관동맥질환에서 저밀도 지단백 입자 크기의 분포

임효영,김인숙,승기배,강동헌,전두수,장기육,박준철,이수영,홍순조,최규보 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.8

한국인의 연조직측모 선호경향에 대한 연구

최준규,이기수 대한치과교정학회 2002 대한치과교정학회지 Vol.32 No.5

연조직 측모는 교정치료와 진단에 있어서 중요한 부분이며, 안모 심미성에 대한 개념은 긴 역사를 가지고 변천하여 왔으며 지역이나 문화, 성별, 인종, 관습 등에 따라서 그 심미관이 상이하다. 본 연구에서는 대중들의 연조직측모 선호도를 조사하기 위하여 교정환자들의 주 연령층인 사춘기성장가속기 전의 초등학생, 사춘기 연령의 학생, 20대의 대학생들과 보호자의 주연령층인 40-50대 층을 대상으로 설문조사를 시행하였다. 설문지의 제작을 위해 기존의 심미적인 안면의 경, 연조직 형태에 관한 연구에서 얻은 연조직 평균계측치에 가까운 연조직 측모를 가진 20대 여성 한 명을 선정한 후 측모천연색 사진을 촬영하여 표준측모로 사용하였다. 전체 설문지는 7 set로 이루어져 있으며, 각 set는 측모에 영향을 줄 수 있는 입술의 돌출도, 코, 이부의 높이와 Sn point를 표준측모에서 변화시킨 천연색 측모형들을 포함하고 있다. 가장 좋다고 생각되는 안모는 1점, 가장 좋지 않다고 생각되는 안모를 5점의 순서로 통계처리를 하여 각 응답자군들의 연조직측모 선호도를 알아보았으며, 성별, 연령에 따른 선호도의 차이를 조사하였다. 또한 대중들이 선호하는 안모와 선호하지 않는 안모와 하안면 측모의 심미적 평가를 위해 기존에 사용되는 기준선들간의 신뢰성을 평가하여 다음의 결과를 얻을 수 있었다. 1. 응답자의 신뢰도를 평가시 유년기에서 다른 group들에 비해 낮은 값을 나타내었다. 이는 유년기에서는 아직은 측모선호도에 대한 관심이 없는 것으로 평가하였다. 2. 측모 선호도의 연령, 성별 차이는 뚜렷하지 않은 것으로 나타났다. 3. 가장 선호하는 측모보다 가장 선호하지 않는 측모에 대한 선택의 일치도가 더 높았다. 4. 응답자의 group별로 순위의 일치성을 나타내는 Kendall의 일치계수(W)는 20대에서 가장 높게 나타났다. 이는 다른 연령에 비해 측모에 대한 선호성에 대한 기준이 명확한 것을 나타낸다. 5. 응답자들이 가장 선호하는 측모의 구순돌출도는 심미적인 안모에 대한 이전 연구에서의 Ricketts의 nose tip-Pog ling(E-line), Burstone의 Sn-Pog line(B-line)에 대한 평균치에 가까운 값을 나타내었다. 이는 이들 기준선들이 임상적으로 유용하게 사용할 수 있음을 의미한다. 6. 응답자들이 가장 선호하지 않는 측모는 E-line과 B-line에 대해 구순이 너무 돌출되거나 후퇴된 경우였다. 7. 응답자들의 측모 선호도는 straight, concave, convex profile순으로 나타났다. Soft tissue profile is a critical area of interest in the development of an orthodontic treatment and diagnosis. The purpose of this study was to determine the facial profile preference of diversified group and to investigate the relationship between most preferred facial profile and existing soft tissue reference lines. A survey instrument of constructed facial silhouettes was evaluated by 894 lay person. The silhouettes had varied nose, lipe, chin and soft tissue subnasale point. Seven sets of facial type were computer-generated by an orthodontist to represent distinct facial types. The varied facial profiles were graded on the basis of most preferred to least preferred. Every facial profile were measured by soft tissue reference lines(Ricketts E-line, Burstone B-line) to observe the most preferred facial profile. The results as follows : 1. In reliability test, the childhood group showed lower value than other groups, which means that this group has no concern on facial profile preference. 2. It appears that sexual and age difference made no significant difference in selecting the profile. 3. An agreement to least preferred facial profile was higher than an agreement to most preferred facial profile. 4. Coefficient of concordance (Kendall W) was higher in the twentieth group. It means that a profile preference of the twentieth is distinct. 5. A lip protrusion (to Ricketts E-line and Burstone B-line) of most preferred facial profile was similar to measurements of previous study that investigate skeletal and soft tissue of esthetic facial profile of young Korean. So these reference lines can be used valuably in clinics. 6. Profile of excessive lip protrusion or retrusion to E-line & B-line was least preferred. 7. Most preferred profile of all respondents group was straight profile. Profile that showing convex profile was not preferred and the least preferred profile was concave profile.

