Role of adjuvant postoperative external beam radiotherapy for well differentiated thyroid cancer

권진이,우홍균,윤여규,이규언,김광현,박두준 대한방사선종양학회 2013 Radiation Oncology Journal Vol.31 No.3

Purpose: To analyze the outcome of adjuvant postoperative external beam radiotherapy (EBRT) in well-differentiated thyroid cancer (WDTC). Materials and Methods: We identified 84 patients treated with EBRT for WDTC from February 1981 to December 2010. Among them, we analyzed 39 patients who received EBRT after initial radical surgery. Twenty-four females and 15 males were included. The median age was 49 years (range, 16 to 72 years). There were 34 papillary thyroid carcinomas and 5 follicular thyroid carcinomas. Most patients showed pathologic T3/T4 stage (54%/26%). Ten patients (25.6%) had gross residual tumors. Five patients (12.8%) had tumor cells at the margin. The median EBRT dose and fraction size were 62.6 Gy and 1.8 to 2.0 Gy, respectively. Results: The median follow-up was 73 months (range, 21 to 372 months). The five-year overall survival (OS) and locoregional recurrence free survival (LRFS) were 97.4% and 86.9%, respectively. Locoregional failures occurred in 5 and all failure sites were the neck node area. In univariate analysis, OS was significantly influenced by invasion of the trachea (p = 0.016) or esophagus (p = 0.006). LRFS was significantly decreased by male (p = 0.020), gross residuum after resection (p = 0.002), close or positive tumor at surgical margin involvement (p = 0.044), and tracheal invasion (p = 0.040). No significant prognostic factor was identified in the multivariate analysis. No patient experienced the Radiation Therapy Oncology Group grade 3 or more toxicity. Conclusion: Our locoregional control rate of 87.2% is comparable to historical controls with surgery alone, even though our study had a large proportion of advanced stage. Adjuvant EBRT may an effective and safe treatment option in patients with WDTC.

MRI 아티팩트의 제거에 관한 연구

권진이,김응규 한밭대학교 정보통신전문대학원 2003 정보통신전문대학원 논문집 Vol.1 No.1

In this study, we present, an algorithm for canceling MRI artifacts due to some translational motion in patient’s head part. Assuming that the head part moves up and down due to patient's breathing which often makes problems during MRI imaging, rigid translational motions are treated here. Unlike the conventional iterative phase retrieval algorithm in which there is no guarantee for the convergence, this method is based on the MRI imaging process and the analysis of image property. A new constraint condition with which the image component and the motion component in the MRI signal can be separated by a simple algebraic operation is extracted After the x(read out) directional Fourier transformation of MRI signal is taken the y(phase encoding) directional spectrum phasing value is just an algebraic sum of the image component and the motion component. Meanwhile, at it is known that the density of subcutaneous fat area is almost uniform in the head tomographs, the density distribution along an y directional line on this fat area is regarded as symmetric shape. If the density function is symmetric, the phase of spectrum changes linearly with the position. Hence, the departure component methods, the motions in the x direction and the y direction are treated simultaneously. However, the x and the y directional motion is canceled by each different algorithm in two steps because the features of x and y directional motions are different from each other in this method. The x directional motion is estimated by detecting the edge boundary between the non-zero area and the zero area of the spectrum and is canceled by shifting the spectrum in inverse direction. The y directional motion is canceled by using the constraint condition which separates the true image component and the motion component. Finally, the effectiveness of this algorithm is shown by using a phantom image with simulated motion.

The Prognostic Impact of the Number of Metastatic Lymph Nodes and a New Prognostic Scoring System for Recurrence in Early-Stage Cervical Cancer with High Risk Factors: A Multicenter Cohort Study (KROG 15-04)

권진이,엄근용,김영석,박원,전미선,이지혜,김용배,윤원섭,김진희,최진화,장세경,정배권,이석호,차지혜 대한암학회 2018 Cancer Research and Treatment Vol.50 No.3

