임신성고혈압에서 Caspase-related M30 CytoDeath 발현을 이용한 영양막세포고사 연구

김호진,박혜숙,김영주,박보현,이화영 대한해부학회 2004 Anatomy & Cell Biology Vol.37 No.1

Pregnancy-induced hypertension (PIH) is a multi-system disorder unique to human pregnancy. Although theetiology of PIH is still unknown, there is a large evidence suggesting that abnormal trophoblast invasion is occurring inearly pregnancy and that this may contribute to relative placental hypoxia and oxidative stress that may furtherexacerbate placental pathology. This study was undertaken to determine placental Cu/Zn superoxide dismutase (SOD)and Mn SOD activities and evaluate the use of M30 CytoDeath antibody to assess trophoblasts apoptotic activity innormal and PIH pregnancies. We also compared apoptotic rates as detected by M30 and TdT-mediated dUTP nickendlabelling (TUNEL). Placental expression of Cu/Zn SOD and Mn SOD were reduced in PIH as compared to normalpregnancies. M30 immunoreactivity occurred predominantly in the syncytiotrophoblasts, and a significantly highernumber of M30 positive cells in the preeclamptic placentas were found when compared with normal placentas. Thenumber of M30 positive cells correlated with another apoptotic index previously detected by TUNEL method. ─임신성고혈압에서 Caspase-related M30 CytoDeath 발현을이용한 영양막세포고사 연구김호진1, 박혜숙2, 김영주3, 4, 박보현2, 이화영1, 4*이화여자대학교 의과대학 1해부학교실, 2예방의학교실, 3산부인과학교실4이화여자대학교 의과학연구소임신성고혈압은 모체와 주산기의 사망률 및 이환률을 높이는 주요 원인이며 이의 발병에 관한 명확한 병리기전은 밝혀져있지 않으나, 태반형성 시 비정상적인 영양막 침윤으로 인한 나선동맥의 불충분한 생리학적 변화와 이로 인한 태반허혈 및산화손상이 모체의 혈관내피세포 기능변화를 유발하고, 태반의 구조적 변화를 악화시키는 것으로 알려져 있다. 본 연구는 임신성고혈압의 태반내 항산화상태와 영양막의 세포고사를 조사하고자, 정상 임산부와 임신성고혈압 환자의 출산 시 분리된태반을 대상으로 태반 내 Cu/Zn superoxide dismutase (SOD) 및 Mn SOD의 함량을 측정하였다. 또한 영양막 세포고사 연구를위하여 근래에 개발된 M30 CytoDeath 발현과 기존의 TdT-mediated dUTP nickend labelling (TUNEL)을 병행하여 관찰하고이를 통계적으로 분석, 비교하였다. 태반에 함유된 Cu/ Zn SOD와 Mn SOD 활성은 정상임신에 비하여 임신성고혈압에서 의미있게 감소되었으며, 세포고사를 표지하는 M30발현을 통하여 임신성고혈압의 융합영양막에서 그 반응성과 발현세포의 숫적증가가 관찰되었다.찾아보기 낱말 : 임신성고혈압, 영양막, 산화손상, 세포고사, SOD, M30Ho Jin Kim, Hyesook Park, Young Ju Kim, Bohyun Park, Hwayoung Lee 59

A Risk Prediction Model for Operative Mortality after Heart Valve Surgery in a Korean Cohort

김호진,김준범,김선옥,윤성철,이삭,임청,최재웅,황호영,김경환,이승현,유재석,성기익,제형곤,홍순창,김윤정,김성현,장병철 대한흉부외과학회 2021 Journal of Chest Surgery (J Chest Surg) Vol.54 No.2

Background: This study aimed to develop a new risk prediction model for operative mortality in a Korean cohort undergoing heart valve surgery using the Korea Heart Valve Surgery Registry (KHVSR) database. Methods: We analyzed data from 4,742 patients registered in the KHVSR who under- went heart valve surgery at 9 institutions between 2017 and 2018. A risk prediction model was developed for operative mortality, defined as death within 30 days after surgery or during the same hospitalization. A statistical model was generated with a scoring system by multiple logistic regression analyses. The performance of the model was evaluated by its discrimination and calibration abilities. Results: Operative mortality occurred in 142 patients. The final regression models identi- fied 13 risk variables. The risk prediction model showed good discrimination, with a c-sta- tistic of 0.805 and calibration with Hosmer-Lemeshow goodness-of-fit p-value of 0.630. The risk scores ranged from -1 to 15, and were associated with an increase in predicted mortality. The predicted mortality across the risk scores ranged from 0.3% to 80.6%. Conclusion: This risk prediction model using a scoring system specific to heart valve surgery was developed from the KHVSR database. The risk prediction model showed that operative mortality could be predicted well in a Korean cohort.