다발성 간종괴의 형태로 나타난 특발성 과호산구 증후군 치험1예

최승오,연규민,이승민,김순제,왕준호,박형석,이재동,진춘조,이창훈,신현준,김정은 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-

Hypereosinophilic syndrome is characterized by persistent blood eosinophilia of 1,500/ul or more in the absence of known causes and multiorgan dysfunction by eosinophil-related tissue damage. In Korea, some cases of hypereosinophilic syndrome with hepatic involvement have been described with prolonged benign clinical courses. Most of them were diffuse or multifocal lesions in imaging studies, and a few case presenting as a single mass has been described. Here we report a case of hypereosinophilic syndrome with hepatic involvement in a 65-year-old man who presented with multifocal mass lesions. By abdominal US and CT scan, multiple, ill-defined nodules were detected in throughout the liver. Liver biopsy revealed severe eosinophilic hepatitis, suggestive of hypereosinophilic syndrome. Hepatic mass lesions improved after steroid administration for several weeks.

골수염의 진단에 있어서의 Tc-99m Hexamethylpropylene amine oxime 백혈구 스캔의 임상적 유용성

최상호,김양수,정준원,정진원,추은주,서동대,배인규,양승오,우준희,류지소 대한화학요법학회 2001 대한화학요법학회지 Vol.19 No.1

배경 : 골수염의 진단에 있어 Technetium-99m을 이용한 삼상 골스캔(Tc-99m MDP스캔)은 단순방사선 검사상 정상소견을 보이는 경우에 쓰이는 1차적 검사로 매우 높은 민감도를 보인다. 그러나 Tc-99m MDP 스캔은 골절이나, 정형외과적 삽입물, 신경병적 관절병변과 같이 뼈의 재형성이 증가되는 상황에서도 양성소견을 보여 특이도가 낮은 단점이 있다. 이러한 단점을 보완하고자 골수염의 진단에 있어 Tc-99m HMPAO 백혈구 스캔의 유용성을 알아보고자 하였다. 대상 및 방법 : 골수염이 의심되어 Tc-99m HMPAO 백혈구 스캔을 시행했던 15명의 의무기록을 후향적으로 분석하였다. 골수염의 확진은 임상관찰 소견과 배양검사 결과와 병리소견을 기준으로 하였다. 결과 : 골수염의 진단에 있어 Tc-99m HMPAO 백혈구 스캔의 민감도와 특이도는 각각 100%와 78%였고 Tc-99m HMPAO 스캔의 경우는 100%와 18%였다. 가장 흔한 원인균은 methicillin-resistant S. aureus였다. Tc-99m MDP 스캔에서 양성소견을 보였던 환자중 3명의 환자가 Tc-99m HMPAO 백혈구 스캔에서 음성 소견을 보였으며 이 환자들은 추적관찰상 골수염이 없는 것으로 확인되었다. 결론 : Tc-99m HMPAO 백혈구 스캔은 골수염의 존재를 진단하는데 있어 민감도와 특이도가 높으며, 특히 뼈의 재형성이 증가되어 Tc-99m MDP 스캔의 특이도가 낮게 나타나는 상황에서 유용하리라 사료된다. Background Three phase bone scintigraphy, performed with technetium-labeled diphosphonates (Tc-99m MDP scan), is the very sensitive radionuclide procedure of choice for diagnosing osteomyelitis. But, Tc-99m MDP scan is less specific when bone remodeling is increased. To overcome this limitation, we evaluated the diagnostic value of technetium-99m hexamethylpropyleneamine oxime (HMPAO) labeled leukocyte scan in osteomyelitis. Methods : We retrospectively reviewed 15 patients with suspected osteomyelitis who performed Tc-99m HMPAO labeled leukocyte scan. The diagnosis of osteomyelitis was based on clinical course and bacterial culture, and pathologic findings. Results The sensitivity and specificity of Tc-99m HMPAO leukocyte scan was 100% and 78%, and those of Tc-99m MDP scan was 100% and 18%, respectively. The most common organism was Methicilein-Resistant S. aureus. Among the patients that showed persistent accumulation on Tc-99m MDP scan, three patients showed no uptake on Tc-99m HMPAO leukocyte scan and these patients were confirmed that had no osteomyelitis. Conclusion : Tc-99m HMPAO leukocyte scan is a useful test for determining the presence or absence of osteomyelitis, especially under condition that bone remodelin is increased.

