통행발생 행태분석을 통한 사회적 배제수준 분석

윤영원(YOON, Young Won),장수은(CHANG, Justin S.) 대한교통학회 2014 대한교통학회 학술대회지 Vol.70 No.-

C57BL/6 마우스 모델에서 NDM 발모제의 모발성장 촉진 효과

남상윤(Sang Yoon Nam),문준환(Jun-Hwan Mun),윤영원(Young Won Yun),백인정(In Jeoung Baek),연정민(Jung Min Yon),김영철(Young Chul Kim),류광철(Kwang Chuel Ryu),이범준(Beom Jun Lee) 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.1

NDM hair tonic is composed of several plant extracts which are known to be used in oriental medicine. This study was carried out to investigate effect of NDM hair tonic on hair growth in an alopecia model of C57BL/6 mice. Hair of six-weeks old mice were removed by topical treatment of Neclean<SUP>Ⓡ</SUP>, The next day, animals were randomized and separated in groups of 6 mice. There were four experimental groups including saline (negative control), 50% ethanol (vehicle control), 3% minoxidil (MXD), and NDM tonic. The test compounds were topically treated with 0.15 ㎖ per mouse per day for 2 weeks. The hair regrowth was determined photographically and histologically and the quantity of endocrine factors, IGF-1 and TGF-β, in the skin of mice using PCR was measured. No clinical signs were found in all animals. The topical treatment of NDM tonic or MXD for 2 weeks to dorsal skin accelerated hair regrowth faster than the controls. The NDM tonic or MXD treatment also promoted hair follicle elongation compared to the controls. The NDM tonic or MXD treatment significantly increased the expression of IGF-1 in the skin of C57BL/6 mice compared to the control (p<0.05). These results suggest that NDM-tonic has hair growth promoting activities and it can be useful for treatment for baldness or alopecia.

Streptozotocin으로 유도된 당뇨 마우스에서 L-carnosine의 혈당강하 효과

허진주,김종수,김준형,남상윤,윤영원,정재황,이범준,Hue, Jin-Joo,Kim, Jong-Soo,Kim, Jun-hyeong,Nam, Sang Yoon,Yun, Young Won,Jeong, Jae-Hwang,Lee, Beom Jun 대한수의학회 2010 大韓獸醫學會誌 Vol.50 No.2

Carnosine is a dipeptide $(\beta-alanyl-L-histidine)$ found in mammalian brain, eye, olfactory bulb and skeletal muscle at high concentrations. Its biological functions include antioxidant and anti-glycation activities. The objectives of this study were to investigate anti-diabetic effects of carnosine as determined by blood glucose levels, glucose tolerance test (GTT), glycosylated hemoglobin, and serum biochemical and lipid levels in streptozotocin-induced diabetic mice. There were five experimental groups including normal (ICR mice), control (saline), and three groups of carnosine at doses of 6, 30, and 150 mg/kg b.w.. Carnosine was orally administered to the diabetic mice everyday for 12 weeks. There was no significant difference in body weight changes in carnosine-treated groups compared to the control. The treatments of carnosine at the dose of 6 mg/kg significantly decreased the blood glucose level compared with the control at 2 and 4 weeks. The treatments of carnosine at the doses of 6 and 30 mg/kg significantly decreased the blood glucose levels in GTT and glycosylated hemoglobin compared with the control. Carnosine significantly increased total proteins compared with the control. Carnosine at the dose of 6 mg/kg significantly decreased total cholesterol and triglyceride in the serum compared to the control. These results suggest that carnosine at a low level has a hypoglycermic effect resulting from reduction of blood glucose and that a carnosine-containing diet or drug may give a benefit for controlling diabetes mellitus in humans.

