Induction of heme oxygenase-1 protects against podocyte apoptosis under diabetic conditions

Lee, Sang Choel,Han, Seung Hyeok,Li, Jin Ji,Lee, Sun Ha,Jung, Dong-Sub,Kwak, Seung-Jae,Kim, Seung Hye,Kim, Dong Ki,Yoo, Tae-Hyun,Kim, Jin Hyun,Chang, Se-Ho,Han, Dae Suk,Kang, Shin-Wook International Society of Nephrology 2009 Kidney international Vol.76 No.8

Heme oxygenase-1 (HO-1) is an anti-oxidant enzyme normally upregulated in response to oxidant injury. Here we determined the role of HO-1 in podocyte apoptosis in glomeruli of streptozotocin-treated rats and in immortalized mouse podocytes cultured in media containing normal or high glucose. HO-1 expression, its activity, the ratio of Bax/Bcl-2 protein, and active caspase-3 fragments were all significantly higher in isolated glomeruli of diabetic rats and in high glucose–treated podocytes. These increases were inhibited by zinc protoporphyrin treatment of the rats or by HO-1 siRNA treatment of the podocytes in culture. The number of apoptotic cells was also significantly increased in the glomeruli of diabetic rats and in high glucose–treated podocytes. Inhibition of HO-1 accentuated the increase in apoptotic cells both in vivo and in vitro. Our findings suggest that HO-1 expression protects against podocyte apoptosis under diabetic conditions.

동일한 환자에서 조혈모세포이식 전후의 호중구감소 기간 중 감염양상에 대한 비교연구 : 중심정맥관 관련 패혈증을 중심으로 Based on Central Venous Catheter Related Septicemia

류재호,노규태,이영석,이영호,권혁찬,김재석,김효진,이영민,박혜원,박근희 대한조혈모세포이식학회 2002 대한조혈모세포이식학회지 Vol.7 No.1

연구배경: 동일한 환자를 대상으로 조혈모세포이식 전 일반 병실에서의 관해유도 항암제치료 및 강화요법으로 인한 호중구감소 기간의 감염양상과 고용량 항암제치료 후 무균실에서의 조혈모세포이식 시 호중구감소 기간의 감염양상을 중심정맥관 관련 패혈증을 중심으로 비교 연구함으로써 효율적인 감염관리지침을 마련하고자 하였다. 대상 및 방법: 1999년 1월부터 2001년 7월까지 2년 7개월간 동아대학교병원 일반병실에서 악성혈액질환으로 항암제 치료를 받다가 조혈모세포이식을 시행받았던 22명을 대상으로 중심정맥관 관련 패혈증의 형태를 비교분석하였다. 결과: 대상 환자들의 일반병실과 무균실에서의 입원기간은 각각 32±13일, 33±19일, 호중구 감소기간은 15±12일, 17±18일, 호중구 감소기간의 발열 횟수는 14회, 14회로서 입원병실의 종류에 따른 차이는 없었다. 환자들의 중심정맥관 사용일수는 일반병실에서 29일(7~545일), 무균실에서 100.5일(25~606일)이었으며, 총 사용일수는 각각 1,515일, 3,250일로서 무균실에서의 중심정맥관 사용일수가 의미 있게 길었다(P=0.001). 중심정맥관 사용 일수에 대한 감염률은 각각 5.28/1,000일, 3.08/1,000일로서 일반병실에서 그 빈도가 높았으나 통계적 유의성은 보이지 않았다(P=0.141). 결론: 중심정맥관 삽입 후 일반병실에서 항암제 치료를 받던 환자가 조혈모세포이식을 위하여 무균실에 입원하는 경우, 중심정맥관을 교체하는 것이 감염관리를 위하여 바람직할 것으로 생각된다. Background: We compared the incidence of central venous catheter (CVC) related septicemia during neutropenic period in the same patient, which developed following chemotherapy for remission induction and consolidation, or hematopoietic stem cell transplantation (HSCT). Methods: We retrospectively reviewed the medical records and laboratory data of 22 patients with hematologic malignancies who received anticancer chemotherapy followed by HSCT at Dong-A University Hospital between January, 1999 and July, 2001. We investigated the duration of hospitalization, duration of neutropenic period, duration of catheterization, microbiologically documented organisms and incidence of CVC related septicemia. Results: The data in general ward (before HSCT) and laminar air flow room (after HSCT) were as follows: duration of hospitalization was 32±13 days and 33±19 days, duration of neutropenic period was 15±12 days and 17±18 days, median duration of catheterization was 29 days (7~545 days) and 100.5 days (25~606 days) (P=0.001), and incidence of CVC related septicemia was 5.28/1000 days and 3.08/1000 days, respectively. In the CVC related septicemia, the most common etiologic organism was coagulase negative staphylococcus. Conclusion: We suggest that the exchange of CVC before admission to laminar air flow room could decrease the incidence of CVC related septicemia in HSCT recipients.

