麻黃의 사람 비점막 섬유아세포 monocyte chemotactic protein 중 MCP - 1 , MCP - 2 , 및 MCP - 3 분비에 대한 효과

김현미,이향숙,김정선,조정제,유영천,안현종,최훈,임강현 대한본초학회 2002 大韓本草學會誌 Vol.17 No.1

Recent reports have proposed that Ephedrae Herba may modulate the immune response on allergy or asthma. Human nasal mucosal fibroblasts are a rich source cytokines, inflammatory mediators, and chemokines. Chemokines are important for the recruitment of leukocytes to sites of infection, which is essential in host defense. Objectives : The objective of this study was to investigate the effect of Ephedrae Herba on the release of the chemokines such as monocyte chemotactic protein(MCP)-1, MCP-2, and MCP-3 in human nasal mucosal fibroblasts after stimulation with cytokines like tumor necrosis factor -α(TNF-α), interferon-γ(IFN-γ), and interleukin -1β(IL-1β).

농촌주민의 혈중 납과 카드뮴 농도에 관한 조사연구

정현숙,조영채,이동배 忠南大學校 環境問題硏究所 1991 環境硏究 Vol.9 No.-

The purpose of this study was to find out blood lead and cadmium concentration levels of rural residents. The blood samples were collected from 140 rural residents in 5 nonpolluted regions in Kunbuk-Myun, Kumsan-Gun, Chungnam province from August 31 to September 30, 1990 and analyzed by atomic absorption spectrophotometry. The results were summerized as follow : The mean concentration level(range) of blood lead was 0.240±0.060㎍/ml(0.130-0.390㎍/ml) for males and 0.237±0.056㎍ /ml(0.120-0.370㎍/m) for females. There was no statistically significant difference among age groups and sexes. The distributions were similar to normal distribution in both sexes. The mean concentration level(range) of blood cadmium was 0.066±0.099㎍/ml(0.012-0.582㎍/ ml) for males and 0.060±0.062㎍/ml(0.015-0.392㎍/ml) for females. There was no statistically significant difference among age groups and sexes. The distributions were skewed to the low level ranges in both sexes. The lead concentration level in whole blood did not show statistically sinificant difference among kinds of farming product. But the cadmium level of the rice-ginseng-tobacco farmers was statistically significantly high (p<0.005). The cadmium concentration level in whole blood was 0.040±0.027㎍/ml for the rice-ginseng farmers, 0.076±0.100㎍/ml ofr the rice-tobacco famers, and 0.158±0.171㎍/ ml for the rice-ginseng-to-bacco farmers. There were no statistically significant difference in blood lead and cadmuim concentration levels among groups classified by drinking habit, smoking habit and exposed years to pesticides. The correlation coefficent between the blood lead and cadmium concentration levels was statistically significant(R=0.2054, P<0.05).

『팔월의 빛』에 나타난 시간의 유동성과 정체성

정현숙 신영어영문학회 1998 신영어영문학 Vol.11 No.-

In the early twentieth century Henri Bergson, French philosopher opened a new vista concerning time. He said the nature of time is duration, and he tried to find the duration in human consciousness. His time theory had a great influence on William Faulkner. Faulkner sees that time as humanly experienced is an unbroken stream flowing out of the depths of his past and moving with a forward surge into a yet unexperienced future. But some characters in his fiction can't accept the fluidity of time and they meet a tragic finality. In Light in August all the main characters except Lena Grove are handicapped by the past in some way or other. Among them Gail Hightower is trapped by the time of “past”. He can't find “father figure” in his father who is a Presbyterian minister and symbolizes horror so he tries to escape from the actual world into the dreamy world. In other words being a lonely child, he developed a greater emotional attachment to the memory of his dead grandfather whose brave behavior was just modified by black slave. So even an adult Hightower can't adjust himself to the real world and often confuses the present with the dreamy illusion. After graduating from a seminary he becomes a minister in Jefferson but he preaches his grandfather galloping on a horse during the Civil War at a sermon. For him his grandfather is a figure enshrined in all the romantic, heroic imagery and becomes the emotional center of his life. So central is this vision for Hightower that it becomes inextricably part of his religion. Finally his wife deserted him and he was forced to resign his pulpit and has lived alone for 25 years. In time, Hightower becomes painfully aware of the distance between the Christian gospel of love and compassion and the stern Calvinist religion of his community. And late in the novel, through Byron Hightower reluctantly helps Lena to give birth to her baby and makes a futile attempt to save Joe Christmas from murder. Having experienced some accidents Hightower comes to realize that he has forfeited his life, and -quite literally- that of his wife. Too late, he comes to recognize that his wife's suicide was in fact his own murder of her and that his vision of grandfather was an illusion, too. These recognitions, though unspeakably painful, can't bring him into the real world and his consciousness focuses on the rushing wheel symbolizing his own past. Hightower has failed to form any vital human relationship because of the great walls of the past. His effort to find a salvation through his grandfather's past is against the fluidity of time and his time is stagnant. In conclusion, Faulkner tries to show dramatically how tragic the obsession of past is because life is motion and to exist is to change and to change is to mature.

