관동화로부터 분리한 sesquiterpene의 nitric oxide synthase 저해활성

정연수,류재하 숙명여자대학교 약학연구소 2004 약학논문집-숙명여자대학교 Vol.20 No.-

Nitric Oxide (NO), derived from L-arginine, is produced by two types of nitric oxide synthases (constitutive NOS: cNOS, inducible NOS: iNOS). The NO produced in large amounts by the iNOS is known to be responsible for the vasodilation and hypotension observed in septic shock and inflammation. The inhibitors of iNOS, thus, may be useful candidates for the treatment of inflammatory diseases accompanied by the overproduction of NO. The activity guided fractionation of the hexane soluble fraction obtained from the methanol extract of Tussilago farfara gave an inhibitory active compound of NO synthesis in LPS-activated macrophages (IC_(50) value was 8.9 μM). The structure of active compound was elucidated as la, 5a-bisacetoxy-8-angeloyloxy-3β, 4β-epoxybisabola-7(14), 10-dien-2-one by spectral analysis. This compound can be a useful candidate for the development of new drugs to treat endotoxemia and inflammation accompanied by the overproduction of NO.

신경회로망을 이용한 이면비드 폭 예측에 관한 연구

정재원,김일수,박창언,김학형,서주환,김인주,심지연 한국공작기계학회 2008 한국공작기계학회 춘계학술대회논문집 Vol.2008 No.-

The development of robotic welding process is a very complex assignment because the system is affected by a number of process parameters which are very difficult to determine or predict in practice. The full automation welding has not yet been achieved partly because the mathematical model for the process parameters of a given welding task is not fully understood and quantified. Several mathematical models to control welding quality, Productivity, micro structure and weld properties in arc welding processed have been studied. However, it is not an easy task to apply them to the various practical situations because the relationship between the process parameters and the bead geometry is non-linear and also they are usually dependent on specific experimental result. Practically, it is difficult, but important to know how to establish a mathematical model that can predict the result of the actual welding process and how to select the optimum welding condition under a certain constraint. In this paper, an attempt has been made to develop an neural network model to predict the back-bead width as a function of key process parameters in the GMA (Gas Metal Arc) welding and to compare the developed models with the experimental results

선천성 결손치에 관한 임상적 연구

정해경,양연미,김재곤,백병주,정진우,김하나,김미아 大韓小兒齒科學會 2009 大韓小兒齒科學會誌 Vol.36 No.2

The congenital missing of teeth is common, which takes place since the proliferation and differentiation are not allowed in that tooth bud fail to start development. The purpose of this study is to research incidence rate, number, and missing part of congenital missing teeth, and to study whether a person who has missing teeth has other abnormality of teeth or not. For this study, 1,520 subjects(aged 2.9~17) who had visited pediatric dentist department of Chonbuk national university dental hospital within 2 years were examined with an panoramic radiograph ; exempting third molar missing state. The obtained results are as follows. 1. 8.88% among total subjects show missing teeth ; male 9.05%, female 8.64% 2. The most frequently missing permanent teeth were the mandibular second premolars(22.3%). The most frequently missing primary teeth are mandibular lateral incisors(50%). 3. 43.3% patients have one permanent missing tooth, 34.3% have two, and 10.4% have more than six, respectively. In primary teeth, 86.7% patients have one missing tooth, and 13.3% have two missing teeth. 4. 18 patients(13.3%) have missing teeth as well as hyperdontia, while some patients have microdont, ectopic eruption, and fusion teeth. 치아의 선천성 결손은 치배의 발육이 시작되지 못하여 치아의 증식, 분화가 일어나지 못함으로서 발생하는 흔한 치아의 발육 이상이다. 이 연구의 목적은 선천성 결손치의 발생률, 결손치의 수, 발생부위와 결손치 환자에게서 나타난 다른 치아이상의 발생여부를 조사하는 것이다. 본 연구는 2006년 7월부터 2008년 6월까지 전북대학교 소아치과에 내원하여 파노라마를 촬영한 1,520명의 환자(2.9~17세)를 대상으로 제 3 대구치를 제외한 선천성 결손치의 분포를 조사하여 다음과 같은 결과를 얻었다. 1. 전체 1,520명 중 총 8.88%에서 결손치가 관찰되었으며, 남자가 9.05%, 여자가 8.64%에서 결손치가 관찰되었다. 2. 총 350개의 영구 결손치 중 하악 제 2 소구치가 22.3%로 가장 발생률이 높았고, 하악 측절치, 상악 제 2 소구치, 하악 중절치, 상악 측절치 순이었다. 또한 총 18개의 유치 결손치 중 하악 유측절치가 가장 높은 발생률(50%)을 보였다. 3. 1개의 영구치 결손치를 가지는 환자는 43.3%, 2개는 34.3%, 3개는 6,7%, 4개는 1.5%, 5개는 3.7%, 6개 이상은 10.4%이었다. 또한 유치 결손치의 수는 1개는 86.7%, 2개는 13.3%이었다. 4. 결손치가 있는 환자 중 과잉치를 가지는 환자는 18명(13.3%)이 있었으며, 왜소치, 이소맹출, 융합치 등의 치아이상을 지닌 환자도 관찰되었다.