Purpose We aimed to assess prognostic value of metastatic pelvic lymph node (mPLN) in early-stage cervical cancer treated with radical surgery followed by postoperative chemoradiotherapy. Also, we sought to define a high-risk group using prognosticators for recurrence. Materials and Methods A multicenter retrospective study was conducted using the data from 13 Korean institutions from 2000 to 2010. A total of 249 IB-IIA patients with high-risk factors were included. We evaluated distant metastasis-free survival (DMFS) and disease-free survival (DFS) in relation to clinicopathologic factors including pN stage, number of mPLN, lymph node (LN) ratio (number of positive LN/number of harvested LN), and log odds of mPLNs (log(number of positive LN+0.5/number of negative LN+0.5)). Results In univariate analysis, histology (squamous cell carcinoma [SqCC] vs. others), lymphovascular invasion (LVI), number of mPLNs ( 3 vs. > 3), LN ratio ( 17% vs. > 17%), and log odds of mPLNs ( 0.58 vs. > 0.58) were significant prognosticators for DMFS and DFS. Resection margin involvement only affected DFS. No significant survival difference was observed between pN0 patients and patients with 1-3 mPLNs. Multivariate analysis revealed that mPLN > 3, LVI, and non-SqCC were unfavorable index for both DMFS (p < 0.001, p=0.020, and p=0.031, respectively) and DFS (p < 0.001, p=0.017, and p=0.001, respectively). A scoring system using these three factors predicts risk of recurrence with relatively high concordance index (DMFS, 0.69; DFS, 0.71). Conclusion mPLN > 3 in early-stage cervical cancer affects DMFS and DFS. A scoring system using mPLNs > 3, LVI, and non-SqCC could stratify risk groups of recurrence in surgically resected early-stage cervix cancer with high-risk factors.

Prognostic Value of Log Odds of Positive Lymph Nodes after Radical Surgery Followed by Adjuvant Treatment in High-Risk Cervical Cancer

권진이,엄근용,김인아,김재성,김용범,노재홍,김기동 대한암학회 2016 Cancer Research and Treatment Vol.48 No.2

Purpose The purpose of this study is to compare the prognostic efficacy of the number and location of positive lymph nodes (LN), LN ratio (LNR), and log odds of positive LNs (LODDs) in highrisk cervical cancer treated with radical surgery and adjuvant treatment. Materials and Methods Fifty high-risk patients who underwent radical hysterectomy and pelvic node dissection followed by adjuvant treatment were analyzed retrospectively. The patients had International Federation of Gynecology and Obstetrics (FIGO) stage IA2-IIB. Upper LN is defined as common iliac or higher LN, and LNR is the ratio of positive LNs to harvested LNs. LODDs is log odds between positive LNs and negative LNs. Radiotherapy was delivered to the whole pelvis with median 50.4 Gy/28 Fx± to the para-aortic regions. Platinum-based chemotherapy was used in most patients (93%). The median follow-up duration was 80 months. Results The 5-year disease-free survival (DFS) rate was 76.1%, and the overall survival (OS) rate was 86.4%. Treatment failure occurred in 11 patients, and distant failure (DF) was the dominant pattern (90.9%). In univariate analysis, significantly lower DFS was observed in patients with perineural invasion, ! 2 LN metastases, LNR ! 10%, upper LN metastasis, and ! –1.05 LODDs. In multivariate analysis, ! –1.05 LODDs was the only significant factor for DFS (p=0.011). Of patients with LODDs ! –1.05, 40.9% experienced DF. LODDs was the only significant prognostic factor for OS as well (p=0.006). Conclusion LODDs ! –1.05 was the only significant prognostic factor for both DFS and OS. In patients with LODDs ! –1.05, intensified chemotherapy might be required, considering the high rate of DF.

A Prognostic Model for Patients with Triple-Negative Breast Cancer: Importance of the Modified Nottingham Prognostic Index and Age

권진이,엄근용,구태률,김병혁,강은영,김성원,김유정,박소연,김인아 한국유방암학회 2017 Journal of breast cancer Vol.20 No.1

Purpose: Considering the distinctive biology of triple-negative breast cancer (TNBC), this study aimed to identify TNBC-specific prognostic factors and determine the prognostic value of the Nottingham Prognostic Index (NPI) and its variant indices. Methods: A total of 233 patients with newly diagnosed stage I to III TNBC from 2003 to 2012 were reviewed. We retrospectively analyzed the patients’ demographics, clinicopathologic parameters, treatment, and survival outcomes. The NPI was calculated as follows: tumor size (cm)×0.2+node status+Scarff-Bloom- Richardson (SBR) grade. The modified NPI (MNPI) was obtained by adding the modified SBR grade rather than the SBR grade. Results: The median follow-up was 67.8 months. Five-year diseasefree survival (DFS) and overall survival (OS) were 81.4% and 89.9%, respectively. Multivariate analyses showed that the MNPI was the most significant and common prognostic factor of DFS (p=0.001) and OS (p=0.019). Young age (≤35 years) was also correlated with poor DFS (p=0.006). A recursive partitioning for establishing the prognostic model for DFS was performed based on the results of multivariate analysis. Patients with a low MNPI (≤6.5) were stratified into the low-risk group (p<0.001), and patients with a high MNPI (>6.5) were subdivided into the intermediate (>35 years) and high-risk (≤35 years) groups. Age was not a prognostic factor in patients with a low MNPI, whereas in patients with a high MNPI, it was the second key factor in subdividing patients according to prognosis (p=0.023). Conclusion: The MNPI could be used to stratify patients with stage I to III TNBC according to prognosis. It was the most important prognosticator for both DFS and OS. The prognostic significance of young age for DFS differed by MNPI.

