Diagnostic and Statistical Manual of Mental Disorders : Ⅳ진단기준에 대한 알코올리즘 선별검사 도구들의 민감도와 특이도 비교

박병강,김종성,이동배 大韓家庭醫學會 2000 Korean Journal of Family Medicine Vol.21 No.11

藥鍼用蜂毒液이 黑色腫細胞에 미치는 抗癌效果에 對한 分子生物學的 硏究

朴贊烈,南相水,金昌煥,李栽東,姜成吉,李潤浩,安秉哲 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-

To study anti-cancer effect and molecular biological mechanism of bee venom for aqua-acupuncture, the effects of bee venom on cell viability, apoptosis, and cell cycle were analyzed using MTT assay, tryphan blue assay, [3H]thymidnine release assay, flow cytometric analysis, activity of caspase-3 protease activity assay, and immunocytometric analysis of PCNA. To explore whether anti-cancer effects of bee venom are associated with the transcriptional control of gene expression, quantitative RT-PCR analysis of apoptosis- and cell cycle-related genes was performed. The obtained results are summarized as follows: 1.The MTT assay demonstrated that cell viability was decreased by bee venom in a dose-dependant manner. 2.Significant induction of apoptosis was identified using tryphan blue assay. [³H]thymidine release assay, and flow cytometric analysis of sub G₁fraction. 3.In analysis of caspase-3 protease activity, the activity had increased significantly, in a dose-dependant manner. 4.Quantitative RT-PCR analysis of the apoptosis-related genes showed that Bcl-2 and Bcl-X□ were down-regulated whereas Bax was up-regulated by bee venom treatment. 5.In flow cytometric analysis of cell cycle and immunocytometric analysis of PCNA expression, cell numbers of G₁phase was increased by a dose-dependant manner. 6.In quantitative RT-PCR analysis of the cell cycle-related genes, p21, p27, and p57 were increased, while Cyclin D1, CDK4, c-Myc, c-Fos, and Histone H3 were decreased. In contrast, there were no remarkable changes in expression levels of CDC2 and c-Jun.

前腕部 經穴 取穴에서 骨度分寸法과 一夫法의 比較 硏究

박히준,채윤병,차웅석,박종배,이혜정,이향숙,인창식,고형균,김수영,최일환,김강식,문정배,배기태,유경환,육근영,정병주,손인철,임사비나 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-

Background : The cun measurement System, an essential and convenient method in locating acupoints, has been widely used in the practice of acupuncture. However, traditional cun measurement has been criticized for its lack of reliability. Objectives : The purposes of this study are to determine if one cun measured by the directional methods have a consistency with that of proportional methods and to investigate which factors are related with these differences, especially in forearm. Methods : The distance between the elbow crease and the wrist crease of forearm was compared to a reference value of one cun obtained by the directional method. In this method, one cun is one third of the distance between index finger and Small finger of a subject, measured at proximal interphalangeal joint. In addition, to investigate the factors influencing the differences between these two methods, we measured the height and body weight and calculated body mass index (BMI). Finally we analyzed the factors correlated with these lengths by linear regression test. Results : The results showed that one cun obtained by the directional methods were significantly different from one cun by the proportional methods in forearm. It was demonstrated that the length acquired with the directional method was more correlated with body weight and body mass index, while the length obtained by the proportional method was more correlated with the height.