제1대구치의 석회화와 맹출 양상

정해경,양연미,김재곤,백병주,소유려 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.3

Among the permanent teeth, the first permanent molars play the greatest role in occlusion and function. So, early diagnosis for congenital missing, abnormal eruption and abnormal formation is very important to the first permanent molars in the course of arch development. The aim of this study is to analyse the differences between right and left first permanent molar's formation and eruption and between upper and lower one. A total of 545 children were selected am ong children who had visited our clinic, investigate eruption and calcification stage of permanent first molar, based on Gleiser and Hunt criteria for this study. 1. Gingival emergence of mandibular first molar is faster than maxillary first molar by 0.75~0.8 years, gingival emergence of maxillary first molar in girls faster than boys by 0.45 years, and that of mandibular first molar in girls faster than boys by 0.5 years. 2. There is the significant difference between right and left first molar on the eruption score and the calcification stage ; 5 year old children show the significant difference on the eruption score. 7 year old children show the significant difference on both the eruption score and calcification stage. 3. It shows the most active eruption movement of crown on the maxilla while the root is rapidly widening its furcation and completing root formation to 2/3, on the other hand, the most active crown emerging on mandible is shown when the root formation completed to 1/4 to 1/2. 제1대구치는 치열의 교합 및 발육에 중요하게 관여하며 기능적, 형태적으로 건전한 교합의 발육 및 유지에 필수적인 치아이다. 치열의 발육과정에 있어서 제1대구치의 형성, 맹출 및 형태의 이상이나 선천결손의 발생여부를 조기에 진단하는 것은 매우 중요하다. 이 연구의 목적은 제1대구치의 맹출과 석회화 양상에 대해 조사하여 형성과 맹출의 상, 하악과 좌, 우 차이에 대해 평가하는 것이다. 2007년 7월부터 2008년 6월까지 전북대학교 치과병원 소아치과에 내원하여 파노라마 방사선사진을 촬영한 545명의 어린이를 대상으로, 제1대구치의 맹출 위치와, Gleiser and Hunt의 석회화단계의 분류를 이용하여 제1대구치의 석회화에 대해 연구한 결과 다음과 같은 결론을 얻었다. 1. 제1대구치의 구강내 출은은 하악 제1대구치의 구강내 출은이 상악 제1대구치의 출은보다 0.75~0.8년 빠르게 일어났으며, 여성은 남성에 비해 상악은 약 0.45년, 하악은 약 0.5년 먼저 출은했다. 2. 제1대구치의 석회화단계와 맹출 정도의 좌, 우 차이는, 5세에서 상악 좌, 우측 맹출 정도와, 7세에서 상악 좌, 우측 맹출정도, 하악 좌, 우측 석회화단계가 유의한 차이를 보였다. 3. 상악은 치근 분지부의 급속한 확대단계와 치근 2/3완성단계 사이에서, 하악은 치근 1/4완성단계와 치근 1/2완성단계 사이에 가장 많은 맹출 이동량을 보였다.