네오마르크스주의와 신좌익운동

김호진 창원대학교 통일문제연구소 1986 통일논총 Vol.1 No.-

한국노사관계의 문제점과 발전방향

김호진 한국식품산업협회 1992 좋은식품 Vol.117 No.-

기획시리즈 : 내고장 우리문화 (12) ; 전북 고창 , 부안

김호진 대한지방행정공제회 1999 地方行政 Vol.48 No.545

Early Postoperative Complications after Heart Transplantation in Adult Recipients: Asan Medical Center Experience

김호진,정성호,김재중,김준범,주석중,윤태진,정철현,이재원 대한흉부외과학회 2013 Journal of Chest Surgery (J Chest Surg) Vol.46 No.6

Background: Heart transplantation has become a widely accepted surgical option for end-stage heart failure in Korea since its first success in 1992. We reviewed early postoperative complications and mortality in 239 patients who underwent heart transplantation using bicaval technique in Asan Medical Center. Methods: Between January 1999 and December 2011, a total of 247 patients aged over 17 received heart transplantation using bicaval technique in Asan Medical Center. After excluding four patients with concomitant kidney transplantation and four with heart-lung transplantation, 239 patients were enrolled in this study. We evaluated their early postoperative complications and mortality. Postoperative complications included primary graft failure, cerebrovascular accident, mediastinal bleeding, renal failure, low cardiac output syndrome requiring intra-aortic balloon pump or extracorporeal membrane oxygenation insertion, pericardial effusion, and inguinal lymphocele. Follow-up was 100% complete with a mean follow-up duration of 58.4±43.6 months. Results: Early death occurred in three patients (1.3%). The most common complications were pericardial effusion (61.5%) followed by arrhythmia (41.8%) and mediastinal bleeding (8.4%). Among the patients complicated with pericardial effusion, only 13 (5.4%) required window operation. The incidence of other significant complications was less than 5%: stroke (1.3%), low cardiac output syndrome (2.5%), renal failure requiring renal replacement (3.8%), sternal wound infection (2.0%), and inguinal lymphocele (4.6%). Most of complications did not result in the extended length of hospital stay except mediastinal bleeding (p=0.034). Conclusion: Heart transplantation is a widely accepted option of surgical treatment for end-stage heart failure with good early outcomes and relatively low catastrophic complications.

COVID-19사태와 금융계약상 쟁점

김호진,하영진 서울대학교 금융법센터 2020 BFL Vol.103 No.-

Naturally Occurring Mediastinal Teratoma with Malignant Transformation in an Adult Male

김호진,김형렬 대한흉부외과학회 2013 Journal of Chest Surgery (J Chest Surg) Vol.46 No.4

We report a rare case of rhabdomyosarcoma spontaneously arising in an anterior mediastinal teratoma in a 47-year-old male. The patient was found to have an anterior mediastinal mass on a chest X-ray, which was taken two months before his presentation to Asan Medical Center. A subsequent computed tomography scan revealed an 8.9×7.1×8.0 cm heterogeneous mass in the anterior mediastinum. He underwent an excision via median sternotomy. The histopathologic study identified a mature teratoma with embryonal rhabdomyosarcoma.

홍삼가공품의 Ginsenoside 함량 규격기준 개선방안 연구

김호진,곽인애,김현정,안종성,손영배 한국식품위생안전성학회 2013 한국식품위생안전성학회지 Vol.28 No.1

Red ginseng is a widely used dietary supplement and medicinal herb, and there are so many forms of ginseng products including tea, extract, capsule and jelly. The purpose of the present study was to propose some amendments on ginsenoside content of red ginseng products in Korea. For this purpose, we analyzed red ginseng products for simultaneous determination of 26 ginsenosides by ultra performance liquid chromatography with diode array detector. Some developmental aspects of Korea’s ginsenoside content standard regulations for red ginseng products are needed to be examined as follows : Firstly, we proposed that four ginsenosides (Rb1, Rg1, Rf and Rg3) would be detected in red ginseng products. Secondly, in case of red ginseng extracts, the sum of Rb1, Rg1 and Rg3 would be 4.0 mg/g. The two proposals are helpful to comprehensive evaluation of quality of red ginseng products. In conclusion,the scientific studies on amendment scheme of ginsenoside content standard regulation of red ginseng product are very important to fortify quality control.

Primary Bronchial Granular Cell Tumor in an Adult Male

김호진,안소연,김형렬 대한흉부외과학회 2014 Journal of Chest Surgery (J Chest Surg) Vol.47 No.2

We report a rare case of granular cell tumor arising in the left lower lobe (LLL) bronchus with secondary obstructive change in a 60-year-old male. The patient was found to have a nodule in the LLL on a computed tomography scan, three months prior to his presentation to the Asan Medical Center. Bronchoscopic biopsies revealed a granular cell tumor. After undergoing LLL lobectomy with bronchoplasty, the patient has not experienced any tumor recurrence.