응급실에서 기관내 삽관후 발생한 후두육아종 1례

조남수,김용배,조수형,송민엽,송성용 大韓應急醫學會 1996 대한응급의학회지 Vol.7 No.1

Endotracheal intubation has been used widely for the maintenance of airway in the emergency patient and CPR in the acute airway obstruction patient and to treat respiratory insufficiency. Endotracheal intubation has many advantages but it may cause several complications which rate about 4% of endotracheal intubation patient. Among these complications, laryngeal granuloma is a relatively rare complication arising about 1 case per 10,000∼20,000 cases. Authors report a case of laryngeal granuloma which developed after endotracheal intubation required during emergency treatment. Case: A 55-year old female patient visited Chosun University Hospital Emergency Room complaining of dyspnea, cyanosis and sweating on Feb. 8th 1995. According to past history, she had a little obesity, dyspnea on exercise and mild hypertension. At arrival, blood pressure was 240/110mmHg, pulse rate 150 rates/min, respiratory rate 12/min, body temperature 36.5℃ and cyanosis with sweating on whole body was observed. And the mental state was semicoma. At 5 minutes after arrival, sudden respiratory arrest developed and immediate endotracheal intubation which emergency treatment was performed it was difficult to intubate endotracheally due to short neck and obesity. At 1 hour after arrival, general condition of the patient recovered well and extubation was done. The patient was transferred to internal medicine department and discharged after 12 days of medical treatment. At 2 months after discharge, the patient felt a progressive hoarseness and foreign body sensation of larynx. She was diagnosed as laryngeal granuloma at ENT department of Chosun University. She underwent the surgical operation and discharged in good health after 7 days of admission.

Genome-wide investigation of a Korean synthetic breed, Woori-Heukdon using the Illumina PorcineSNP60K BeadChip

Yong‑Min Kim,Ha‑Seung Seong,Jung‑Jae Lee,Da‑Hye Son,Jin‑Su Kim,Soo‑Jin Sa,Young‑Sin Kim,Tae‑Jeong Choi,Kyu‑Ho Cho,Joon‑Ki Hong,Jung‑Woo Choi,Eun‑Seok Cho 한국유전학회 2020 Genes & Genomics Vol.42 No.12

Background: Woori-Heukdon (KWH) is a Korean synthetic pig breed generated using Chookjin-Duroc (KCD), Chookjin-Chamdon (KCC), and their crossbreds. Currently, there is a severe lack of studies investigating the Korean breed populations including wild boars (KWB) throughout the genome. Objective: This study was performed to investigate the genetic characteristics of Korean pig populations at the genome-wide level. Methods: Using the SNP dataset derived from genotyped and downloaded datasets using the Illumina PorcineSNP60K BeadChip, we compared the genomes of 532 individuals derived from 23 pig breeds to assess the genetic diversity, inbreeding coefficient, genetic differentiation, and population structure. Results: KWB showed the lowest average expected heterozygosity (HE = 0.1904), while KWH showed the highest genetic diversity (HE = 0.02859) among Korean populations. We verified that the genetic composition of KWH, showing USD of 74.8% and KCC of 25.2% in ADMIXTURE analysis. In population structure analyses, KCC was consistently shown to be separated from other pig populations. In addition, we observed gene flow from Western pigs to a part of Chinese populations. Conclusion: This study showed that Korean native pigs, KCC have genetic differences in comparison with Chinese and Western pigs; despite some historical records and recent genetic studies, we could not find any clear evidence that KCC was significantly influenced by Chinese or Western breeds in this study. We also verified the theoretical genomic composition of KWH at the molecular level in structure analyses. To our knowledge, this is the first genomic study to investigate the genomic characteristics of KWH and KCC.

용접공들의 면역능에 관한 연구

이수일,조봉수,김영욱,고광욱,조원근,김영실,강수용,황인경,조병만,김돈균 大韓産業醫學會 1997 대한직업환경의학회지 Vol.9 No.1

The authors examined human immunity indicators such as CD4, CD8, Natural Killer(NK) cell, IgG, IgA, and IgM, and heavy metals such as Pb, Cr, Cd to evaluate the health hazard of welders. We selected total 126 male subjects, 60 welders who had more than 5 year working history as an exposure group, and 66 office workers and medical college students as a control group. This immunity evaluation approach is the first newly designed study that has never been tried in past studies on welder's heath evaluation. And the results were as follows. 1. Total lymphocyte count of peripheral blood was significantly higher in welder group, 2,615±650 ea/㎕ compared with 2,368±681 ea/㎕ in control group(p>0.05). 2. The proportion of CD4, CD8, NK cell in welder group was 37.5±9.4%, 24.0±8.8%, and 21.0±9.5%, respectively, and 35.5±6.5%, 25.0±6.9%, and 19.6±8.8% in control group. CD4 and NK cell were slightly higher, and CD8 was slightly lower in welder group. but there was no statistical significance between two groups(p≥0.05). 3. IgG, IgA, and IgM in welder group were 15.9㎎/㎗, 2.7㎎/㎗ and 1.5㎎/㎗, respectively, and 15.6㎎/㎗, 2.9㎎/㎗ and 1.7㎎/㎗ in control group. There was no statistical significance between two groups(p≥0.05). 4. Blood lead, cadmium and chromium concentrations were 4.2±1.8㎍/㎗, 0.4±0.38㎍/㎗, 1.2±0.6㎍/㎗ in welder group and 3.2±1.7㎍/㎗, 0.44±0.29㎍/㎗, 1.1±0.6㎍/㎗ in control group, respectively, and these value were within normal ranges.

