Ki-67 labeling index as a prognostic marker in advanced stomach cancer

Sang Hyuk Seo,Kwang Hee Kim,Sang Hoon Oh,Yunseon Choi,Ki Jung Ahn,Ji Young Lee,Sang Min Lee,박지선,Woo Gyeong Kim 대한외과학회 2019 Annals of Surgical Treatment and Research(ASRT) Vol.96 No.1

Purpose: Proliferation marker Ki-67 is widely used in cancer prognosis prediction. We tried to investigate the role of Ki-67 as a prognostic factor in stomach cancer after surgery in this study. Methods: We retrospectively evaluated 251 patients who underwent curative resection for gastric cancer from 2010 to 2015. In pathologic examination, Ki-67 labeling index was defined as the percentage of Ki-67 antigen positive cells. Prognostic significance of Ki-67 for gastric cancer was evaluated. Disease-free survival (DFS) was assessed as a primary end-point. Results: The median follow-up period was 28.0 months. Thirty-one patients (12.4%) showed Ki-67 labeling index (LI) lower than 25%. Sixty-eight patients (26.6%) showed recurrence during follow-up period. Recurrence was associated with Ki- 67 LI level (≤25%, P = 0.016), and lymph node metastasis status (P = 0.002). High Ki-67 LI level (>25%) was also related to p53 positivity (P < 0.001) and poorly cohesive type (P = 0.002). The 3-year DFS was 69.4%. Low Ki-67 LI level (≤25%) was related with low DFS (47.6% vs. 72.6%, P = 0.016). T stage (P < 0.001), N stage (P = 0.006), lymphovascular invasion (P = 0.010), and neuronal invasion (P = 0.001) also affected the DFS. In addition, T stage (P = 0.03) and Ki-67 LI (P = 0.035) were independent prognostic factors for DFS. In patients treated with adjuvant chemotherapy (n = 239, 93.4%), low Ki-67 (≤25%) was a poor prognostic factor for DFS (P = 0.013). Conclusion: Low Ki-67 LI predicts high rate of progression and low DFS of stomach cancer. Ki-67 LI can be a predictive marker in resected stomach cancer treated with surgery and adjuvant chemotherapy.

부산 동래부 군현지도의 유형과 내용분석

김기혁 釜山大學校 韓國民族文化硏究所 2002 한국민족문화 Vol.19·20 No.-

This study is to classify old county-maps of Dongrae-bu, Busan and to analyze place names in maps comparatively. Nineteen maps covering Dongrae-bu was collected from the antique map books and related literature. 1. By the comparative analysis of contents, those maps can be classified into the four types. Haedong-Jido and Jiseung belong to the first type. Jiseung is a copy from Haedong-Jido. Bibyunsa-Jido, Yeongnam-Jido, Gakeup-Jido and Gwangyeo-do belong to the sencond type. Yeongnam-Jido is a copy from Bibyunsa-Jido, but a part of contents are from Haedong-Jido. Gakeup-Jido and Gwangyeo-do are copies from Yeongnam-Jido, but during the process of coping, some place names are abbreviated. Gunhyu-Jibangjido, Busan-Gojido, Dongraebusan-Gojido and Dongraebu-Jido (attachedn to the Eupji) belong to the third group. Those maps are drawn from actual scene and the original copy is Gunyun-Jibangjido. The fourth types are Daedongyeo-Jido, Dongyeodo, cheongkudo and Dongyeobigo, which are from the large scale maps of Korean penninsula. In spite that Daedongyeo-Jido and Cheongkudo was drawn by the same authors, their contents are diffenent in some parts. 2. Types of toponyms which were included in maps are different by the purpose of map-drawing. In the first type, place names from military, and administrative contents are written. In the second type, generic names from military, and administrative contents are written. In the second type, generic names especially from military and transportation and Japanese residence area. In the third types, city-walls and castles are drawn exaggeratively and detailed generic name from village are written in those maps. In the fourth types, generic name from natural environment, such as mountain and islands are very fluent.

