Mixing Effect of Animal Fat and Vegetable Oil in Biodiesel Production

허진주,조혜진,박윤신,이승범,이재동 한국공업화학회 2011 한국공업화학회 연구논문 초록집 Vol.2011 No.-

2,6-Dimethylphenol의 중합반응 조건이 3,3’,5,5’-tetramethyl-4,4’- diphenoquinone (DPQ)의 생성에 미치는 영향

허진주,김기수,김용태,김지흥,김영준 한국공업화학회 2014 한국공업화학회 연구논문 초록집 Vol.2014 No.1

Cu(I)/amine 리간드 촉매 시스템을 이용한 2,6-dimethylphenol의 중합 시 중합반응조건이 DPQ 생성 및 중합 특성에 미치는 영향을 조사하였다. 2,6-dimethylphenol 단량체는 dry hexane을 이용하여 재결정 후 사용했고, 아민 리간드는 aromatic, aliphatic을 구분하여 사용하였다. 반응조건에 따른 중합거동의 변화를 살펴보기 위해 여러 가지의 온도조건에서 실험하였다. 또한 촉매, 리간드의 비율과 용매의 영향이 고분자 형성에 어떤 영향을 미치는지 보기 위해 비율을 달리하여 실험하였다. 2,6-dimethylphenol의 중합 시 부 생성물인 3,3’,5,5’-tetramethyl-4,4’-diphenoquinone (DPQ)를 자외선-가시광선 분광분석(UV-Vis)로 측정하였다. Poly(2,6-dimethyl-1,4-phenylene ether)의 물성분석을 위해 겔 투과 크로마토그래피 (gel permeation chromatography, GPC)를 이용하였고, 점도계(Ubbelohde Viscometer)를 이용하여 Intrinsic viscosity를 측정하였다. 또한, 고분자의 구조적인 분석을 위해 1H-NMR spectroscopy를 이용하였다.

Streptozotocin으로 유도된 당뇨 마우스에서 L-carnosine의 혈당강하 효과

허진주,김종수,김준형,남상윤,윤영원,정재황,이범준,Hue, Jin-Joo,Kim, Jong-Soo,Kim, Jun-hyeong,Nam, Sang Yoon,Yun, Young Won,Jeong, Jae-Hwang,Lee, Beom Jun 대한수의학회 2010 大韓獸醫學會誌 Vol.50 No.2

Carnosine is a dipeptide $(\beta-alanyl-L-histidine)$ found in mammalian brain, eye, olfactory bulb and skeletal muscle at high concentrations. Its biological functions include antioxidant and anti-glycation activities. The objectives of this study were to investigate anti-diabetic effects of carnosine as determined by blood glucose levels, glucose tolerance test (GTT), glycosylated hemoglobin, and serum biochemical and lipid levels in streptozotocin-induced diabetic mice. There were five experimental groups including normal (ICR mice), control (saline), and three groups of carnosine at doses of 6, 30, and 150 mg/kg b.w.. Carnosine was orally administered to the diabetic mice everyday for 12 weeks. There was no significant difference in body weight changes in carnosine-treated groups compared to the control. The treatments of carnosine at the dose of 6 mg/kg significantly decreased the blood glucose level compared with the control at 2 and 4 weeks. The treatments of carnosine at the doses of 6 and 30 mg/kg significantly decreased the blood glucose levels in GTT and glycosylated hemoglobin compared with the control. Carnosine significantly increased total proteins compared with the control. Carnosine at the dose of 6 mg/kg significantly decreased total cholesterol and triglyceride in the serum compared to the control. These results suggest that carnosine at a low level has a hypoglycermic effect resulting from reduction of blood glucose and that a carnosine-containing diet or drug may give a benefit for controlling diabetes mellitus in humans.

Investigation on crosslinked polystyrene-co-poly(phenylene oxide)-based anion exchange membrane with outstanding power density for reverse electrodialysis

허진주,차민석,신희영,이장용,홍영택 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.1

Reverse electrodialysis (RED) is a promising technology for green energy. Important requisites for ion exchange membrane in this application are low price and high power density. In this work, novel anion exchange membranes (AEMs) are composed with different mixtures of functionalized poly(2,6-dimethyl-1,4-phenylene oxide) (PPO) and polystyrene (PS) in polyethylene composite. The selected composite membranes were crosslinked to improve their stability related to swelling ratio in salinity water. Membrane properties, such as chemical composition (NMR), water uptake, ion exchange capacity, pH tolerance, permselectivity, area resistance were measured. Membranes were also evaluated measuring the power density with RED stack system. In conclusion, APSPPO-5.0 that we proposed showed 2.3% power density relatively greater than commercial AMX membrane under the equivalent condition.

