (ER)-based influenza-like illness (ILI) surveillance and severe acute respiratory infection (SARI) surveillance. Although limited to eastern China, avian A/H7N9 influenza virus is considered to have the highest pandemic potential among currently circulating influenza viruses. During the study period between October 1st, 2013 and April 30th, 2016, 11 cases presented with ILI within seven days of travel return. These patients visited China, Hong Kong, or neighboring Southeast Asian countries, but none of them visited a livestock market. Seasonal influenza virus (54.5%, 6 among 11) was the most common cause of ILI among returning travelers, and avian A/H7N9 influenza virus was not detected during the study period.</P>
Increased cell-free DNA concentrations in patients with obstructive sleep apnea
Shin, Chol,Kim, Jin K.,Kim, Je H.,Jung, Ki H.,Cho, Kyung J.,Lee, Chang K.,Lee, Seung G. Blackwell Publishing Asia 2008 PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol.62 No.6
<P>Aim: </P><P>Blood concentrations of cell-free DNA, which is considered to be released during apoptosis, are elevated under some pathological conditions such as cardiovascular disease and cancer. The association between obstructive sleep apnea (OSA) and cell-free DNA concentrations has not been reported so far. The purpose of the present study was to examine the association between OSA and plasma DNA concentrations.</P><P>Methods: </P><P>A case–control study was conducted using a total of 164 men aged 39–67 years, who were free of coronary heart disease and cancer. Laboratory-based overnight polysomnography was performed for all participants.</P><P>Results: </P><P>On the basis of polysomnography, patients with an apnea–hypopnea index (AHI) = 5–30 events/h were defined as having mild–moderate OSA (<I>n</I> = 33) and those with >30 events/h were defined as having severe OSA (<I>n</I> = 49). All 82 controls had AHI < 5 events/h. Plasma DNA concentrations from all participants were analyzed for the &bgr;-globin gene using fluorescence-based real-time polymerase chain reaction. Patients with severe OSA had significantly higher plasma DNA concentrations than persons with mild–moderate OSA and those without OSA (<I>P</I> < 0.05). AHI was significantly associated with body mass index (<I>P</I> < 0.001), hypertension (<I>P</I> < 0.001), and plasma DNA concentration (<I>P</I> < 0.05).</P><P>Conclusion: </P><P>After taking into account hypertension and other potential risk factors, persons with high plasma DNA concentrations (>8 µg/L) had approximately fourfold higher odds of OSA than those with low DNA levels. Further data are warranted to confirm the association for men and to evaluate the association for women.</P>
박기현,김현만,허갑범,이현철,김경래,김한수,김주항,김세광 대한내분비학회 1988 Endocrinology and metabolism Vol.3 No.1
It has been recognized that hyperthyroidism occur in patients with trophoblastic disease, either hydatidiform moles or choriocarcinomas. In the past decade, several lines of evidence have shown that human chorionic gonadotropin, secreted by the trophoblastic disease, is a thyroid stimulator and causes hyperthyroidism. In order to evaluate the relationship between level of thyroid hormone and human chorionic gonadotropin in patients with trophoblastic disease, level of thyroid hormone, serum -HCG and amount of urinary excretion of HCG were measured and analyzed in 24 patients with hydatidiform mole and 11 patients with choriocarcinoma who were admitted to Yonsei University Severance Hospital during the period from January 1981 to December 1986. The results are summarzed as follows: 1) Hyperthyroidism was observed in 33.3% of the patients with hydatidiform mole and in 18.2% of the patients with choriocarcinoma. 2) The amount of 24 hour urinary excretion of HCG in patients with hyperthyroidism was more than that in euthroid patients. 3) There was no difference in the level of thyroid hormone, serum -HCG, and amount of 24 hour urinary excretion of HCG in patients with hydatidifrom mole and choriocarcinoma. 4) The amount of 24 hour urinary excretion of HCG had significant correlation with FT4, whereas no similar correlation was observed between the levels of thyroid hormone and serum -HCG. In conclusion, the occurrence of hyperthyroidism is closely related with the amount of urinary excretion of HCG in patients with trophblastic disease.