르노아르(Renoir) 그림에 나타난 여자 복식의 분석

鄭賢淑 복식문화학회 1997 服飾文化硏究 Vol.5 No.3

This study analyzes the factors of the pleasure principle through female costume in the paintings of Renoir, based on the Freud theory. The factors of the pleasure principle pursuing the desire-satisfaction are described as follows : narcissism exhibitionism, extension of the bodily self, the emphasis of erogenous zone, and muscle-erotism.

CFA Analysis에 의한 구강세균의 동정

정현자,조명숙,지원대 한국위생과학회 2002 한국위생과학회지 Vol.8 No.2

충치환자의 병변으로부터 세균을 분리하여 동정하였다. 10종의 세균 CHJ-1, CHJ-2, CHJ-3, CHJ-4, CHJ-6, CHJ-7, CHJ-8, CHJ-9, CHJ-10, CHJ-12이 순수분리되었고, 미국 Analytical Services, Inc.의 Cellular fatty acid analysis에 의한 identification system으로 동정한 결과, CHJ-1, CHJ-2, CHJ-3과 CHJ-12는 각각 Bradyrhizobium japonicum, Arthrobacter pascens, Staphylococcus epidermidis 및 Arthrobacter pascens와 유의성이 0.5이상으로 나타났다. Oral bacteria were isolated and identified. Ten Kinds of bacteria, such as CHJ-1, CHJ-2, CHJ-3, CHJ-4, CHJ-6, CHJ-7, CHJ-8, CHJ-9, CHJ-10, CHJ-12, were isolated from oral cavity of dental patients. These bacteria were identified by cellular fatty acid(CFA) analysis system at Analytical Services Inc. in USA. Similarity index values of bacteria, CHJ-1, CHJ-2, CHJ-3, CHJ-5, CHJ-11 and CHJ-12 were above 0.5 to Bradyrhizobium japonicum, Arthrobacter pascens, Staphylococcus epidermidis and Arthrobacter pascens, respectively.

蕙園 申潤福의 風俗畵에 나타난 服飾의 象徵性

鄭賢淑,金鎭玖 복식문화학회 1993 服飾文化硏究 Vol.1 No.2

This study analyzes the symbolism of costume in the genre paintings of Yoon Bok Shin, the great artist of Korea in eighteenth century, baseed on the symbolic interaction theory, We classify the symbolic character into two categories, the symbolism of social status and position as a social factor, and erotic symbol as a sexual factor. The symbolism of the social status and position include the sex, age, class, occupation, and dignity. From the costume in the paintings, the symbolic character of the clothing in the social and sexual contexts can be visualized.

예술사조와 패션과의 Parallelism에 관한 연구 : Focusing on Modernism and the Flapper Look 모더니즘과 플래퍼 룩을 중심으로

정현숙,김진구 服飾文化學會 1995 服飾文化硏究 Vol.3 No.2

This paper analyzes the parallelism between the art trend and the fashion. As a representative case, we consider the Modernism and the Flapper look. The Modernism rejected the tradition of the past and pursued something new. This trend was in parallel with the fashion called flapper look which was against the tradition and made a drastic change. The factors which represent the spirit of the age of the Modernism are the simplicity, the rejection of the tradition, the individualism and the subfectivity, the functionalism, the fragmetnation of the self, and the straight line, We discuss the fashion style of the flapper look in terms of these factors.