당뇨 마우스에서 카르노신의 혈당강하 효과

허진주,김종수,김준형,남상윤,윤영원,정재황,이범준 한국식품위생안전성학회 2009 한국식품위생안전성학회지 Vol.24 No.4

Carnosine is a dipeptide (β-alanyl-L-histidine) found in mammalian brain, eye, olfactory bulb and skeletal muscle at high concentrations. Its biological functions include antioxidant and anti-glycation activities. The objectives of this study were to investigate anti-diabetic effects of carnosine as determined by blood glucose levels in glucose tolerance test (GTT) and insulin tolerance test (ITT), insulin level and serum biochemical and lipid levels in male C57BL/6J db/db mice. There were five experimental groups including normal (C57BL/6J), control (vehicle), and three groups of carnosine at doses of 6, 30, and 150 mg/kg b.w. Carnosine was orally administered to the diabetic mice everyday for 8 weeks. There was no significant difference in body weight changes in carnosine-treated groups compared to the control. The treatments of carnosine significantly decreased the blood glucose level in the diabetic mice compared with the control (p < 0.05) after 5 weeks. The treatments of carnosine also significantly decreased the blood glucose levels in GTT and ITT and glycosylated hemoglobin (HbA1c), compared with the control (p < 0.05). Carnosine at the dose of 6 mg/kg significantly decreased the serum insulin level compared to the control (p < 0.05). Carnosine significantly increased total proteins but significantly decreased lactate dehydrogenase and blood urea nitrogen compared with the control (p < 0.05). Carnosine also significantly decreased glucose, LDL, and triglyceride in the serum of diabetic mice compared to the control (p < 0.05). These results suggest that carnosine has a hypoglycermic effect resulting from reduction of glucose and lipid levels and that high carnosine-containing diets or drugs may give a benefit for controlling diabetes mellitus in humans.

식육에서 피틴산염과 인산염의 Escherichia coli O157:H7균에 대한 항균효과

허진주,리란,이예은,이기남,남상윤,윤영원,정재황,이상화,유한상,이범준 한국식품위생안전성학회 2007 한국식품위생안전성학회지 Vol.22 No.1

approval of use of certain fod-grade phosphates as fod additives in a wide variety ofmeat products greatly stimulated research on the applications of phosphates in foods. Although phosphates havenever ben classified as antimicrobial agents, a number of investigators have reported that phosphates haveantimicrobial activities. Phytic acid is a natural plant inositol hexaphosphate constituting 1-5% of most cereals,nuts, legumes, oil seeds, pollen, and spores. In this study, we investigated antibacterial activities of sodium phytateEscherichia coli O157:H7 on tryptic soybroth and in beef, pork and chicken. In tryptic soy broth, SPT, SPP and STPP at the concentrations of 0.05, 0.1,and 0.5% effectively inhibited the growth of Escherichia coli O157:H7 in a concentration-dependent manner. Thebactericidal activity of SPT was the stronger than that of SPP or STPP at the same concentrations. In addition,the antibacterial effects of SPT, SP and STP at the concentrations of 0.05, 0.1, 0.3, and 0.5% on Escherichiacoli O157:H7 were also investigated in raw or cooked meats including beef, pork and chicken. SPT, SP andSPT was stronger than that of SP or STPP. The addition of SPT, SP and STPP in meats increased meat pHs.SPP and STPP also increased the levels of soluble orthophosphate in meats but SPT did not. These results indicatethat SPT is very effective for inhibition of bacterial growth and that can be used as a muscle fod additive forincreasing functions of meats.

