척수압박으로 발현된 급성 골수성 백혈병에 동반된 과립구성 육종 1 례

윤상준,김영곤,김희종,박유환,정춘해,김양수,김태균,박영진,전호종 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1

저자들은 척수압박으로 하지마비를 보인 환자에서 수술 후에 급성 백혈병에 동반된 과립구성 육종으로 진단된 환자 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Granulocytic sarcoma(GS) is an uncommon tumor composed of immature cells of the granulocytic series. Most case of GS occur in the course of acute leukemia and the blast crisis of chronic leukemia, Rarely, however, it may present before leukemia becomes clinically apparent. It may also occur in patients with myeloproliferative disoders. GS has been reported that it occurs in 3% to 9% of patients with acute myelogenous leukemia(AML) and the incidence of GS is reported to be higher in patients with t(8;21). GS occurs relatively commonly in africa and has been reported to affect 10-25% of black children presenting with AML. This is very rare case of granulocytic sarcoma with AML(FAB M5) presented with spinal cord compression which was supported by decompression laminectomy.

분말충진방법과 가공정도에 따른 Ag/BSCCO 초전도선재의 특성

지봉기,김태우,김정호,김중석,주진호 成均館大學校 科學技術硏究所 1998 論文集 Vol.49 No.1

We evaluated the effects of processing variables on interface irregularity. microstructure. and resultant Jc of BSCCC superconductor tape. For the tapes made by PIT technique. the degree of interface irregularity was varied with powder packing methods and forming process variables. It was observed that the degree of interface irregularity of the tape by CIP method was more reduced. compared to that of the tape by ram method. In addition. the degree of interface irregularity was promoted with decreasing the dimension of tape during forming process. As the dimension of wire/tape were changed from diameter of 3.25mm to thickness of 200㎛ during forming process. Jc value was observed to be increased by 10 times. It was likely that the improvenment of Jc was mainly result from the enhanced texturing of 2223 grain. Microstructural investigation showed the degree of texturing was degraded by the existence of both second phases and interface irregularity. If the interface was flat, larger grain size and better texturing near interface were developed compared to those inside superconducting core, The improvements of microstructure near interface may be result of reaction between Ag and superconductor phase.

감마선과 훈증처리가 건고추의 저장 중 이화학적 특성에 미치는 영향

김병근,권중호 한국식생활문화학회 2004 韓國食生活文化學會誌 Vol.19 No.5

In order to study the quarantine and sanitization methods for dried red pepper, comparative effects of commercial fumigation (methyl bromide/MeBr, phosphine gas/PH₃) and gamma irradiation (5, 10 kGy) were investigated in terms of its physicochemical properties. There were no noticeable chances in pH and soluble solids among the untreated control, irradiated and fumigated samples soon after treatments, but some decrease was found in stored samples (especially soluble solid in fumigated samples) for 8 months under room temperature. Total sugar content was influenced by storage time rather than both treatments. Immediately after treatments, reducing sugar content was significantly reduced in the samples including pericarp when exposed to fumigants (p〈0.05), while an apparent decrease was observed in the stored samples including seeds with negligible differences among treatment groups. The electron donating ability (EDA) of the extracts was high in the order of pericarp, whole pepper, powdered pepper and seeds, which was reduced during storage for 8 months particularly in the samples containing seeds. The EDA of irradiated samples during storage was equal to that of the control sample, whereas that of fumigated samples was relatively low (p〈0.05).