Flexible Sensor on the Basis of Aligned Piezoelectric Nanofibers for Measurement of Small Deformations and its Application to Pulse Monitoring

이한빛(Han Bit Lee),김영원(Young Won Kim),박진호(Jeanho Park),윤종헌(Jonghun Yoon),박석희(Suk-Hee Park) Korean Society for Precision Engineering 2020 한국정밀공학회지 Vol.37 No.2

Recently, applying nanoscale functional materials, there have been great advances in the flexible sensor system, which provides a large number of applications for soft electronics, such as skin-attachable sensors, artificial electronic skins, and soft robotic systems. Here, we developed a highly sensitive and flexible device on the basis of polymeric piezoelectric nanofibers and elastomeric packing structures. To produce the nanofibers, we applied the electrospinning process with a representative piezoelectric co-polymer, poly (vinylidenefluoride-co-trifluoroethylene) (PVDF-TrFE). Unlike the conventional electrospinning, we applied an anisotropic fiber collection system, which could obtain uniaxially aligned nanofiber array. The aligned nanofibers were sandwich-packed with bridge-shaped PDMS substrates, thereby integrating the flexible piezoelectric sensor. As an external force made a deflection of the bridge in the sensor, the embedded nanofibers generated piezoelectricity in a longitudinal direction of the fibers. The piezoelectric sensor generated good discernable outputs versus the varied mechanical input deflection from tens of micrometers to the sub-micrometer. With this great sensing ability, we could monitor heart pulse signals on the wrist skin by measuring tiny deflections generated from the expansion of the radial artery underneath the skin. Our study suggests a potential application of flexible sensor in the field of wearable health-monitoring medical systems.

감초가 랫드의 배ㆍ태자 발생에 미치는 영향

신선희(Sunhee Shin),장자영(Ja Young Jang),백인정(In-Jeoung Baek),연정민(Jung-Min Yon),남상윤(Sang-Yoon Nam),윤영원(Young Won Yun),조대현(Dae-Hyun Cho),김순선(Soon-Sun Kim),이규식(Gyu-Seek Rhee),곽승준(Seung-Jun Kwack),김윤배(Yun-Bae 한국독성학회 2005 Toxicological Research Vol.21 No.4

The developmental toxicity of water extract of licorice (Glycyrrhiza glabra) was evaluated in rats. Licorice extract (500, 1,000 or 2,000 ㎎/㎏) was dissolved in drinking water and orally administered to male rats from 9 weeks before mating to the day of copulation, and to females from 2 weeks before mating to gestational day 19. On gestational day 20, the animals were sacrificed for Cesarian section, and maternal and fetal abnormalities were examined. Licorice extract neither induce clinical signs, nor affect the body weight gain, feed and water intake, estrous cycle, copulation and fertility rates, blood 17β-estradiol level and organ weights of dams. Also, the implantation and development including body weights, absorption and death of embryos and fetuses were not influenced by in utero exposure to licorice. In addition, there were no increases in external, visceral and skeletal abnormalities of fetuses. Taken together, it is suggested that no observed adverse effect level of licorice extract is higher than 2,000 ㎎/㎏, and that long-term in utero exposure to licorice might not cause developmental toxicities of embryos and fetuses.

C57BL/6J db/db생쥐에서 여주 (Momordica Charantia)의 항당뇨 효과

정재황,이상화,허진주,이기남,남상윤,윤영원,정성훈,이영호,이범준,Jeong, Jae-Hwang,Lee, Sang-Hwa,Hue, Jin-Joo,Lee, Ki-Nam,Nam, Sang Yoon,Yun, Young Won,Jeong, Seong-woon,Lee, Young Ho,Lee, Beom Jun 대한수의학회 2008 大韓獸醫學會誌 Vol.48 No.3