알코올리즘 선별검사 도구들의 진단 효율 비교

박병강,이동배,이태용,조영채,권윤형 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.1

To compare the clinical usefulness of four alcoholism-screening tests frequently used in Korea such as MAST, NAST, AUDIT, CAST, 96 drinking males were given diagnostic interview based on DSM-IV criteria and scores from four tests were obtained and analyzed. Of 96 subjects, 52.1% were normal without drinking problems, 38.5% with alcohol abuse and 9.4% with alcohol dependence. In terms of reliability of items in screening tests, four items in MAST were not found to have statistically significant item-total correlation. The appropriate cut-off value for screening tests to detect alcohol use disorders were above 15 points in AUDIT, above 5 points in MAST, above one item in NAST and above 2 items in CAGE. In terms of sensitivity for detection of alcohol use disorders, NAST was highest with 93.5%, and specificity, CAGE was highest with 90.0%. Considering the lowest sensitivity of 76.0% in CAGE and 76.J% of specificity in MAST, AUDIT and NAST were the most appropriate in screening alcohol abuse. The appropriate standard values for screening alcohol dependence were above 26 pants in AUDIT, above 13 points in MAST, above 5 items in NAST, and above 3 items in CAGE. In screening alcohol dependence AUDIT had the highest sensitivity of 100.0%, and both AUDIT and NAST had the highest specificity of 94.3%, respectively. The sensitivity of three screening tools except AUDIT were the same with the value of 88.9% and therefore AUDIT were the most appropriate in detecting alcohol dependence taking into consideration the relatively low specificity of 85.1% in CAGE.

관상동맥질환 환자에서 스텐트 시술 후 재협착에 관한 연구

강진환,권영주,박상호,한대희,이상철,김명구,변정득,최병조,심규혁,온영근,현민수,김성구 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background and aims : In the coronary artery disease, a rate of restenosis was much decreased by placement of coronary stent than when percutaneous transluminal coronary angioplasty has been applied, but there are still important clinical problems of restenosis. There has been many progressive studies about various factors contributed to this restenosis. So, we studied a relation between restenosis after placement of coronary stent in the coronary artery disease and many clinical factors, characteristics of stenotic lesion and procedural factors, and also assessed the restenosis rate of various coronary stents. Methods : Total 58 lesions(46 cases of patients ; man 30, woman 16) were evaluated, which has been performed a follow-up coronary angiography after 6 months (mean 188 days) since coronary stent had been placed. Various stents were implanted and assessed a relation between restenosis and many factors. Results : Of 58 lesions were target stenotic studies, there were 22 of restenotic lesions(37.9%), and the restenosis rate wes statistically significant difference in the relation with diabetes mellitus(p<0.05), group of acute myocardial infarction(p<0.05) among clinical diagnosis of ischemic heart disease(stable angina, unstable angina and acute myocardial infarction) in clinical factors and with high dilation pressure of stent(p<0.05) in procedural factors. When the rate of restenosis was evaluated among implanted stents, it was lowest in the Multilink^(®) stent and highest in the Nir Royal^(®) stent(60%). Conclusion : In this study of restenosis and various factors after placement of stents in the coronary artety disease, factors such as diabetes mellitus, group of acute myocardial infarction and a dilation pressure of stent were significant related with restenosis and the restenosis rate of Multilink^(®) stent was lowest and the highest restenosis rate was of Nir Royal^(®) stent.

정수처리용 응집제 주입율 및 경제성에 관한 연구

박성천,문병석,김강석 東新大學校 工業技術硏究所 1997 工業技術硏究 Vol.3 No.-

The purpose of this study was to compare the characteristics of coagulant LAS (Liquid Aluminum Sulfate) with PAC (Poly Aluminum Chloride) and to determine their injection rate for the water treatment. LAS have been used as a coagulant for the water treatment in the city of Kwangju. PAC is considered as an alternation of LAS. The injection rate of the coagulant in water treatment is one of main factors affecting the whole water treatment process. The injection rate have been adjusted based on the jar test results obtained daily. There are a number of factors affecting the flocculation such as turbidity, pH, temperature, alkalinity. If we relate somehow these factors as well as jar test results, more scientific and theoretical approach for adjusting the injection rate of coagulant is possible. Therefore, two flocculants, LAS and PAC, were examined in this study in water drawn from the Ju-am dam. The comparison between LAS and PAC was accomplished with the Jar-Test results and other factors involved in coagulation and settling such as pH, turbidity, water temperature, and alkalinity. The data were gathered and subjected to multivariate regression analysis. Analysis of the subordinate and independent correlation variables were conducted to determine which factor in the model supported the best correlation. As a results of analysis, it was found that PAC is more suitable than LAS and that the statistical formula for the injection rate was found to be suitable for practical application in real water purification plants