랫드에서 azoxymethane으로 유도된 대장 전암병변에 대한 피티산의 방어 효과

허진주,이예은,이기남,남상윤,안병우,윤영원,이범준 한국식품위생안전성학회 2008 한국식품위생안전성학회지 Vol.23 No.3

Phytic acid (PA) (Inositol hexaphosphate, IP6) is a naturally occurring polyphosphorylated carbohydrate that is present in substantial amounts in almost all plants and mammalian cells. Recently PA has received much attention for its role in anticancer activity. In the present study, the preventive effects of PA on colon carcinogenesis were investigated. Six-week old Fisher 344 male rats were fed a AIN-93G purified diet and PA (0.5% or 2% PA in water) for 8 weeks. The animals received two (1st and 2nd week) injections of azoxymethane (AOM, 15 mg/kg b.w.) to induce colonic aberrant crypt foci (ACF). After sacrifice, the total numbers of aberrant crypts (AC) and ACF in colonic mucosa were examined after staining with methylene blue. Blood and serum were analyzed with a blood cell differential counter and an automatic serum analyzer. AOM induced the total numbers of 142.3 ± 22.3 ACF/colon and 336.6 ± 55.1 AC/colon. PA at the doses of 0.5 and 2% decreased the numbers of ACF and AC/colon in a dosedependent manner. The numbers of ACF/colon and AC/colon by PA at the dose of 0.5% were 124.4 ± 28.5 and 302.7 ± 67.3, respectively. PA at the dose of 2% significantly decreased the ACF and AC numbers to 109 ± 18.1 and 254.8 ± 50.6, respectively (p < 0.01). Especially, 2% PA significantly reduced the number of large ACF ( ≥ 4 AC/ ACF) from 26.8 ± 6.2 ACF/colon to 15 ± 6.7 ACF/colon (p < 0.01). Although some parameters in blood counts and serum chemistry were changed compared with the control, no specific toxicity was found. These findings suggest that phytic acid can be a chemopreventive agent for colon carcinogenesis resulting from inhibition of the development of ACF in the F344 rat. Phytic acid (PA) (Inositol hexaphosphate, IP6) is a naturally occurring polyphosphorylated carbohydrate that is present in substantial amounts in almost all plants and mammalian cells. Recently PA has received much attention for its role in anticancer activity. In the present study, the preventive effects of PA on colon carcinogenesis were investigated. Six-week old Fisher 344 male rats were fed a AIN-93G purified diet and PA (0.5% or 2% PA in water) for 8 weeks. The animals received two (1st and 2nd week) injections of azoxymethane (AOM, 15 mg/kg b.w.) to induce colonic aberrant crypt foci (ACF). After sacrifice, the total numbers of aberrant crypts (AC) and ACF in colonic mucosa were examined after staining with methylene blue. Blood and serum were analyzed with a blood cell differential counter and an automatic serum analyzer. AOM induced the total numbers of 142.3 ± 22.3 ACF/colon and 336.6 ± 55.1 AC/colon. PA at the doses of 0.5 and 2% decreased the numbers of ACF and AC/colon in a dosedependent manner. The numbers of ACF/colon and AC/colon by PA at the dose of 0.5% were 124.4 ± 28.5 and 302.7 ± 67.3, respectively. PA at the dose of 2% significantly decreased the ACF and AC numbers to 109 ± 18.1 and 254.8 ± 50.6, respectively (p < 0.01). Especially, 2% PA significantly reduced the number of large ACF ( ≥ 4 AC/ ACF) from 26.8 ± 6.2 ACF/colon to 15 ± 6.7 ACF/colon (p < 0.01). Although some parameters in blood counts and serum chemistry were changed compared with the control, no specific toxicity was found. These findings suggest that phytic acid can be a chemopreventive agent for colon carcinogenesis resulting from inhibition of the development of ACF in the F344 rat.

Distribution and accumulation of Cy5.5-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles in the tissues of ICR mice

허진주,이후장,전상용,남상윤,윤영원,김종수,이범준 대한수의학회 2013 JOURNAL OF VETERINARY SCIENCE Vol.14 No.4

Free Cy5.5 dye and Cy5.5-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION)have been routinely used for in vivo optical imaging. However, there is little information about the distribution and accumulation of free Cy5.5 dye and Cy5.5-labeled TCL-SPION in the tissues of mice. Free Cy5.5 dye (0.1 mg/kg body weight) and Cy5.5-labeled TCL-SPION (15 mg/kg body weight) were intravenously injected into the tail vein of ICR mice. The biodistribution and accumulation of the TCL-SPION and Cy5.5 were observed by ex vivo optical imaging and fluorescence signal generation at various time points over 28 days. Cy5.5 dye fluorescence in various organs was rapidly eliminated from 0.5 to 24 h post-injection. Fluorescence intensity of Cy5.5 dye in the liver, lung, kidney,and stomach was fairly strong at the early time points within 1 day post-injection. Cy5.5-labeled TCL-SPION had the highest fluorescence density in the lung at 0.5 h post-injection and decreased rapidly over time. Fluorescence density in liver and spleen was maintained over 28 days. These results suggest that TCL-SPION can be useful as a carrier of therapeutic reagents to treat diseases by persisting for long periods of time in the body.

MIM커뮤니케이션에서 이모티콘 활용이 사용자 이미지메이킹과 자기표현 만족감에 미치는 영향

허진주(Jin Ju Heo),고혜영(Hye Young Ko) 한국멀티미디어학회 2017 멀티미디어학회논문지 Vol.20 No.7

디자인 경영전략 관점에서 디자인 아이덴티티를 통한 기업이미지에 대한 사용자의 시각적 경험 연구

허진주(Jin Ju Heo),고혜영(Hye Young Ko),강이환(Leehwan Kang) 한국멀티미디어학회 2016 멀티미디어학회논문지 Vol.19 No.5