사회적 음주자에서 매운 맛 선호도가 급성 음주 반응에 대한 Naltrexone 효과에 미치는 영향

정희정,김성곤,김종현,박숙현,강철중 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.6

Capsaicin과 알코올이 각각 중추신경 아편계 활성도를 증가시킨다는 선행 연구들이 있다. 이에 본 연구는 매운맛 선호도에 따라 급성 음주 반응에 차이가 있는지와 급성 음주 반응에 naltrexone이 미치는 영향에 차이가 있는지를 조사하고자 하였다. 12명의 의과대학 남학생을 대상으로 두 군으로 나눈 후 cross-over design을 사용하여, 한 군(6명)은 naltrexone 25 mg을 실험 1일째에, 50 mg을 실험 2일러에 주었고, 다른 군(6명)은 naltrexone 25 mg을 실험 8일째에, 50mg을 실험 9일째에 주었다. 실험 2일째와 9일째에 각대상자의 Biphasic Alcohol Effects Scale (BAES)로 측정한 급성 음주 반응과 음주갈망, 혈중알코을 농도 등을 음주 전, 음주(0.6 ml/kg) 후 15분, 30분, 60분에 측정하였다. 통계 분석 시 Food Preference Scale 점수에 따라 모든 대상자를 매운 맛을 선호하는 군(strong preference for hot food, SP)과 매운 맛을 덜 선호하는 군(lesser preference for hot food, LP)의 두 군으로 다시 나누어 분석하였다. 결과는 다음과 같다. 1) Naltrexone을 투여 여부에 관계없이 알코올의 급성 흥분 효과는 매운 맛 선호도에 따른 차이가 없었다. 그리고 LP에서도 naltrexone의 투여 여부에 따른 알코올의 급성 흥분 효과의 차이가 없었다. 그러나 SP에서는 알코올의 급성 흥분 효과가 naltrexone 투여 시 유의하게 억제되었다. 2) 알코올의 급성 진정 효과, 음주 갈망 및 혈중 알코올 농도는 매운 맛 선호도 혹은 naltrexone 투여 여부에 따른 차이가 없었다. 본 연구에서 매운맛을 선호하는 경우 알코올의 급성 흥분효과가 naltrexone에 의해 억제되었다. 이것으로 naltrexone이 매운맛을 선호하는 군에서 알코을 의존 재발 예방 효과가 더 클 가능성을 제시한다. Objectives : Both capsaicin, a pungent substance of hot food, and alcohol, are known to affect central opioid activity. The purpose ofthis study was to investigate the difference in the subjective acute responses to alcohol and the effect of naltrexone on them among those who prefer hot food to varying degrees. Methods : Twelve male medical students were divided into two groups using a cross-over design. One group was given naltrexone on only the first (25 mg) and the second day (50 mg), and the other group was given naltrexone on only the eighth (25 mg) and the ninth day (50 mg). On the second and the ninth day, the acute effect of alcohol was assessed in all subjects, using the Biphasic Alcohol Effects Scale (BAES) just before drinking and at 15 minutes, 30 minutes and 60 minutes after drinking (0.6 ml/kg). Alcohol craving was also measured, using Visual Analogue Scale for craving (VAS-C) and blood alcohol concentration (BAC), at the same interval. For statistical analysis, subjects of both group were re-divided into two group, those with a strong preference and those with a less preference (LP) for hot (spicy) food (SP), using the Food Preference Scale. Results : 1) Repeated measures of ANOVA (2 preference groupsX4 time blocks) on the stimulative subscale of BAES yielded no significant group by block interaction of naltrexone administration. Repeated measures of ANOVA (2 drug groupsX4 time blocks) on the stimulative subscale of BAES revealed a significant group by block interaction in SP (p=0.028), but not in LP. The paired t-test revealed that significant suppression of the stimulative subscale of BAES was observed at 15 minutes and 30 minutes after drinking when naltrexone condition was compared with no-medication condition in SP(p=0.014 ; p=0.007). 2) For the sedative subscale ofBAES, VAS-C and BAC, repeated measures of ANOVA yielded nosignificant group by block interaction by either hot food preference or naltrexone administration. Conclusion : For those who prefer hot food, the effect of stimulative acute alcohol was suppressed by naltrexone. This result strongly suggests that naltrexone could prevent relapse more effectively in those who prefer hot food.

서울지역 일부 과체중 및 적절체중 학령기 아동의 신체계측, 체지방률, 혈액지표 및 영양소 섭취 상태의 비교 분석 연구

이정숙,이정윤,임현정,조미란,차성호,조여원 대한영양사협회 2003 대한영양사협회 학술지 Vol.9 No.4

This study was carried out to compare the characteristics of the over weight elementary school students with those of desirable-weight children. Anthropometric parameters such as height, weight, BMI body fat percentile, triceps skin fold thickness were measured. Dietary assessment and blood analysis were performed. The average ages of over weight children and desirable-weight children were 10.9f2.5 and 10.2±2.8 years, respectively. The means body fat percentile of over weight children and desirable-weight children were 27.5±3.7% and 20.2± 3.8%. respectively. Plasma levels of TG. total cholesterol, LDL cholesterol, and HDL cholesterol of over weight children and desirable-weight children were 179.3±30.0. 104.9f26.6, 52.3f6.7 and 178.3±84.l㎎/dl and those of desirable-weight children were 86.1±43.5, 183.7f16.5, 101.0f2.1 and 67.7±20.0㎎/dl respectively. Plasma TG levels of over weight children were significantly higher than those of desirable weight chddren. On the other hand plasma HDL-cholesterol levels of over weight children were significantly lower than those of desirable-weight children Plasma levels of GOT ,and GPT were in normal range in both group. However, GPT level of over weight children was &her than that of desirable weight children. Plasma levels of albumin, globulin and BUN were all in normal range and no differences were found in both groups. Hematologic data did not show any difference between two group except WBC, KBC and Hgb levels which were significantly higher in over weight group than those of desirable-weight children. DAY nutrients intake of over weight children and desirable-weight children were very similar and they were around the Korean KDA levels for each nutrients. However, the intake of calcium of both groups were little over 50% of KDA. The consumption of d e b fiber was very low and the cholesterol intake was very high shorn that the habitual meals of Korean school children were not well balanced.

임신 중 발견된 대망 종괴 1례

조인숙,김태의,김정식,이해혁,이권해,김희경,남계현 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

A case of omental mass during Pregnancy Omental cyst is a rare lesion and occur primarily during childhood and young adulthood. When encountered, most of them are benign and intraabdominal masses. It shows a large mass but not palpable and often asymptomatic. The precise diagnosis is made by most commonly at surgery or during pathologic examination. So, we report this case with brief review of literatures.