Combination treatment for onychomycosis using 1,064 Nd:YAG laser and efinaconazole 10% topical solution

( Sang Ju Lee ),( Dong Woo Suh ),( Won Soon Chung ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: Onychomycosis is one of the most common nail disease around the world. No specific treatment other than drug therapy and surgery was suggested till present. Systemic antifungal drugs for onychomysosis are effective. However, they require a long treatment time and not suitable for people with other systemic disease. Furthermore, they may cause many side effects such as liver disease. Also, many patients prefer topical drugs or physical treatment. Objectives: The objective of this study was to evaluate the efficacy of combination treatment with a 1064 Nd:YAG laser and efinaconazole 10% Topical Solution. Methods: Ten patients with onychomycosis were treated with 1064 Nd:YAG laser (PinPointe FootLaser, Cynosure, Westford, MA, USA) once a month with application of 10% eifnaconazole solution(Jublia, Dong-A EST) once a day. The effectiveness of treatment were evaluated with before and after photographs. Results: Improvement were shown in 90% of patients after the treatment. However, 10% of patients had no response. Conclusion: This clinical study suggests that combination treatment of a 1064 Nd:YAG laser and efinaconazole 10% Topical Solutionis an effective, safe, and convenient treatment method for onychomycosis.

Three Poems by Yun Dong-ju

Yun Dong-ju,Lee In-soo(번역자) The Academy of Korean Studies 1965 Korea Journal Vol.5 No.9

Combination treatment for onychomycosis using 1,064-Nd:YAG laser and efinaconazole 10% topical Solution

( Sang Ju Lee ),( Dong Woo Suh ),( Won Soon Chung ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Onychomycosis is one of the most common nail disease around the world. No specific treatment other than drug therapy and surgery has been suggested till present. Systemic treatment with antifungal drugs for onychomysosis is effective. However, a long treatment time is required and it is not suitable for people with other systemic disease. Furthermore, it may cause many side effects such as liver diseases. For that reasons, topical drugs or physical treatments are preferred by many patients. Recently laser treatment for onychomycosis has been proposed. The efficacy of treatment is less than systemic drugs but, laser is more convenient, safe and accessible in treatment. As a result, the combination therapy using 1064 Nd:YAG laser and efinaconazole 10% topical solution was performed. Two patients with onychomycosis were treated with 1064 Nd:YAG laser (PinPointe FootLaser, Cynosure, Westford, MA, USA) once a month with application of 10% eifnaconazole solution(Jublia, Dong-A EST) once a day. All three patients were treated successfully. We considered a combination treatment of a 1064 Nd:YAG laser and efinaconazole 10% topical solutions would be an effective, safe, and convenient treatment method for onychomycosis.

Alkylhalide가 Mouse의 LDH isozyme 분포에 미치는 영향 : Cellulose Acetate Electrophoresis Method

권미경,김영옥,박은주,이동화,이명미,이문희,이양자 曉星女子大學校 藥學大學 學生會 1988 曉星藥誌 Vol.4 No.-

The effect of Carbontetrachloride administration on Lactatedehydrogenase isozyme patterns were analyzed by cellulose acetate electrophoresis for the brain, heart, kidney, lung, liver and mouse muscle. Each other tissue was found to have a characteristic distribution of these isozymes. At normal condition, aerobic tissue such as brain, heart, kidney, and lung were found to have all five isozymes from LDH_1 to LDH_5, while anaerobic tissues such as liver and muscle were found to have superiorly LDH_5 The toxicity of Carbontetrachloride administration was most prominence in the liver, and lung toxicity was occured also.

열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

비접촉 IC Card기반 생체인식 사용자 인증 시스템의 구현

주동현,염동훈,박수형,이상학,김두영 동아대학교 정보기술연구소 2002 情報技術硏究所論文誌 Vol.9 No.2

This paper is research about the certification rate improvement of system that identify user who use face, iris, voice that is biometrics element using data of non contact ic card. The proposed system is User verification system based on face image that is inputed by CCD camera, iris image and voice signal password that is consisted of 4 numbers. We compare biometrics element information of the realtime user information(based on registerd code of non contact ic card) with biometrics information of user information that is already registerd database : user verification database that is constructed from the existing users. Through the result of real time experimentation, this paper shows that the identification rate of the proposed system outperforms conventional identification system.

杜詩章法硏究

李永朱 한국중국어문학회 2000 中國文學 Vol.33 No.-

杜詩盡發古今之體勢, 而無所不備, 尤其是章法, 卓然獨高, 古今無比, 當謂詩家之模辯. 自筆者所窺而說之, 其章法略有三指向. 其一, 要融合相反相背之二律. 其二, 要探究所以貫通諸體之章法. 其三, 要試作變格,拙讀, 緣於地面限制, 不得不止於其一之一部分而已. 其餘期於下回續論. 此回所論, 大槪始 一, 杜誇融合相反之二律, 以造咸其所擅長之嚴密結構, 當展開誇想時, 置重於轉變, 又資脈絡應接, 因此文勢自有似斷不斷, 相應相避之妙, 恰如行雲流水, 或流暘, 或頓挫, 變化無窮, 而不露斧遊. 二, 杜誇, 無古律無長短, 每篇布置整密, 每段分界謹嚴, 行文自有起伏. 各段句數, 必訓於漏意, 多寡勻稱, 詳略相應. -篇之內, 必有開頭本論末謠之結構, 開頭破題以領下, 末尾承上暇或就題結, 彧開一步, 本論所言, 井幷有條, 意興迭出, 以示章法之妙諦.