Many herbal extracts have been reported to have a preventive or therapeutic effect of on diabetes mellitus. Momordica Charantia commonly known as bitter melon or karela has been reported to be a medicinal plant for treating various diseases including cancers and diabetes. The objectives of this study were to investigate anti-diabetic effects of bitter melon (BM) as determined by blood glucose levels, glucose tolerance test (GTT), insulin tolerance test (ITT), insulin and HbA1C activities in serum, serum biochemical and lipid levels, histopathology, immunohistochemistry and AMPK-${\alpha}2$ expression of skeletal muscle in male C57BL/6J db/db mice. There were four experimental groups including vehicle control, BM 10 mg/kg, BM 50 mg/kg, and BM 250 mg/kg. BM at doses of 10, 50, and 250 mg/kg was orally administered to the diabetic mice everyday for 8 weeks. The treatments of BM 10, 50, and 250 mg/kg significantly decreased the blood glucose level in the diabetic mice compared with vehicle control (p < 0.05). The treatments of BM 10 and 50 mg/kg significantly decreased the GTT, ITT and HbA1c levels in the diabetic mice compared with vehicle control (p < 0.05). All BM groups significantly decreased GOT, GPT, BUN, LDL and glucose levels in the diabetic mice compared with the vehicle control mice (p < 0.05). The livers of mice treated with the BM 10, 50, and 250 mg/kg showed a remarkable decrease in the number of lipid droplets compared with the vehicle control. The pancreas of mice treated with the BM 10, 50, and 250 mg/kg showed a remarkable increase in insulin concentration of ${\beta}$-cells compared with the vehicle control. In addition, the treatments of BM 10, 50, and 250 mg/kg actually increased the expression of AMPK-${\alpha}2$ compared with vehicle control. These results suggest that BM has a respectable anti-diabetic effect resulting from inhibition of blood glucose level and lipid level in serum and that consumption of BM may give a benefit for controlling diabetes mellitus in humans.

Isoproterenol 정주에 의한 심박수의 변화가 고혈압 환자의 대동맥 경직도에 미치는 영향

이무용 ( Moo Yong Rhee ),권나영 ( Na Young Kwon ),김재덕 ( Jae Deok Kim ),송승호 ( Seung Ho Song ),윤영원 ( Young Won Yoon ),이명용 ( Myoung Yong Lee ),김영권 ( Young Kwon Kim ) 대한내과학회 2003 대한내과학회지 Vol.64 No.1

목적 : 고혈압 환자에서 대동맥 경직도의 증가는 심혈관 질환의 위험도를 반영하는 독립적인 위험인자로, 혈압의 상승이나 교감신경계의 항진은 대동맥의 경직도를 증가시킨다. 그러나 인공심박기에 의한 심박수의 상승은 대동맥의 경직도를 증가시키지 않는 것이 보고되고 있다. 본 연구에서는 고혈압 환자에서 교감신경계 흥분제인 isoproterenol을 투여하여 심박수를 상승시켰을 때 대동맥 경직도의 변화를 연구하였다. 방법 : 고혈압 환자를 대상으로 하였으며, 연구 Background : Increased aortic stiffness (AS) is an independent risk factor of cardiovascular disease in patients with hypertension. Elevation of blood pressure (BP) or sympathetic tone increases AS. It was reported that acute changes in heart rate by arti

에리스리톨과 자일리톨의 Streptococcus mutans 와 Lactobacillus casei 에 대한 성장 억제 효과

김경민(Kyung Min Kim),강민영(Min Young Kang),남민지(Min Gee Nam),유해민(Hea Min Yoo),윤영원(Young Won Yoon),조유라(Yu Ra Jo),정순정(Soon-Jeong Jeong) 한국구강보건과학회 2017 한국구강보건과학회지 Vol.5 No.1

To investigate the inhibitory effect of erythritol and xylitol, which are sugar substitutes, on growth of major caries-inducing bacteria, Streptococcus mutans and Lactobacillus casei and dental plaque formation, the saliva was collected after application of sterilized water, sugar, erythritol and xylitol solutions, the experimental results are as follows. 1. Xylitol was found to be the substitute for sugar, which can effectively block the growth of S. mutans and L. bacillus in the oral cavity. The erythritol showed a lower effect than the xylitol. In case of S. mutans , high growth was observed after application of sugar solution but decreased when erythritol and xylitol were applied. In the case of L. casei , the degree of growth was significantly increased when the sugar solution was applied compared to S. mutans . Therefore, it was confirmed that it was more sensitive to the sugar solution. And decreased with the application of erythritol and xylitol. 2. Xylitol can reduce the growth of general oral microorganisms most effectively, and erythritol is also effective in reducing general oral microorganisms. 3. Xylitol is a substitute for sugar that can effectively reduce the adhesion rate of dental plaque on the tooth surface, and that erythritol has a slight effect. Thus, it is considered that the erythritol and xylitol have a sufficient value as a substitute for sugar that has caries preventive effects, because erythritol and xylitol reduce the number of oral bacteria including S. mutans and L. casei and inhibit the formation of dental plaque.

