후각신경아세포종의 치료 및 결과

우홍균,김일한,Wu Hong-Gyun,Kim Il Han 대한방사선종양학회 2000 대한방사선종양학회지 Vol.18 No.3

Purpose : Rarity of olfactory neuroblastoma makes it difficult for treating Physician to Practice with a consistent protocol. This study is peformed to analyze our experience with various treatment modalities for patients with olfactory neuroblastoma. Discussion includes review of some recently published literatures. Methods and Materials : Between June of 1979 and April of 1997, 20 patients were treated under the diagnosis of olfactory neuroblastoma at Seoul National University Hospital. There were 14 male and 6 female patients. Age at initial treatment ranged from l3 to 77 years with median or 24 years. fifteen or 20 patients had Kadish stage C. They were treated with various combinations of surgery, radiation therapy and chemotherapy; surgery+postoperative radiation therapy+adjuvant chemotherapy for 2 patients, surgery+postoperative radiation therapy for 6, neoadjuvant chemotherapy+surgery for 1, surgery+adjuvant chemotherapy for 1, surgery only for 2, neoadiuvant chemotherapy+ radiation therapy for 3, radiation therapy+adjuvant chemotherapy for 1, radiation therapy only for 3, and no treatment for 1 patient. Results : Follow-up ranged from 2 month to 204 months with mean of 39.6 months. The overall 5- and 10-year survival rates are 20% and 10%, respectably. Four patients are alive at the time of data analysis. One of four living patients was treated with radical surgery, postoperative radiation therapy and adjuvant chemotherapy, two patients with radical surgery and postoperative radiation therapy, and one with radical surgery only. Conclusion : Multidisciplinary approach, including radical surgery, pre- or post-operative radiation therapy and chemotherapy, should be addressed at the initial time of diagnosis. Although limited by small number of the patients, this study suggests importance of local treatment modality, especially radical surgery in the treatment of lofactory neuroblastoma.

식도암의 방사선치료 성적 - 장기 추적관찰의 결과

우홍균,박석원,박찬일,Wu Hong-Gyun,Park Suk-Won,Park Charn-Il 대한방사선종양학회 1998 대한방사선종양학회지 Vol.16 No.4

Purpose : The incidence of esophageal carcinoma is increasing. Radical surgery is the treatment of choice, but large proportion of the esophageal cancer patients are with unresectable disease at the time of initial diagnosis, so radiation therapy has been the major treatment modality. We carried out retrospective analysis to see the outcome and prognostic factors of radiation therapy alone for esophageal carcinoma. Methods and Materials : From June of 1979 through December 1992, 289 patients with esophageal carcinoma were treated with radiation therapy alone at Department of Therapeutic Radiology, Seoul National University Hospital. Of these patients, 84 patients were excluded as they were ineligible for the current analyses. Twenty-two patients had distant metastasis other than supraclavicular lymph node metastasis, 52 patients received less than 45 Gy, and 10 patient were lost from follow-up. Therefore 205 patients constituted the base population of this study. According to AJCC s1aging system, there were 2 patients with stage 1, 104 with stage IIA, 26 with stage IIB, 48 with stage III, and 25 with stage IV Radiation dose ranged from 4500 cGy to 6980 cGy with median dose of 5940 cGy. Follow-up period of the alive patients ranged from 77 to 180 months. Results : The Median survival period of all the patients was II months and the 2-, 5-, and 10-year overall survival rates were 22.4$\%$, 10.2$\%$ and 5.3$\%$, respectively. Most of the failures were local recurrences. Of 169 failures, 134 had local failure as a component and 111 had local recurrence only. The Lymph node was most common distant metastatic site and the next was the lung. The stage, T-stage, N-stage, functional status, tumor size, and aim of treatment were statistically significant prognostic factors for survival by univariate analyses. But only tumor size and N-stage were significant by multivariate analyses. Conclusion : We could get 10.2$\%$ of 5 year survival rate and 5.3$\%$ of 10 year survival rate with radiation therapy alone. The size of tumor and N-stage were statistically significant prognostic factors for survival on multivariate analyses.

심박조율기를 장착한 환자에서의 방사선치료 -증례 보고 -

우홍균,김보경,강위생,박진흥,Wu Hong-Gyun,Kim Bo-Kyoung,Kang Wee-Saeng,Park Jin Hong 대한방사선종양학회 2000 대한방사선종양학회지 Vol.18 No.1

A 70 years old female patient with thyroid cancer received palliative radiation therapy for neck swelling and hemoptysis. She had a cardiac pacemaker under her chest due to complete AV block since 8 years ago. We present clinical detail and review previously reported articles.