장애인 및 노약자를 위한 생활관련 시설의 연계방향

강병근,성기창,박광재,윤영삼,김상운,정현정,류상오 한국의료복지시설학회 2009 의료·복지 건축 Vol.15 No.1

This study aims to plan connecting living facilities considering on the Barrier Free Walking of the disabled and the elderly in the residential area. We had found several physical problems on the peestrian's way that becomes the major factor of disturbing the barrier free movement for using living facilities in the local area by investigations and enquetes. We had suggested the arrangement method for these physical problems on the pedestrian's way and building the ideal area for living facilities by the disposition stages with the result of investigations and enquetes. After these process, we had planned connecting living facilities considering on the Barrier Free WaIking of the disabled and the elderly in the residential area.

국내·외 관련 제도 및 실태분석을 통한 한국형 장애인 자립생활센터의 계획방향에 관한 연구

강지혜,윤영삼,김상운,성기창,박광재,강병근 한국의료복지시설학회 2006 의료·복지 건축 Vol.12 No.2

The wealth of Korean disability people’s paradigm has developed by the meaning of whole rehabilitation of the small society for acception and protection. Today, that meaning has been changed to make and choose disability people’s future plans by themselves. The CENTER FOR INDEPENDENT LIVING in Korea has been accepted through the American and Japanese’s activity systems with no objection. Following result of the real reserching, because the CENTER FOR INDEPENDENT LIVING in Korea have no legal basement, so there are little support for these centers and no proper rules and check systems. Therefore, we have to make the legal basement of CENTER FOR INDEPENDENT LIVING and separate by each parts of system and to specialize about them. That means, each parts of system have to mark role mode for doing well, and each systems have to develop new programs and services, and to specialize for in Korea. To add, we should have more small CENTER FOR INDEPENDENT LIVING in each area, and the CENTER FOR INDEPENDENT LIVING which are already started should make network system to contact with other centers in society for giving support of proper information.

알코올 의존 환자들의 가정 폭력

박병강,김종성 충남대학교 의학연구소 2001 충남의대잡지 Vol.28 No.2

Alcohol has been suggested to be the principal risk factor for violence. However, few studies have been performed on domestic violence in the context of alcoholism. Authors reviewed the domestic violence patterns of 125 male alcoholics and following results were obtained. 1. The rate of domestic violence in alcoholics during 1-month period prior to admission was 53.6% and the statistically significant factors related to the rate of violence included patient's age(P<0.01), presence of psychiatric diseases(P<0.05), and adaptability of family(P<0.05). 2. The violence patterns showed verbal aggression only(43.4%), verbal and physical aggression(35.8%), and the combination of verbal, physical aggression and weapon use(42.3%). The violence pattern were significantly related to the victim's coping styles to the violence(P<0.05). 3. The objects against which violence was done were spouse and offsprings(40.3%), parents(32.8%), objects as in window smashing(l7.9%) and non-cohabitant(11.9%). The statistically significant variables related to violence objects were marital status(P<0.01) and the family's APGAR scores(P<0.05). 4. Drunken state preceding violence was 83.6% and its statistically significant variable was the victim's coping style(P<0.001). The above results have suggested that comprehensive point of view considering alcoholism as a disease of an alcoholic's whole family and not an individual alcoholic, is required as we approach its treatment.