위암환자의 복강내에 투여한 Mitomycin C-Carbon Particle의 Mitomycin 용출에 관한 연구

노승무,조영훈,정경수,오정연,김진향,양준묵,강대영,송규상,조준식,최선웅,이진호,민병무,김용백,김창식,박근성,인현빈,정현용,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherpy seems a logical choice for cancer chemotherapy. The Mitomycin C(MMC) adsorbed by the activated charcoal particles(CH) is relatively released when the drug concentration surrounding the carbon particles becomes low in the peritoneum of the peritoneal cavity. For the intraperitoneal chemotherapy on the advanced gastric adenocarcnoma, mitomycin C adsorbed on activated carbon particles was administered in the peritoneal cavity just before abdominal wall closure. The closed drainage tubes were inserted in the peritoneal cavity and clamped for tuo hours after completion of operation. MMC concentrations were serially measured in peritoneal fluid, plasma and urine at 2hour, 48 hour, 72 hour and 168 hour following its administration in order to study the efficacy of the MMC-CH as a drug delivery system. There were minimal toxicities in born marrow, liver, and gastrointestinal system after intraperitoneal MMC-CH administration. The data of this study suggested that MMC-CH may have a somewhat more beneficial effect than surgery alone when administered in optimal dose and schedules, but the MMC concentration of the peritoneal fluid was not sufficient to eradicate remnant cancer cells, and effective duration of maintenance was only below 24 hours in the peritoneal fluid and plasma.

동물과 사람유래 Vancomycin 내성 장구균의 항균제 감수성 비교

조윤상,이희수,김종만,류판동,박용호,유한상,이문한 한국수의공중보건학회 2003 예방수의학회지 Vol.27 No.1

It has been recently reported the possibility in the bansfer of antimicrobial resistance to other animals and humans. In particular, vancomycin resistant enterococci (VRE), which have been known as a principal antimicrobial resistant bacteria in humans, have been increased as a pathogen of nosocomial infections. And then animal VRE were suspected as an origin of human VRE. In this study, we isolated Enterococcus spp. from animals, identified by bio- chemical tests, examined for antimicrobial susceptibility, and then compared the antimicrobial susceptibility of VRE among each other as well as human VRE. Enterococcus iecium (29%) was predominant in Enterococcus species (n=122) isolated from animal feces in this study. E. hirae, E. iecalis, E. casseliflam and E. gallinarum were also isolated as rates of 24%, 21%, 16% and 7%, respectively. The resistance of enterococci to penicillin and tetracycline were 66% and 78%, respectively, and the susceptibility of them to chloramphenicol was 66%. Antimicrobial susceptibility test has shown that 91% of VRE from humans (n=11) was susceptible to chloramphenicol and all resistant to penicillin, rifampin and streptomycin. Seventy-five percentage of VRE from chickens (n = 12) was susceptible to rifampin and resistances of them to penicillin, tetracycline and sbeptomycin were 75%, 83%, and l00%, respectively. Therefore, we confirmed the difference of antimicrobial susceptibility from animals and humans, and the antimicrobial susceptibility test could be one of the simple and useful methods for the epidemiological survey of VRE.

급성 약물 중독에 대한 임상적 고찰

조수형,조남수,김용배 대한응급의학회 1995 대한응급의학회지 Vol.6 No.2

A clinical observation was made on 194 cases of drug intoxication to Chosun University hospital via emergency room during one year from January 1994 to December 1994. The observed results were summarized as follows; 1. The ratio of drug intoxicated patients to total patients of emergency room was 1.3%(194 patients of the total 14,836 patients) 2. Female was slightly more than male (54% : 46%) and the age group of the third decade was of the largest proportion. 3. In monthly distribution, September had the largest propotion(14.4%). The largest proportion of the time interval on arrival to emergency room and of presumed time of poisoning was night(8 p.m. ∼12 p.m.). 4. Suicidal attempt was the most common motive of drug intoxication(82.5%). 5. The most common drug of intoxication was S.H.T.(sedatives, hypnotics, tranquilizer)(24.7%). 6. The abnormal signs on arrival to emergency room were tachycardia, tachypnea, hypertension in order of frequency. 7. The observed abnormal laboratory findings on arrival to emergency room were leukocytosis(97 cases), glucosuria(21 cases), proteinuria(10 cases) in order of frequency. 8. The outcome of the patients were recovery(42.8%), against discharge(35%), hopeless discharge(16%), death(6,2%).