중국유가철학에 있어서의 이성과 욕망의 관계 연구

정상봉,황갑연,전병술,안재호 한국철학사상연구회 2003 시대와 철학 Vol.14 No.2

중국유가철학에서는 공자가 극기복례를 말한 이래 맹자의 과욕론을 제기하면서 욕망의 절제를 강조하였다. 그 근거로는 사람을 도덕이성의 담지자로 규정한 것을 들 수 가 있다. 사람이 살아가면서 욕망을 추구하는 것은 자연스러운 일이다. 욕망을 대표하는 것으로는 식욕ㆍ성욕ㆍ물질적 이익 추구 등이 있지만 욕망의 추구가 도덕이성의 기준, 즉 도리에 합당하지 않다면 욕망을 절제해야 한다는 것이 송대까지의 기본적인 관점이었다. 천리를 보존하고 인욕을 없애야 한다는 신유학의 구호도 사실 공과 사의 기준에 입각하여 주장된 것이다. 그러나 명대에 이후 사회구조에 변화가 생기면서 몸[身]과 욕망[欲]을 중시하는 태주학파가 등장하였고 청대의 왕부지는 욕망 긍정을 주장하게 까지 되었다. 이것은 도덕이성과 욕망의 이분법적 대립구조의 해체를 반영하고 있으며 근대 문화의 초석을 깔았다고 평가할 수 있다. In Chinese Confucianism, Kongzi laid emphasis on Ke-ji-fu-li(克己復禮), and Mengzi insisted upon the theory of unselfishness. It is on the assumption that man has a moral reason innately. As long as we live, it is natural that we pursue our desires, e.g. desire to eatㆍsexual desireㆍthe pursuit of material benefits etc. But if the pursuit of desires didn't appropriate to the standard of moral reason, it needs to control our desires. This is a basic viewpoint till Song Dynasty. The slogan of Neo-Confucianism, "Cun-tienliㆍQu-renyu(存天理ㆍ去人欲)" was based upon the public and private affairs. After Ming Dynasty, as the structure of society has been changed, the school of Taizhou stressed on body and desire. Wang Fu-Zi in Cheng Dynasty affirmed the importance of desires. It represented the destruction of dichotomy between moral reason and desire, and laid the foundation of modern culture.

학령기 아동을 위한 통합적 독서치료 프로그램 개발

채혜정,이재연 숙명여자대학교 아동연구소 2004 兒童硏究 Vol.17 No.2

The purpose of this study was to design and perform the program for school age children. The program was designed to help children understand and express their feeling, and to learn communication skills through the fairy tales. The subjects were 23 children who were 3th graders of M elementary school in Keungkido. These children, teacher and their parents were evaluated to examine the need of elementary school counselling, there children before developing the program. The Bilio-counselling program for elementary school children consisted of a total of 43 sessions in three parts. The present program developed for this study consisted of 20 60-minute sessions by counselor, 18 20-minute sessions in the class by teacher, and 5, 20-minute sessions in home by parents. The content of the program was employed the children counselling approaches such as a biblio therapy, play therapy, art therapy, theraplay, and drama therapy. And the 33 fairy tales were used in the program. The biblio-counselling program employed in the present study was developed and implemented as a multiple counselling program in elementary school to foster the psychological growth of children. However, it is expected that the present program will prove to be useful in effectiveness for elementary school.

개에서 발생한 추간판 탈출증의 수술적 치료 1례

조재금,이재연,정성목,김명철 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2011 動物醫科學硏究誌 Vol.18 No.1

Seven-year old, castrated male pekingese was presented with sudden onset of pain and tetraparesis. He was diagnosed with multiple intervertebral disc disease (lesion: C6-7 [mild], T12-13 [mild], L2-3 [moderate] via MRI in 2006. After undergoing conservative therapy at local hospital, he had more severe symptom in December 2009 than before. In order to identify exact site, he had been taken second MRI and transferred to CNU VMTH. Definitive diagnosis is also multiple intervertebral disc disease (IVDD) with the same lesion except C3-4 (+++). The spinal cord between C3 and C4 is ventrally compressed by intervertebral disc and the compression is much more severe than other lesions. Since the symptoms were severe and took place rapidly and didn't respond to medical treatment, surgical treatment, ventral slot for new lesion(C3-4) was planned. After the ventral compression of spinal cord between C3 and C4 was achieved, he showed enhancement which is gradual return to normal neurologic response, sternal recumbency, and occasional standing. After postoperative treatment at local hospital, he fully recovered to the normal. It was considered that accurate diagnosis timely adequate treatment are essential for the cure of IVDD.