포도종실 추출물이 Methylcellulose 필름 성질에 미치는 영향

유승모,박준서,정하열,심재용,김병호,박장우 한국산업식품공학회 2003 산업 식품공학 Vol.7 No.4

The film with methylcellulose(MC) and grape seed extract(GSE) were prepared by casting their aqueous solution at 80℃ and drying at 23℃ for 48 hrs. Effect of grape seed extract(GSE) on the barrier permeabilities and the thermomechanical property of methylcellulose(MC) film was studied. The barrier permeabilities and the thermomechanical property of MC film containing various contents of GSE were evaluated in terms of water vapor, oxygen permeabilities, and dynamic mechanical analysis(DMA). The rate of water vapor permeability of MC film decreased with GSE contnets in the MC films. Also, the rate of oxygen permeability also decreased with GSE contents indicating higher oxygen barrier property of MC film. The results showed that GSE had a good miscibility with MC and acted as a plasticizer for MC film resuling in lowering the glass transition temperature of the film.

간세포암의 십이지장침윤에 의한 상부위장관 출혈 1 예

유태현,한광협,박성하,김형길,문영명,한재호,조상호 대한소화기내시경학회 1999 Clinical Endoscopy Vol.19 No.2

Recent advances in both the diagnosis and treatment of hepatocellular carcinoma have improved the prognosis and changed the clinical significance of the recently increasing distant metastases. Distant metastases found after successful treament of the primary lesions are of great clinical significance for the treatment of hepatocellular carcinoma. The duodenum is a rare site of hematogenous metastases or direct invasion from hepatocellular carcinoma. A 23 year old man was admitted with upper gastrointestinal bleeding. He had been diagnosed with hepatocellular carcinoma and treated by a left lobectomy and chemoembolization. The patient was admittted for 12 months after the treatment of the primary tumor. Endoscopic examination revealed a mass in the duodenal bulb that protruded into the lumen. He died due to massive hematemesis. We report on a rare case of hepatocellular carcinoma with duodenal invasion in a 23-year-old male patient.

강화방법이 중년여성의 운동지속 및 건강에 미치는 영향

류호상,현정희,변재철,김한철 한국스포츠심리학회 2002 한국스포츠심리학회지 Vol.13 No.3

최근 10여년 동안 운동과학에 대한 다량의 문헌들에도 불구하고 여성들을 대상으로 운동지속(exercise adherence)과 운동효과에 대한 연구들은 많지 않다. 이 연구의 목적은 강화방법이 여성의 운동지속과 건강에 미치는 영향을 규명하기 위한 것이었다. 생활체육으로 에어로빅댄스를 하고자 방문한 31명의 중년여성들이 자신들이 원하는 세 개의 다론 시간대의 수업에 각각 등록을 하였다. 각 교실은 체지방 측정치로 피드백을 제공받는 집단(n=10), 출석이 양호할 시 에어로빅무용복을 보상받는 집단(n=11), 그리고 통제 집단(n=10)이 되어 실험에 참가하였다. 피험자들을 같은 강사의 지도로 하루에 45분, 주 5회(월-금), 8주 동안 에어로빅댄스를 실시하였다. 일원변량분석 결과 체지방으로 피드백을 제공받으며 운동한 집단은 다른 두 집단에 비해 높은 출석률을 보였다(p<.05). 공변량분석(ANCOVA)에서는 피드백 집단이 통제 집단보다 체지방율과 POMS의 총정서장애(Total mood disturbance)에서 유의하게 낮은 수치를 보였다(p<.05). 안면피부상태에서는 집단 간에 유의한 차이를 보이지 않았지만, 집단을 합한 운동 전·후간에는 차이가 있게 나타났다(p<.05). 이 연구는 생활체육 현장에서 피드백을 제공하여 강화를 시키면 중년여성들의 운동지속(exercise adherence)을 높일 수 있고 건강 증진에도 효과적이라는 결론에 도달하였다. 그 외 연구결과를 토대로 운동지속을 높이는 관점에서 논의가 이루어지고 장래연구를 위한 방향도 제시되었다. Despite decades of physical activity research, little is known about the patterns and effects of physical activity among women. The purpose of this research was to examine whether reinforcement strategy would positively influence participation adherence and health in women. Thirty one middle-aged females participating in an aerobic dance class were randomly assigned to three different conditions; feedback (n=10), reward (n=11), or control (n=10). The provide of feedback group was weekly informed of their body fat(%), while participant reward group was announced to win an aerobic dance tights if they miss less than 5 times over an 8 week period meeting 5 times per week. One-way ANOVA showed that the feedback group was higher than the other 2 groups in the number of attendances (p<.05). ANCOVA indicated that the feedback group exhibited statistically greater improvements in the body fat (p<.05) and the total mood disturbance (p<.05) than did the control. The facial skin condition was independently associated with reinforcement. However, repeated t-test showed that the after condition was better than the before condition. It was concluded that provide of feedback is an effective mean in increasing the exercise attendance rate and the health of middle-aged females. The findings were discussed in terms of the importance of increasing exercise adherence and mental health.