노인들의 종합사회복지관 사회체육 활동실태에 관한 연구

김윤래,석혁기,김주영 도립 강원전문대학 2000 道立 江原專門大學 論文集 Vol.3 No.-

The Objective of this study was to find the activity that the actual condition of Sport For All programs run at Central Figure Social Welfare Organs in K province and provide the basic material for activation of Sport For All programs. Subjects of study were selected from the people who participated in Sport For All programs run six at Central Figure Social Welfare Organs located in K province : male : 73, female : 146, total : 219. Results of this study as following; 1) It was participating motive on Sport For All of Central Figure Social Welfare Organs, and to maintain their health, serve as diversion, get rid of stress, and maintain personnel relations and society. 2) The degree of satisfaction on these programs was low, because of facilities and contents of programs. 3) Over 50% participants came 4 times in one week and participation ratio of male to female is higher than in verse. 4) Participants in these programs mainly came with their friends or alone and over 50% of the participants were influenced by their own motive and the others enhanced by public administrations and sport leader were rare. 5) When they participated in program of Sport For All of Central Figure Social Welfare Organs, the degree of satisfaction for facilities was low and favorite events were archery, gate ball, gymnastics and jogging etc. 6) They showed deep interest in the necessity of the sport leader.

초음파 어레이를 이용한 이동 로봇의 장애물 회피에 관한 연구

김병남,권오상,김기호,이응혁 建陽大學校 1999 建陽論叢 Vol.- No.7

For mobile robot, the navigation effectiveness can be improved by providing autonomy, but this autonomy requires the mobile robot to detect unknown obstacles and avoid collisions while moving it toward the target. This paper presents an effective method for autonomous navigation of the mobile robot in structured environments. This method uses ultrasonic sensor array to detect obstacles and utilizes force relationship between the obstacles and target for avoiding collisions. Accuracy of sensory data produced by ultrasonic sensors is improved by employing error eliminating rapid ultrasonic firing (EERUF) technique. Navigation algorithm controlling both the velocity and steering simultaneously is developed, implemented to the mobile robot and tested on the floor filled with the cluttered obstacles. It is verified that from the results of the field tests the mobile robot can move at a maximum speed of 0.66 m/sec without any collisions.

음악요법이 산부인과 수술환자의 활력징후와 마취회복 및 동통에 미치는 영향

김혜숙,이철갑,정혁,김기순 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1

Background and Purpose: The purpose of this study was to prove the effect of music therapy on anesthetic recovery, vital signs and pain control for postoperative patients in the recovery room as a nursing intervention. Methods: We compared 35 experimental groups who received music therapy with 35 control groups. All of the subjects were obstetric and gynecological operation patients. The experimental and control groups were observed for the level of anesthetic recovery (PAR score), the frequency of supplement analgesic use for pain control, and vital signs at arrival and after 15, 30, 60 minute in recovery room. Statistical data analysis using repeated measures ANOYA and x^2-tests were performed. Result; Vital signs did not show a significant difference when comparing the two groups except for the respiration rate. For anesthetic recovery, there were significant changes in respiration state in the experimental group compared to the control group. The frequency of analgesics administration was significantly reduced in the experimental group compared to the control group by music therapy. The 63 % of the experimental group responded comfortably and peacefully in subjective feelings. Conclusion: This study showed the effects o3 music therapy, which applied to helping postoperative patients recover from anesthesia and reducing the frequency of supplement analgesic use for pain. It is recommended to apply music therapy right after surgery in the recovery room as a nursing intervention if a patient wants.

절수에 의한 Mongolian Gerbil 장기중량변화에 관한 분석연구

김무강,이기훈,이강이,송치원,이경열,권효정,박미선,정승혁,이행연,김명철 충남대학교 수의과대학 동물의과학연구소 2000 動物醫科學硏究誌 Vol.8 No.-

In this study, authors measured the each organ weight of the long term water deprived Mongolian gerbil, after then we calculated the mean, standard deviation, variance coefficient of the real measured organ weight and induced the organ weight change quantity, rate of quantity, deviation between measured and theological organ weight, deviation rate, sum of deviation rate, organ weight change rate, rate of organ weight by the mathematical formula. The results obtained as follow 1. The weight of the brains, lung, and testis were abruptly decreased after water deprived until the 5th day, after then slowly decreased until the 20th day. 2. The weight of the heart was decreased gradually from the first day until the 20th day. 3. The weight of the liver was abruptly decreased until the 10th day, after then the more slowly decreased until the 20th day. 4. The weight of the thymus, spleen, kidney, and pancreas were abruptly decreased until the 15th day, after then increased slowly until 20th day but the weight of the kidney was abruptly increased from the 10th day. 5. The organ weight change rate and the rate of the each day organ weight were very diversified.

