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갈색세포종의 외과적 치료에서 복강경수술과 전통적인 개복수술 간의 비교 분석
신현백,임혜인,길원호,최준호,이정언,윤성현,허진석,김지수,노재형,남석진,최성호,김성주,전호경,이석구,양정현,김정한,Hyun-Baek Shin,Hye-In Lim,Won-ho Kil,Jun-Ho Choe,Jeong-Eon Lee,Seong-Hyeon Yun,Jin-Seok Heo,Jee-Soo Kim,Jae-Hyung Noh,Seok-Jin Nam,Seong 대한갑상선-내분비외과학회 2008 The Koreran journal of Endocrine Surgery Vol.8 No.2
<B>Purpose:</B> This study comparedthe effectiveness and safety of laparoscopic adrenalectomy with conventional open adrenalectomy for the treatment of pheochromocytoma. <B>Methods:</B> Medical records of 100 patients who underwent surgical removal of pheochromocytoma (open adrenalectomy, n=59; laparoscopic adrenalectomy, n=39) at Samsung Medical Center from June 1995 to August 2007 were retrospectively reviewed. <B>Results:</B> To draw an appropriate comparison, patients with a tumor less than 7 cm in size were evaluated (open adrenalectomy, n=23; laparoscopic adrenalectomy n=31). No statistically significant differences were evident according to age, gender and tumor size. The mean operating time was 158 min for the open surgery group and 114 minfor the laparoscopic group (P<0.01). The mean postoperative hospital stay was 10.4 days following open surgery and 5.6 days following laparoscopic surgery (P<0.01). The mean volume of the estimated blood loss for the laparoscopic surgery group (482 ml) was less than for the open surgery group (mean 229 ml) (P=0.06), and the time to first oral intake was 1.7 days after laparoscopic adrenalectomy and 3.5 days after open surgery (P<0.01). The frequency of using analgesics for postoperative pain after laparoscopic adrenalectomy was markedly lower than following conventional open adrenalectomy. There was no recurrence or complications during the follow-up periods (mean: 30 mon</B>ths). <B>Conclusion:</B> Laparoscopic adrenalectomy offers advantages of less postoperative pain, shorter operative time and a shorter hospital stay as compared with conventional open adrenalectomy. Laparoscopic adrenalectomy for treating pheochromocytoma is a minimally invasive alternative to conventional open adrenalectomy. <B>(Ko</B><B>rean J En</B><B>do</B><B>crine Surg 2008;8:106-111)</B>
Ultrasonically Activated Shears를 이용한 갑상선 수술에 대한 전향적 연구
김완욱,허성모,김성훈,이세경,임혜인,최재혁,김상민,이정언,김정한,김지수,남석진,양정현,최준호,Wan Wook Kim,M.D.,Sung Mo Hu,M.D.,Sung Hoon Kim,M.D.,Se-Kyung Lee,M.D.,Hye In Lim,M.D.,Jae Hyuck Choi,M.D.,Sangmin Kim,Ph.D.,Jeong Eon Lee,M.D.,Jung 대한갑상선-내분비외과학회 2009 The Koreran journal of Endocrine Surgery Vol.9 No.2
Purpose: Adequate hemostasis in thyroidectomy is important to reduce postoperative complications including bleeding and hematoma. The object of this study was to evaluate the utility of thyroidectomy using ultrasonically activated shears. Methods: This was a prospective randomized controlled study. It was conducted on 95 patients who underwent total thyroidectomy between January and March 2009. Patients were divided into two groups according to operation method used: group A (n=49) underwent total thyroidectomy using ultrasonically activated shears, group B (n=46) involved the conventional clamp and tie maneuver. Comparisons included operation time, drain amount, hospitalization, postoperative complications and off-thyroglobulin. Results: The two groups had no significant differences regarding drain amount, hospitalization, postoperative complications and off-thyroglobulin. Operation time was statistically shorter in group A than group B (96.6±22.7 min vs 114.6±24.3 min) (P=.00). Conclusion: Thyroidectomy using ultrasonically activated shears reduces operation time significantly, and enables a complete and safe operation without postoperative complications. We recommend the use of ultrasonically activated shears in thyroidectomy. (Korean J Endocrine Surg 2009;9:69-73)
