주머니 모형을 이용한 고밀도 핵물질 내 케이 중간자에 관한 연구

현창호,유충열 대구대학교 2008 敎育硏究 Vol.4 No.1

본 연구에서는 케이 중간자의 반입자를 쿼크와 반쿼크의 결합체인 MIT 주머니로 취급하여 고밀도 핵물질 내에서 입자의 성질을 연구하였다. 우선 쿼크-중간자 결합 모형을 보완한 변형 쿼크-중간자 결합 모형을 바탕으로 케이 중간자를 주머니로 다룰 때 나타나는 케이 중간자의 질량 등을 주머니를 기술하는 변수들로 구하였다. 모형의 변수들 중에서 케이 중간자와 핵물질과의 상호작용을 나타내는 퍼텐셜 에너지의 결합상수는 그 값이 아직 결정되지 않은 상태이기 때문에 미지의 변수로 취급하였다. 이 결합상수의 값이 바뀜에 따라 케이 중간자의 질량 등이 자유 상태에 있을 때의 질량에 비해 어떻게 변화하는지 등을 고찰하였다. 수치계산의 결과는 i) 케이 중간자를 쿼크의 결합체인 주머니로 다룰 때의 성질 변화가 점입자로 다룰 때의 변화와 다르고 ii) 케이 중간자와 핵물질 간의 상호작용 퍼텐셜 에너지의 결합상수 값에 따라 변화가 상당한 차이를 보였으며 iii) 기묘도를 갖는 쿼크의 상호작용도 무시할 수 없을 정도의 기여도가 있음을 보였다. 케이 중간자가 고밀도 핵물질의 상태방정식에 미치는 영향을 알아보기 위하여 케이 중간자 응축이 중성자별 내부에서 발생할 때 중성자별의 크기와 질량을 계산하였다. 결과로서 케이 중간자 응축이 중성자 별의 크기, 질량 등에 미치는 영향은 가시적이기는 하나 하이퍼 중입자의 역할에 비해서는 부차적임을 알게 되었다.

돼지정액으로부터 오염미생물의 분리 및 항생제감수성

정기화,이현택,유차열,이상원 진주산업대학교 산업과학기술연구소 2007 산업과학기술연구소보 Vol.- No.14

4개소의 인공수정센터로부터 돼지정액을 제공 받아 돼지정액 중에 서식 중인 미생물을 순수분리하고, 그 미생물에 대한 항생제 감수성 검토를 행하였다. 2006년 7월과 9월에 채취한 시료의 원액에서 각각 3.6×10^(2)~2.6×10^(9) 및 3.8×10^(2)~5.5×10^(3)의 콜로니가 나타났으며, 희석정액의 보존일 수가 길어질수록 총균수가 많은 것으로 나타났다. 돼지정액 중에서 검출된 미생물로는 Bacillus sp., Staphylococcus sp. 및 E. coli와 같은 세균이 대부분이었으며, 그 이외에 Pseudomonas sp. 및 Norcardia sp. 등의 미생물들이 검출되었다. 이들 미생물에 대한 여러 종류의 항생제 감수성을 검토한 결과 enrofloxacin과 neomycin은 분리한 모든 미생물에 대하여 감수성을 나타내었으며, cefoxitin과 norfloxacin은 Norcardia sp.을 제외한 다른 미생물에 감수성을 나타내었다. Bacterial contaminants from boar semen, which was provided by the different 4 Artificial Insemination Centers in Korea, were isolated and investigated for antibiotic sensitivity. Bacterial flora were 3.6 × 10^(2) ~ 2.6 × 10^(9) CFU/mL and 3.8 × 10^(2) ~ 5.5× 10^(9) CFU/mL from raw boar semen collected from the period June ~ July to August ~ September 2006, respectively. Total viable cells of diluted boar semen were increased according to storage period. Isolated microbes were mostly detected as bacterial cells such as Bacillus sp., Staphylococcus sp. and Escherichia coli, followed by Pseudomonas sp. and Norcardia sp. All the microbes isolated from boar semen were sensitive to antibiotic enrofloxacin and neomycin. Norcardia sp. was only resistant and the others cells were sensitive to antibiotic cefoxitin and norfloxacin.