노인외상환자의 예후 인자

문철규,전정민,최성혁,문준동,이성우,홍윤식 大韓應急醫學會 1999 대한응급의학회지 Vol.10 No.2

Background: It has been documented that certain prognostic factors may affect the outcomes of the old aged victims by trauma. Considering that trauma is the sixth most common cause of death in people over the age of 65 years and there is a rapid growth of elderly population, it is paramount to understand the prognostic factors when dealing with geriatric trauma patients. Hypothesis and Goals: It can be hypothesized that the prognostic factors should be determined independently between populations being consisted of different races, countries, socio-economic states, cultures, or so on. Thus, the study was designed to evaluate the factors affecting the outcomes of elderly Korean trauma patients. Methods: One hundred forty six patients aged over 65 years were retrospectively reviewed, who visited the Emergency Center of Korea University from January, 1997 to June, 1998. Of 146 patients, 7 were excluded due to discharge against advice or transfer to the other hospitals. Parameters analyzed were age, sex, mechanism of injuries, body region injured, Injury Severity Score (ISS), previous medical illness, hospital morbidity, duration of hospital stay, and cost. Each patient was classified into improved or not-improved group depending on the outcomes, and young-old or old-old group depending on the age. The factors affecting the hospital stay in improved patients were analyzed in the parameters of previous medical illness, hospital morbidity, multiple injuries, ISS, and age. All statistical tests were conducted with two-tailed levels of 0.05. Results: Of 139 patients, the mean age was 74±7.1 years, mean ISS 9.3±7.26, mean hospital stay 27±27.1 days. Most commonly injured body region was the extremities due to fall from a level surface. Rate of previous illness showed 0.94 medical diseases per person and were aggravated after trauma in 39 patients (60.9%). Hospital morbidity rate was 0.46 incidents per person. There were no differences in age and duration of hospital stay between the improved and the not-improved group. Substantial differences were noted in affected body region, incidence of previous illness, and hospital morbidity between the groups (p=NS). Not-improved group had higher ISS(p<0.05). ISS, previous illness and hospital morbidity affected the duration of hospital stay in the improved group. Hospital stay was 40±25.1 days in patients with ISS over 6 while 6±8.6 days in those with ISS 5(p<0.05). Hospital stay in the improved was 26±26.9 days while 31±24.8 days in the improved old-old group (p=NS). Hospital stay in the young-old minor trauma (ISS5) patients with previous illness and hospital morbidity was 26±10.1 days while 4±7.3 days in those without previous illness and hospital morbidity (p<0.05). Conclusion: Previous medical illness and hospital morbidity, not age, are predictive of outcomes of geriatric trauma patients with respect to hospital stay. As most of the hospital morbidity was a trauma-induced aggravation of previous medical illness and hospital morbidity contributing poor outcomes can be potentially avoidable, routine aggressive care for the geriatric trauma patients with previous medical illnesses is needed.

가상기업을 위한 멀티에이전트 기반 태스크할당시스템에 관한 연구

허준규,최경현,이석희 한국공작기계학회 2003 한국생산제조학회지 Vol.12 No.3

With the paradigm shifting from the principal of manufacturing efficiency to business globalism and rapid adaptation to its environments, more and more enterprises are being virtually organized as manufacturing network of different units in web. The formation of these enterprise called as Virtual Enterprise(VE) is becoming a growing trend as enterprises concentrating on core competence and economic benefit. This paper proposes multi-agent based task assignment system for VE, which attempts to address he selection of individually managed partners and the task assignment to them. A case example is presented to illustrate how the proposed system can assign the task to partners.