치위생과 학생들의 전공교육 및 직업관에 대한 의식 조사 연구

정재연,최정이 韓國學校保健學會 2000 韓國學校保健學會誌 Vol.13 No.1

For the fBfose of strer]gthening Derltal Hygiene studerlts'confidence and nutivation in the Deltal Hygiene Deparaent and helping consant Wer pffssionalisf survey on Derltal Hygiene studnlts' consciousness of attitude to and satigfEction of the coursE career plan and occupation mind set was carried out 530 ttuee year students in 8 Derltal Hygiene academies in Seoul and Kyonggi pvince were WuestionaE The results of the survny are as follows:. 1. Derltal Hygiene students'rretives consisted pimarily of gieloyrnerlt and a desire fer professionalism 25% of them entered the course after one feilure in the entrance semination and 17% had family mernbns algeing in the dentistry field 84%, the largest portiorL were from an academic high school. 24% had senne howledge of Dental Hygiene, which they had aeluired from seniors, friends, and teachers. 2. Patient car and IreatmBrlt assistance related mattns were not considned important in the cgurst. The weak pints of the course hkned out to be ecUcation in computaT and frreign languages, but the weakest was the ability of patient care during dinical 03inine. S3% had experiences had thought of changing their major while in the course because it didn't rmtch their aptitude and intarst. 3. As for a career after graduatiof 49% worried about it Most students wanted to work at a dental hospital or genafl hospital, The rmst favored duty was coordination or recoption or oral disease reventive wnt They wanted to work untill they had a stable living. 68% answered they would get a job at an oral clinic and 70% said they would continue studying for self-realization. 4. Satisfaction with the rmjor was high in studerlts whose aptitude and interest rmtched the course, who had background hlowledge of the major, and who didn't think of changing the major but would continue studying resulting in statistically slight difference (p$lt;0.001). As to satisfaction with the flrulties, itwas high in the studnlts whose aptitude and intenfst rmtched the major and who didn't think about a career after graduation showing a slight difference (P$lt;05, p$lt;01). As for satisfEction with clinical trainine, studnlts whose aptitude and interest matched the imjor and who didn't consider changing the major answned positively showing a statistically slight difference (p$lt;.001, p$lt;.01). As to satisfaction with the course, it was high in the students who entered with aptitude and interest who had peliminary Dowledge who didn't consider changing the major, and who didn't think about a career after graduation showing a statistically slight difference (p$lt;.001, p$lt;.05). 5. Occupation mind-set w3s positive for students who entned with interest and aptitude, who had reliminary Cowledge, and who had not considered changing the rmjor showing a statistically slight diffennce (p$lt;.001). The higher the satisfaction with the major, feculty and clinical training was, the mme positive the oRrpation mind-set was(p$lt;.001).

數學敎育의 現況分析과 改善方案 (Ⅱ) : 中·高校 數學科 運營과 敎師 現況分析 Analysis of administrations and teachers of today's math. department in the middle and high schools

林在圭,奇宇恒,金演哲,金正遠 慶北大學校 師範大學 1981 敎育硏究誌 Vol.23 No.-

Owing to the curriculum's revision of primary and high school in the beginning of 1970, several elementary concepts of modern mathematics were introduced as new teaching contents. So the efficient ways to reeducate the present teachers and to publish a desirable textbook have been badly needed. In this paper, we investigate the present situations of administration and teachers of mathematics department in the city and rural area. On the basis of these results, we find out the better ways of mathematics education from the following points of view: 1. The general administrations of mathematics department. 2. The reeducation and education for mathematics teachers. 3. Mathematics textbooks. 4. Evaluations and tests.

국내 시판 항생제의 허가 용량 및 용법의 적정성에 대한 고찰 : 국내 약제사용설명서(package insert)와 미국 Physicians' Desk Reference의 비교 Comparison of Domestic Package Inserts with Physicians' Desk Reference