연폭로 근로자들에 있어서 신(腎)기능 장해 지표에 관한 연구

이상주,홍영습,김성률,김동일,김준연,정갑열 大韓産業醫學會 1996 대한직업환경의학회지 Vol.8 No.2

A range of indicators is available to assess renal dysfunction in lead exposure. This study was undertaken to find out which indicators were most valuable as markers of renal dysfunction. We selected 75 male workers from the secondary lead smelter, plastic stabilizer and radiator manufacturing industries (the "exposed" group) and 64 male office workers (the "control" group). Blood lead; blood zinc protoporphyrin; urine lead; urine coproporphyrin; δ-aminolevulinic acid dehydratase activity; and urine δ-aminolevulinic acid were chosen as indicators of lead exposure. Blood urea nitrogen; serum creatinine; serum uric acid; N-acetyl-β-D-glucosaminidase; urine albumin; urine α₁-microglobulin; and urine β₂-microglobulin were used as indicators of renal dysfunction. Urine α₁-microglobulin level was significantly associated with the lead exposre level. Blood urea nitrogen, urine N-acetyl-β-D-glucosaminidase and urine α₁-microglobulin levels were highly correlated with indicators of lead exposure. Urine α₁-microglobulin had the highest correlation with other indicators of renal function. In addition, the proportion of subjects with high urine α₁-microglobulin levels showed a gradient with lead exposure. Conclusively, blood urea nitrogen, urine N-acetyl-β-D-glucosaminidase and urine α₁-microglobulin are useful indicators, but urine α₁-microglobulin is the early and the most valuable indicator of renal dysfunction related to lead exposure.

28세 여성에서 Epinephrine 국소 주사 후 발생한 스트레스성 심근병증 1예

임주견,곽성동,박재영,천재홍,최성열,차태준,이준상 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.1

Stress induced cardiomyopathy is characterized by transient left ventricular dysfunction with typical regional wall motion abnormality of basal segment hyperkinesia and apical hypokinesia after physical or psychological stress. Stress induced cardiomyopathy mimics acute myocardial infarction but coronary angiography shows normal and usually recovers rapidly. Stress induced cardiomyopathy appears to occur almost exclusively in old females. Only a few cases have been reported in younger women but not yet in korea. The pathogenesis is not well known. Currently, it is thought that catecholamine may play important role. Especially, epinephrine may be most important catecholamine in the pathogenesis of steress induced cardiomyopathy. We report a case of stress induced cardiomyopathy occurred in young female after local epinephrine injection for hemostasis during tonsillectomy. 스트레스성 심근병증은 고령의 여성에서 주로 발생하며 카테콜라민 중 특히 epinephrine이 병리기전의 주요한 원인의 하나로 생각되어지고 있다. 저자들은 28세의 젊은 여성에서 편도절제술 도중 지혈을 목적으로 epinephrine을 국소 주사한 후 발생한 스트레스성 심근병증 1예를 경험하여 문헌 고찰과 함께 보고하는 바이다.

연령 및 가정에서의 인터넷 환경이 인터넷 이용행태에 미치는 영향

이현주,심성훈,신동일 한국항공대학교 경영연구소 2001 경영연구 Vol.8 No.1

인터넷이 확산되면서 정보접근에 있어 사회 계층별로 더 큰 격차를 보이게 되었다. 초고속 인터넷 접속서비스의 급속한 보급으로 우리나라가 세계 최고 수준의 인터넷 이용률을 보이게 되면서 가정에서의 초고속 인터넷 접속 서비스 이용여부가 가구원 개인의 정보이용에 적잖은 영향을 미치고 있으며, 또한 연령대에 따라서도 많은 차이를 보이고 있다. 본 연구에서는 실증분석을 통해 이 두 변수에 의한 집단구분이 인터넷 이용장소, 이용시간, 이용빈도, 즐겨 찾는 사이트, 전자상거래 이용경험과 같은 인터넷 이용행태에 유의적인 차이를 발생시킴을 보이고 있다. The growth of internet use makes larger difference in information access among social classes. Rapid diffusion of broadband internet access at home enables Korea the highest internet penetration among OECD countries. So the accessibility of broadband service effects a lot on the information usage and also great difference with age. This study shows that there is significant difference in internet access location, time, frequency of access, favorite site and use of e-commerce according to two variables through empirical investigation.