최근 5년간 급성 A형 간염으로 입원한 환자들에 대한 입원 내용 분석

장재영,유병욱,조용진,오정은,홍성호,조주연 순천향대학교 의학연구소 2009 Journal of Soonchunhyang Medical Science Vol.15 No.1

Abstract Background : Due to improvements in Korea's sanitary conditions, antibody rates to the hepatitis A virus is decreasing rapidly and admission due to the disease is increasing, Patients who were admitted for hepatitis A during the last 5 years were selected and yearly differences in admission, clinical picture, medical fees, and differences according to age and gender were analyzed. Methods : Patients who were admitted to the Seoul Soonchunhyang University Hospital during the 5 year period between May of 2003 and April of 2008 and tested positive for IgM anti-HAV were selected and their medical records retrospectively analyzed. Results : 156 subjects [91 male (58%), 65 female (42%) were selected. The average age was 29.2 years (range; 21.4-37), average admission period 12.6 days (range; 12.5-1 7.7) days, and average medical fees 2,295,151 (range; 932,097-3,658,205) KRW(Korean Won), Yearly incidence rates were as follows : 10 for May, 2003 to April, 2004, 14 for May, 2004 to April, 2005, 23 for May, 2005 to April, 2006, 69 for May, 2006 to April, 2007, and 41 for May, 2007 to April, 2008, The maximum value median of AST, ALT, and bilirubin during admission was 989 IU/L, 1999 IU/L, and 5.6 mg/dL each, Each factors were all positively correlated with the patient's age. Conclusions : Recent decrease in antibody positivity of the hepatitis A virus and subsequent surge of acute hepatitis A is a cause of rising socioeconomic costs. A large scale epidemiologic research on whether HAV vaccination should be made mandatory and health insurance applied seems to be needed. Key words : Hepatitis A, Age, Medical fees, Vaccination

십이지장 궤양 환자와 만성 위염 환자의 염증 분포의 차이 및 H. pylori 집락도와 염증도의 상관관계

유광하,진춘조,박형석,이재동,김예리,윤성욱,이수인,윤호상 건국대학교 의과학연구소 1998 건국의과학학술지 Vol.8 No.-

An inflammatory difference between the gastric antrum, body and fundus was studied in 39 H.pylroi positive duodenal ulcer and 29 H. pylori chronic gastritis patients. Also we studied correlation of H. pylori colony count and inflammatory severity. Patients with newly diagnosed duodenal ulcer and chronic gastritis were endoscoped and two biopsy secimens each taken from the antrum, body and fundus. Although intestinal metaplasia in antrum and inflammatory activity in fundus were more severe in chronic gastritis patients. another inflammatory difference was equally likely to be found between two groups. There was no definite histological inflammatory difference between duodenal ulcer and chronic gastritis patients. A positive correlation was found between the number of H. pylori and the severity of inflammation.