상아모세포 관련 유전자, OD314의 발현과 기능 연구 : OD314

김두현,김흥중,정문진,손호현,박주철 大韓齒科保存學會 2004 Restorative Dentistry & Endodontics Vol.29 No.4

Odontoblasts are responsible for the formation and maintenance of dentin. They are known to synthesize unique gene products including dentin sialophosphoprotein (DSPP). Another unique genes of the cells remain unclear. OD314 was isolated from the odontoblasts/pulp cells of rats and partially characterized as an odonto-blast-enriched gene (Dey et al., 2001). This study aimed to elucidate the biological function of OD314, relating to odontoblast differentiation and dentinogenesis. After determining the open reading frame (ORF) of OD314 by transient transfection analysis using green fluorescent protein (GFP) expression vector, mRNA in-situ hybridization, immunohistochemistry, reverse transcription-polymerase chain reaction (RT-PCR) and western analysis were performed. The results were as follows: 1. In in-situ hybridization, OD314 mRNAs were expressed in odontoblasts of developing coronal and root pulp. 2, OD314 was a novel protein encoding 154 amino acids, and the protein was mainly expressed in cyto-plasm by transient transfection analysis. 3. Mineralized nodules were associated with multilayer cell nodules in the culture of human dental pulp cells and first detected from day 21 using alizarin-red S staining. 4. In RT-PCR analysis, OD314, osteocalcin (OC) and DSPP strongly expressed throughout 28 days of culture. Whereas, osteonectin (ON) mRNA expression stayed low up to day 14, and then gradually decreased from day 21. 5. Western blots showed an approximately 17 kDa band. OD314 protein was expressed from the start of culture and then increased greatly from day 21. In conclusion, OD314 is considered as an odontoblast-enriched gene and may play important roles in odontoblast differentiation and dentin mineralization.

자가 말초혈액 조혈모세포 이식술의 임상적용

김혁,안명주,오석중,이영열,김인순,정태준,최일영,오미란,임호준,이항,김신규 한양대학교 의과대학 1999 한양의대 학술지 Vol.19 No.1

Responses to chemotherapy correlate with the increased dose of chemotherapeutic agents in some cancers, e.g. breast cancer, Ewing's sarcoma, Hodgkin's disease(HD) and non-Hodgkin's lymphoma(NHL), then for the improvement of the chemotherapy responsiveness, high-dose chemotherapy(HDCT) was proposed. But, it's application was limited due to complications, especially bone marrow suppression. HDCT and succeeding autologous peripheral blood stem cell transplantation(APBSCT) was introduced to overcome this problem. This study was designed to determine the clinical pictures including clinical parameters and the responsiveness of HDCT followed by APBSCT in Hanyang University Hospital. Ten patients were enrolled. They were 8 adults (3 breast cancers, 3 multiple myelomas, 1 HD, 1 NHL) and 2 children (1 acute myelogenous leukemia (AML), 1 neuroblastoma). Mobilization chemocherapy(MCT) followed by Granulocyte Colony Stimulating Factor(G-CSF) was administered to mobilize stem cells from bone marrow to peripheral blood. The stem cells were collected by using CS-3000 and cryopreserved at -196℃ with programmed controlled rate freezer as the mixture with 10% dimethyl sulfoxide(DMSO). HDCT was administered and cryopreserved peripheral stem cells were infused on day 0 as planned. Patients' mean age was 41 years old. After induction chemotherapy three patients achieved complete response and 5 partial response. The median time for bone marrow recovery after MCT was 11.5 days for neutrophil(〉500/㎣) and 4.8 days for platelet(〉20,000/㎣). There were three cases of neutropenic fever and one case of gingivitis. After HDCT with APBSCT, one patient was converted partial response to complete response, and one patient achieved complete response after HDCT without induction chemotherapy. The median time for bone marrow recovery was 12.7 days for neutrophil(〉500/㎣) and 14.7 days for platelet(〉20,000/㎣). Eight patients developed neutropenic fever and required systemic antibiotics. Transfusion was required 1.6 pints for packed red cell and 23.4 pints for platelet concentrates. Toxicity consisted mainly of vomiting, diarrhea, and mucositis which were mild. HDCT with APBSCT can be performed safely with minimal complications. For the evaluation of the exact role of HDCT with APBSCT in malignant diseases, further studies are required as a large scale of patients and lung-term follow up.