아플라톡신을 간회 투여한 랫드의 간에서 CYP450 1A1, p53의 발현과 DNA adduct의 형성

이범준,이숙진,김태명,김대중,남상윤,현상환,강종구,홍진태,김철규,윤영원,Lee, Beom Jun,Lee, Sook Jin,Kim, Tae Myoung,Kim, Dae Joong,Nam, Sang Yoon,Hyun, Sang Hwan,Kang, Jong Koo,Hong, Jin Tae,Kim, Cheul Kyu,Yun, Young Won 대한수의학회 2004 大韓獸醫學會誌 Vol.44 No.4

Aflatoxins are produced mainly by Aspergillus flavus and Aspergillus parasiticus that grow in improperly stored cereals. Aflatoxin B1 ($AFB_1$) is a potent hepatocarcinogen in a variety of experimental animals including human beings. In spite of a high attention to the hepatocarcinogenecity of $AFB_1$, the relative toxicity of aflatoxins ($AFB_2$ and $AFG_1$) is not fully clarified. Sprague-Dawley male rats were orally administered with $AFB_1$, $AFB_2$, and $AFG_1$ at the dose of 250 ${\mu}g/kg$ (additionally including a dose of $1250{\mu}g/kg $ for $AFB_1$) body weight. Animals were then killed at 12, 24 or 48 hrs following aflatoxin exposure. Subsequently the immunohistochemical examination of p53, cytochrome p450 1A1 (CYP450 1A1), and glutathione-S-transferase placental form (GST-P) were performed. The level of the 8-OxodG in the liver was determined. Expressions of CYP450 1A1 and p53 were high in the liver of rats through 48 hrs after treatment of $AFB_1$ at the single dose of $250{\mu}g/kg $. This pattern was more clear as increasing doses. The treatment of $AFB_2$ and $AFG_1$ did not affect the expression of CYP450 1A1 but it caused weak expression of p53. The activity of GST were not found in the liver of rats treated with aflatoxins. The formation of 8-OxodG by $AFB_1$ increased in a dose-dependent manner up to 24 hrs after a single treatment of $AFB_1$ thereafter decreased to the level of control. The treatment of $AFB_2$ and $AFG_1$ did not affect the levels of 8-OxodG in the liver of rats with increasing time. These results in the present study indicate that $AFB_1$ among aflatoxins with low comparable levels is the most toxic as determined by early biomarkers such as CYP450 1A1, p53, GST-P, and 8-OxodG.

경부고속철도 2단계 개통 후 교통수단별 속도-거리 비교우위 분석

이상조(Sang Jo Lee),장수은(Justin S. Chang),이상준(Sang Jun Lee),윤영원(Young Won Yoon) 한국철도학회 2013 한국철도학회 학술발표대회논문집 Vol.2013 No.5

2010년 11월 1일 경부고속철도 2단계 건설사업이 완공됨에 따라 경부선 전구간(대전·대구 도심 통과지역 제외)에 걸쳐 고속철도 전용선이 개통되었다. 그리고 저가항공사가 장거리 수송시장에 진입하면서 승객들의 수단선택 대안이 증가했다. 즉 교통수단간의 경쟁이 강화됨에 따라 지역간 교통체계의 수단분담률의 변화가 나타나고 있다. 따라서 본 연구는 서울과 주요도시간의 수단별 실적자료를 이용하여 고속철도 2단계 개통전후 수단분담률 변화를 분석하여 통행패턴의 변화를 파악하고자 한다. 또한 국내 교통여건이 반영된 수단별 속도-거리 비교우위를 제시하고자 한다. Gyeongbu high-speed railway construction project Phase Ⅱ completed on November 1, 2010, as a to Gyeongbu all sectors (without Daejeon and Daegu city pass), across a exclusive high-speed rail line was opened. And low-cost carriers enter the market, the alternative mode choice has increased for the longdistance transport of passengers. Following strengthening competition between transportation, it has appeared changes in the share of the regional transportation system.ut abstract text here. Thus, this study analyzes changes in modal shares about before and after the opening of the high-speed railway between Seoul and major cities using the performance data by means to understand the change of traffic patterns. It also presents comparative advantage of speed-distance reflected in domestic traffic conditions by modes.