새로운 Carbapenem 유도체의 합성

배형준,정윤성,함원훈,정영훈 성균관대학교 약학연구소 1996 成均藥硏論文集 Vol.8 No.1

The class of β-lactam containing compounds known as carbapenems has been the focus of countless chemical and biological studies since the naturally occurring structural type was reported in 1976. The discovery of thienamycin, with its extraordinary potent broad-spectrum antibacterial profile, prompted a rigorous search for efficient and general routes to total and partial synthesis of carbapenems. Wile many strategies of carbapenem construction have been brought to fruit, only two approaches (and conceptually related ones) have emerged with the general usefulness. In fact, they have been applied relentlessly in analogue programs around the world. This thesis utilize a rhodium catalyzed carbene insertion to establish the bicyclic ring system. The resulting β-keto ester is transformed into carbapenem via vinyl phosphate. Thiol addition-phosphate elimination occurs readily to incorporate the new side-chain thiol. New carbapenem derivative, {ally(1R, 5S, 6S)-2-(N-carboben-oxycarboxydiethylamido cysteine)-6-[(IR)-1-hydroxyethyl]-1-methyl-carbapen-2-em-3-carboxylate} was synthesized via 10 steps.

Methacholine 유발검사에 의한 기관지 반응도의 변화

배형준,김현정 서울保健大學 1997 論文集 Vol.17 No.1

We examined adult patient 223cases be questionable as bronchial asthma by methacholine challenge test, and the results were as follows. Total positive rate was 44.8%, the positive rate had no significantly differ between male and female, that had no significantly differ as increase of age. The positive rate was raised as increase of weight, but that had no relationship by height. In positive group, the threshold of bronchus reactivity on methacholine had a high value in higher concentration group than lower group. Average value of baseline FEV_(1)/FVC was augmented as increase of concentration, also average value of PC_(20) FEV_(1)/FVC was increased, but reduction rate of FEV_(1)/FVC had no significantly differ between baseline and PC_(20) in positive group. Futher both FEV_(1)/FVC of baseline and PC_(20) were higher negative group than positive group.

산화질소 억제가 혈압, 심박동수 및 체중에 미치는 영향

배형준 임상병리검사과학회 1999 임상병리검사과학회지 Vol.31 No.2

This study examined the physiological and histological changes in Sprague-Dawley rats with induced hypertension by chronic treatment of NG-nitro-L-arginine methyl ester(L-NAME), nitric oxide synthesis inhibitor. Systolic blood pressure of L-NAME treatement experimental group was significantly higher compared with untreated control group by 28.5%(44.2mmHg)(p<0.001). Changing rates on systolic blood pressure of L-NAME treated groups according to during L-NAME treatment period were significantly higher than control groups by 16.1% in 2weeks, 15.1% in 4weeks(p<0.05), 29.1% in 6weeks(p<0.01) and 28.5%(p<0.001). However, heart rate and body weight did all not significant differ between L-NAME treated group and control group, between L-NAME posttreated rats and pretreated rats. Systolic blood pressure had each low correlation with heart rate and body weight. In conclusion, chronic inhibition of nitric oxide by L-NAME treatment had significant effect on systolic blood pressure, but not affect on heart rate and body weight. Thus, this study suggested that nitric oxide had important role to control for blood pressure and to modulation for function of organs associated with blood pressure.