토목공사 정보관리를 위한 Uniclass 시스템의 활용성 분석

김창학,곽중민,강정호,강인석 진주산업대학교 2000 산업과학기술연구소보 Vol.- No.7

A standardized construction information classification system is essential for organizing construction CALS and CM. In 1997, Uniclass system was developed for superseding CI/SfB system that was being used as a representative WBS. Uniclass system is organized on the basis of ISO frame and consists of tables for classifying information related to construction management and electronic commerce. This study was implemented for the analysis of applicability of Uniclass system, comparing with CI/SfB system, as a WBS for the construction CALS. This study suggests a alternative table of Uniclass to improve applicability in practical use. Uniclass system was analyzed as the best classification system for the civil engineering project among the existing systems, howewer, the classified items for CM and construction CALS need to be modified with more detailed items.

단지양 근위축증(Monomelic Amyorophy) 3례 : 증례 보고 Case Report

김기찬,정호중,정상욱,정흥채,조근열 고신대학교 의학부 1999 高神大學校 醫學部 論文集 Vol.14 No.1-2

Monomelic amyotrophy is a rare form of motor neuron disease which is insidious onset in the second and fourth decades, male preponderance, sporadic occurrence, wasting and weakness confined to one limb, and absence of involvement of the cranial nerves, cerebrum, brain, stem, and sensory system. Symptoms and signs often progress for several years before spontaneously arresting. Neurologic findings and electrophysiologic studies are only useful for the diagnosis of monomelic amyotrophy and other laboratory testing are frequently normal or nonspecific. We reported three cases of typical monomelic amyotrophy with review of the articles.

호텔기업 여성종사원의 성차별에 관한 연구

김시중,장호찬 우송대학교 부설 산업연구원 1999 산업연구 Vol.1 No.1

The purpose of this research was to analyze the sexual discrimination level of woman employee in hotel industry. This research was based on a survey. The survey was conducted on 130 individuals who were working in hotels in Seoul. With collected data, regression analysis, T-Test and analysis of variances were utilized using SAS program. The results showed that there were no evidences of sexual disrimination among the individuals' educatination, sexual harassment, discrimination against employment, and workload among the position levels within a corporation. Finally, the analysis showed that there were sexual discrimination in a promotion policy, retirement policy, workload, and employment during employment period. However, there were no evidences of sexual discfrimination in other areas.

한국인 두피의 조직학적 층에 관한 형태계측학적 연구

서중석,김대중,김호덕,라봉진 대한해부학회 1995 Anatomy & Cell Biology Vol.28 No.4

단순남성임균성 요도염에 대한 Clavulanatepotentiated Amoxycillin(CPA)의 치료효과

김성호,김중환,허훈,김영태 한양대학교 의과대학 1987 한양의대 학술지 Vol.7 No.1

At the Venerel Disease Clinic of Choong-Ku Public Health Center in Seoul 103 patients with uncomplicated gonococcal urethritis were allocated randomly into one of 2 treatment regimens and 101 male patients were followed. All 51 patients, including PPNG infections, treated with clavulante-potentiated amoxycillin, 375 mg, PO, t.i.d for 5 days recovered (100%). Two (4%) of 50 patients treated with clavulanate-potentiated amoxycillin, 3.25g, PO plus probvenecid, 1g, PO failed to recover. These cases were 2 of 25 Penicillinase Producing Neisseria gonorrhoeae (PPNG) infections (failure rate of 8%) and all 25 non-PPNG infections recovered (100%). The antibiotics susceptibility pattern of pre-and post-treatment isolates from these cases did not give conclusive evidence of reinfection and the patients denied having has sexual intercourse during the follow up period. The fact that these treatment failure cases showed negative culture on the first follow up (at 24 hours) and positive result on the second follow up at 3rd post treatment day suggests that test of cure culture at 24 hours after treatment is not the optimal time. It is suggested that both of these clavulanate-potentiated amoxycillin regimens have simiarly good effect with minimal side effects in the treatment of gonococcal urethritis and , because of high rate of PPNGs among circulating N.gonorrhoeae, they can be recommended as the first line treatment for gonorrhoea in Korea.