채소류에 의한 카드뮴과 납의 흡수에 관한 연구

박병윤,이부용,양소영,강상재,이동훈 대구효성가톨릭대학교 응용과학연구소 1997 응용과학연구논문집 Vol.6 No.1

본 연구에서는 전통적으로 우리 식탁의 주요 부식으로 이용되어온 콩나물과 미나리를 Cd와 Pb가 함유된 배양액으로 재배하는 동안 이들 채소에 Cd와 Pb 가 어느 정도 흡수되는가를 조사하였다. 또한 수경재배에서 Cd와 Pb에 의한 콩나물의 생육장해 정도를 조사하였다. 배양액속에 함유된 Pb이온은 재배기간 동안 미나리와 콩나물 체내로 쉽게 흡 수되었다. 그리고 미나리는 콩나물보다 더 많은 양의 Pb를 흡수하였는데, 이 는 미나리의 줄기에 다량의 뿌리가 붙어있기 때문인 것으로 생각된다. 또한 배양액속의 Pb의 농도와 미나리와 콩나물 체내에 축적된 Pb의 함량과는 높은 상관성을 나타내었는데, 각각의 상관계수(r^2)는 0.9411, 0.9828이었다. Cd역시 Pb와 마찬가지로 재배기간 동안 미나리와 콩나물 체내로 쉽게 흡수되 었다. 또한 배양액속의 Cd의 농도와 미나리와 콩나물 체내에 축적된 Cd의 함 량과는 높은 상관성을 나타내었는데, 각각의 상관계수(r^2)은 0.9900, 0.9054이었다. 그러나 두 식물체에서 Pb의 흡수 경우와는 달리 배양액속에 함유되어 있는 Cd의 농도가 높을 경우 콩나물이 미나리보다 더 많은 Cd을 흡수하였다. 콩나물의 경우에는 Cd과 Pb이 재배기간 동안 거의 비슷한 양으로 흡수되었으며, 그리고 배양액 속에 함유된 이들 중금속들과 콩나물 체내에 축적된 중금속들 사이의 직선회귀선의 기울기도 거의 유사하였다. 그러나 미나리의 경우에는 Pb이 Cd보다 상당히 많은 양이 흡수되었으며, 또한 직선회귀선의 기울기도 Cd보다 Pb의 경우 상당히 크게 나타났다. Cd와 Pb의 농도가 1mg/l일 경우에는 콩나물 길이의 성장 또는 외관상의 생육에 거의 영향이 없었다. 그러나 10mg/l 농도에서부터는 길이의 성장장해뿐만 아니라 외관상으로도 분명한 장해현상이 나타났다. 50mg/l와 100mg/l의 농도에서는 콩나물의 생육장해가 더욱 심해졌다. Pb의 경우에는 100mg/l의 농도에서, Cd의 경우에는 50mg/l의 농도에서부터 재배기간 동안 콩나물의 상당 부분이 썩는 현상이 나타났다. This study was conducted to investigate the uptake of Cd and Pb by vegetables. Bean sprout and dropwort, which are very important for traditional korean dishes, were cultivated in culture fluid added with Cd and Pb cations, and the content of Cd and Pb absorbed by these vegetables were measured. Pb cations in culture fluid were easily absorbed into bean sprout and dropwort. And dropwort absorbed Pb more than bean sprout did. Pb contents of bean sprout and dropwart dramatically increased with increasing Pb concentration in culture fluid. The correlation coefficients(r^2) between Pb contents in dropwort and bean sprout and Pb concentrations in culture fluid were 0.9411 and 0.9828, respectively. Cd cations were also easily absorbed into bean sprout and dropwort. The correlation coefficients(r^2) between Cd contents in dropwort and bean sprout and Cd concentrations in culture fluid were 0.9900 and 0.9054, respectively. The growth of bean sprout was not hindered at the concentration of 1mg/ℓ Cd and Pb in culture fluid. But high Cd and Pb concentrations hindeded remarkably the growth of this vegetable. A large part of bean sprout was rotten at the concentrations of 50 mg/ℓ Cd, and 100 mg/ℓ Pb.