지방중소도시 환경개선을 위한 Super Graphic에 관한 연구 : 아파트를 중심으로 Focus On Apartments

김기준,신승혁 경복대학 2001 京福論叢 Vol.5 No.-

도시공간에 있어 수퍼그래픽은 시민의 정서적 안정과 도시 미관을 개선한다는 입장에서 제작되기 시작했고 지금에 와서는 도시 환경디자인의 빼놓을 수 없는 분야가 되었다. 도시환경을 개선한다는 일차적 목적 이외에도 지역주민의 상징과 공동체 의식을 높여주고 때에 따라서는 랜드마크나 광고선전 매체로 활용되며 도시환경의 시각요소로서 수퍼그래픽은 도시민들에게 친근감있게 부합 할 수 있어야 하며 주거환경과 지역적 특성을 살려 대중적인 의미로 전달 활용되어야 한다. 그러므로 도시 아파트 수퍼그래픽을 체계적으로 연구 조사하여 현대 사회를 살아가는 인간의 생활환경에 맞게 개선할 수 있는 방안을 모색하고자 한다. 이에 지방중소도시 아파트의 수퍼그래픽을 중심으로 문제점을 제기하고 유형과 특성을 분석하여 특색있는 만드는데 도움이 되고자 한다. In urban spaces, Super Graphic has been produced focusing on improving civil emotional stability and urban beauty, and now is an indispensable field of urban environmental design. This has to improve not only urban environment but also regional resident symbol and community consciousness, be used for a landmark or advertising media on occasions, be familiar with urban citizens as a visual element of urban environment, and be used for a popular meaning considering residential environment and regional characteristics. Therefore this study focuses on systematically researching and investigating the Super Graphic that can harmonize with modem human living environment. And this is for the purpose of presenting a problems based on the Super Graphic of regional small and medium cities and analyzing their types and features to construct characteristic environment.

居昌 古地圖의 類型과 收錄 地名 硏究

김기혁 부산대학교 한국민족문화연구소 2007 한국민족문화 Vol.29 No.-

This paper is to classify old county-maps of Geochang-bu(居昌府) in late-Chosun dynasty and to analyze place names in maps comparatively. 31 maps covering Geochang-bu were collected from the old county-map atlas(郡縣地圖帖) and Eupji(邑誌). By the comparative analysis of contents, those maps can be classified into four types. The first type(named 'Picture county map') included 7 county-maps in which information of military, and administrative contents are mainly mapped. the second type(named '1-ri grid system county map') included 5 county maps in which information about beacon routes and road systems were regarded as very important. The third type(named '20-ri grid-system map(方眼式地圖)') included 4 county-maps which were drawn as same scale with 20-ri(里) grids. The fourth type(named 'Local county-map(地方郡郡縣地圖)') included 7 county mops which were drown by local moppets. Comparative analysis of place names between those four types revealed that Grid-system mops were developed toward the large scale whole mop of Korea in the 19th century. Types of toponyms which were included in maps ore different by the purpose of map-drawing. In the picture county mops, place names from military, and administrative contents are written. In the 1-ti grid system county mops, place names especially from military and transportation ore fluent. In the 20-ri grid system county mops, generic name from natural environment, such ay mountain and islands are very fluent. In the local county mops, city-walls and castles are drown exoggetotively and detailed generic name from warehouses and villages ore written in those mops.

도시공간구조에 따른 존별 첨두율 예측모형 연구 : 대구광역시 중존을 중심으로

김태헌,김택근,김기혁 계명대학교 산업기술연구소 1998 産業技術硏究所 論文報告集 Vol.21 No.1

The aim of this research is to find out the characteristics of peak hour rate and to estimate the peak hour by spatial structure and social factors in the urban area The data used to estimate peak rate was based on Taegu city's person trip survey in 1992. Multiple regression analysis have used to develop the prediction equations for the peak hour trip by various types of land use and urban characteristics data.

보조동사의 생산성

김기혁 연세대학교 국어국문학과 1983 연세어문학 Vol.16 No.-