2006년 춘천지역 산사태 유발 강우와 사면의 기하 특성에 관한 연구

유남재,이용원,김호진 江原大學校 産業技術硏究所 2010 産業技術硏究 Vol.30 No.B

This paper is results of analyzing the characteristics of rainfall triggering landslides and geometry of slopes, caused by the heavy rainfall and antecedent precipitation by Typhoons Ewiniar and Bilis at Chuncheon area in Gangwondo around July in 2006. As results of analyzing the characteristics of rainfall, landslides in 131 sites were found to happen due to the heavy rainfall having the maximum intensity of rainfall in an hour during July 15 and antecedent precipitation during July 12 to 14 causing the ground to be weak by increasing the degree of saturation previously. From results of analyzing the geometrical characteristics of 131 slopes where landslides occurred, the slope width were in the range of 6~10m. The average slope length and angle were 46m and 51.8°, which was relatively steep slope, respectively. Landlises occurred in the elevation of 400 - 500 m with the most probable frequency.

운동형태가 청소년의 상태불안 감소에 미치는 영향

류호상,염민선,변재철,박승한 한국스포츠심리학회 2002 한국스포츠심리학회지 Vol.13 No.2

과거의 운동심리학(exorcise psychology) 문헌들은 일회(acute) 운동 후에 상태불안이 감소되어 기분이 좋아지는 효과를 얻을 수 있다고 밝혀왔다. 이 연구의 목적은 어떤 형태(유산소 대 무산소)의 일회 운동이 청소년의 상태불안과 그에 관련된 생리변인들에 보다 긍정적인 영향을 미치는 지를 비교하고자 하는 것이었다. 12명의 남자중학교 학생들을 6명씩 두 집단으로 나누어 한 집단에게는 유산소운동을 다른 집단에게는 무산소운동을 시킨 후, 1주일 후에는 서로 역할을 교대시키는 반복측정을 하였다. 유산소운동은 심박수를 이용하여 최대운동능력(VO_2peak)의 75%강도로 트레드밀에서 20분간 달리기를 하는 것이었고, 무산소운동은 5개의 웨이트트레이닝을 십회반복최대(10RM)의 75% 강도로 돌아가며 20분간 실시하는 것이었다. 각 운동 전·후에는 20분 동안 안정을 취한 뒤 상태불안, 체온, 그리고 혈압을 차례로 측정하였다. 각 운동조건의 평균을 비교하기 위한 통계분석을 사전점사 결과를 공변인으로 하고 사후점사 결과를 종속변인으로 하는 공변량분석(ANCOVA)을 실시하였다. 자료처리 결과, 유산소운동과 무산소운동 후 어떤 변인들에도 유의한 차이가 나타나지 않았다(p<.05). 따라서 청소년의 상태불안을 감소시키는 데는 운동형태간에 차이가 없으며 그러한 연구에 대해 지속적인 관심과 필요성이 강조되었다. The purpose of this study was to examine aerobic versus anaerobic exercise effect on state anxiety reduction and related physiological variables in middle school students. A total of twelve male subjects were assigned to 20-minute condition in each exercise with the intensity of 75% of VO_2peak and 75% of 10 Repetition Maximum. State anxiety(Spielberger, Gorsuch, Lushene, Vagg, & Jacobs, 1983), body temperature, and blood pressure were assessed 20-minute before and after each exercise. One-way analysis of covariance(ANCOVA) indicated that the self-reported state anxiety, the body temperature, and the blood pressure were not significantly different between the 2 types of exercise. In conclusion, it is too premature to state that aerobic exercise is better than anaerobic exercise on state anxiety reduction in adolescents.

ATM망 트래픽 제어 알고리즘 연구

유진호,손준영,안재환,박성우,김명수,장혁수 明知大學校 産業技術硏究所 1996 産業技術硏究所論文集 Vol.15 No.-

ATM(Asynchronous Transfer Mode) is a transmission technique for the B-lSDN(Broadband Integrated Service Digital Network). Congestion problems are unavoidable in the ATM networks, since various traffic typos coexist in the networks. The preventive congestion control algorithm is widely used for the real time traffics such as voice and video. The reactive congestion control algorithm works well for the non-real time traffic within a short distance. A mixed traffic control algorithm is proposed, which works either preventively or reactively based on traffic types. The proposed algorithm sets a high and low threshold value at the output buffers and modifies the EPRCA(Enhanced Proportion Rate Control Algorithm) to control loss-sensitive cells. Delay-sensitive cells are handled by the priority control and the UPC(Usage Parameter Control) algorithm. The performance analysis shows that the proposed traffic control algorithm works well for both the VBR(Variab1e Bit Rate) and ABR(Available Bit Rate) traffic with small buffers