Salivary Gland Cancer - Advances in the Radiation Therapy

우홍균 대한두경부종양학회 2004 대한두경부종양학회 학술대회 논문집 Vol.2004 No.1

설암의 방사선치료

우홍균 대한두경부종양학회 2007 대한두경부종양학회 학술대회 논문집 Vol.2007 No.1

Evaluating Ice Nucleation Ability (INA) of Cellulose for Cloud Seeding Using Droplet Freezing Method

우홍균,이혜미,김정규,박성민,엄준식,이재준 한국고분자학회 2025 한국고분자학회 학술대회 연구논문 초록집 Vol.50 No.1

Morphologically Engineered Cellulose Crystals for Ecofriendly Cloud Seeding

우홍균,이동현,이재준 한국고분자학회 2025 한국고분자학회 학술대회 연구논문 초록집 Vol.50 No.2

New Fiduciary Plate and Orientation Marker forHigh Energy Radiation Therapy

우홍균,허순녕,김학재 대한방사선종양학회 2004 대한방사선종양학회지 Vol.22 No.1

Purpose: A new fiduciary plate and orientation marker have been devised to assist the quality assurance (QA) procedures for port films in radiation therapy department. The plate is used in conjunction with the film/cassette combination during weekly QA procedures, at Seoul National University Hospital (SNUH), in order to verify treatment fields in high energy radiation therapy. Materials and Methods: A new fiduciary plate was fabricated using an acrylic plate, cerrobend, standard blocking tray and mercury. The acrylic plate had the dimension of 1×25×25 cm, with two fiduciary markers. The plate was rigidly attached onto the standard blocking tray, thus making it easier to set the fiduciary plate to the center of the radiation field of the linear accelerator. The plate had two 2-mm vertical and horizontal lines, with the minor scales in 2-cm steps. The orientation marker was a small mercury filled disk, which was inserted into the plate. Results: The geometrical structure of the lines in the plate makes it easier to correlate two different images between the simulation and port films. The marker clearly indicated the orientation of the film, for example, the anterior, posterior, left, right and various oblique orientations, without the placement of a conventional orientation marker. Also, the new orientation marker could easily be applied to the simulator by placing the small orientation marker onto the image intensifier or in front of the film/cassette holder. Conclusions: The new fiduciary plate appears to be useful in verifying the treatment fields, and the new orientation marker makes the film orientation simple, which is expected to lower the block fabrication errors. 목 적: 선형가속기를 이용한 방사선 치료시 치료부위의 확인을 위한 하나의 방법으로 port film이 사용되고 있다. 서울대학병원에서는 port film 촬영 시 기계적 변수를 port film상에 나타내기 위하여 방향성 표시기(orientation marker)를 갖는 fiduciary plate를 개발하였다. 대상 및 방법: Fiduciary plate의 제작에는 아크릴 plate와 cerrobend, 수은이 사용되었다. 아크릴 plate의 크기는 1 cm×25 cm×25 cm로 그 내부에 두 개의 방향성 표시기가 내재되었고, 선형가속기의 blocking tray slot에 삽입이 가능하도록 제작되었다. Plate 내부에는 2 cm 간격으로 2 mm 두께의 수평과 수직으로 만들어진 cerrobend line이 위치해 있고, 방향성 표시기 내부에는 수은으로 채워져 있다. 결 과: 아크릴 plate의 cerrobend line은 simulation films과 port films간의 치료 영역의 비교를 용이하게 한다. 수은을 이용하여 만들어진 방향성 표시기는 납으로 만들어진 일반적인 표시기가 없이도 전후좌우와 다양한 각도로 경사진 방향을 구분할 수 있게 한다. 또한 방향성 표시기는 film/cassette holder에 부착함으로써 simulation 시에도 이용될 수 있다. 결 론: Fiduciary plate는 치료 영역 확인에 유용하고, 수은을 이용한 방향성 표시기내의 혼합액의 기하학적인 모양에 따라 port film의 촬영 parameter를 용이하게 파악할 수 있어 치료과정에서 촬영한 port film 간의 임상정도관리에 유용한 방법이 될 수 있다.

Significance of Supraclavicular Lymph Node Involvement on Determination of Clinical Staging for Thoracic Esophageal Carcinoma

우홍균,박찬일,하성환,김일한,Wu Hong-Gyun,Park Chan Il,Ha Sung Whan,Kim Il Han The Korean Society for Radiation Oncology 1999 대한방사선종양학회지 Vol.17 No.2

Background and Purpose : Involvement of supraclavicular Iymph nodes (SCL) is considered distant metastasis for thoracic esophageal carcinoma in AJCC staging system revised in 1997. We investigated significance of SCL involvement compared to other regional Iymph node involvement. Materials and Methods : Two-hundred eighty-nine patients with unresectable esophageal carcinoma were treated with radiation therapy from June of 1979 through December 1992. Of these patients, 25 were identified having SCL involvement. Survival rate and relapse patterns were compared with that of mediastinal and perigastric Iymph node positive patients to evaluate prognostic significance of SCL involvement. Results : Median survival for patients with SCL involvement was 7 months and 2- and 5-year overall survival rates were 12.0$\%$ and 4.0$\%$ respectably. Corresponding features for regional node positive patients were 9 month, 17.0$\%$ and 3.8$\%$. There was no significant difference between two groups. There was also no difference in patterns of recurrence. Conclusions : Results of this analysis showed that SCL involvement should be staged as nodal disease in contrast to present classification of metastatic disease.

