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혈관성 파킨슨증의 경사에코 자기공명촬영 소견 : 환자-대조군 연구 A Case-Control Study
배희준,김병건,구자성,김현숙 대한치매학회 2002 Dementia and Neurocognitive Disorders Vol.1 No.2
Background & objective : Changes of signal intensity in the various Structures of basal ganglia(BG), Which can be detected by gradient echo MRI(GE-MRI). have been reported in different kinds of parkinsonism Altered iron content in these structures may be a possible explanation of above phenomenon Vascular parkinsonism is a kind of parkinsonism syndrome and is common However. There have been no reports about the BG signal changes on GE-MRI in vascular parkinsonism Methods : We investigated the difference of signal intensity in various BG and midbrain structures between 36 patients with vascular parkinsonism. which was defined as clinical parkinsonism+evidence of relevant vascular lesion on MRI+poor or no response to levodopa, and age-& sex- matched controls. The intensity of BG on GE-MRI was graded as 0-3 relative to cortical gray matter Results : There were no significant differences in clinical characteristics between two groups Among patients with vascular parkinsonism, hypointensity was observed in globus pallidus in 94.4%. in putamen in 58.3% in head of caudate in 33.3%, in substantia nigra in 72.2%,& in red nucleus in 52.8% There was no significant linear trend in the association between signal intensity of above structures and the presence of vascular parkinsonism (p>0 05 on Mantel-Haenszel chi-square test) However, the correlation between the degree of white matter lesions and the presence of vascular parkinsonism was statistically significant (p=003). Conclusions : Our GE-MRI study fails to prove that iron content of various BG structures in patients with vascular parkinsonism is different from controls.
열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구
배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2
Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.
정보제공자와의 면담에 의해 진단된 뇌졸중후치매의 유병률과 상관인자에 관한 연구
배희준,이건세,김형수,김병건,구자성,권오현,박종무 대한치매학회 2004 Dementia and Neurocognitive Disorders Vol.3 No.2
Background and Objectives: With increasing age of population, stroke and dementia become greater health problems in Korea. However, there have been no studies on poststroke dementia in Korea. We intended to elucidate the frequency and clinical correlates of poststroke dementia in a hospital-based cohort. Methods: From July 2001 to July 2002, 372 patients were hospitalized to Eulji General Hospital within 7 days from onset with acute stroke or transient ischemic attack. Two hundred-eight patients (55.9%) were followed up and interviewed more than 1 year later (451 ±83.3 days). Dementia was diagnosed by Korean Dementia Screening Questionnaire (KDSQ) obtained by a direct interview. Based on Eulji Stroke Registry, demographic factors, risk factors for stroke, stroke characteristics, and stroke outcomes were gathered and examined. Results: Of 208 patients, poststroke dementia was detected in 36 patients (17.3%, 20 males, age=64.5±9.4 years). Poststroke dementia was associated with history of stroke, aphasia, modified Rankin Disability Scale (MRDS) at 3 month after stroke and when interviewed, and Barthel index at 6 months after stroke (p;0.05). Its correlation with diabetes mellitus and National Institute of Health Stroke Scale at discharge were marginally significant (0.05;p;0.1). Conclusions: Post-stroke dementia is common in Korean stroke patients. Its frequency is comparable to that in other countries. The correlates of poststroke dementia and their clinical meanings are demonstrated.
배준우,황재근,박경흠,양희준,이춘열 嶺南大學校 工業技術硏究所 2004 工業技術硏究所論文集 Vol.32 No.1
Recently, force measurement systems are commonly used in many industrial fields and the precision of the measurement system is getting more important as the industry needs more precise tools and instruments to make high quality products. However, a high precision force measurement system is hard to make unless we know precisely the causes, quality and quantity of measurement errors in advance. In this work, many possible mechanical causes of measurement errors are reviewed including ratio of length to diameter of sensing part, radius of contact area, radius of bearing part, ratio of material properties and change of boundary conditions. Also, the measurement errors are analyzed by nonlinear finite element method and the nonlinear behavior of the errors are investigated. The results can be used to design force measurement systems and expected to be very useful especially for compact type load cells.
배희준 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2
Mild cognitive impairment (MCI) is a recently described syndrome that is currently thought of as transition phase between healthy cognitive aging and dementia At the moment, many treatment strategies for Alzheimer's disease were extrapolated to interventional strategies in MCI Most investigators believe that by the time the clinical diagnosis of Alzheimer's disease is made, sufficient neuronal damage has taken place in the brain to make reversal of the condition unlikely. Therefore, it is a more effective strategy to treat patients in preclinical stage of Alzheimer's disease, such as MCI, than to treat in its advanced stage This article reviews currently available symptomatic treatments and visionary treatments for Alzheimer's disease and MCI. A number of clinical trials for MCI, which are ongoing at now, are discussed.
운동, 흡연, 음주 습관이 운동부하검사성적에 미치는 영향
김희균,강인숙,황은주,배형준 임상병리검사과학회 1998 임상병리검사과학회지 Vol.30 No.3
Although there have been many studies on the risk factors for coronary artery disease, but there have been rare an attempt to examine the effect of risk factors on exercise test The purpose of this study was to research the effects of training, smoking and drinking habit on results of treadmill exercise test. The subject of study was adult patient 530 cases be questionable as coronary artery disease in Dept. of Cardiovascular Center, Kang Dong Sacred Heart Hospital between May 1997 to February 1998. In this study used to modified Bruce protocol(Case 16, Marquette co.). Total positive rate was 30.8%(144 cases) by treadmill exercise test, it was male higher than female(16.3%:14.6%), that was seen significantly differ as increase of age. As training habit, positive rate of nontraining group was higher than training group(18.4%:12.4%), have been no relationship both regularity and frequency between nontraing and traning groups, but performance degree of workload level was high in training group. As smoking habit, positive rate of smoking group was higher than nonsmoking group in males (57.9%:42.1%), 9 cases of total 20 cases in females, there was have been high positive rate(45%). As drinking habit, positive rate of between drinking and nondrinking groups was no significantly differ, but positive rate of drinking group was a few higher than nondrinking group in male and female groups.