국내 소재 글로벌 제약사의 연구개발 규모 및 현황 : 2016~2020년 5년 간 설문조사
오인선(In-Sun Oh),조혜원(Hye Won Cho),이현주(Hyun Joo Lee),송혜원(Hye Won Song),한나래(Na Rae Han),김초롱(Cho Rong Kim),임혜인(Hye In Lim),신주영(Ju-Young Shin) 대한약학회 2021 약학회지 Vol.65 No.6
While the importance of the global pharmaceutical industry is growing owing to continued new drug developments and R&D investments, the scale of global pharmaceutical companies in Korea remains unclear. We therefore investigated the R&D status of global pharmaceutical companies in Korea through an annual survey from 2016 to 2020. We assessed five factors annually and their trend over the 5-year period: costs, personnel, number of clinical trials, number of clinical trial subjects, and others. We then examined the correlation among factors and further compared the trend between each factor and the gross domestic product (GDP). Of 35 companies that responded, 25 responded for five consecutive years and showed a steady increase in the cost, personnel, and the number of clinical trials. While costs and personnel increased more than the GDP over the 5-year period, the number of clinical trials remained similar; number of clinical trial subjects highly fluctuated year-by-year. Moreover, a high correlation was found for cost and personnel (r>0.8852), and cost and the number of clinical trials (r>0.8452). In conclusion, costs, personnel, and the number of clinical trials of global pharmaceutical companies in Korea steadily increased from 2016 to 2020 and thus, have continuously contributed to the domestic economy.
위선암에서 p53과 bcl-2의 발현이 예후와 생존율에 미치는 영향
홍종현,신동우,백소야,김일동,김기호,박진수,서병선,김상욱,임혜인,Hong, Jong-Hyun,Shin, Dong-Woo,Paik, So-Ya,Kim, Il-Dong,Kim, Ki-Ho,Park, Jin-Soo,Suh, Byung-Sun,Kim, Sang-Wook,Lim, Hye-In 대한위암학회 2009 대한위암학회지 Vol.9 No.3
목적: 세포자멸사의 중요인자인 p53과 bcl-2의 개별발현 및 동시 발현이 갖는 위선암의 예후 인자로서의 역할과 생존율에 미치는 영향을 알아보고자 하였다. 대상 및 방법: 1999년 12월에서 2007년 7월까지 위선암으로 분당제생병원 외과에서 근치적 위절제술을 시행 받은 238명의 환자들을 대상으로 자료의 후향적 분석을 시행하였다. p53과 bcl-2의 발현은 DAKO사의 Envision kit로 면역조직화학 염색을 하여 발현군을 양성으로 정의하였다. 결과: 전체 환자 중 p53은 149예(62.5%)에서 발현되었으며, 다른 임상병리학적 예후 인자와의 상관관계를 조사한 결과 세포분화도(P=0.028), TNM 병기(P<0.001)에서 유의성을 나타냈다. bcl-2은 29예(12.2%)가 발현되었으며, TNM 병기(P=0.005)에서 유의성을 나타냈다. 단변량 생존율 분석을 통해 p53과 bcl-2는 생존율 감소에 영향이 있으며, 다변량 생존율 분석을 통해 p53은 독립적 예후 인자로서의 확인되었다. 또한 두 단백의 동시 발현군도 TNM 병기(P=0.002)와 의미 있는 상관관계를 보였으며, 개별 발현 때보다 동시 발현 시 유의한 생존율 감소를 보였다(P<0.001). 결론: p53과 bcl-2의 개별 발현은 나쁜 예후를 나타내며, 이들의 동시 발현은 더욱 나쁜 예후를 나타냈다. 그러나 bcl-2는 다변량 분석에서 독립 예후인자로서 의미는 부족하여 더 많은 분석을 통해 명확히 할 필요가 있겠다. Purpose: p53 and bcl-2 are important markers of apoptosis. The expression of p53 and bcl-2 in gastric adenocarcinoma was examined in relation to prognosis and survival rate. Materials and Methods: The clinicopathologic data from 238 patients who underwent gastrectomies for gastric adenocarcinoma between December 1999 and July 2007 were reviewed. Immunohistochemical staining of gastric adenocarcinoma tissues embedded in paraffin blocks was performed using an Envision kit (DAKO, Glostrup, Denmark). Statistical comparisons were made between age, gender, tumor invasion, lymph node metastasis, TNM stage, Lauren's classification, cell differentiation, and the relationship with p53 and bcl-2. Results: The expression of p53 was related to cell differentiation (P=0.028) and UICC TNM stage (P<0.001). The expression of bcl-2 was related to UICC TNM stage (P=0.005). The co-expression of p53 and bcl-2 was related to UICC TNM stage (P=0.002). The co-expression group exhibited a greater reduction in the survival rate (P=0.001). Conclusion: The expression of p53 and bcl-2 nuclear proteins has significant relationships with other conventional prognostic factors and the survival rate. bcl-2 will be characterized through analysis of a greater number of patients and comparison with survival data over a longer period of time.