Radiation Therapy of Testicular Seminoma

우홍균(Hong Gyun Wu),오도훈(Do Hoon Oh),하성환(Sung Whan Ha) 대한방사선종양학회 1994 대한방사선종양학회지 Vol.12 No.3

연구목적 : 고환의 정상피종은 방사선치료에 매우 민감한 종양으로서 초기 정상피종에 있어서 근치적 고환절제술 후 보조적 방사선치료로 좋은 결과를 얻을 수 있는 것으로 알려져 있다. 10년간 서울대학교병원 치료방사선과에서 치료를 받은 28명의 환자를 대상으로 치료성적의 분석을 실시하였다. 대상 및 방법 : 1980년 8월에서 1990년 2월까지 서울대학교병원에서 치료를 받은 고환 정상피종환자 32명을 대상으로 후향적 분석을 하였다. 27명의 환자는 근치적 고환절제술 후에 그리고 5명은 재발 후에 방사선치료를 받았는데 각군에서 2명씩을 불완전한 방사선치료로 연구대상에서 제외되었다. 고환절제술후 치료를 받은 환자들의 병기별 분포는 Ⅰ기 18명, ⅡA기 5명, ⅢB기 1명 ⅡC기 1명이었다. 재발 후 방사선치료를 받은 3명은 첫 진단시 병기를 알 수 없었다. 전체 환자 중 6명 환자에서 동측 고환, 2명에서 반대편 고환, 그리고 1명은 양측에서 잠복고환이 관찰되었다. 후복막 및 골반 임파절에 대한 방사선치료 선량의 중앙치는 2900cGy(1550-4550cGy)이었다. 종격동조사를 시행한 환자는 Ⅰ기 1명, ⅡA기 4명, ⅢB기 1명 그리고 재발된 환자가 1명이었다. 항암화학요법은 ⅡB기 1명, ⅡC기 1명, 재발된 1명에서 방사선치료 전에 시행되었다. 환자들의 중앙추적기간 104개월 (3-144개월)이다. 결과 : 전체 국소치유율은 5년에 1005를 보였고, Ⅰ기 환자 1명에서 종격동 전이로 인한 사망을 보여 생존율은 5년에 Ⅰ기 94.4%, Ⅱ기 100%, 그리고 재발한 경우에서 100%를 보였다. 결론 : 고환 정상피종에 있어서 방사선치료는 근치적 고환절제술 후의 보조적 목적뿐 아니라 국소적으로 재발한 경우에 있어서도 우수한 치료방법으로 생각된다. Purpose : Testicular seminomas are radiosensitive and adjuvant radiation therapy after orchiectomy results in long term survival in early stage diseases. Ten year results of radiation therapy after orchiectomy and results of definitive treatment of recurrent seminoma are presented. Materials and Methods : Between August 1980 and February 1990, 32 patients with testicular seminumas were treated at the Department of Therapeutic Radiology. Seoul National University Hospital. Twenty-seven patients received radiation therapy after orchiectomy and 5 patients for treatment of recurrent tumors. Two of postoperatively treated patients and 2 of recurrent patients wre excluded from the study because of incomplete treatment. Of the patients treated postoperatively. 18 were stage I, 5 were stage ⅡA, on was stage ⅡB, and one was stage ⅡC. There were 4 ipsilateral and 2 contralateral cryptorchids. Preoperatively, β-HCG levels were elevated in 5 patients. Median dose to pelvic and paraaortic lymph node area was 2900 cGy (1550-4550 cGy). One patients with stage Ⅰ, 4 with stage ⅡA, and 1 with stage ⅡB received prophylactic mediastinal irradiation. Two patients were treated with chemotherapy before radiation therapy. Median follow-up period was 104(3-144) months. Results : Local control rates were 100% at 5 years after orchiectomy. five year survival rates were 94.4% in Stage Ⅰ and 100% in Stage Ⅱ patients. One patient with stage Ⅰ disease died 3 months after surgery due to mediastinal metastasis.. All the 3 patients treated for recurrent disease are alive without disease. Conclusion : Postorchiectomy radiation to the pelvis and para-aortic area remains the treatment of choice for patient with early stage testicular seminoma. Radiation therapy is also an excellent treatment modality for recurrent seminoma.