건축조형을 위한 스키마작용과 이미지

조용수,오신욱,김정현 東亞大學校 建設技術硏究所 2006 硏究論文集 Vol.30 No.1

The objectives of this paper aims at investigating the characteristics of image which appears by schema during the concept design process of an architect. The image is an efficient tool for the design process as well as a useful medium for creative design idea. It affects design process to interpretate given conditions and helps to shape the initial form at the elementary stage of design. The image is able to be translated as the expression of an architect's schema. Architects will create the final form of the design from this schematic images including his own design language. This paper searches the images affected on architect's projects, and verifies the influence of schema on the common images, and analyses the relationship between schema and image.

대기압 스트리머 코로나방전특성 및 이산화탄소 전환특성

조문수,김학규,곽동주,신용섭 경성대학교 공학기술연구소 2001 공학기술연구지 Vol.8 No.-

Deep interests have been paid on the application of non-thermal plasma technique th solve the environmental pollution problems. CO_2 is one of the severe pollutants which cause the acid rain and global warming. In this study, in order to improve the conversion efficiency of CO_2, the streamer corona discharge plasma and barrier discharge plasma reactors were made, and the conversion characteristics of CO_2 by the corona discharge plasma and some discharge characteristics of these discharge chambers are studied experimentally.

Polytrop Blue B 및 hydroxydodecyl-trimethyl ammonium bromide에 依한 微量銅의 吸光度定量에 關한 硏究

趙誠烋,金永洙,鄭鐘南 朝鮮大學校 1977 綜合論文集 Vol.1977 No.-

We Can notice reaction of PolytropBlue B with Cu in the existance of hydroxydodecyl trimethyl. Ammonium bromide to make a blue ion-assossiation chelate. The chelate turns out stable in aquesous pyridine solution maximum absoption of this was measured at 591nm, and the absorbance is Constant from, pH, 8.0 to 9.2. When molar extintion Coefficient is 1.19×10??, very high Sensitivity was noticed. This Value is 8 times higher than that of batho-cupronin chelate. Considerable interference was detected from Co, Ni, Zn, U, Ce, Cr, Fe, and Sn. From over 0.2㎍ Cu/ml the absorbance follows Beer's Law.

아드레날린 수용체 중개에 의한 Catecholamine의 Synaptosome을 통한 칼슘 이동의 조절

조성진,이정수,신용규,이광수 중앙대학교 의과대학 의과학연구소 1988 中央醫大誌 Vol.13 No.1

The presynaptic α-adrenoceptors medicate a negative feedback mechanism which leads to inhibition of neurotransmitter release probably by restricting the calcium available for the excitation-secretion coupling. It is reported that norepinephrine may shorten the duration of plateau phase in action potential by decreasing a voltage sensitive, slow inward calcium current and this action of norepinephrine is antagonized by α-adrenergic blocking agents. It is also suggested that there is a direct linkage between adrenoceptors and Na+-K+ ATPase. In the present study, therefore, effects of norepinephrine, dopamine an 5-hydroxytryptamine on the calcium uptake, Na+-Ca++ exchange and membrane potential in rat brain synaptosomes were investigated. The actions of neurotransmitters on the regulators for cellular calcium transport were also studied by investigation effects of catecholamines on synaptosomal Na+-k+ ATPase, Ca++ ATPase and Na+-Ca++ ATPase activities with or without adrenergic blocking agents. In the reaction mixture containing calcium without potassium, the addition of ATP induced the synaptosomal calcium uptake only slightly. The further addition of potassium is followed by a marked increase in calcium uptake with concomittent development of membrane depolarization. Amounts of calcium uptake were increased with increasing concentrations of potassium but decreased in the presence of extracellular sodium. Norepinephrine, dopamine and 5-hydroxytryptamine inhibited the potassium induced calcium uptake but had no effect on membrane potential. Na+-K+ ATPase, Mg++ ATPase and Ca++ ATPase activities were stimulated by these amines and stimulatory effects of catecholamines were antagonized by phentolamine and propranolol. Ouabain enhanced potassium induced calcium uptake but significantly inhibited Na+-K+ ATPase activity. Diltiazem and dibucaine effectively inhibited the depolarization induced calcium uptake, but had a variable effects on ATPase activities. Dibucaine significantly inhibited Ca++ ATPase. Among various agents tested, dibucaine alone was shown to slow down the development of membrane depolarization. Norepinephrine, dopamine and 5-hydroxytryptamine inhibited both the sodium dependent calcium efflux and Na+-Ca++ ATPase activity. The inactivation of Na+-CA++ ATPase by catecholamines was reversed by phentolamine and propranolol. These results suggest that there is a linkage between presynaptie adrenoceptors and regulatory apparatus for calcium transport across the synaptic membrane. Catecholamines appear to inhibit the calcium transport by the indirect effect on the ATPases, particulary Na+-K+ ATPase at plasma membrane which is mediated by adrenoceptors and also by possible action on the calcium conductance mechanism. On the other hand, adrenergic agonists may affect the Na+ dependent Ca++ efflux in synaptic membranes.