유방암 환자의 감시림프절 생검술에서 발견되는 고립종양세포의 의미
김균지(Gyunji Kim),최재혁(Jae Hyuck Choi),김완욱(Wan Wook Kim),이세경(Se Kyung Lee),임혜인(Hye In Lim),조은윤(Eun Yoon Cho),이정언(Jeong Eon Lee),남석진(Seok Jin Nam),양정현(Jung-Hyun Yang) 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.77 No.6
Purpose: Sentinel lymph node (SLN) biopsy has replaced unnecessary axillary dissection in breast cancer surgery except when the nodes are positive for macrometastasis. But guidelines for isolated tumor cells (ITCs) found in SLNs has not yet been established and further study is ongoing. The goal of this study was to consider the implication of the isolated tumor cells found in the SLNs of Korean breast cancer patients. Methods: Between September 2003 and March 2008, 985 primary breast cancer patients underwent SLN biopsy. On reviewing the medical records, 81 patients were found to have ITCs in SLNs without macrometastasis or micrometastasis. ITCs were detected by serial sectioning and immunohistochemistry. Results: The mean number of detected SLNs was 3.5±1.7. Thirty three patients had multifocally distributed ITCs and 9 had ITCs in multiple SLNs whose N stage was N0 (i+). Completion axillary dissection has been performed in 9 patients and 3 of them (33.3%) finally were found to be N1 or N1mi. Conclusion: The characteristics of ITCs are not clear yet and their prognostic value is still under investigation. Until the significance of ITCs found in SLNs become definite, axillary dissection should be more aggressively considered.
복강경 담낭절제술 시 일률적인 담관조영술을 통해 확인한 간내담관의 변이 및 무증상 담관석에 대한 고찰
김세룡 ( Se Young Kim ),김기호 ( Ki Ho Kim ),김일동 ( Il Dong Kim ),서병선 ( Byung Sun Suh ),신동우 ( Dong Woo Shin ),김상욱 ( Sang wook Kim ),박진수 ( Jin Soo Park ),임혜인 ( Hye In Lim ) 대한소화기학회 2011 대한소화기학회지 Vol.58 No.6
Background/Aims: Intraoperative cholangiogram (IOC) during laparoscopic cholecystectomy (LC) has been used to evaluate bile duct stone. But, the routine use of IOC remains controversial. With routine IOC during LC, we reviewed the variation of hepatic duct confluence and try to suggest the diagnostic criteria of asymptomatic common bile duct (CBD) stone. Methods: We reviewed the medical record of 970 consecutive patients who underwent LC with IOC from January 1999 to December 2009, retrospectively. Results: Nine hundered seventy patients were enrolled. IOC were successful in 957 (98.7%) and unsuccessful in 13 (1.3%). Eighty two of 957 patients (8.2%) were excluded because of no or poor radiologic image. According to Couinaud`s classification, 492 patients (56.2%) had type A hepatic duct confluence, 227 patients (26.1%) type B, 15 patients (17%) type C1, 43 patients (4.9%) type C2, 72 patients (8.2%) type D1, 21 patients (2.4%) type D2, 1 patient (0.1%) type E1, 1 patient (0.1%) type E2, 2 patients (0.2%) type F, and 1 patient (0.1%) no classified type. The CBD stone was found in 116 of 970 (12.2%) patients. In 281 patients, preoperative serologic and radiologic tests did not show abnormality. When preoperative findings were not remarkable, there was no difference of clinical features between patients with or without CBD stones. Conclusions: Although IOC during LC has some demerits, it is a safe and accurate method for the detection of CBD stone and the anatomic variation of intrahepatic duct. (Korean J Gastroenterol 2011;58:338-345)