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플라스틱 Scintillator와 NaI(TI) 검출기를 이용한 다수의 방사선원 위치를 3차원으로 판별하는 측정시스템 개발
곽동훈,고태영,이승호,Kwak, Dong-Hoon,Ko, Tae-Young,Lee, Seung-Ho 한국전기전자학회 2018 전기전자학회논문지 Vol.22 No.3
본 논문에서는 플라스틱 Scintillator와 NaI(TI) 검출기를 이용하여 움직이는 차량 적재물에 존재하는 다수의 방사선원 위치를 3차원으로 판별하는 측정시스템을 제안한다. 제안하는 시스템은 방사선량 측정용 플라스틱 Scintillator, 2채널 펄스 카운터, 핵종 분석용 NaI(TI) 검출기 및 1채널 MCA Board 등으로 구성된다. 방사선원 위치판별 알고리즘은 방사선량의 거리의 자승에 반비례한 특성($1/r^2$)과 장치와의 각도(${\theta}$)에 따른 보상을 통해 계산된 방사선원의 CPS 값의 비율을 SVM 분류를 통하여 방사선원의 위치(X, Y)를 구할 수 있다. (Z) 좌표 값은 단위 시간당 움직이는 대상체의 속도에 따라 정해지게 되며 이는 단위주기당 백그라운드 스펙트럼을 제외한 순수 핵종의 스펙트럼을 분석한 후 핵종 유무 판별을 진행한 뒤 해당 핵종의 위치를 판별하게 된다. 본 논문에서 제안한 시스템의 위치 판별 실험 결과 ${\pm}1m$ 이내의 국제표준오차를 나타내었다. 따라서 본 논문에서 제안한 시스템의 유효성이 입증되었다. In this paper, we develop a measurement system that uses 3D Scintillator and NaI(TI) Detector to 3-dimensionally identify the location of multiple radiation sources in moving vehicle loads. The radiation measurement system consists of radiation measurement (plastic scintillator), 2-channel Pulse Counter Board, nuclide analysis (NaI(TI) detector) and 1 channel MCA Board. The source locator algorithm calculates the coordinate value of the ratio of the CPS value($1/r^2$) of the source according to the angle(${\theta}$) in inverse proportion to the square of the distance(X, Y) through the SVM classification. The coordinate values are input every predetermined period of the spectrum, and after analyzing the spectrum per unit cycle, the position of the nuclide at the time is calculated by determining whether or not the nuclide is present in the remaining part except for the background area. As a result of the position discrimination test, the error within the international standard of ${\pm}1m$ was shown. Thus, the utility of the proposed system has been demonstrated.
곽동훈,추영국,유재성,Chang-Hyun Kim,고기성,마진열,Kyung-A Hwang 생화학분자생물학회 2011 Experimental and molecular medicine Vol.43 No.12
The human colorectal carcinoma-associated GA733antigen epithelial cell adhesion molecule (EpCAM) was initially described as a cell surface protein selectively expressed in some myeloid cancers. Gangliosides are sialic acid-containing glycosphingolipids involved in inflammation and oncogenesis. We have demonstrated that treatment with anti-EpCAM mAb and RAW264.7 cells significant inhibited the cell growth in SW620 cancer cells, but neither anti-EpCAM mAb nor RAW264.7 cells alone induced cytotoxicity. The relationship between ganglioside expression and the anti-cancer effects of anti-EpCAM mAb and RAW264.7was investigated by high-performance thin-layer chromatography. The results demonstrated that expression of GM1 and GD1a significantly increased in the ability of anti-EpCAM to inhibit cell growth in SW620cells. Anti-EpCAM mAb treatment increased the expression of anti-apoptotic proteins such as Bcl-2, but the expression of pro-apoptotic proteins Bax, TNF-α,caspase-3, cleaved caspase-3, and cleaved caspase-8were unaltered. We observed that anti-EpCAM mAb significantly inhibited the growth of colon tumors, as determined by a decrease in tumor volume and weight. The expression of anti-apoptotic protein was inhibited by treatment with anti-EpCAM mAb, whereas the expression of pro-apoptotic proteins was increased. These results suggest that GD1a and GM1 were closely related to anticancer effects of anti-EpCAM mAb. In light of these results, further clinical investigation should be conducted on anti-EpCAM mAb to determine its possible chemopreventive and/or therapeutic efficacy against human colon cancer.