1,4-나프토퀴논 유도체의 항균 및 항진균 작용

유충규,류재천,정세영,김동현 梨花女子大學校 藥學硏究所 1992 藥學硏究論文集 Vol.- No.2

In order to evaluate the antimicrobial effect of 2,3-substituted-1.4-naphthoquinone derivatives, we newly synthesized several 2-chloro, 2-bromo and 2-hydroxy-1, 4-naphthoquinones and subjected to antibacterial and antifungal activites, in vitro, against Escherichia coli NIHJ, Staphylococcus aureus ATCC6538p, Candida albicans 10231, Aspergillus niger 1231 and Tricophyton mentagrophytes 6085. Among these derivatives 3, 9, 18 and 23 showed the potent antibacterial activities. 18, 23 and 28 have the antifungal activities. However, these compounds have no significant hemolytic activity at concentrations higher than that required for showing the antibacterial and antifungal activities.

혈액투석중인 말기신부전 환자에서 Fludrocortisone acetate (FCA) 투여 후 혈청 칼륨 저하 효과

류봉관,강대웅,정지용,윤나라,신병철,박경희,정종훈,김현리 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.1

Background: Hyperkalemia is a commonly encountered problem in dialysis patients with end-stage renal disease. In this study we evaluated the effect of mineralocorticoid therapy (fludrocortisono acetate) on serum potassium level in the serum of hyperkalemic end-stage renal disease patients. Methods: Fourteen patients on hemodialysis receiving fludrocortisone acetate (FCA) 0.1 mg/day were observed for 2 months periods. Consecutive monthly biochemical profiles were compared for the druration of the pre-and post-treatment of FCA. Result: Fourteen patients with mean age (±SE) of 51.5 years (4 males and 10 females) and mean hemodialysis period of 51.9 months were studied. Mean serum potassium levels significantly fell (p<0.05) during the post-FCA period (5.2±0.66 mEq/L) compared with potassium levels during the pre-FCA (5.8±0.43 mEq/L) period. Pre-and post-FCA values were not different for sodium, chloride, protein, albumin, AST/ALT, glucose, blood nitrogen, creatinine, phosphate and calcium. Conclusions: FCA appears to decrease serum potassium value in patients with end-stage renal disease. These results suggested that FCA could be effective to treat hyperkalemia without any adverse effect in patients undergoing hemodialysis.

급성하벽심근경색에서 전흉부유도 ST절 하강의 의의

정병천,배호상,곽동훈,김영태,배용학,황종현,임현주,류재근,조용근,채성철,전재은,박의현 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.2