답차운동부하검사법에 의한 관상동맥질환의 심전도학적 연구

배형준,김주옥 서울保健大學 1996 論文集 Vol.16 No.1

We examined adult patient l,000cases be questionable as coronary artery disease by treadmill exercise test, and the following results were obtained. 1. Total positive rate was 10.1%, and it was significantly differ between male and female(p<.05), and it was significantly differ as increase of age(p<.00l). 2. The stop reasons of treadmill exercise test were significantly differ between male and female, because of chest pain of female higher than male (p<.00l), and it was significantly differ as increase of age(p<.05), and it was significantly differ between positive and negative groups, because of most frequent stop reaseons were chest pain in the positive group and dyspnea in the negative group(p<.001). 3. Average maximum workload level of male was significantly higher than female(p<.001), and it was significantly decresed as increase of age(p<.001), and it was significantly differ between the total positive groups(81±2.7METS) and negative groups(9.3±2.4METS). And performance degree of maximum workload level in the positive group was most frequent as stage 3(42.6%). 4. Average maximum heart rate was not significantly differ between sexual groups in the positive group, but it was significantly differ between sexual groups in the negative groups(p<.001), and it was significantly decrease-as increase of age(p<.001), and it was differ between the total positive groups(158.5±23.0bpm) and negative groups(162.7±20.5bpm)(p<.0.1). 5. The reaching level of target maximum heart rate was not significantly differ as between sexual groups, as between age groups in the positive groups, but it was significantly differ in the negative groups, and it was not significantly differ between the total positive groups (93.2±l1.6%) and negative groups (94.2.±l0.l%). 6. Decreased cases of systolic blood pressure were 28cases in the toal positive groups, and most decreased as stage 2, and most frequently decreased level was lower than l0mmHg. 7. Decreased cases of ST segment were 93cases in the total positive groups, most frequently decreased level was higher than 1 mm under the baseline.

심실성 조기박동의 심전도학적 연구

배형준 서울保健大學 1995 論文集 Vol.15 No.1

A study on the ventricular premature beats was made on 123 cases diagnosed by surface electrocardiographic examination. The results were as follows : 1. Ventricular premature beats were observed in 123 cases of the 5,456 adult patients and the incidence of ventricular premature beats was 2.3%. 2. The ratio of male to female was 44.7% to 55.3%. The most frequent age group was 5th decade, and the incidence of ventricular premature beats rose suddenly over the 5th decade. 3. Atrial fibrillation was one of the most frequent arrhythmias associated with ventricular premature beats, being 24 cases(19.5%) Second most associating arrhythmias was bundle branch block with or without fascicular block, being 9 cases(7.3%). 4. Ventricular premature beats with interpolated beat were 8 cases(6.5%), with retrograde-P wave were 18 cases(14.6%), and end-diastolic ventricular premature beats were 8 cases(14.6 %). 5. 66 cases(53.7%) were classified as having ventricular premature beats originated in the right ventricle, 52 cases(42.3%) were originated in the left ventricle, and 5 cases(4.1%) had septal ventricular premature beats. 6. Ventricular bigeminy were 10 cases(8.1%), ventricular trigeminy were 4 cases(3.3%), and ventricular Quadrigeminy was 1 case(0.8%).

병원내 생리기능 검사실의 적정 업무환경에 관한 연구

배형준,윤기은,김승곤,나동진,문희주,김태전,박정오 서울보건대학 1999 서울보건대학 부설 병원경영연구소 논문집 Vol.4 No.2

The purpose of this study was to suggest guideline for optimal work environment of physiological laboratory in hospital. Therefore this study was carried out to analyze the actual condition of laboratory system, major equipments and persons. The period of survey was from September to November 1997 and the objects were 123 laboratory. The major results of this study were as follows. 1. The optimal areas of general ECG room, exercise ECG room and echocardiology room were all 9-18㎡, that of Holter ECG room was 3-12㎡. The optimal areas of neurosystem laboratory were all 9-12㎡, those of respiratory system laboratory were all 9-18㎡. 2. The optimal number of persons laboratory of hospital 500 beds and less were 2∼3, those of 501∼700 beds were 3∼4.701∼1.000 beds were 4∼5 and over 1.001 beds were 7∼8 persons in circulatory system laboratory. The optimal number of persons laboratory of hospital 500 beds less than were 1∼2, those of 501∼700 beds were 3∼4, 701∼1.000 beds were 6∼7 and over 1.001 beds were over 8 persons in neurosystem laboratory. The optimal number of persons laboratory of hospital 500 beds and less 1. those 501∼1.000 beds were 1∼2 and over 1.001 beds were 2∼3 persons in repiratory system laboratory. 3. The optimal number of equipments of general ECG were 2∼3 in the 500∼1.000 beds hospital. there were 3∼4 units in the 1,001 beds. The optimal number of equipment EEG were both 1∼2 in the hospital 500 beds and less and 501∼700 beds. those were 4∼5 units in hospital over 701 beds. The optimal number of equipments of spirograph were both 1∼2 in the hospital 500 and less and 501∼1.000 beds. those were 2∼3 units in the over 1.001 beds. 4. In view of speciality and legal problem of physiofunctional test. we sugget that non-licensee were so quickly change place licensee in the interests of optimal work environment. 5. We suggest that to upgrade qualitative level of domestic equipment and to the more amplify utilization with respect to domestic equipment for the purpose of reducing loss of foreign money.