Synthesis and Characterization of Cardanol-based Surfactant and its Application as Cathode Coating Material for Lithium-Sulfur Batteries

권진,정다운,이종찬 한국고분자학회 2023 한국고분자학회 학술대회 연구논문 초록집 Vol.48 No.1

영남문집해제 : 야일집

권진 영남대학교 민족문화연구소 1988 민족문화연구소 자료총서 Vol.4 No.-

심장이식후 면역억제 치료 중 발생한 Listeria Monocytogenes에 의한 뇌막염 1예

권진일,김영준,최경림,최상진,김은아,정원호,손민수,오세진,최인석,신익균 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.9

청키-스타일 니트웨어의 미적 특성에 관한 연구

권진,우현리 한국니트디자인학회 2020 패션과 니트 Vol.18 No.3

Clothing expressed with volume and fullness appears in both woven wear and knit wear. Especially, a volume of softer and massier silhouette can be found in knit wear than woven wear. Such a bulky style unique in knitwear with soft lines can be referred to as chunky style knitwear. At present, chunky style knitwear faces development into various kinds of design. And yet, its specific study is very insufficient. Considering this, more detailed examination about chunky style in knit wear is needed. Therefore, this study aims at development of knitwear design by analyzing the chunky style based on modern knitwear. This work proceeds to analysis on type of knitwear expression and its aesthetic nature As a results of the study on chunky style knitwear, this study shows that the expression style in it is divided into human body-focused chunky style and human body-distorted chunky style. Aesthetic characteristics in chunky style knitwear give structural solid beauty, deconstructive ornamental beauty, and deconfining changing beauty. This study helped to organize and put forth design theories needed to comprehend the expression types and aesthetic characteristics in chunky style knitwear and also confirm the diversity of knitwear design realm.

선진기업복지제도 도입지원사업의 경제적 효과성 분석

권진아(Jin-A Kwon),안영규(Young-Gyu Ahn),김현수(Hyun-Soo Kim),박경일(Kyung-Il Park) 한국콘텐츠학회 2017 한국콘텐츠학회논문지 Vol.17 No.10

본 연구는 자료포락분석(DEA : Data Envelopment Analysis)을 이용하여 선진기업복지제도 실행에 따른 경제적 효과성을 분석하여, 중소기업들이 선진기업복지제도를 적극 도입 시행하도록 기여하는데 그 목적이 있다. 이를 위해, 설문회수 자료 중 투입-산출 지표와 관련된 3가지 유형의 - A유형(기본+심화, 도입)기업 36개, B유형(기본+심화, 미도입)기업 5개, C유형(기본, 미도입)기업 7개 - 총 48개 기업을 표본대상으로 하여 선진기업복지제도 도입과 관련된 경제적 효과성을 측정해 보았다. 분석 결과, 컨설팅을 받은 후 선진기업복지제도 중 어떤 하나의 제도라도 도입한 기업의 경제적 효과성이 컨설팅을 받은 후 관련 제도를 도입하지 않은 기업의 경제적 효과성보다 대체로 높게 나타나, 근로복지공단에서 실시하는 컨설팅을 통해 제도를 도입할 경우 긍정적인 경제적인 효과가 있음을 확인할 수 있었다. 이러한 연구결과를 통해 근로복지공단에서는 컨설팅을 보다 적극적으로 실시할 필요가 있으며 컨설팅만 받고 관련 제도 도입을 망설이는 기업을 찾아내고 그 이유에 대하여 구체적으로 파악해 볼 필요가 있음을 시사하고 있다. The purpose of this study is to analyze the economic effectiveness of advanced enterprise welfare system utilizing DEA(Data Envelopment Analysis) and contribute to the adoption and implementation of the system conducted by Korea Workers’ Compensation & Welfare Service(COMWEL). We classified 48 sample data into 3 categories : A category(basic consulting & intensive consulting, adoption) is 36, B category(basic consulting & intensive consulting, non-adoption) is 5, and C category(only basic consulting, adoption) is 7. A consulting fee is used as input variable, earning per employee and average employee tenure are used as output variables. As a result from DEA, we find out the fact that the economic effectiveness of A category is better than the economic effectiveness of B and C category and it comes to the conclusion that the consulting service provided by COMWEL has a positive effect on the adoption and implementation of advanced enterprise welfare system. Therefore, COMWEL is required to perform consulting service to small & medium business more actively and is needed to look at the reason why some businesses hesitate to accept the relevant system.