목적 : 급성하벽심근경색증 환자에서 심전도상 흔히 동반되는 전흉부유도 ST절 하강의 의의를 알아보았다. 방법 : 심근경색후 24시간에서 48시간에 얻은 심전도를 기준으로 52명의 급성하벽심근경색증 환자를 전흉부유도에서 ST절의 하강이 있는 군과 없는 군으로 나누었으며 심도자, 관상동맥조영술, 심초음파도 및 방사성 핵종을 이용한 좌심구혈율 측정 등을 시행하였다. 결과 : 1) 좌심실확장기말압은 전흉부유도에서 ST절의 하강이 있는 경우에서 16.9±5.33mmHg로 없는 경우의 11.0±4.02mmHg보다 유의하게 높았다(p<0.05). 그러나 운동량 및 좌심구혈을은 흥부 유도상 ST절의 하강이 있는 경우 7.6±3.0 METs 및 53.9±9.1%로 없는 경우의 9.1±2.7 METs 및 54.6±9.5%보다 낮았으나 통계적 유의성은 없었다(p=0.180, p=0.823). 2) 관상동맥조영술상 전흉부 ST절의 하강이 동반된 군에서는 유의한 좌전하행지나 좌회선지의 협착이 있는 경우가 60.9% 및 57.9%로 ST절의 하강이 없는 군에서의 34.5% 및 7.7%와 비교해 좌관상동맥에 협착이 동반된 경우가 많았다(p=0.050, p=0.001). 3) 관상동맥조영술상 세 혈관질환의 빈도는 흉부유도상 ST절의 하강을 보인 23예에서 10예로 ST절 하강이 없었던 29예중 2예에 비하여 유의하게 많았고(P=0.007), 단 혈관질환의 빈도는 ST절의 하강을 보인 군에서 23예중 5예로 ST절 하강이 없었던 29예중 17예에 비하여 유의하게 적었다(P=0.002). 두 혈관질환의 경우에는 각각 8예와 10예로 양군간에 유의한 차이가 없었다. 4) 흉부유도상 ST절 하강의 빈도는 단 혈관질환 22예 중 5예에서, 두 혈관질환 18예중 8예, 세 혈관질환 12예 중 10예에서 관찰되어 협착이 있는 관상동맥의 수가 많을수록 ST절의 하강이 나타나는 빈도가 많음을 보였다(p=0.00308). 그러나 흉부유도상 나타난 ST절의 하강을 모두 합하여 구한 ST절 하강의 합은 협착이 있는 관상동맥의 수와 통계적인 유의성이 없었다. 5) 심초음파도상 좌심실 하벽의 벽운동은 ST절 하강을 보인 군에서는 akinesia가 83.3%, hypokinesia가 11.1%, 정상 벽운동이 5.6%로, ST절 하강이 없었던 군에서의 dyskinesia가 3.6%, akinesia가 39.3%, hypokinesia가 25.0%, 정상 벽운동이 32.1%와 비교하여 ST절의 하강이 있는 군에서 유의하게 벽운동의 장애가 빈번함을 보였다(p=0.03891). 그러나 좌심실전벽, 측벽 및 중격부위에서는 유의한 벽운동의 차이가 없었다. 결론 : 급성하벽심근경색증 환자의 전흉부유도에서 ST절의 하강이 동반되는 경우 다혈관 질환의 가능성이 높으며 좌심실확장기말압이 상승되었고 운동능력은 감소되어 있었다. 또한 심초음파도상 좌심실하벽의 벽운동장애도 심하였다. 따라서 전흉부 ST절의 하강을 동반한 급성하벽심근경색증 환자는 전흉부유도에 ST절 하강이 없는 경우보다 예후가 불량할 것으로 생각되며, 보다 적극적인 치료가 필요할 것으로 생각된다. The purpose of this study was to determine the significance of precordial ST segment depression appearing during acute inferior myocardial infarction and to assess the correlation of that with angiographic finding. 52 patients were allocated into two groups based on the existence of precordial ST segment depression : 23 patients with ST segment depression and 29 patients without ST segment depression. The extent of coronary artery disease as well as the prevalence of significant stenosis (≥70%) in left anterior descending artery were more frequent in patients showing precordial ST segment depression than in patients not showing them (p=0.050) and the result were similar in cases of left circumplex artery (p=0.001). On echocrdiographic examination of left ventricular (LV) wall motion, it showed more severely decreased inferior LV wall motion in patients showing precordial ST segment depression than in patients not showing them (p=0.03891) even though the other segment of LV wall motion didn't show the statistical difference between both groups. The other cardiac parameters such as LVEDP, exercise amount (METs) and ejection fraction were tend to showing bad profile in patients with precordial ST segment depression. From the above results, we could deduce that patients with precordial ST segment depression have relatively large infarction or concomitant left coronary artery disease, so they need more caution and intensive theraphy.

白茯笭이 肥滿誘導 흰쥐의 體重, 副睾丸,脂肪組織, 血液 및 遺傳子 變化에 미치는 影響

류은경,정석희,이종수,김성수,신현대 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-

Objectives : These experimental studies were designed to investigate the effects of Poria cocos extract on the weight control and the lipid metabolism of the obese rats induced by high fat diet. They were designed to find out what was changed in the serum, and how the leptin and the leptin m-RNA were affected. Methods : The measurement has been performed for 6 weeks with obese rats. Results: 1.In the sample I (fat diet & Poria cocos group), the weight decrease significantly occurred throughout the whole research period, whereas in the sample II(normal diet & Poria cocos group), the ratio of weight decrease was significantly observed at the 4th, 5th, and 6th week(p < 0.05) 2.In the sample I, the epididymal fat weight and average size significantly decreased at the 6th week(p < 0.05). 3.In the sample I, the number of epididymal fat cell significantly decreased at the 3rd & 6th week(p < 0.05). 4.With the view of hematologic findings, I observed the increasing tendency of glucose in the sample I & II, and the significant decreasing of triglyceride at the 6th week(p < 0.05). 5.The leptin decreased in the sample I, whereas it came to increasing tendency in the sample II(p > 0.05). 6.The leptin m-RNA decreased a little in the sample I, whereas it increased in the sample(p > 0.05).