방실차단 및 심실내전도장애에 관한 통계적 고찰

배형준 대한임상병리사협회 1994 대한임상병리사회지 Vol.26 No.1

A statistical study was done on atrioventricular block and intraventricular conduction disturbance in 127 cases taken on 1,761 patients subjected to electrocardiographic examination. The results were as follows 1. Total incidence of conduction disturbance was 7.21%, atrioventricular block was 2.67% and intraventricular block was 4.54% of total patients. Among of these, first degree atrioventricular block was 2.44% which was the most common occurred one, and complete right bundle branch block(2.33%), incomplete right bundle branch block (1.13%), left anterior hemiblock(0.74%), third degree atrioventricular block and left bundle branch block(each 0.17%), bifascicular block(0.11%), second degree atrioventricular block and left posterior hemiblock(erach 0.06%) in the order of frequency. 2. The ratio of male to female was 1.2:1 for atrioventricular block and 1.4:1 for intraventricular block. Atrioventricular block and intraventricular block were both common in over fifth decade. 3. The abnormal ECG findings wjth first degree atrioventricular block were sinus bradycardia(27.3%), left ventricular hypertrophy(21.2%), atrial enlargement(12.2%). In third degree atrioventricular block, the majority(50.0%) showed atrioventricular junctional escape rhythm. In complete right bundle branch block, there were 22.8% of atrial fibrillation and 14.3% of myocardial infarction. In incomplete right bundle branch block, there were 29.4% of both atrial enlargement and atrial fibrillation. In left anterior hemi-block. there was 21.5% of sinus bradycardia.

심전도검사에 의한 심방세동의 통계적 고찰

배형준 서울保健大學 1994 論文集 Vol.14 No.1

A statistical study was done on atrial fibrillation in 2,414 adult patients subjected to electrocardiographic examinations at S University Hospital from Jan 1994 to Apr 1994. The results were as follows: 1) Atrial fibrillation were observed in 159 cases of the 2,414 adult patients and the incidence of atrial fibrillation was 6.59%. 2) Sex distribution showed no significant difference and the majority of patients(65.3%) were observed over fifth decade. 3) The average rates of ventricular response to atrial fibrillation were varible with normal range(61~100BPM) in 74.2%, tachycardia(over 101BPM) in 15.7%, bradycardia(less 60BPM) in 10.1%. 4)Total cases of associated electrocardiographic finding of atrial fibrillation were 107 cases: left ventricular hypertrophy(22.4%), ventricular premature beat(14.9%), myocardial ischemia(11.2%), right ventricular hypertrophy(10.3%), complete right bundle branch block(9.4%), aberrant conduction(8.4%), myocardial infarction(6.6%), incomplete right bundle branch block(5.6%), atrial flutter-fibrillation(3.7%), atrioventricular junctional escape rhythm(2.8%), complete atrioventricular block and left anterior hemiblock(each 1.9%), biventricular hypertrophy(0.9%) in the order of frequency.

무선 생체정보 인식 센서들을 활용한 원격의료 구급차

배형준(Hyung-Joon Bae),이승주(Seung-Joo Lee),이준희(Jun-Hee Lee),이광재(Kwangjae Lee) 대한전기학회 2019 대한전기학회 학술대회 논문집 Vol.2019 No.11

Nitric Oxide의 만성적인 억제로 인한 고혈압성 SD 랫드에서 Insulin 및 전해질의 변화

배형준(Hyung-Joon Bae),김길수(Kil-Soo Kim),양제훈(Je-Hoon Yang),진복희(Bok-Hee Jin) 한국실험동물학회 1999 Laboratory Animal Research Vol.15 No.2