이재갑,이연주,황병연,정혜원,정성주,김성범,정희진,김우주,김민자,박승철 대한감염학회 2003 감염과 화학요법 Vol.35 No.5

목적 : 국내 시판중인 항생제의 1일 투여량과 투여간격의 적정성을 확인하고 적응증 및 중증도에 따른 항생제 용량 제시 여부를 확인하기 위하여 항생제 시판시 KFDA의 허가사항을 담은 약제사용설명서을 미국 FDA 공인 약제에 대한 사용지침으로 쓰이고 있는 PDR(Physicians' Desk Peference)과 비교하였다. 방법 : PDR에 등재되어 있는 항생제 중에서 시럽 및 도포용 항생제를 제외한 총 61종에서, 국내에 시판되어 있는 51종 항생제의 약제사용설명서를 대상으로 1일 투여량, 투약횟수, 적응증 및 중증도에 따른 설명 정도를 비교하였다. 결과 : 1) 1일 투여량 비교 : 비교 가능한 전체 항생제에서, 약제사용설명서가 PDR보다 적은 용량을 제시한 경우는 경구용 8종, 주사용 11종으로 총 19종(37%)였으며, 많은 용량을 제시한 경우는 경구용만 2(4%)종이었고, 동일하거나 비슷한 용량을 제시한 경우는 경구용 15종, 주사용 15종으로 총 30(59%)종이었다. 약제사용설명서에서 적은 용량이 제시된 항생제 중 경구용인 cefdnir, cefixime, cefpodoxime, ofloxacin, levofloxacin, norfloxacin(6종), 주사용인 cefazolin, cefotetan, ceftizoxime, meropenem (4종) 등 반수이상의 약제가 일본제약회사로부터 국내에 수입된 약들이었으며 일본의 약제 사용설명서와 동일한 용량을 제시한 것을 알 수 있다. 2) 투여간격 비교 : 비교가능한 항생제 51종 중에서 국내약제사용설명서가 PDR과 동일한 투약횟수, 투여간격을 제시한 항생제는 30종(59%)이었다. 국내 약제사용설명서가 PDR보다 적은 투약횟수, 긴 투여간격을 제시한 항생제는 9종(17%)이었다. 오히려 많은 투약횟수, 짧은 투여간격을 제시한 항생제가 12종(24%)이나 되었다. 경구용만 비교하였을 경우 국내 약제사용설명서가 PDR보다 적은 투약횟수를 제시한 항생제는 없었으며, 동일하세 제시한 경우는 15종, 빈번한 투약횟수를 제시한 경우는 10종이었다. 주사용 항생제에서 국내 약제사용설명서가 PDR보다 긴 투여간격을 제시한 항생제는 9종, 동일한 경우는 15종, 짧은 투여간격을 제시한 경우는 2종이었다. 3) 적응증 및 중증도에 따른 비교 : 약제사용설명서에서 적응증 또는 중증도에 따른 용량에 대한 설명이 부족한 경우는 경구용 13종, 주사용 7종으로 총 20종(39%)이었으며, PDR에서는 경구용 1종, 주사용 2종으로 총 3종(6%)이었다. 결론 : 항생제에 첨부되는 약제사용설명서 및 약제사용설명서를 바탕으로 편집되는 의약품집이 항생제를 처방하는 의사들이 용법과 용량을 결정함에 있어 참고 역할을 하고 있으나, 국내의 시판 허가사항을 담은 약제사용설명서가 많은 수에서 적응증 또는 중증도에 따른 1일 투여량과 투여간격에 대한 정확한 정보를 제공하고 있지 못하고 있다. Background : The appropriate usage of antibiotics needs informations such as its effectiveness for a given infection, administration route, the amount of effective dose, and the dose intervals. In this study, in order to find any significant discrepancy regarding to the details of explanation of the necessary information for appropriate antibiotic usages, we compares informations about 51 antibiotics, one from package inserts in Korea and the other from physician's desk reference (PDR) certified by FDA in the United States of America. Materials and Methods : Package inserts about antibiotics, only oral or parenteral agent, wereperused to collect three categories of data: the recommended dosage, dose interval, and adjustment of dose to indications or the severity of infection. These data available in Korea were compared with 61 antibiotics (32 oral and 29 parenteral agents) cited in PDR. Results : Package inserts for 51 antibiotics were gathered, because the remaining 10 antibiotics in PDR are not domestically commercialized. Among data on antibiotics comparable with those in PDR, 59% (30 cases: 15 oral and 15 parenteral agents) suggested the dose similar to that of PDR, 37% (19 cases: 8 oral and 11 parenteral agents) recommend less dose, and 4% in only 2 oral agents showed more dose. About half of the drugs recommending lower dosage were imported from Japanese pharmaceutical company, and the recommended doses of these antimicrobial agents were similar to those in Japan. About 59% (30 cases: 15 oral and 15 parenteral agents) directed dose interval or duration similar to those of PDR and 17% (9 parenteral agents) suggested less administration or longer duration. Surprisingly, in contrast to only 6% (3 cases) of PDR, 24% (12 cases : 10 oral and 2 parenteral agents) recommended more administration or shorter duration. About 39% (24 cases: 13 oral and 7 parenteral agents) revealed no information for dose adjustment commons to indications or the severity of infection. Conclusion : This study revealed that many guidelines in Korea recommend lower doses and/or unreasonable dose intervals. In future studies, improved antibiotic usage guidelines should be established based on pharmacokinetic and pharmacodynamic researches, on the aspect of optimal dosage, dose interval, and dose adjustment commensurate to the indications and the severity of the infection.