조직배양 감자의 플러그육묘재배에 있어서 식물재료가 지하괴경 형성에 미치는 영향

이현숙(Hyun Suk Lee),정재동(Jae Dong Chung),류정아(Iung A Ryu1),황형백(Huyng Baek Hwang),최경배(Kyung Bae Choi) 한국원예학회 2002 한국원예학회 학술발표요지 Vol.2002 No.3

치은부에 이중인공진피(Terudermis^(�) 이식 후 조직학적 평가

김민정,정현주,류승희,박병주 전남대학교 치의학연구소 2003 구강과학 Vol.15 No.4

The autogenous free gingival graft is the most predictable procedure currently used to increase the width of the attached gingiva in periodontal therapy. But the major disadvantage of the procedure is to create the 2ndary multiple surgical wounds at both a donor site and a recipient site. The other problem is the limited amount of available graft material. Therefore, recent researches have been focused on the development of the biomaterial to substitute gingival tissue. The purpose of this study was to compare the histologic healing after grafting of bilayer artificial dermis and free gingival graft. Four non-smoking subjects (mean age, 32.5 years) in systemically healthy state and good oral hygiene were selected according to their particular needs for correction of mucogingival deformities as suggested by Nabers : 1) zones of minimal attached gingiva, 2) areas of thin gingiva, 3) areas of inadequate vestibular formation, and 4) frenum problems. The recipient sites were prepared through the conventional free gingival graft procedure and were grouped according to the graft materials : Experimental group-bilayer artificial dermis (Terudermis ; Terumo Co. Japan)(n=5) ; Control group-free gingival graft with autogenous palatal mucosa(n=6). Biopsies were harvested from 11 sites (containing adjacent attached gingiva and graft) at 1, 2, 3 and 6 weeks postsurgery to evaluate histologic healing. At the third week in the experimental group and at the second week of in the control group, the grafts has been stabilized on the recipient bed and the graft border has been blended into the surrounding tissue. In the experimental group, the epitheial migration from the adjacent tissue to graft was observed after 1 week of grafting and the distribution of the inflammatory cells were reduced, collagen layer of the artificial dermis was lost and the basement membrane was formed after 3 weeks of grafting. At 6 weeks of grafting, both groups demonstrated orthokeratinized epithelium and increased thickness of epithelial tissue, similar to the adjacent tissue and the rete peg formation. It was difficult to distinguish the graft from adjacent normal tissue. Histologic evaluation revealed a biologic acceptance and incorporation of the collagen layers of the graft tissue to the host tissue, without severe inflammatory response. In conclusion, a bilayer artificial dermis is essentially similar to autogeneous free gingival graft in the correction of mucogingival problems, and has the advantages of decreased patient morbidity(no donor site) and availability of abundant amounts of graft material when needed.

6-(3,4-디클로로페닐)아미노-7-클로로-5,8-퀴놀린디온의 항진균작용 및 안전성 평가

윤여표,김동현,이병무,허문영,정해문,강혜영,최정아,김도희,유충규 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

6-(3.4-Dichlorophenyl)amino-7-chloro-5.8-quinolinedione (RCK50) was tested for antifungal activities in mice systemically infected with Candida albicans. The therapeutic potential of RCK50 was also assessed in comparison with ketoconazole. RCK50 had ED_50 0.22±0.01 ㎎/㎏. Ketoconazole as a positive control had ED_50 6.00±1.70 ㎎/㎏. Intraperitoneally administered RCK50 at the ED_50 for 7 days and 14 days reduced Candida albicans colony count in the kidneys and liver. And administered RCK50 at the ED_50 for 14 days improved survival rates. The genotoxicities of RCK50 had been evaluated. RCK50 was negative in Ames test with Salmonella typhimurium and chromosomal aberration test in CHL cells. RCK50 did not show any clastogenic effect in mouse peripheral blood and was negative in mouse micronucleus assay. These results indicate that RCK50 has no genotoxic potential under these experimental conditions. Acute oral toxicity studies of RCK50 were carried out in ICR mice of both sexes. RCK50 did not show acute oral toxicities and LD_50 values were over 2.850 ㎎/㎏ in ICR mice.

류마티스 관절염과 전신경화증의 중복증후군 1예

이은지,서광원,유충헌,박봉수,허민영,김지현,김혜란,김동욱 인제대학교 2008 仁濟醫學 Vol.29 No.-

Overlap syndrome is a disease that combines major features of more than one rheumatic disease in the same patient. A 58 year-old female who was diagnosed as rheumatoid arthritis (RA) developed skin thickening and dyspnea. Clinical and laboratory findings revealed that she was affected by systemic sclerosis (SSc) and interstitial lung disease. Finally, she was diagnosed as overlap syndrome consistent with RA combined with SSc. The authors report a case of RA-SSc overlap syndrome with relevant literatures.