정형외과 영역에 있어서 Posilane-Gel^(�)의 임상적 연구

이준규,이정구,최규종 최신의학사 1991 最新醫學 Vol.34 No.1

무기고분자응집제를 이용한 조류의 응집제거

김규동,최영균,김희준,곽종운,정태학 대한상하수도학회 2002 상하수도학회지 Vol.16 No.5

An Experimental study was conducted for the removal of algae using various inorganic coagulants. Cultivation of algae, investigation of turbidity and chlorophyll-a removal efficiency according to the dosage of coagulants were conducted in series using a jar-tester in this study. Alum, PAC (Polyaluminum chloride), PAC-2 (Concentrated Polyaluminum chloride), PAC-Ca (PAC with Ca), PFC (Polyferricchloride) and PACS (Polyaluminum chlorinate silicate) with various SiO_2 content were used as coagulants. Algae grew up to about 1,500㎍ chlorophyll-a/l in 30 days. Cultivated algae was diluted to 150㎍ chlorophyll-a/l for the laboratory experiment. Decrease of pH was the lowest when PACS-5 was used as a coagulant, while it was the highest when PAC was used. Host of the coagulants showed high turbidity removal rate when the dosage was 1-3 mg Al/l. PFC showed stable turbidity removal efficiency and 80% of removal efficiency could be obtained when the dosage was 1.34 mg Fe/l. Among the coagulants, PACSs showed relatively higher removal efficiency of chlorophyll-a and it was the highest when PACS-5 was used. It means that inorganic coagulant including silicate is more advantageous in the removal of algae, and appropriate content of silicate on the basis of molar ratio of Al to Si is an important factor affecting the stability and settleability of the alum floc.

한국산 감잎의 Polyphenol 화합물의 생리활성물질의 화학구조 및 효소저해효과

안봉전,최희진,손준호,우희섭,한호석,박정혜,손규목,최청 한국식생활문화학회 2003 韓國食生活文化學會誌 Vol.18 No.5

The lyophilization of the solution extracted from 60 percent of acetone applied to persimmon leaves, the compounding process in accordance with the solution's concentration, and the gel filteration through Sephadex G-50 of biologically activated substances obstructing enzyme activity, such as tyrosinase, xanthine oxidase, and angiotesin converting enzyme (ACE) led to the assumption that polyphenol was the compound serving as biologically activated substances obstructing enzyme activity. Xanthine oxidase involved in pruine metabolism oxidizes hypoxanthine to xanthine and xanthine to uric acid. In the continuous study for natural compound, nine flavan-3-ois have been isolated from the persimmon leaves. The structures of (+)-catechin, (+)-gallocatechin, procyanidin B-1, pyrocyanidin C-1, prodelphinidin B-3, gallocatechin-(4α→8)-catechin, procyanidin B-7-3-O-gallate, procyanidin C-1-3'-3''-3'''-O-trigallate and (-)-epigallocatechin-(4β→8)-epigallocatechin-(4β→8)-catechin were established by NMR and their inhibitory effect on xanthine oxidase activity was investigated. Procyanidin C-1-3'-3''-3'''-O-trigallate showed 94%, 90.69%, 80.90% inhibition at 100(μ)M and inhibited on the angiotension converting enzyme respectively. Procyanidin B-7-3-O-gallate and procyanidin 1-3'-3''-3'''-O-trigallate showed 66%, 63% inhibition at 100(μ)M and inhibited on the xanthine oxidase competitively. Procyanidin C-1-3'-3''-3'''-O-trigallate showed 70% inhibition at 100(μ)M inhibited on the thyrosinase competitively.

플루옥세틴 캅셀제의 지원자에 대한 생체이용율 및 대사율 비교

강원구,박용순,조규행,최준식,권광일 충남대학교 약학대학 의약품개발연구소 1998 藥學論文集 Vol.14 No.-

Fluoxetine is a nontricyclic antidepressant which blocks serotonin reuptake selectively. Its N-demethyl metabolite, norfluoxetine is also selective inhibitor of serotonin uptake. This study was carried out to compare the bioavailability of Myung-in fluoxetine (20 ㎎/cap with that of Prozac?. The bioavailability was conducted on 24 healthy volunteers who received a single dose (80 ㎎) of each drug in the fasting state, in a randomized balanced 2-way crossover design. After dosing, serial blood samples were collected for a period of 48 hours. plasma was analyzed for fluoxetine and norfluoxetine by a sensitive and validated HPLC assay. The major pharmacokinetic parameters (AUC_0-48hr, Cmax, Tmax. AUC_inf.. MRT. T_1/2. Vd and Cl) were clculated from the plasma fluoxetine concentration-time data of each volunteer. The microcomputer program. "WinNonlin' was used for compartmental analysis. A two-compartment model with first-order inpot, first-order output and no lag time was chosen as the most appropriate phamacokinetic model. The data were best described by using a weighting factor of 1/y^2. Though the plasma fluoxetine concentrations of Myung-in fluoxetine were higher than those of Prozac® at all observed time from 7.9% to 16.9% (P<0.05 at 6, 7 and 10 hr), the bioavailability of Myung-in fluoxetine appeared to be bioequivalent with that of Prozac®. There were no statistical significant differences between the two drugs in al pharmacokinetic parameters including AUC_0-48hr of norfluoxetine.